{"id":"https://openalex.org/W1993885632","doi":"https://doi.org/10.4161/mabs.23654","title":"Therapeutic antibody engineering","display_name":"Therapeutic antibody engineering","publication_year":2013,"publication_date":"2013-03-01","ids":{"openalex":"https://openalex.org/W1993885632","doi":"https://doi.org/10.4161/mabs.23654","mag":"1993885632"},"language":"en","primary_location":{"id":"doi:10.4161/mabs.23654","doi":"https://doi.org/10.4161/mabs.23654","is_oa":true,"landing_page_url":"https://doi.org/10.4161/mabs.23654","pdf_url":"https://www.tandfonline.com/doi/pdf/10.4161/mabs.23654?needAccess=true","source":{"id":"https://openalex.org/S169123381","display_name":"mAbs","issn_l":"1942-0862","issn":["1942-0862","1942-0870"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315740","host_organization_name":"Landes Bioscience","host_organization_lineage":["https://openalex.org/P4310315740"],"host_organization_lineage_names":["Landes Bioscience"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"mAbs","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.tandfonline.com/doi/pdf/10.4161/mabs.23654?needAccess=true","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5039190287","display_name":"Paul W.H.I. Parren","orcid":"https://orcid.org/0000-0002-4365-3859","observed_orcids":["https://orcid.org/0000-0002-4365-3859"]},"institutions":[{"id":"https://openalex.org/I266595603","display_name":"Genmab (United States)","ror":"https://ror.org/05258cy55","country_code":"US","type":"company","lineage":["https://openalex.org/I266595603","https://openalex.org/I4210163256"]},{"id":"https://openalex.org/I4210102253","display_name":"Genmab (Netherlands)","ror":"https://ror.org/01ajp8153","country_code":"NL","type":"company","lineage":["https://openalex.org/I4210102253","https://openalex.org/I4210163256"]},{"id":"https://openalex.org/I4210163256","display_name":"Genmab (Denmark)","ror":"https://ror.org/057pe1087","country_code":"DK","type":"company","lineage":["https://openalex.org/I4210163256"]}],"countries":["DK","NL","US"],"is_corresponding":true,"raw_author_name":"Paul W.H.I. Parren","raw_affiliation_strings":["Genmab; Utrecht, the Netherlands","Genmab","Utrecht, the Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genmab; Utrecht, the Netherlands","institution_ids":["https://openalex.org/I4210102253"]},{"raw_affiliation_string":"Genmab","institution_ids":["https://openalex.org/I266595603","https://openalex.org/I4210102253","https://openalex.org/I4210163256"]},{"raw_affiliation_string":"Utrecht, the Netherlands","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5113792277","display_name":"Alexey A. Lugovskoy","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210124791","display_name":"Merrimack Pharmaceuticals (United States)","ror":"https://ror.org/034dw6775","country_code":"US","type":"company","lineage":["https://openalex.org/I4210124791"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Alexey A. Lugovskoy","raw_affiliation_strings":["Merrimack Pharmaceuticals Inc.; Cambridge, MA, USA","Cambridge, MA, USA","Merrimack Pharmaceuticals Inc"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Merrimack Pharmaceuticals Inc.; Cambridge, MA, USA","institution_ids":["https://openalex.org/I4210124791"]},{"raw_affiliation_string":"Cambridge, MA, USA","institution_ids":[]},{"raw_affiliation_string":"Merrimack Pharmaceuticals Inc","institution_ids":["https://openalex.org/I4210124791"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5039190287","https://openalex.org/A5113792277"],"corresponding_institution_ids":["https://openalex.org/I266595603","https://openalex.org/I4210102253","https://openalex.org/I4210124791","https://openalex.org/I4210163256"],"apc_list":{"value":2915,"currency":"GBP","value_usd":3575},"apc_paid":{"value":2915,"currency":"GBP","value_usd":3575},"fwci":3.3459,"has_fulltext":false,"cited_by_count":33,"citation_normalized_percentile":{"value":0.90972754,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"5","issue":"2","first_page":"175","last_page":"177"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11124","display_name":"Protein purification and stability","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12255","display_name":"Biosimilars and Bioanalytical Methods","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/therapeutic-monoclonal-antibodies","display_name":"therapeutic monoclonal antibodies","score":0.9380000233650208},{"id":"https://openalex.org/keywords/antibody-engineering","display_name":"antibody engineering","score":0.9599999785423279},{"id":"https://openalex.org/keywords/therapeutic-antibodies","display_name":"therapeutic antibodies","score":0.7990000247955322},{"id":"https://openalex.org/keywords/phage-display","display_name":"phage display","score":0.7839999794960022},{"id":"https://openalex.org/keywords/antibody-discovery","display_name":"antibody discovery","score":0.7789999842643738},{"id":"https://openalex.org/keywords/biopharmaceutical-industry","display_name":"biopharmaceutical industry","score":0.7710000276565552},{"id":"https://openalex.org/keywords/knowledge-sharing","display_name":"knowledge