{"id":"https://openalex.org/W1993953124","doi":"https://doi.org/10.1097/prs.0b013e318299ff53","title":"A Multicenter Study of the Safety and Effectiveness of Hyaluronic Acid with a Cohesive Polydensified Matrix for Treatment of Nasolabial Folds in Subjects with Fitzpatrick Skin Types IV, V, and VI","display_name":"A Multicenter Study of the Safety and Effectiveness of Hyaluronic Acid with a Cohesive Polydensified Matrix for Treatment of Nasolabial Folds in Subjects with Fitzpatrick Skin Types IV, V, and VI","publication_year":2013,"publication_date":"2013-10-01","ids":{"openalex":"https://openalex.org/W1993953124","doi":"https://doi.org/10.1097/prs.0b013e318299ff53","mag":"1993953124","pmid":"https://pubmed.ncbi.nlm.nih.gov/24077010"},"language":"en","primary_location":{"id":"doi:10.1097/prs.0b013e318299ff53","doi":"https://doi.org/10.1097/prs.0b013e318299ff53","is_oa":false,"landing_page_url":"https://doi.org/10.1097/prs.0b013e318299ff53","pdf_url":null,"source":{"id":"https://openalex.org/S100736837","display_name":"Plastic & Reconstructive Surgery","issn_l":"0032-1052","issn":["0032-1052","1076-5751","1529-4242"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Plastic and Reconstructive Surgery","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5043668229","display_name":"Jeanine B. Downie","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I137853757","display_name":"Howard University","ror":"https://ror.org/05gt1vc06","country_code":"US","type":"education","lineage":["https://openalex.org/I137853757"]},{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]},{"id":"https://openalex.org/I4210126237","display_name":"Vitiligo and Pigmentation Institute of Southern California","ror":"https://ror.org/032685859","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126237"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeanine B. Downie","raw_affiliation_strings":["Montclair, N.J.; Los Angeles, Calif.; Washington, D.C.; and Glenn Dale, Md. From private practice; the Vitiligo and Pigmentation Institute of Southern California; the Department Dermatology, University of California, Los Angeles; Howard University School of Medicine; and the Callender Skin and Laser Center","Montclair, N.J"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Montclair, N.J.; Los Angeles, Calif.; Washington, D.C.; and Glenn Dale, Md. From private practice; the Vitiligo and Pigmentation Institute of Southern California; the Department Dermatology, University of California, Los Angeles; Howard University School of Medicine; and the Callender Skin and Laser Center","institution_ids":["https://openalex.org/I137853757","https://openalex.org/I161318765","https://openalex.org/I4210126237"]},{"raw_affiliation_string":"Montclair, N.J","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056537776","display_name":"Pearl E. Grimes","orcid":"https://orcid.org/0000-0001-6663-2471","observed_orcids":["https://orcid.org/0000-0001-6663-2471","https://orcid.org/0000-0003-3642-756X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Pearl E. Grimes","raw_affiliation_strings":["Los Angeles, Calif","and Glenn Dale, Md"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Los Angeles, Calif","institution_ids":[]},{"raw_affiliation_string":"and Glenn Dale, Md","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5055242180","display_name":"Valerie Dawn Callender","orcid":"https://orcid.org/0000-0003-1297-5270","observed_orcids":["https://orcid.org/0000-0003-1297-5270"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Valerie D. Callender","raw_affiliation_strings":["Los Angeles, Calif","and Glenn Dale, Md","Washington, D.C"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Los Angeles, Calif","institution_ids":[]},{"raw_affiliation_string":"and Glenn Dale, Md","institution_ids":[]},{"raw_affiliation_string":"Washington, D.C","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.8727,"has_fulltext":false,"cited_by_count":32,"citation_normalized_percentile":{"value":0.92932073,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"132","issue":"4 Suppl 2","first_page":"41S","last_page":"47S"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11322","display_name":"Facial Rejuvenation and Surgery Techniques","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11322","display_name":"Facial Rejuvenation and Surgery Techniques","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11172","display_name":"Dermatologic Treatments and Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11258","display_name":"Breast Implant and Reconstruction","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hyaluronic-acid","display_name":"hyaluronic acid","score":0.8479999899864197},{"id":"https://openalex.org/keywords/nasolabial-fold-correction","display_name":"nasolabial fold correction","score":0.8500000238418579},{"id":"https://openalex.org/keywords/dermal-fillers","display_name":"dermal fillers","score":0.8500000238418579},{"id":"https://openalex.org/keywords/hyperpigmentation","display_name":"hyperpigmentation","score":0.8410000205039978},{"id":"https://openalex.org/keywords/hypopigmentation","display_name":"hypopigmentation","score":0.9990000128746033},{"id":"https://openalex.org/keywords/scar-formation","display_name":"scar formation","score":0.9580000042915344},{"id":"https://openalex.org/keywords/adverse-events","display_name":"adverse events","score":0.6549999713897705},{"id":"https://openalex.org/keywords/wrinkle-severity","display_name":"wrinkle