{"id":"https://openalex.org/W1994009442","doi":"https://doi.org/10.1523/jneurosci.5317-07.2008","title":"A Specific Role for Ca2+-Dependent Adenylyl Cyclases in Recovery from Adaptive Presynaptic Silencing","display_name":"A Specific Role for Ca2+-Dependent Adenylyl Cyclases in Recovery from Adaptive Presynaptic Silencing","publication_year":2008,"publication_date":"2008-05-14","ids":{"openalex":"https://openalex.org/W1994009442","doi":"https://doi.org/10.1523/jneurosci.5317-07.2008","mag":"1994009442","pmid":"https://pubmed.ncbi.nlm.nih.gov/18480272","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2684782"},"language":"en","primary_location":{"id":"doi:10.1523/jneurosci.5317-07.2008","doi":"https://doi.org/10.1523/jneurosci.5317-07.2008","is_oa":true,"landing_page_url":"https://doi.org/10.1523/jneurosci.5317-07.2008","pdf_url":"https://www.jneurosci.org/content/jneuro/28/20/5159.full.pdf","source":{"id":"https://openalex.org/S5555990","display_name":"Journal of Neuroscience","issn_l":"0270-6474","issn":["0270-6474","1529-2401"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319739","host_organization_name":"Society for Neuroscience","host_organization_lineage":["https://openalex.org/P4310319739"],"host_organization_lineage_names":["Society for Neuroscience"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Neuroscience","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://www.jneurosci.org/content/jneuro/28/20/5159.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5066244105","display_name":"Krista L. Moulder","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Krista L. Moulder","raw_affiliation_strings":["Department of Psychiatry, Washington University School of Medicine, St. Louis, Missouri 63110, USA. moulderk@psychiatry.wustl.edu","Department of Psychiatry, Washington University School of Medicine, St. Louis, Missouri 63110, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, Washington University School of Medicine, St. Louis, Missouri 63110, USA. moulderk@psychiatry.wustl.edu","institution_ids":["https://openalex.org/I204465549"]},{"raw_affiliation_string":"Department of Psychiatry, Washington University School of Medicine, St. Louis, Missouri 63110, USA","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101669592","display_name":"Xiaoping Jiang","orcid":"https://orcid.org/0000-0002-5160-4037","observed_orcids":["https://orcid.org/0000-0002-5160-4037"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xiaoping Jiang","raw_affiliation_strings":["Department of Psychiatry , Washington University School of Medicine , 660 South Euclid Avenue , Box 8134 , St. Louis , MO 63110","Washington University \u2013 St Louis"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry , Washington University School of Medicine , 660 South Euclid Avenue , Box 8134 , St. Louis , MO 63110","institution_ids":["https://openalex.org/I204465549"]},{"raw_affiliation_string":"Washington University \u2013 St Louis","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048087900","display_name":"ChunYun Chang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"ChunYun Chang","raw_affiliation_strings":["Graduate Program in Development , Washington University School of Medicine , St. Louis , Missouri 63110","Washington University \u2013 St Louis"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Graduate Program in Development , Washington University School of Medicine , St. Louis , Missouri 63110","institution_ids":["https://openalex.org/I204465549"]},{"raw_affiliation_string":"Washington University \u2013 St Louis","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111763326","display_name":"Amanda Taylor","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Amanda A. Taylor","raw_affiliation_strings":["Department of Psychiatry , Washington University School of Medicine , 660 South Euclid Avenue , Box 8134 , St. Louis , MO 63110","Washington University \u2013 St Louis"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry , Washington University School of Medicine , 660 South Euclid Avenue , Box 8134 , St. Louis , MO 63110","institution_ids":["https://openalex.org/I204465549"]},{"raw_affiliation_string":"Washington University \u2013 St