{"id":"https://openalex.org/W1994031802","doi":"https://doi.org/10.4062/biomolther.2008.16.4.328","title":"Honokiol Potentiates Pentobarbital-Induced Sleeping Behaviors through GABAAReceptor Cl-Channel Activation","display_name":"Honokiol Potentiates Pentobarbital-Induced Sleeping Behaviors through GABAAReceptor Cl-Channel Activation","publication_year":2008,"publication_date":"2008-12-31","ids":{"openalex":"https://openalex.org/W1994031802","doi":"https://doi.org/10.4062/biomolther.2008.16.4.328","mag":"1994031802"},"language":"en","primary_location":{"id":"doi:10.4062/biomolther.2008.16.4.328","doi":"https://doi.org/10.4062/biomolther.2008.16.4.328","is_oa":true,"landing_page_url":"https://doi.org/10.4062/biomolther.2008.16.4.328","pdf_url":"http://koreascience.or.kr:80/article/JAKO200803544701704.pdf","source":{"id":"https://openalex.org/S2593996","display_name":"Biomolecules & Therapeutics","issn_l":"1976-9148","issn":["1976-9148","2005-4483"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","kci-registered","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4362643885","host_organization_name":"Korean Society of Applied Pharmacology","host_organization_lineage":["https://openalex.org/P4362643885"],"host_organization_lineage_names":["Korean Society of Applied Pharmacology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomolecules and Therapeutics","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"http://koreascience.or.kr:80/article/JAKO200803544701704.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100998292","display_name":"Yuan Ma","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I163753206","display_name":"Chungbuk National University","ror":"https://ror.org/02wnxgj78","country_code":"KR","type":"education","lineage":["https://openalex.org/I163753206"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Yuan Ma","raw_affiliation_strings":["Research Institute of Veterinary Medicine, Chungbuk National University, Cheongju 361-763, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Institute of Veterinary Medicine, Chungbuk National University, Cheongju 361-763, Republic of Korea","institution_ids":["https://openalex.org/I163753206"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103521915","display_name":"Hong Ma","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I163753206","display_name":"Chungbuk National University","ror":"https://ror.org/02wnxgj78","country_code":"KR","type":"education","lineage":["https://openalex.org/I163753206"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Hong Ma","raw_affiliation_strings":["College of Pharmacy, Chungbuk National University, Cheongju 361-763, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Pharmacy, Chungbuk National University, Cheongju 361-763, Republic of Korea","institution_ids":["https://openalex.org/I163753206"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077032787","display_name":"Young-Jun Jo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I163753206","display_name":"Chungbuk National University","ror":"https://ror.org/02wnxgj78","country_code":"KR","type":"education","lineage":["https://openalex.org/I163753206"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Young-Jun Jo","raw_affiliation_strings":["College of Pharmacy, Chungbuk National University, Cheongju 361-763, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Pharmacy, Chungbuk National University, Cheongju 361-763, Republic of Korea","institution_ids":["https://openalex.org/I163753206"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102748003","display_name":"Dong-Seon Kim","orcid":"https://orcid.org/0000-0002-1711-0906","observed_orcids":["https://orcid.org/0000-0002-1711-0906"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Dong-Seon Kim","raw_affiliation_strings":["UniGen, Inc, Songjung, Byeongcheon, Cheonan, Chungnam 330-863, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UniGen, Inc, Songjung, Byeongcheon, Cheonan, Chungnam 330-863, Republic of Korea","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076057395","display_name":"Sung\u2010Sick Woo","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sung-Sick Woo","raw_affiliation_strings":["UniGen, Inc, Songjung, Byeongcheon, Cheonan, Chungnam 330-863, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UniGen, Inc, Songjung, Byeongcheon, Cheonan, Chungnam 