{"id":"https://openalex.org/W1993842356","doi":"https://doi.org/10.1523/jneurosci.0827-05.2005","title":"Developmental Changes in AMPA and Kainate Receptor-Mediated Quantal Transmission at Thalamocortical Synapses in the Barrel Cortex","display_name":"Developmental Changes in AMPA and Kainate Receptor-Mediated Quantal Transmission at Thalamocortical Synapses in the Barrel Cortex","publication_year":2005,"publication_date":"2005-05-25","ids":{"openalex":"https://openalex.org/W1993842356","doi":"https://doi.org/10.1523/jneurosci.0827-05.2005","mag":"1993842356","pmid":"https://pubmed.ncbi.nlm.nih.gov/15917466","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6724821"},"language":"en","primary_location":{"id":"doi:10.1523/jneurosci.0827-05.2005","doi":"https://doi.org/10.1523/jneurosci.0827-05.2005","is_oa":true,"landing_page_url":"https://doi.org/10.1523/jneurosci.0827-05.2005","pdf_url":"https://www.jneurosci.org/content/jneuro/25/21/5259.full.pdf","source":{"id":"https://openalex.org/S5555990","display_name":"Journal of Neuroscience","issn_l":"0270-6474","issn":["0270-6474","1529-2401"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319739","host_organization_name":"Society for Neuroscience","host_organization_lineage":["https://openalex.org/P4310319739"],"host_organization_lineage_names":["Society for Neuroscience"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Neuroscience","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://www.jneurosci.org/content/jneuro/25/21/5259.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5029174394","display_name":"Neil J. Bannister","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I36234482","display_name":"University of Bristol","ror":"https://ror.org/0524sp257","country_code":"GB","type":"education","lineage":["https://openalex.org/I36234482"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Neil J. Bannister","raw_affiliation_strings":["Medical Research Council Centre for Synaptic Plasticity, Department of Anatomy, University of Bristol, Bristol BS8 1TD, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Research Council Centre for Synaptic Plasticity, Department of Anatomy, University of Bristol, Bristol BS8 1TD, United Kingdom","institution_ids":["https://openalex.org/I36234482"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037953901","display_name":"Tim A. Benke","orcid":"https://orcid.org/0000-0002-6969-5061","observed_orcids":["https://orcid.org/0000-0002-6969-5061"]},"institutions":[{"id":"https://openalex.org/I4210087413","display_name":"University of Colorado Health","ror":"https://ror.org/0107w4315","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087413"]},{"id":"https://openalex.org/I921990950","display_name":"University of Colorado Denver","ror":"https://ror.org/02hh7en24","country_code":"US","type":"education","lineage":["https://openalex.org/I921990950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Timothy A. Benke","raw_affiliation_strings":["Department of Pediatrics, University of Colorado Health Sciences Center, Denver, Colorado 80262,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, University of Colorado Health Sciences Center, Denver, Colorado 80262,","institution_ids":["https://openalex.org/I4210087413","https://openalex.org/I921990950"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023011366","display_name":"Jack R. Mellor","orcid":"https://orcid.org/0000-0002-7706-8105","observed_orcids":["https://orcid.org/0000-0002-7706-8105"]},"institutions":[{"id":"https://openalex.org/I36234482","display_name":"University of Bristol","ror":"https://ror.org/0524sp257","country_code":"GB","type":"education","lineage":["https://openalex.org/I36234482"]},{"id":"https://openalex.org/I90344618","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517","country_code":"GB","type":"government","lineage":["https://openalex.org/I4210087105","https://openalex.org/I90344618"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Jack Mellor","raw_affiliation_strings":["Medical Research Council Centre for Synaptic Plasticity, Department of Anatomy, University of Bristol, Bristol BS8 1TD, United Kingdom,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Research Council Centre for Synaptic Plasticity, Department of Anatomy, University of Bristol, Bristol BS8 1TD, United