Louis","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053236515","display_name":"Ann M. Benz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ann M. Benz","raw_affiliation_strings":["Department of Psychiatry , Washington University School of Medicine , 660 South Euclid Avenue , Box 8134 , St. Louis , MO 63110","Washington University \u2013 St Louis"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry , Washington University School of Medicine , 660 South Euclid Avenue , Box 8134 , St. Louis , MO 63110","institution_ids":["https://openalex.org/I204465549"]},{"raw_affiliation_string":"Washington University \u2013 St Louis","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049437745","display_name":"Alana C. Conti","orcid":"https://orcid.org/0000-0003-1384-4950","observed_orcids":["https://orcid.org/0000-0003-1384-4950"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alana C. Conti","raw_affiliation_strings":["Departments of 1 Psychiatry , Pediatrics ,","Washington University \u2013 St Louis"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of 1 Psychiatry , Pediatrics ,","institution_ids":[]},{"raw_affiliation_string":"Washington University \u2013 St Louis","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080833691","display_name":"Louis J. Muglia","orcid":"https://orcid.org/0000-0002-0301-8770","observed_orcids":["https://orcid.org/0000-0002-0301-8770"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Louis J. Muglia","raw_affiliation_strings":["Departments of 1 Psychiatry , Pediatrics ,","Developmental Biology , and","Washington University \u2013 St Louis"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of 1 Psychiatry , Pediatrics ,","institution_ids":[]},{"raw_affiliation_string":"Developmental Biology , and","institution_ids":[]},{"raw_affiliation_string":"Washington University \u2013 St Louis","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5013396820","display_name":"Steven J. Mennerick","orcid":"https://orcid.org/0000-0003-0868-0664","observed_orcids":["https://orcid.org/0000-0003-0868-0664"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Steven Mennerick","raw_affiliation_strings":["Anatomy and Neurobiology , and","Washington University \u2013 St Louis"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Anatomy and Neurobiology , and","institution_ids":[]},{"raw_affiliation_string":"Washington University \u2013 St Louis","institution_ids":["https://openalex.org/I204465549"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I204465549"],"apc_list":null,"apc_paid":null,"fwci":2.2498,"has_fulltext":true,"cited_by_count":55,"citation_normalized_percentile":{"value":0.86257457,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":99},"biblio":{"volume":"28","issue":"20","first_page":"5159","last_page":"5168"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10448","display_name":"Memory and Neural Mechanisms","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/adenylyl-cyclase-1","display_name":"adenylyl cyclase 1","score":0.8299999833106995},{"id":"https://openalex.org/keywords/adenylyl-cyclase-8","display_name":"adenylyl cyclase 8","score":0.9990000128746033},{"id":"https://openalex.org/keywords/camp-signaling","display_name":"cAMP signaling","score":0.9449999928474426},{"id":"https://openalex.org/keywords/synaptic-plasticity","display_name":"synaptic plasticity","score":0.9160000085830688},{"id":"https://openalex.org/keywords/forskolin","display_name":"forskolin","score":0.6060000061988831},{"id":"https://openalex.org/keywords/synaptic-depression","display_name":"synaptic depression","score":0.3199999928474426},{"id":"https://openalex.org/keywords/glutamate-signaling","display_name":"glutamate signaling","score":0.5379999876022339}],"concepts":[{"id":"https://openalex.org/C4141045","wikidata":"https://www.wikidata.org/wiki/Q83183","display_name":"Depolarization","level":2,"score":0.6467922925949097},{"id":"https://openalex.org/C2779178603","wikidata":"https://www.wikidata.org/wiki/Q356257","display_name":"Adenylyl cyclase","level":3,"score":0.6403989195823669},{"id":"https://openalex.org/C197341189","wikidata":"https://www.wikidata.org/wiki/Q863533","display_name":"Postsynaptic