{"id":"https://openalex.org/W1994030997","doi":"https://doi.org/10.1159/000063228","title":"Superoxide Anion Production by Granulocytes Incubated with HeLa 229 Cells Persistently Infected with Influenza Virus B/Lee/40","display_name":"Superoxide Anion Production by Granulocytes Incubated with HeLa 229 Cells Persistently Infected with Influenza Virus B/Lee/40","publication_year":2002,"publication_date":"2002-01-01","ids":{"openalex":"https://openalex.org/W1994030997","doi":"https://doi.org/10.1159/000063228","mag":"1994030997","pmid":"https://pubmed.ncbi.nlm.nih.gov/12145537"},"language":"en","primary_location":{"id":"doi:10.1159/000063228","doi":"https://doi.org/10.1159/000063228","is_oa":false,"landing_page_url":"https://doi.org/10.1159/000063228","pdf_url":null,"source":{"id":"https://openalex.org/S64836871","display_name":"Intervirology","issn_l":"0300-5526","issn":["0300-5526","1423-0100"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","medline","norway-1","oarl","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310317820","host_organization_name":"Karger Publishers","host_organization_lineage":["https://openalex.org/P4310317820"],"host_organization_lineage_names":["Karger Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Intervirology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5064522764","display_name":"Yukiharu Hayase","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I146500386","display_name":"Jichi Medical University","ror":"https://ror.org/010hz0g26","country_code":"JP","type":"education","lineage":["https://openalex.org/I146500386"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yukiharu Hayase","raw_affiliation_strings":["Department of Virology, Jichi Medical School, Tochigi, Japan. yuhayase@jichi.ac.jp","Department of Virology, Jichi Medical School, Tochigi, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Virology, Jichi Medical School, Tochigi, Japan. yuhayase@jichi.ac.jp","institution_ids":["https://openalex.org/I146500386"]},{"raw_affiliation_string":"Department of Virology, Jichi Medical School, Tochigi, Japan","institution_ids":["https://openalex.org/I146500386"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110132691","display_name":"Kiyotake Tobita","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kiyotake Tobita","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":1250,"currency":"CHF","value_usd":1250},"apc_paid":null,"fwci":0.1054,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.43372267,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"45","issue":"2","first_page":"67","last_page":"70"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11597","display_name":"Neutrophil, Myeloperoxidase and Oxidative Mechanisms","score":0.6869999766349792,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11597","display_name":"Neutrophil, Myeloperoxidase and Oxidative Mechanisms","score":0.6869999766349792,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10167","display_name":"Influenza Virus Research Studies","score":0.28859999775886536,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.0027000000700354576,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/superoxide-radicals","display_name":"superoxide","score":0.9179999828338623},{"id":"https://openalex.org/keywords/granulocytes","display_name":"granulocytes","score":0.9010000228881836},{"id":"https://openalex.org/keywords/viral-persistence","display_name":"viral persistence","score":0.8610000014305115},{"id":"https://openalex.org/keywords/hela-229-cells","display_name":"HeLa 229 cells","score":0.8920000195503235},{"id":"https://openalex.org/keywords/fmlp-stimulation","display_name":"fMLP stimulation","score":0.6119999885559082},{"id":"https://openalex.org/keywords/cytotoxicity","display_name":"cytotoxicity","score":0.7300000190734863},{"id":"https://openalex.org/keywords/latent-phase","display_name":"latent phase","score":0.32199999690055847},{"id":"https://openalex.org/keywords/polyclonal-antibodies","display_name":"polyclonal antibodies","score":0.4569999873638153}],"concepts":[{"id":"https://openalex.org/C2780795997","wikidata":"https://www.wikidata.org/wiki/Q413283","display_name":"Superoxide","level":3,"score":0.839173436164856},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5992806553840637},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.5969729423522949},{"id":"https://openalex.org/C2777366897","wikidata":"https://www.wikidata.org/wiki/Q847482","display_name":"HeLa","level":3,"score":0.552722692489624},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.5223849415779114},{"id":"https://openalex.org/C956191","wikidata":"https://www.wikidata.org/wiki/Q930144","display_name":"Polyclonal antibodies","level":3,"score":0.4892866313457489},{"id":"https://openalex.org/C2777546802","wikidata":"https://www.wikidata.org/wiki/Q834390","display_name":"Influenza A virus","level":3,"score":0.4852728545665741},{"id":"https://openalex.org/C2911126560","wikidata":"https://www.wikidata.org/wiki/Q51916573","display_name":"Influenzavirus