Kingdom,","institution_ids":["https://openalex.org/I36234482","https://openalex.org/I90344618"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073359869","display_name":"Helen L. Scott","orcid":"https://orcid.org/0000-0003-2656-4034","observed_orcids":["https://orcid.org/0000-0003-2656-4034"]},"institutions":[{"id":"https://openalex.org/I36234482","display_name":"University of Bristol","ror":"https://ror.org/0524sp257","country_code":"GB","type":"education","lineage":["https://openalex.org/I36234482"]},{"id":"https://openalex.org/I90344618","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517","country_code":"GB","type":"government","lineage":["https://openalex.org/I4210087105","https://openalex.org/I90344618"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Helen Scott","raw_affiliation_strings":["Medical Research Council Centre for Synaptic Plasticity, Department of Anatomy, University of Bristol, Bristol BS8 1TD, United Kingdom,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Research Council Centre for Synaptic Plasticity, Department of Anatomy, University of Bristol, Bristol BS8 1TD, United Kingdom,","institution_ids":["https://openalex.org/I36234482","https://openalex.org/I90344618"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021975532","display_name":"Esra G\u00fcrdal","orcid":"https://orcid.org/0000-0002-6186-6532","observed_orcids":["https://orcid.org/0000-0002-6186-6532"]},"institutions":[{"id":"https://openalex.org/I36234482","display_name":"University of Bristol","ror":"https://ror.org/0524sp257","country_code":"GB","type":"education","lineage":["https://openalex.org/I36234482"]},{"id":"https://openalex.org/I74897591","display_name":"Marmara University","ror":"https://ror.org/02kswqa67","country_code":"TR","type":"education","lineage":["https://openalex.org/I74897591"]},{"id":"https://openalex.org/I90344618","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517","country_code":"GB","type":"government","lineage":["https://openalex.org/I4210087105","https://openalex.org/I90344618"]}],"countries":["GB","TR"],"is_corresponding":false,"raw_author_name":"Esra G\u00fcrdal","raw_affiliation_strings":["Department of Anatomy, Marmara University School of Medicine, Haydarpasa 34668, Istanbul, Turkey, and","Medical Research Council Centre for Synaptic Plasticity, Department of Anatomy, University of Bristol, Bristol BS8 1TD, United Kingdom,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anatomy, Marmara University School of Medicine, Haydarpasa 34668, Istanbul, Turkey, and","institution_ids":["https://openalex.org/I74897591"]},{"raw_affiliation_string":"Medical Research Council Centre for Synaptic Plasticity, Department of Anatomy, University of Bristol, Bristol BS8 1TD, United Kingdom,","institution_ids":["https://openalex.org/I36234482","https://openalex.org/I90344618"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017771197","display_name":"John W. Crabtree","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I36234482","display_name":"University of Bristol","ror":"https://ror.org/0524sp257","country_code":"GB","type":"education","lineage":["https://openalex.org/I36234482"]},{"id":"https://openalex.org/I90344618","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517","country_code":"GB","type":"government","lineage":["https://openalex.org/I4210087105","https://openalex.org/I90344618"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"John W. Crabtree","raw_affiliation_strings":["Medical Research Council Centre for Synaptic Plasticity, Department of Anatomy, University of Bristol, Bristol BS8 1TD, United Kingdom,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Research Council Centre for Synaptic Plasticity, Department of Anatomy, University of Bristol, Bristol BS8 1TD, United Kingdom,","institution_ids":["https://openalex.org/I36234482","https://openalex.org/I90344618"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5029309237","display_name":"John T. R. Isaac","orcid":"https://orcid.org/0000-0002-7946-1277","observed_orcids":["https://orcid.org/0000-0002-7946-1277"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I36234482","display_name":"University of