potential","level":3,"score":0.6221519708633423},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5724828243255615},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.5687037706375122},{"id":"https://openalex.org/C61174792","wikidata":"https://www.wikidata.org/wiki/Q420510","display_name":"Glutamate receptor","level":3,"score":0.49369725584983826},{"id":"https://openalex.org/C98229152","wikidata":"https://www.wikidata.org/wiki/Q1551556","display_name":"Synaptic plasticity","level":3,"score":0.46823209524154663},{"id":"https://openalex.org/C2779276759","wikidata":"https://www.wikidata.org/wiki/Q412747","display_name":"Forskolin","level":3,"score":0.45280930399894714},{"id":"https://openalex.org/C119056186","wikidata":"https://www.wikidata.org/wiki/Q1431332","display_name":"Gene silencing","level":3,"score":0.4297049045562744},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3302302956581116},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.2578304409980774},{"id":"https://openalex.org/C24998067","wikidata":"https://www.wikidata.org/wiki/Q4114622","display_name":"Stimulation","level":2,"score":0.19619661569595337},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.09826496243476868},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.09256136417388916},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000200","descriptor_name":"Action Potentials","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D000222","descriptor_name":"Adaptation, Physiological","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D000242","descriptor_name":"Cyclic AMP","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D000262","descriptor_name":"Adenylyl Cyclases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000262","descriptor_name":"Adenylyl Cyclases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002490","descriptor_name":"Central Nervous System","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D002490","descriptor_name":"Central Nervous System","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D004734","descriptor_name":"Energy Metabolism","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D005089","descriptor_name":"Exocytosis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006706","descriptor_name":"Homeostasis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009433","descriptor_name":"Neural Inhibition","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D009435","descriptor_name":"Synaptic Transmission","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D017729","descriptor_name":"Presynaptic Terminals","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018698","descriptor_name":"Glutamic Acid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020013","descriptor_name":"Calcium Signaling","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D025461","descriptor_name":"Feedback, Physiological","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1523/jneurosci.5317-07.2008","doi":"https://doi.org/10.1523/jneurosci.5317-07.2008","is_oa":true,"landing_page_url":"https://doi.org/10.1523/jneurosci.5317-07.2008","pdf_url":"https://www.jneurosci.org/content/jneuro/28/20/5159.full.pdf","source":{"id":"https://openalex.org/S5555990","display_name":"Journal of Neuroscience","issn_l":"0270-6474","issn":["0270-6474","1529-2401"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319739","host_organization_name":"Society for Neuroscience","host_organization_lineage":["https://openalex.org/P4310319739"],"host_organization_lineage_names":["Society for Neuroscience"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Neuroscience","raw_type":"journal-article"},{"id":"pmid:18480272","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18480272","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of neuroscience : the official journal of the Society for Neuroscience","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2684782","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC2684782/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Neurosci","raw_type":"Text"},{"id":"pmh:oai:europepmc.org:1443234","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/articles/PMC2684782","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:digitalcommons.wayne.edu:med_neurosurgery-1006","doi":null,"is_oa":false,"landing_page_url":"https://digitalcommons.wayne.edu/med_neurosurgery/7","pdf_url":null,"source":{"id":"https://openalex.org/S171990522","display_name":"Human