330-863, Republic of Korea","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083457524","display_name":"Rihua Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I7446070","display_name":"Woosuk University","ror":"https://ror.org/00emz0366","country_code":"KR","type":"education","lineage":["https://openalex.org/I7446070"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Rihua Li","raw_affiliation_strings":["College of Pharmacy, Woosuk University, Chonbuk, Samrye, 565-701, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Pharmacy, Woosuk University, Chonbuk, Samrye, 565-701, Republic of Korea","institution_ids":["https://openalex.org/I7446070"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007610160","display_name":"Jin Tae Hong","orcid":"https://orcid.org/0000-0002-6534-9575","observed_orcids":["https://orcid.org/0000-0002-6534-9575","https://orcid.org/0000-0003-0692-4469"]},"institutions":[{"id":"https://openalex.org/I163753206","display_name":"Chungbuk National University","ror":"https://ror.org/02wnxgj78","country_code":"KR","type":"education","lineage":["https://openalex.org/I163753206"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Jin-Tae Hong","raw_affiliation_strings":["College of Pharmacy, Chungbuk National University, Cheongju 361-763, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Pharmacy, Chungbuk National University, Cheongju 361-763, Republic of Korea","institution_ids":["https://openalex.org/I163753206"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059983071","display_name":"Dong\u2010Cheul Moon","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I163753206","display_name":"Chungbuk National University","ror":"https://ror.org/02wnxgj78","country_code":"KR","type":"education","lineage":["https://openalex.org/I163753206"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Dong-Cheul Moon","raw_affiliation_strings":["College of Pharmacy, Chungbuk National University, Cheongju 361-763, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Pharmacy, Chungbuk National University, Cheongju 361-763, Republic of Korea","institution_ids":["https://openalex.org/I163753206"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059501412","display_name":"Ki\u2010Wan Oh","orcid":"https://orcid.org/0000-0001-8054-9260","observed_orcids":["https://orcid.org/0000-0001-8054-9260"]},"institutions":[{"id":"https://openalex.org/I163753206","display_name":"Chungbuk National University","ror":"https://ror.org/02wnxgj78","country_code":"KR","type":"education","lineage":["https://openalex.org/I163753206"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Ki-Wan Oh","raw_affiliation_strings":["College of Pharmacy, Chungbuk National University, Cheongju 361-763, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Pharmacy, Chungbuk National University, Cheongju 361-763, Republic of Korea","institution_ids":["https://openalex.org/I163753206"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5068325891","display_name":"Jae-Soon Eun","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I7446070","display_name":"Woosuk University","ror":"https://ror.org/00emz0366","country_code":"KR","type":"education","lineage":["https://openalex.org/I7446070"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Jae-Soon Eun","raw_affiliation_strings":["College of Pharmacy, Woosuk University, Chonbuk, Samrye, 565-701, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Pharmacy, Woosuk University, Chonbuk, Samrye, 565-701, Republic of Korea","institution_ids":["https://openalex.org/I7446070"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.0687,"has_fulltext":true,"cited_by_count":15,"citation_normalized_percentile":{"value":0.7957903,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"16","issue":"4","first_page":"328","last_page":"335"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13677","display_name":"Magnolia and Illicium research","score":0.7681000232696533,"subfield":{"id":"https://openalex.org/subfields/2742","display_name":"Rehabilitation"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T13677","display_name":"Magnolia and Illicium research","score":0.7681000232696533,"subfield":{"id":"https://openalex.org/subfields/2742","display_name":"Rehabilitation"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.11749999970197678,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10436","display_name":"Anesthesia