Bristol","ror":"https://ror.org/0524sp257","country_code":"GB","type":"education","lineage":["https://openalex.org/I36234482"]},{"id":"https://openalex.org/I4210110767","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210110767"]},{"id":"https://openalex.org/I90344618","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517","country_code":"GB","type":"government","lineage":["https://openalex.org/I4210087105","https://openalex.org/I90344618"]}],"countries":["GB","US"],"is_corresponding":true,"raw_author_name":"John T. R. Isaac","raw_affiliation_strings":["Medical Research Council Centre for Synaptic Plasticity, Department of Anatomy, University of Bristol, Bristol BS8 1TD, United Kingdom,","National Institute of Neurological Disorders and Stroke, National Institutes Health, Bethesda, Maryland 20892"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Research Council Centre for Synaptic Plasticity, Department of Anatomy, University of Bristol, Bristol BS8 1TD, United Kingdom,","institution_ids":["https://openalex.org/I36234482","https://openalex.org/I90344618"]},{"raw_affiliation_string":"National Institute of Neurological Disorders and Stroke, National Institutes Health, Bethesda, Maryland 20892","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210110767"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5029309237"],"corresponding_institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I36234482","https://openalex.org/I4210110767","https://openalex.org/I90344618"],"apc_list":null,"apc_paid":null,"fwci":1.5536,"has_fulltext":true,"cited_by_count":49,"citation_normalized_percentile":{"value":0.79475832,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"25","issue":"21","first_page":"5259","last_page":"5271"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11818","display_name":"Nicotinic Acetylcholine Receptors Study","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10581","display_name":"Neural dynamics and brain function","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ampa-receptors","display_name":"AMPA receptors","score":0.906000018119812},{"id":"https://openalex.org/keywords/kainate-receptors","display_name":"kainate receptors","score":1.0},{"id":"https://openalex.org/keywords/thalamocortical-synapses","display_name":"thalamocortical synapses","score":0.9599999785423279},{"id":"https://openalex.org/keywords/barrel-cortex","display_name":"barrel cortex","score":0.8629999756813049},{"id":"https://openalex.org/keywords/layer-4","display_name":"layer 4","score":0.7250000238418579},{"id":"https://openalex.org/keywords/synaptic-development","display_name":"synaptic development","score":0.5899999737739563},{"id":"https://openalex.org/keywords/miniature-epscs","display_name":"miniature EPSCs","score":0.8349999785423279},{"id":"https://openalex.org/keywords/single-channel-conductance","display_name":"single-channel conductance","score":0.8309999704360962},{"id":"https://openalex.org/keywords/receptor-coactivation","display_name":"receptor coactivation","score":0.38100001215934753}],"concepts":[{"id":"https://openalex.org/C160268369","wikidata":"https://www.wikidata.org/wiki/Q295251","display_name":"AMPA receptor","level":4,"score":0.8499985933303833},{"id":"https://openalex.org/C189184402","wikidata":"https://www.wikidata.org/wiki/Q3454536","display_name":"Kainate receptor","level":5,"score":0.8152869343757629},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.7828636169433594},{"id":"https://openalex.org/C2781347215","wikidata":"https://www.wikidata.org/wiki/Q4863332","display_name":"Barrel cortex","level":3,"score":0.6886477470397949},{"id":"https://openalex.org/C154559735","wikidata":"https://www.wikidata.org/wiki/Q7514768","display_name":"Silent synapse","level":5,"score":0.5624184608459473},{"id":"https://openalex.org/C200170125","wikidata":"https://www.wikidata.org/wiki/Q969316","display_name":"Neurotransmission","level":3,"score":0.46405306458473206},{"id":"https://openalex.org/C172227984","wikidata":"https://www.wikidata.org/wiki/Q1400397","display_name":"Barrel (horology)","level":2,"score":0.45408254861831665},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4244387745857239},{"id":"https://openalex.org/C61174792","wikidata":"https://www.wikidata.org/wiki/Q420510","display_name":"Glutamate receptor","level":3,"score":0.3684951663017273},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.36594733595848083},{"id":"https://openalex.org/C172497186","wikidata":"https://www.wikidata.org/wiki/Q328835","display_name":"Somatosensory