{"id":"https://openalex.org/W1993920096","doi":"https://doi.org/10.1093/infdis/149.4.489","title":"Biosynthesis of Androgen from Cortisol by a Species of Clostridium Recovered From Human Fecal Flora","display_name":"Biosynthesis of Androgen from Cortisol by a Species of Clostridium Recovered From Human Fecal Flora","publication_year":1984,"publication_date":"1984-04-01","ids":{"openalex":"https://openalex.org/W1993920096","doi":"https://doi.org/10.1093/infdis/149.4.489","mag":"1993920096","pmid":"https://pubmed.ncbi.nlm.nih.gov/6725987"},"language":"en","primary_location":{"id":"doi:10.1093/infdis/149.4.489","doi":"https://doi.org/10.1093/infdis/149.4.489","is_oa":false,"landing_page_url":"https://doi.org/10.1093/infdis/149.4.489","pdf_url":null,"source":{"id":"https://openalex.org/S54542293","display_name":"The Journal of Infectious Diseases","issn_l":"0022-1899","issn":["0022-1899","1537-6613"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Infectious Diseases","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5000293504","display_name":"Victor D. Bokkenheuser","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"V. D. Bokkenheuser","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021749496","display_name":"George N. Morris","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G. N. Morris","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036671422","display_name":"Alfred E. Ritchie","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A. E. Ritchie","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108800745","display_name":"Lillian V. Holdeman","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"L. V. Holdeman","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5110171756","display_name":"Joseph Winter","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J. Winter","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4763,"currency":"USD","value_usd":4763},"apc_paid":null,"fwci":4.4436,"has_fulltext":false,"cited_by_count":46,"citation_normalized_percentile":{"value":0.94996611,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"149","issue":"4","first_page":"489","last_page":"494"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13736","display_name":"Steroid Chemistry and Biochemistry","score":0.986299991607666,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T13736","display_name":"Steroid Chemistry and Biochemistry","score":0.986299991607666,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.003599999938160181,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12421","display_name":"Adrenal Hormones and Disorders","score":0.002400000113993883,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/androgen-biosynthesis","display_name":"androgen production","score":0.8600000143051147},{"id":"https://openalex.org/keywords/cortisol","display_name":"cortisol","score":0.9120000004768372},{"id":"https://openalex.org/keywords/clostridium","display_name":"Clostridium","score":0.8920000195503235},{"id":"https://openalex.org/keywords/bacterial-isolation","display_name":"bacterial isolation","score":0.44200000166893005},{"id":"https://openalex.org/keywords/bacterial-growth-requirements","display_name":"bacterial growth requirements","score":0.38499999046325684},{"id":"https://openalex.org/keywords/antibiotic-susceptibility","display_name":"antibiotic susceptibility","score":0.7020000219345093}],"concepts":[{"id":"https://openalex.org/C67101536","wikidata":"https://www.wikidata.org/wiki/Q5535910","display_name":"George (robot)","level":2,"score":0.48392897844314575},{"id":"https://openalex.org/C2777234453","wikidata":"https://www.wikidata.org/wiki/Q2033092","display_name":"Flora (microbiology)","level":3,"score":0.47268205881118774},{"id":"https://openalex.org/C95457728","wikidata":"https://www.wikidata.org/wiki/Q309","display_name":"History","level":0,"score":0.38162684440612793},{"id":"https://openalex.org/C161191863","wikidata":"https://www.wikidata.org/wiki/Q199655","display_name":"Library science","level":1,"score":0.3539559841156006},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3372308015823364},{"id":"https://openalex.org/C74916050","wikidata":"https://www.wikidata.org/wiki/Q841090","display_name":"Classics","level":1,"score":0.33467864990234375},{"id":"https://openalex.org/C52119013","wikidata":"https://www.wikidata.org/wiki/Q50637","display_name":"Art