and Sedative Agents","score":0.030899999663233757,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/honokiol","display_name":"honokiol","score":1.0},{"id":"https://openalex.org/keywords/pentobarbital","display_name":"pentobarbital","score":0.9620000123977661},{"id":"https://openalex.org/keywords/sleeping-behavior","display_name":"sleeping behavior","score":0.8199999928474426},{"id":"https://openalex.org/keywords/gaba-a-receptor","display_name":"GABAA receptor","score":0.9100000262260437},{"id":"https://openalex.org/keywords/chloride-channels","display_name":"chloride channels","score":0.7770000100135803},{"id":"https://openalex.org/keywords/cerebellar-granule-cells","display_name":"cerebellar granule cells","score":0.9580000042915344},{"id":"https://openalex.org/keywords/gad65-67","display_name":"GAD65/67","score":0.7979999780654907},{"id":"https://openalex.org/keywords/sleep-quality-improvement","display_name":"sleep improvement","score":0.3959999978542328},{"id":"https://openalex.org/keywords/righting-reflex","display_name":"righting reflex","score":0.5759999752044678}],"concepts":[{"id":"https://openalex.org/C2781334404","wikidata":"https://www.wikidata.org/wiki/Q5896650","display_name":"Honokiol","level":2,"score":0.8924562931060791},{"id":"https://openalex.org/C2776755955","wikidata":"https://www.wikidata.org/wiki/Q409632","display_name":"Pentobarbital","level":2,"score":0.8278625011444092},{"id":"https://openalex.org/C131783052","wikidata":"https://www.wikidata.org/wiki/Q7333746","display_name":"Righting reflex","level":3,"score":0.5961558222770691},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5525467991828918},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.5248337388038635},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5127142667770386},{"id":"https://openalex.org/C2779652256","wikidata":"https://www.wikidata.org/wiki/Q130983","display_name":"Cerebellum","level":2,"score":0.46912598609924316},{"id":"https://openalex.org/C168258287","wikidata":"https://www.wikidata.org/wiki/Q60147","display_name":"GABAA receptor","level":3,"score":0.41968560218811035},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3839631676673889},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3599398136138916},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2765691876411438},{"id":"https://openalex.org/C83974742","wikidata":"https://www.wikidata.org/wiki/Q179405","display_name":"Reflex","level":2,"score":0.264032244682312},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2599797248840332},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2588857114315033}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.4062/biomolther.2008.16.4.328","doi":"https://doi.org/10.4062/biomolther.2008.16.4.328","is_oa":true,"landing_page_url":"https://doi.org/10.4062/biomolther.2008.16.4.328","pdf_url":"http://koreascience.or.kr:80/article/JAKO200803544701704.pdf","source":{"id":"https://openalex.org/S2593996","display_name":"Biomolecules & Therapeutics","issn_l":"1976-9148","issn":["1976-9148","2005-4483"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","kci-registered","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4362643885","host_organization_name":"Korean Society of Applied Pharmacology","host_organization_lineage":["https://openalex.org/P4362643885"],"host_organization_lineage_names":["Korean Society of Applied Pharmacology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomolecules and Therapeutics","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.4062/biomolther.2008.16.4.328","doi":"https://doi.org/10.4062/biomolther.2008.16.4.328","is_oa":true,"landing_page_url":"https://doi.org/10.4062/biomolther.2008.16.4.328","pdf_url":"http://koreascience.or.kr:80/article/JAKO200803544701704.pdf","source":{"id":"https://openalex.org/S2593996","display_name":"Biomolecules & Therapeutics","issn_l":"1976-9148","issn":["1976-9148","2005-4483"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","kci-registered","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4362643885","host_organization_name":"Korean Society of Applied Pharmacology","host_organization_lineage":["https://openalex.org/P4362643885"],"host_organization_lineage_names":["Korean Society of Applied