system","level":2,"score":0.32441723346710205},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.2988501787185669},{"id":"https://openalex.org/C205649164","wikidata":"https://www.wikidata.org/wiki/Q1071","display_name":"Geography","level":0,"score":0.06042271852493286},{"id":"https://openalex.org/C166957645","wikidata":"https://www.wikidata.org/wiki/Q23498","display_name":"Archaeology","level":1,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000831","descriptor_name":"Animals, Newborn","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001224","descriptor_name":"Aspartic Acid","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002540","descriptor_name":"Cerebral Cortex","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D002540","descriptor_name":"Cerebral Cortex","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":false},{"descriptor_ui":"D002614","descriptor_name":"Chelating Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004307","descriptor_name":"Dose-Response Relationship, Radiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004347","descriptor_name":"Drug Interactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004533","descriptor_name":"Egtazic Acid","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004558","descriptor_name":"Electric Stimulation","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D007608","descriptor_name":"Kainic Acid","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008959","descriptor_name":"Models, Neurological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009010","descriptor_name":"Monte Carlo Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009431","descriptor_name":"Neural Conduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009431","descriptor_name":"Neural Conduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009431","descriptor_name":"Neural Conduction","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":false},{"descriptor_ui":"D009434","descriptor_name":"Neural Pathways","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009434","descriptor_name":"Neural Pathways","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009435","descriptor_name":"Synaptic Transmission","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D013324","descriptor_name":"Strontium","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D013569","descriptor_name":"Synapses","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D013788","descriptor_name":"Thalamus","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D013788","descriptor_name":"Thalamus","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018091","descriptor_name":"Receptors, AMPA","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D018092","descriptor_name":"Kainic Acid Receptors","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D018350","descriptor_name":"alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D018408","descriptor_name":"Patch-Clamp Techniques","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D018690","descriptor_name":"Excitatory Amino Acid Agonists","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D019706","descriptor_name":"Excitatory Postsynaptic Potentials","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D019706","descriptor_name":"Excitatory Postsynaptic Potentials","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D019706","descriptor_name":"Excitatory Postsynaptic Potentials","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066298","descriptor_name":"In Vitro Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":8,"locations":[{"id":"doi:10.1523/jneurosci.0827-05.2005","doi":"https://doi.org/10.1523/jneurosci.0827-05.2005","is_oa":true,"landing_page_url":"https://doi.org/10.1523/jneurosci.0827-05.2005","pdf_url":"https://www.jneurosci.org/content/jneuro/25/21/5259.full.pdf","source":{"id":"https://openalex.org/S5555990","display_name":"Journal of Neuroscience","issn_l":"0270-6474","issn":["0270-6474","1529-2401"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319739","host_organization_name":"Society for Neuroscience","host_organization_lineage":["https://openalex.org/P4310319739"],"host_organization_lineage_names":["Society for Neuroscience"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Neuroscience","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:5689094","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6724821","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:15917466","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15917466","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of