severity","score":0.8579999804496765},{"id":"https://openalex.org/keywords/aesthetic-enhancement","display_name":"aesthetic improvement","score":0.6389999985694885}],"concepts":[{"id":"https://openalex.org/C2777529286","wikidata":"https://www.wikidata.org/wiki/Q337231","display_name":"Hyaluronic acid","level":2,"score":0.8463612794876099},{"id":"https://openalex.org/C2992435398","wikidata":"https://www.wikidata.org/wiki/Q6934595","display_name":"Multicenter study","level":3,"score":0.5043472051620483},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4596225321292877},{"id":"https://openalex.org/C16005928","wikidata":"https://www.wikidata.org/wiki/Q171171","display_name":"Dermatology","level":1,"score":0.33651459217071533},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.28055882453918457},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.12398296594619751},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.09713682532310486}],"mesh":[{"descriptor_ui":"D003357","descriptor_name":"Cosmetic Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006820","descriptor_name":"Hyaluronic Acid","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D006820","descriptor_name":"Hyaluronic Acid","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010859","descriptor_name":"Pigmentation Disorders","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D012449","descriptor_name":"Safety","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015595","descriptor_name":"Skin Aging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D060052","descriptor_name":"Nasolabial Fold","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1097/prs.0b013e318299ff53","doi":"https://doi.org/10.1097/prs.0b013e318299ff53","is_oa":false,"landing_page_url":"https://doi.org/10.1097/prs.0b013e318299ff53","pdf_url":null,"source":{"id":"https://openalex.org/S100736837","display_name":"Plastic & Reconstructive Surgery","issn_l":"0032-1052","issn":["0032-1052","1076-5751","1529-4242"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Plastic and Reconstructive Surgery","raw_type":"journal-article"},{"id":"pmid:24077010","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24077010","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Plastic and reconstructive surgery","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9789000153541565,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":12,"referenced_works":["https://openalex.org/W167719327","https://openalex.org/W1970282295","https://openalex.org/W1971712285","https://openalex.org/W1979660768","https://openalex.org/W1985186533","https://openalex.org/W1990893816","https://openalex.org/W1994797214","https://openalex.org/W2014699201","https://openalex.org/W2056345929","https://openalex.org/W2062371037","https://openalex.org/W2082573631","https://openalex.org/W2395029983"],"related_works":["https://openalex.org/W1985186533","https://openalex.org/W4233161546","https://openalex.org/W4401579626","https://openalex.org/W1979660768","https://openalex.org/W1971712285","https://openalex.org/W1970282295","https://openalex.org/W4385693322","https://openalex.org/W2056345929","https://openalex.org/W2782644117","https://openalex.org/W2101501305"],"abstract_inverted_index":{"BACKGROUND:":[0],"Although":[1],"the":[2,5,49,54,64,106,125,156],"use":[3],"of":[4,48,56,66,81,93,127,149,158,174,187],"hyaluronic":[6,12,61,121,153,203],"acid":[7,13,62,154,204],"with":[8,20,35,71,117,163,177,191,214],"cohesive":[9,58,118,150],"polydensified":[10,59,119,151,201],"matrix":[11,60,120,152,202],"has":[14],"been":[15],"well":[16],"explored":[17],"in":[18,33,63,69,98,105,161],"subjects":[19,34,70,95,162,213],"lighter":[21],"skin":[22,25,37,73,165,216],"(i.e.,":[23],"Fitzpatrick":[24,36,72,164,215],"types":[26,38,74,166,217],"I,":[27],"II,":[28],"and":[29,41,77,84,135,144,169,197,208,220],"III),":[30],"further":[31],"exploration":[32],"IV,":[39,75,167,218],"V,":[40,168,219],"IV":[42],"is":[43,205],"warranted.":[44],"The":[45],"primary":[46],"purpose":[47],"study":[50,145],"was":[51,87],"to":[52,193],"assess":[53],"safety":[55],"a":[57,206],"correction":[65,116],"nasolabial":[67,114,159],"folds":[68,160],"V":[76],"VI,":[78],"especially":[79],"assessment":[80],"hyperpigmentation,":[82,179],"hypopigmentation,":[83,178],"scarring.":[85,181],"Effectiveness":[86],"also":[88],"assessed.":[89],"METHODS:":[90],"A":[91],"total":[92],"93":[94],"were":[96,110,185],"enrolled":[97],"this":[99],"24-week":[100],"investigation":[101],"at":[102],"three":[103],"sites":[104],"United":[107],"States.":[108],"All":[109],"injected":[111,130],"bilaterally":[112],"for":[113,155,212],"fold":[115],"acid.":[122],"Assessments":[123],"included":[124],"recording":[126],"adverse":[128],"events;":[129],"volumes;":[131],"wrinkle":[132],"severity":[133],"ratings;":[134],"global":[136],"aesthetic":[137],"improvement":[138],"by":[139],"evaluating":[140],"investigators,":[141,143],"treating":[142],"subjects.":[146],"RESULTS:":[147],"Injection":[148],"treatment":[157],"VI":[170],"showed":[171],"no":[172],"evidence":[173],"an":[175],"association":[176],"or":[180],"Adverse":[182],"events":[183],"reported":[184],"typical":[186],"dermal":[188,210],"filler":[189,211],"injections":[190],"respect":[192],"type,":[194],"rate,":[195],"duration,":[196],"severity.":[198],"CONCLUSION:":[199],"Cohesive":[200],"safe":[207],"well-tolerated":[209],"VI.":[221]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":4},{"year":2021,"cited_by_count":2},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