Pharmacology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomolecules and Therapeutics","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.766700029373169,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320322349","display_name":"Ministry of Education, Science and Technology","ror":"https://ror.org/01p262204"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1994031802.pdf","grobid_xml":"https://content.openalex.org/works/W1994031802.grobid-xml"},"referenced_works_count":39,"referenced_works":["https://openalex.org/W175721692","https://openalex.org/W1597102052","https://openalex.org/W1965334496","https://openalex.org/W1965892484","https://openalex.org/W1972475208","https://openalex.org/W1974992652","https://openalex.org/W1977647185","https://openalex.org/W1978453275","https://openalex.org/W1979955228","https://openalex.org/W1986888271","https://openalex.org/W1988725623","https://openalex.org/W1996630711","https://openalex.org/W2012713479","https://openalex.org/W2014598010","https://openalex.org/W2015738565","https://openalex.org/W2016011459","https://openalex.org/W2016707261","https://openalex.org/W2022378061","https://openalex.org/W2023013953","https://openalex.org/W2029725104","https://openalex.org/W2044356399","https://openalex.org/W2051797430","https://openalex.org/W2052705350","https://openalex.org/W2056945518","https://openalex.org/W2062186332","https://openalex.org/W2063272372","https://openalex.org/W2063544265","https://openalex.org/W2063938916","https://openalex.org/W2064887450","https://openalex.org/W2075984442","https://openalex.org/W2080890378","https://openalex.org/W2082007973","https://openalex.org/W2083702798","https://openalex.org/W2088521360","https://openalex.org/W2106001183","https://openalex.org/W2113373744","https://openalex.org/W2137084591","https://openalex.org/W2419041405","https://openalex.org/W2949998354"],"related_works":["https://openalex.org/W1986083079","https://openalex.org/W1986140004","https://openalex.org/W2005127981","https://openalex.org/W2092236355","https://openalex.org/W2062215749","https://openalex.org/W1562600987","https://openalex.org/W1994242711","https://openalex.org/W2022356161","https://openalex.org/W6977744223","https://openalex.org/W2056221262"],"abstract_inverted_index":{"This":[0],"study":[1],"was":[2,52,70],"undertaken":[3],"to":[4,45,87],"investigate":[5],"whether":[6],"honokiol":[7,164,181],"could":[8,182],"enhance":[9],"the":[10,26,46,49,61,67,73,89,99,111,141,152,173],"pentobarbitalinduced":[11],"sleeping":[12,55,75,112,185],"behaviors":[13],"through":[14,186],"$\\gamma$":[15,157],"-aminobutyric":[16],"acid":[17],"(GABA)":[18],"receptor":[19,93,143,188],"$Cl^-$":[20,81,96,130,189],"channel":[21,190],"activation.":[22,191],"Thirty":[23],"minutes":[24],"after":[25],"oral":[27],"administration":[28],"of":[29,48,66,91,154,175],"honokiol,":[30],"mice":[31],"were":[32,85],"received":[33],"sodium":[34],"pentobarbital":[35,43,116],"(42":[36,117],"mg/kg,":[37],"i.p.).":[38],"The":[39,57,177],"time":[40,58,113],"elapsed":[41,59],"from":[42],"injection":[44],"loss":[47,62],"righting":[50,68],"reflex":[51,69],"taken":[53],"as":[54,72],"latency.":[56],"between":[60],"and":[63,80,95,107,125,138],"voluntary":[64],"recovery":[65],"considered":[71],"total":[74],"time.":[76],"Western":[77],"blot":[78],"technique":[79],"sensitive":[82],"fluorescence":[83],"probe":[84],"used":[86],"detect":[88],"expression":[90],"$GABA_A$":[92,142,187],"subunits":[94],"influx":[97,131],"in":[98,119,132,165],"primary":[100,133,166],"cultured":[101,134,167],"cerebellar":[102,135,168],"granule":[103,136],"cells.":[104],"Honokiol":[105,123],"(0.1":[106],"0.2":[108],"mg/kg)":[109,118],"prolonged":[110],"induced":[114],"by":[115],"a":[120],"dosage-dependent":[121],"manner.":[122],"(20":[124],"50":[126],"${\\mu}M$":[127,163],")":[128],"increased":[129,140],"cells,":[137],"selectively":[139],"$\\alpha$":[144],"-subunit":[145],"expression,":[146],"but":[147],"had":[148],"no":[149],"effect":[150],"on":[151],"abundance":[153,174],"$\\beta$":[155],"or":[156],"-subunits.":[158],"Chronic":[159],"treatment":[160],"with":[161],"20":[162],"neurons":[169],"did":[170],"not":[171],"affect":[172],"GAD65/67.":[176],"results":[178],"suggested":[179],"that":[180],"potentiate":[183],"pentobarbital-induced":[184]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2016-06-24T00:00:00"}