B","level":5,"score":0.47043153643608093},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.4383578300476074},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.4291737675666809},{"id":"https://openalex.org/C25642318","wikidata":"https://www.wikidata.org/wiki/Q1992532","display_name":"Incubation","level":2,"score":0.42208653688430786},{"id":"https://openalex.org/C2781416681","wikidata":"https://www.wikidata.org/wiki/Q287246","display_name":"Orthomyxoviridae","level":4,"score":0.4031285047531128},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.30004632472991943},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.19040745496749878},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.1622018814086914},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.1398651897907257}],"mesh":[{"descriptor_ui":"D000914","descriptor_name":"Antibodies, Viral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003574","descriptor_name":"Cytochrome c Group","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006098","descriptor_name":"Granulocytes","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D006367","descriptor_name":"HeLa Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009981","descriptor_name":"Influenza B virus","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D010084","descriptor_name":"Oxidation-Reduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013481","descriptor_name":"Superoxides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D020133","descriptor_name":"Reverse Transcriptase Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066298","descriptor_name":"In Vitro Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1159/000063228","doi":"https://doi.org/10.1159/000063228","is_oa":false,"landing_page_url":"https://doi.org/10.1159/000063228","pdf_url":null,"source":{"id":"https://openalex.org/S64836871","display_name":"Intervirology","issn_l":"0300-5526","issn":["0300-5526","1423-0100"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","medline","norway-1","oarl","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310317820","host_organization_name":"Karger Publishers","host_organization_lineage":["https://openalex.org/P4310317820"],"host_organization_lineage_names":["Karger Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Intervirology","raw_type":"journal-article"},{"id":"pmid:12145537","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12145537","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Intervirology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":16,"referenced_works":["https://openalex.org/W1979386084","https://openalex.org/W1986873057","https://openalex.org/W1998083617","https://openalex.org/W2022253114","https://openalex.org/W2027888325","https://openalex.org/W2039409172","https://openalex.org/W2050673652","https://openalex.org/W2065152876","https://openalex.org/W2066252710","https://openalex.org/W2070409266","https://openalex.org/W2105102773","https://openalex.org/W2117757513","https://openalex.org/W2148168338","https://openalex.org/W2282755628","https://openalex.org/W2333229677","https://openalex.org/W4301735840"],"related_works":["https://openalex.org/W2148168338","https://openalex.org/W2333229677","https://openalex.org/W1759771635","https://openalex.org/W1832990773","https://openalex.org/W7100944125","https://openalex.org/W2750601736","https://openalex.org/W2181547996","https://openalex.org/W2121679723","https://openalex.org/W2154106112","https://openalex.org/W2069353978"],"abstract_inverted_index":{"OBJECTIVE:":[0],"The":[1,28,115],"purpose":[2],"of":[3,30,49,65,146,171],"this":[4],"study":[5],"was":[6,55,82],"to":[7,14,124,167],"determine":[8],"whether":[9],"granulocytes":[10,54,87,166,179],"can":[11],"be":[12],"primed":[13,165],"produce":[15,168],"superoxide":[16,50,66,172],"anion":[17,51,67],"by":[18,52,57,105,111,121,177],"incubation":[19,33],"with":[20,24,34,40,71,80,86,89],"cells":[21,37,73,95,128,160],"persistently":[22,38],"infected":[23,39],"influenza":[25,41,156,185],"viruses.":[26],"METHODS:":[27],"effect":[29],"in":[31,74,96,129,161,183,190],"vitro":[32],"HeLa":[35,91],"229":[36,92],"virus":[42],"B/Lee/40":[43],"(He/Le":[44],"cells)":[45],"on":[46,158],"the":[47,75,97,125,130,147,162],"generation":[48],"human":[53],"examined":[56],"a":[58],"cytochrome":[59],"c":[60],"reduction":[61],"assay.":[62],"RESULTS:":[63],"Generation":[64],"from":[68],"granulocytes,":[69],"preincubated":[70,88],"He/Le":[72,94,127,159],"productive":[76,98,148,163],"phase":[77,99,149,164],"and":[78,107,137],"stimulated":[79],"formyl-methionine-leucine-phenylalanine,":[81],"significantly":[83],"enhanced":[84],"compared":[85],"uninfected":[90],"cells.":[93],"were":[100,118],"positive":[101],"for":[102,108,134],"viral":[103,109,135,138],"proteins":[104,136],"immunofluorescence":[106],"particles":[110],"scanning":[112],"electron":[113],"microscopy.":[114],"priming":[116],"effects":[117],"concentration-dependently":[119],"inhibited":[120],"polyclonal":[122],"antibodies":[123],"virus.":[126],"latent":[131],"phase,":[132],"negative":[133],"particles,":[139],"did":[140,150],"not":[141,151],"prime":[142,152],"granulocytes.":[143,153],"Culture":[144],"supernatants":[145],"CONCLUSION:":[154],"Unreleased":[155],"viruses":[157],"excessive":[169],"amounts":[170],"anion,":[173],"suggesting":[174],"that":[175],"cytotoxicity":[176],"hyperresponsive":[178],"could":[180],"take":[181],"place":[182],"persistent":[184],"infection":[186],"as":[187,189],"well":[188],"acute":[191],"infection.":[192]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}