Biology","issn_l":"0018-7143","issn":["0018-7143","1534-6617"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","erih-plus","jufo-1","norway-1","poland-40","russia-white-list-1"],"host_organization":"https://openalex.org/P4310316469","host_organization_name":"Wayne State University Press","host_organization_lineage":["https://openalex.org/P4310316469"],"host_organization_lineage_names":["Wayne State University Press"],"type":"journal"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Neurosurgery Faculty Publications","raw_type":"article"},{"id":"mag:2187627270","doi":null,"is_oa":false,"landing_page_url":"https://www.jneurosci.org/content/28/20/5159.full.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"doi:10.1523/jneurosci.5317-07.2008","doi":"https://doi.org/10.1523/jneurosci.5317-07.2008","is_oa":true,"landing_page_url":"https://doi.org/10.1523/jneurosci.5317-07.2008","pdf_url":"https://www.jneurosci.org/content/jneuro/28/20/5159.full.pdf","source":{"id":"https://openalex.org/S5555990","display_name":"Journal of Neuroscience","issn_l":"0270-6474","issn":["0270-6474","1529-2401"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319739","host_organization_name":"Society for Neuroscience","host_organization_lineage":["https://openalex.org/P4310319739"],"host_organization_lineage_names":["Society for Neuroscience"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Neuroscience","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1655780616","display_name":"Genetic Analysis of Ethanol Sensitivity in Mice","funder_award_id":"R01AA012957","funder_id":"https://openalex.org/F4320337330","funder_display_name":"National Institute on Alcohol Abuse and Alcoholism"},{"id":"https://openalex.org/G2632464076","display_name":"Axonal Signaling in the Hippocampus","funder_award_id":"R01NS054174","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G3591310947","display_name":"Washington University Center for Translational Neuroscience","funder_award_id":"P30NS057105","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G5707074576","display_name":"CONTROL OF SYNAPTIC GLUTAMATE RELEASE","funder_award_id":"R01MH078823","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"},{"id":"https://openalex.org/G8212113217","display_name":"Adenylyl Cyclases in the Behavioral Response to Stress","funder_award_id":"R01AG018876","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G8781069333","display_name":"Homeostatic Effects of Activity on Neurotransmission","funder_award_id":"K01DA018109","funder_id":"https://openalex.org/F4320337347","funder_display_name":"National Institute on Drug Abuse"}],"funders":[{"id":"https://openalex.org/F4320306229","display_name":"American Health Assistance Foundation","ror":"https://ror.org/03cvfxv40"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337330","display_name":"National Institute on Alcohol Abuse and Alcoholism","ror":"https://ror.org/02jzrsm59"},{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"},{"id":"https://openalex.org/F4320337346","display_name":"National Institute of Mental Health","ror":"https://ror.org/04xeg9z08"},{"id":"https://openalex.org/F4320337347","display_name":"National Institute on Drug Abuse","ror":"https://ror.org/00fq5cm18"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1994009442.pdf","grobid_xml":"https://content.openalex.org/works/W1994009442.grobid-xml"},"referenced_works_count":46,"referenced_works":["https://openalex.org/W1481828225","https://openalex.org/W1482358500","https://openalex.org/W1573090244","https://openalex.org/W1818600491","https://openalex.org/W1965960354","https://openalex.org/W1972644575","https://openalex.org/W1983682905","https://openalex.org/W1988189113","https://openalex.org/W1993378387","https://openalex.org/W1994896596","https://openalex.org/W2006214613","https://openalex.org/W2008792865","https://openalex.org/W2011264238","https://openalex.org/W2012199594","https://openalex.org/W2012666208","https://openalex.org/W2015629948","https://openalex.org/W2015701831","https://openalex.org/W2017506170","