neuroscience : the official journal of the Society for Neuroscience","raw_type":"Comparative Study"},{"id":"pmh:oai:pubmedcentral.nih.gov:6724821","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC6724821/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Neurosci","raw_type":"Text"},{"id":"pmh:oai:openaccess.marmara.edu.tr:11424/241936","doi":null,"is_oa":true,"landing_page_url":"https://openaccess.marmara.edu.tr/bitstreams/1f05609d-05ea-4596-9bbe-a2da737738d4/download","pdf_url":null,"source":{"id":"https://openalex.org/S4306401380","display_name":"Dspace Repository (Marmara \u00dcniversitesi)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I74897591","host_organization_name":"Marmara University","host_organization_lineage":["https://openalex.org/I74897591"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:openaccess.marmara.edu.tr:11424/117213","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/11424/117213","pdf_url":null,"source":{"id":"https://openalex.org/S4306401380","display_name":"Dspace Repository (Marmara \u00dcniversitesi)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I74897591","host_organization_name":"Marmara University","host_organization_lineage":["https://openalex.org/I74897591"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"article"},{"id":"pmh:oai:openaccess.marmara.edu.tr:11424/87968","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/11424/87968","pdf_url":null,"source":{"id":"https://openalex.org/S4306401380","display_name":"Dspace Repository (Marmara \u00dcniversitesi)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I74897591","host_organization_name":"Marmara University","host_organization_lineage":["https://openalex.org/I74897591"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"article"},{"id":"mag:2188304968","doi":null,"is_oa":false,"landing_page_url":"https://www.jneurosci.org/content/25/21/5259.full.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"doi:10.1523/jneurosci.0827-05.2005","doi":"https://doi.org/10.1523/jneurosci.0827-05.2005","is_oa":true,"landing_page_url":"https://doi.org/10.1523/jneurosci.0827-05.2005","pdf_url":"https://www.jneurosci.org/content/jneuro/25/21/5259.full.pdf","source":{"id":"https://openalex.org/S5555990","display_name":"Journal of Neuroscience","issn_l":"0270-6474","issn":["0270-6474","1529-2401"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319739","host_organization_name":"Society for Neuroscience","host_organization_lineage":["https://openalex.org/P4310319739"],"host_organization_lineage_names":["Society for Neuroscience"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Neuroscience","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G8075762561","display_name":"Impact of Early-Life Seizures on Synaptic Plasticity","funder_award_id":"K08NS041267","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"}],"funders":[{"id":"https://openalex.org/F4320311904","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08"},{"id":"https://openalex.org/F4320320360","display_name":"University of Bristol","ror":"https://ror.org/0524sp257"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1993842356.pdf","grobid_xml":"https://content.openalex.org/works/W1993842356.grobid-xml"},"referenced_works_count":67,"referenced_works":["https://openalex.org/W1483947092","https://openalex.org/W1514879561","https://openalex.org/W1536892466","https://openalex.org/W1549420856","https://openalex.org/W1567320500","https://openalex.org/W1571689838","https://openalex.org/W1604295762","https://openalex.org/W1620537156","https://openalex.org/W1641016126","https://openalex.org/W1644616682","https://openalex.org/W1662302126","https://openalex.org/W1858013900","https://openalex.org/W1858043581","https://openalex.org/W1962526731","https://openalex.org/W1965377078","https://openalex.org/W1967230415","https://openalex.org/W1968214267","https://openalex.org/W1977976400","https://openalex.org/W1983252720","https://openalex.org/W1987636575","https://openalex.org/W1996208391","https://openalex.org/W1996456984","https://openalex.org/W1997185941","https://openalex.org/W1997381540","https://openalex.org/W1997759665","https://openalex.org/W2002173877","https://openalex.org/W2004496381","