history","level":1,"score":0.2588774561882019},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2065507471561432},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.11869567632675171},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000735","descriptor_name":"Androstenedione","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D000735","descriptor_name":"Androstenedione","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D003013","descriptor_name":"Clostridium","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D003013","descriptor_name":"Clostridium","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D003013","descriptor_name":"Clostridium","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D003470","descriptor_name":"Culture Media","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005243","descriptor_name":"Feces","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006854","descriptor_name":"Hydrocortisone","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008190","descriptor_name":"Lyases","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D010100","descriptor_name":"Oxygen","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1093/infdis/149.4.489","doi":"https://doi.org/10.1093/infdis/149.4.489","is_oa":false,"landing_page_url":"https://doi.org/10.1093/infdis/149.4.489","pdf_url":null,"source":{"id":"https://openalex.org/S54542293","display_name":"The Journal of Infectious Diseases","issn_l":"0022-1899","issn":["0022-1899","1537-6613"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Infectious Diseases","raw_type":"journal-article"},{"id":"pmid:6725987","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6725987","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of infectious diseases","raw_type":"Journal Article"},{"id":"pmh:oai:open-archive.highwire.org:jinfdis:149/4/489","doi":null,"is_oa":false,"landing_page_url":"http://jid.oxfordjournals.org/cgi/content/short/149/4/489","pdf_url":null,"source":{"id":"https://openalex.org/S4406923041","display_name":"HighWire Press Open Archive","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"TEXT"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.6240000128746033,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":15,"referenced_works":["https://openalex.org/W1447097018","https://openalex.org/W1488512044","https://openalex.org/W1507367739","https://openalex.org/W1602183542","https://openalex.org/W1687178005","https://openalex.org/W1701486583","https://openalex.org/W1913751852","https://openalex.org/W1932471691","https://openalex.org/W1980732308","https://openalex.org/W1997722140","https://openalex.org/W2003532408","https://openalex.org/W2037803839","https://openalex.org/W2069112933","https://openalex.org/W2077282263","https://openalex.org/W2156616124"],"related_works":["https://openalex.org/W2077282263","https://openalex.org/W2123963171","https://openalex.org/W2109013909","https://openalex.org/W2994625296","https://openalex.org/W2044865975","https://openalex.org/W2407233393","https://openalex.org/W1488512044","https://openalex.org/W7099562332","https://openalex.org/W4232005344","https://openalex.org/W1997722140"],"abstract_inverted_index":{"A":[0],"hitherto":[1],"unknown":[2],"species":[3],"of":[4,16,32,57,84],"Clostridium,":[5],"provisionally":[6],"designated":[7],"strain":[8,22,58,64],"19,":[9],"was":[10],"isolated":[11],"from":[12],"the":[13,29,82],"fecal":[14,55],"flora":[15],"a":[17,24],"healthy":[18],"human":[19],"adult.":[20],"This":[21],"synthesizes":[23],"constitutive":[25],"desmolase":[26],"that":[27],"cleaves":[28],"side":[30],"chain":[31],"cortisol":[33],"to":[34,68,92,97],"form":[35],"11":[36],"beta-hydroxy-4-androstene-3,17-dione.":[37],"The":[38,54,63,88],"enzymatic":[39],"conversion":[40],"is":[41,60,79,90],"best":[42],"demonstrated":[43],"in":[44,49],"supplemented":[45],"peptone":[46],"broth":[47],"and":[48,73,95,101],"prereduced":[50],"brain-heart":[51],"infusion":[52],"broth.":[53],"concentration":[56],"19":[59],"10(7)-10(8)":[61],"cells/g.":[62],"adapts":[65],"with":[66],"difficulty":[67],"growth":[69],"on":[70],"Mueller-Hinton":[71],"agar":[72,75],"Columbia":[74],"base;":[76],"colony":[77],"formation":[78],"enhanced":[80],"by":[81],"addition":[83],"5%":[85],"sheep":[86],"blood.":[87],"organism":[89],"sensitive":[91],"penicillin":[93],"G":[94],"resistant":[96],"tetracycline,":[98],"chloramphenicol,":[99],"clindamycin,":[100],"erythromycin.":[102]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":3},{"year":2023,"cited_by_count":2},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