sharing","score":0.9120000004768372}],"concepts":[{"id":"https://openalex.org/C4438859","wikidata":"https://www.wikidata.org/wiki/Q186117","display_name":"Timeline","level":2,"score":0.6809989809989929},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4267314672470093},{"id":"https://openalex.org/C95457728","wikidata":"https://www.wikidata.org/wiki/Q309","display_name":"History","level":0,"score":0.16903945803642273},{"id":"https://openalex.org/C166957645","wikidata":"https://www.wikidata.org/wiki/Q23498","display_name":"Archaeology","level":1,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.4161/mabs.23654","doi":"https://doi.org/10.4161/mabs.23654","is_oa":true,"landing_page_url":"https://doi.org/10.4161/mabs.23654","pdf_url":"https://www.tandfonline.com/doi/pdf/10.4161/mabs.23654?needAccess=true","source":{"id":"https://openalex.org/S169123381","display_name":"mAbs","issn_l":"1942-0862","issn":["1942-0862","1942-0870"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315740","host_organization_name":"Landes Bioscience","host_organization_lineage":["https://openalex.org/P4310315740"],"host_organization_lineage_names":["Landes Bioscience"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"mAbs","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2887793","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/articles/PMC3893228","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3893228","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3893228","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"MAbs","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.4161/mabs.23654","doi":"https://doi.org/10.4161/mabs.23654","is_oa":true,"landing_page_url":"https://doi.org/10.4161/mabs.23654","pdf_url":"https://www.tandfonline.com/doi/pdf/10.4161/mabs.23654?needAccess=true","source":{"id":"https://openalex.org/S169123381","display_name":"mAbs","issn_l":"1942-0862","issn":["1942-0862","1942-0870"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315740","host_organization_name":"Landes Bioscience","host_organization_lineage":["https://openalex.org/P4310315740"],"host_organization_lineage_names":["Landes Bioscience"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"mAbs","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":false},"content_urls":{"pdf":"https://content.openalex.org/works/W1993885632.pdf"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2081641593","https://openalex.org/W2126169274","https://openalex.org/W2353138579","https://openalex.org/W2038860894","https://openalex.org/W4232208192","https://openalex.org/W4413037210","https://openalex.org/W2467667673","https://openalex.org/W2025691842","https://openalex.org/W64973136","https://openalex.org/W4205191131"],"abstract_inverted_index":{"It":[0],"is":[1,18,90,136],"an":[2,10,85],"important":[3],"event":[4],"in":[5,12,37,96,157,171,176,185,191,196,232],"any":[6],"knowledge":[7,24,62],"area":[8,193],"when":[9],"authority":[11],"the":[13,38,45,110,119,205,242],"field":[14,206],"decides":[15],"that":[16,60,109],"it":[17],"time":[19,111],"to":[20,43,81,114,222,234],"share":[21],"all":[22],"accumulated":[23],"and":[25,52,54,79,87,122,132,142,146,165,174,195,219,225],"learnings":[26],"by":[27,203],"writing":[28],"a":[29,67,72,77,116,160],"text":[30],"book.":[31],"This":[32],"does":[33],"not":[34],"occur":[35],"often":[36],"biopharmaceutical":[39],"industry,":[40],"likely":[41],"due":[42],"both":[44],"highly":[46],"dynamic":[47],"environment":[48,89],"with":[49,76],"tight":[50],"timelines":[51],"policies":[53],"procedures":[55],"at":[56,167,179,217],"many":[57],"pharmaceutical":[58],"companies":[59],"hamper":[61],"sharing.":[63],"To":[64],"take":[65],"on":[66],"task":[68],"like":[69],"this":[70,192],"successfully,":[71],"strong":[73,144],"drive":[74],"combined":[75],"desire":[78],"talent":[80],"teach,":[82],"but":[83],"also":[84],"accommodating":[86],"stimulating":[88],"required.":[91],"Luckily":[92],"for":[93,134],"those":[94],"interested":[95],"therapeutic":[97,246],"monoclonal":[98],"antibodies,":[99],"Dr.":[100,128,150,198],"William":[101],"R.":[102],"Strohl":[103,151,199],"decided":[104],"about":[105,118],"two":[106],"years":[107],"ago":[108],"was":[112],"right":[113],"write":[115],"book":[117],"past,":[120],"present":[121],"future":[123],"of":[124,163,207,244],"these":[125],"fascinating":[126],"molecules.":[127],"Strohl\u2019s":[129],"great":[130],"expertise":[131],"passion":[133],"biotechnology":[135],"evident":[137],"from":[138],"his":[139,143,182],"life":[140],"story":[141],"academic":[145],"industry":[147,177,189],"track":[148],"record.":[149],"pioneered":[152],"natural":[153,187],"product":[154],"biotechnology,":[155],"first":[156],"academia":[158],"as":[159],"full":[161],"professor":[162],"microbiology":[164],"biochemistry":[166],"Ohio":[168,173],"State":[169],"University":[170],"Columbus,":[172],"later":[175],"while":[178],"Merck.":[180],"Despite":[181],"notable":[183],"advances":[184],"recombinant":[186],"products,":[188],"interest":[190],"waned":[194],"2001":[197],"sought":[200],"new":[201],"opportunities":[202],"entering":[204],"antibody":[208,212,247],"therapeutics.":[209],"He":[210],"initiated":[211],"discovery":[213,243],"through":[214],"phage":[215],"display":[216],"Merck,":[218],"then":[220],"moved":[221],"Centocor":[223],"Research":[224],"Development":[226],"Inc.":[227],"(now":[228],"Janssen":[229],"Biotech,":[230],"Inc.)":[231],"2008":[233],"head":[235],"Biologics":[236],"Research,":[237],"where":[238],"he":[239],"now":[240],"directs":[241],"innovative":[245],"candidates.":[248]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":3},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":7},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-27T15:51:10.671819","created_date":"2016-06-24T00:00:00"}