https://openalex.org/W2023459285","https://openalex.org/W2034743076","https://openalex.org/W2037184237","https://openalex.org/W2041475044","https://openalex.org/W2044991031","https://openalex.org/W2046046616","https://openalex.org/W2048126627","https://openalex.org/W2057315110","https://openalex.org/W2057637786","https://openalex.org/W2061905631","https://openalex.org/W2068768680","https://openalex.org/W2071366993","https://openalex.org/W2074316051","https://openalex.org/W2076700300","https://openalex.org/W2078078069","https://openalex.org/W2079428986","https://openalex.org/W2085207885","https://openalex.org/W2087444289","https://openalex.org/W2089769736","https://openalex.org/W2091215810","https://openalex.org/W2095042541","https://openalex.org/W2114745427","https://openalex.org/W2123279902","https://openalex.org/W2128806021","https://openalex.org/W2129108032","https://openalex.org/W2132273329","https://openalex.org/W2134907695","https://openalex.org/W2136304943","https://openalex.org/W2137960481","https://openalex.org/W2139541849","https://openalex.org/W2140899588","https://openalex.org/W2142879924","https://openalex.org/W2153240389","https://openalex.org/W2155760865","https://openalex.org/W2158126393","https://openalex.org/W2162520530","https://openalex.org/W2166167622","https://openalex.org/W2167000365","https://openalex.org/W2403046355","https://openalex.org/W4406059073"],"related_works":["https://openalex.org/W1644616682","https://openalex.org/W2166167622","https://openalex.org/W2092885887","https://openalex.org/W2119534814","https://openalex.org/W2007344655","https://openalex.org/W1991363361","https://openalex.org/W1971095704","https://openalex.org/W1983446514","https://openalex.org/W2144471136","https://openalex.org/W2024763972"],"abstract_inverted_index":{"During":[0],"the":[1,23,29,46,86,128,144,153,185,194,203,217,227],"first":[2,129],"week":[3],"of":[4,32,49,77,100,131,148,158,164,196,205,224],"life,":[5],"there":[6],"is":[7],"a":[8,74,98,105,191],"shift":[9],"from":[10],"kainate":[11,35,52,61,135,149,165,173,197],"to":[12,82,156,190,209,240],"AMPA":[13,33,50,59,95,159,171,178,206],"receptor-mediated":[14,36,53,62,150],"thalamocortical":[15,87,124,238],"transmission":[16,37,54,63,157,231],"in":[17,170,177,193,202,216,230],"layer":[18,241],"IV":[19],"barrel":[20],"cortex.":[21],"However,":[22],"mechanisms":[24],"underlying":[25],"this":[26,140],"change":[27,187],"and":[28,34,51,60,104,111,139,162,199],"differential":[30],"properties":[31,48,68,219],"remain":[38],"essentially":[39],"unexplored.":[40],"To":[41],"investigate":[42],"this,":[43],"we":[44,212],"studied":[45],"quantal":[47,67,146,154,174,218],"using":[55],"strontium-evoked":[56],"miniature":[57],"EPSCs.":[58],"exhibited":[64,97],"very":[65],"different":[66,83],"but":[69],"were":[70,181],"never":[71],"coactivated":[72],"by":[73],"single":[75],"quantum":[76],"transmitter,":[78],"indicating":[79,115],"complete":[80],"segregation":[81],"synapses":[84,198,207],"within":[85],"input.":[88],"Nonstationary":[89],"fluctuation":[90],"analysis":[91],"showed":[92],"that":[93,116,163,184],"synaptic":[94,134],"receptors":[96,136,160,166],"range":[99],"single-channel":[101],"conductance":[102],"(gamma)":[103],"strong":[106],"negative":[107],"correlation":[108],"between":[109],"gamma":[110,132,180],"functional":[112],"channel":[113],"number,":[114],"these":[117,221],"two":[118,222],"parameters":[119],"are":[120],"reciprocally":[121],"regulated":[122],"at":[123,237],"synapses.":[125],"We":[126],"obtained":[127],"estimate":[130],"for":[133,143,220],"(<2":[137],"pS),":[138],"primarily":[141],"accounted":[142],"small":[145],"size":[147],"transmission.":[151,210],"Developmentally,":[152],"contribution":[155],"increased":[161],"decreased.":[167],"No":[168],"changes":[169],"or":[172,176],"amplitude":[175],"receptor":[179],"observed,":[182],"demonstrating":[183],"developmental":[186,228],"was":[188],"attributable":[189],"decrease":[192],"number":[195,204],"an":[200],"increase":[201],"contributing":[208],"Therefore,":[211],"demonstrate":[213],"fundamental":[214],"differences":[215],"types":[223],"synapse.":[225],"Thus,":[226],"switch":[229],"will":[232],"dramatically":[233],"alter":[234],"information":[235],"transfer":[236],"inputs":[239],"IV.":[242]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":3},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}