https://openalex.org/W2018461674","https://openalex.org/W2020246535","https://openalex.org/W2031071883","https://openalex.org/W2031848247","https://openalex.org/W2051524905","https://openalex.org/W2052969380","https://openalex.org/W2055374196","https://openalex.org/W2055746023","https://openalex.org/W2058712930","https://openalex.org/W2063423731","https://openalex.org/W2076837924","https://openalex.org/W2081841874","https://openalex.org/W2091013445","https://openalex.org/W2092949773","https://openalex.org/W2096258030","https://openalex.org/W2105100736","https://openalex.org/W2113408108","https://openalex.org/W2118233379","https://openalex.org/W2125638123","https://openalex.org/W2134700332","https://openalex.org/W2136425602","https://openalex.org/W2141315977","https://openalex.org/W2143397316","https://openalex.org/W2144607109","https://openalex.org/W2153700958","https://openalex.org/W2166291087","https://openalex.org/W2169528566","https://openalex.org/W2297631995"],"related_works":["https://openalex.org/W1992482740","https://openalex.org/W2054343388","https://openalex.org/W2162715513","https://openalex.org/W7132918688","https://openalex.org/W1481828225","https://openalex.org/W2400896074","https://openalex.org/W1989611834","https://openalex.org/W2091865834","https://openalex.org/W1984931692","https://openalex.org/W7070751012"],"abstract_inverted_index":{"Glutamate":[0],"generates":[1],"fast":[2],"postsynaptic":[3],"depolarization":[4],"throughout":[5],"the":[6,71,74,78,89,100,126,135,153,173,196,217,235],"CNS.":[7],"The":[8,191],"positive-feedback":[9],"nature":[10],"of":[11,33,73,91,99,113,156,182,195,237],"glutamate":[12],"signaling":[13,115],"likely":[14],"necessitates":[15],"flexible":[16],"adaptive":[17,29],"mechanisms":[18,46,61],"that":[19,47,105],"help":[20],"prevent":[21],"runaway":[22],"excitation.":[23],"We":[24,207],"have":[25],"previously":[26],"explored":[27],"presynaptic":[28,64,96,179],"silencing,":[30,180],"a":[31,228],"form":[32],"synaptic":[34],"plasticity":[35],"produced":[36],"by":[37,42],"ongoing":[38],"neuronal":[39],"activity":[40,215],"and":[41,51,83,110,124,140,151,167,222],"strong":[43,178,245],"depolarization.":[44],"Unsilencing":[45],"maintain":[48],"active":[49,84,118,141,157,223,238],"synapses":[50,104,158,241],"restore":[52],"normal":[53,183,211],"function":[54,93,184],"after":[55,94,177,242],"adaptation":[56,243],"are":[57,106,131],"also":[58],"important,":[59],"but":[60,203,225],"underlying":[62],"such":[63],"reactivation":[65],"remain":[66],"unexplored.":[67],"Here":[68],"we":[69],"investigate":[70],"involvement":[72],"cAMP":[75,101,114],"pathway":[76,102],"in":[77,149,172,188,201,232],"basal":[79],"balance":[80,137,218,236],"between":[81,138,219],"silenced":[82],"synapses,":[85,166,224],"as":[86,88],"well":[87],"recovery":[90,181,193],"baseline":[92,136,154],"depolarization-induced":[95],"silencing.":[97],"Activation":[98],"activates":[103],"silent":[107,139,221,240],"at":[108],"rest,":[109],"pharmacological":[111],"inhibition":[112],"silences":[116],"basally":[117],"synapses.":[119,142,190],"Adenylyl":[120],"cyclase":[121,214],"(AC)":[122],"1":[123],"AC8,":[125,152],"major":[127],"Ca2+-sensitive":[128],"AC":[129],"isoforms,":[130],"not":[132,204],"crucial":[133],"for":[134],"In":[143],"cells":[144],"from":[145],"mice":[146],"doubly":[147],"deficient":[148],"AC1":[150],"percentage":[155],"was":[159,170,185,199],"only":[160],"modestly":[161],"reduced":[162],"compared":[163],"with":[164],"wild-type":[165],"forskolin":[168],"unsilencing":[169],"similar":[171],"two":[174],"genotypes.":[175],"Nevertheless,":[176],"strongly":[186],"inhibited":[187],"AC1/AC8-deficient":[189],"entire":[192],"phenotype":[194],"double":[197],"null":[198],"reproduced":[200],"AC8-deficient":[202],"AC1-deficient":[205],"cells.":[206],"conclude":[208],"that,":[209],"under":[210],"conditions,":[212],"redundant":[213],"maintains":[216],"presynaptically":[220],"AC8":[226],"plays":[227],"particularly":[229],"important":[230],"role":[231],"rapidly":[233],"resetting":[234],"to":[239,244],"activity.":[246]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":7},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":5}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}