{"id":"https://openalex.org/W1993816098","doi":"https://doi.org/10.1039/b507691a","title":"Controlled intracellular localization and enhanced antisense effect of oligonucleotides by chemical conjugation","display_name":"Controlled intracellular localization and enhanced antisense effect of oligonucleotides by chemical conjugation","publication_year":2005,"publication_date":"2005-01-01","ids":{"openalex":"https://openalex.org/W1993816098","doi":"https://doi.org/10.1039/b507691a","mag":"1993816098","pmid":"https://pubmed.ncbi.nlm.nih.gov/16132084"},"language":"en","primary_location":{"id":"doi:10.1039/b507691a","doi":"https://doi.org/10.1039/b507691a","is_oa":false,"landing_page_url":"https://doi.org/10.1039/b507691a","pdf_url":null,"source":{"id":"https://openalex.org/S179810352","display_name":"Organic & Biomolecular Chemistry","issn_l":"1477-0520","issn":["1477-0520","1477-0539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-2","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310320556","host_organization_name":"Royal Society of Chemistry","host_organization_lineage":["https://openalex.org/P4310320556"],"host_organization_lineage_names":["Royal Society of Chemistry"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Organic &amp; Biomolecular Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5000366018","display_name":"Takanori Kubo","orcid":"https://orcid.org/0000-0002-7609-7094","observed_orcids":["https://orcid.org/0000-0002-7609-7094"]},"institutions":[{"id":"https://openalex.org/I73613424","display_name":"National Institute of Advanced Industrial Science and Technology","ror":"https://ror.org/01703db54","country_code":"JP","type":"government","lineage":["https://openalex.org/I73613424"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takanori Kubo","raw_affiliation_strings":["On-site Sensing and Diagnosis Research Laboratory, National Institute for Advanced Industrial Science and Technology (AIST) Kyushu, 807-1 Shuku-machi, Tosu, Saga 841-0052, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"On-site Sensing and Diagnosis Research Laboratory, National Institute for Advanced Industrial Science and Technology (AIST) Kyushu, 807-1 Shuku-machi, Tosu, Saga 841-0052, Japan","institution_ids":["https://openalex.org/I73613424"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078458496","display_name":"Zhivko Zhelev","orcid":"https://orcid.org/0000-0002-0106-2401","observed_orcids":["https://orcid.org/0000-0002-0106-2401"]},"institutions":[{"id":"https://openalex.org/I73613424","display_name":"National Institute of Advanced Industrial Science and Technology","ror":"https://ror.org/01703db54","country_code":"JP","type":"government","lineage":["https://openalex.org/I73613424"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Zhivko Zhelev","raw_affiliation_strings":["On-site Sensing and Diagnosis Research Laboratory, National Institute for Advanced Industrial Science and Technology (AIST) Kyushu, 807-1 Shuku-machi, Tosu, Saga 841-0052, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"On-site Sensing and Diagnosis Research Laboratory, National Institute for Advanced Industrial Science and Technology (AIST) Kyushu, 807-1 Shuku-machi, Tosu, Saga 841-0052, Japan","institution_ids":["https://openalex.org/I73613424"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073720264","display_name":"Rumiana Bakalova","orcid":"https://orcid.org/0000-0002-5309-3250","observed_orcids":["https://orcid.org/0000-0002-5309-3250"]},"institutions":[{"id":"https://openalex.org/I73613424","display_name":"National Institute of Advanced Industrial Science and Technology","ror":"https://ror.org/01703db54","country_code":"JP","type":"government","lineage":["https://openalex.org/I73613424"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Bakalova Rumiana","raw_affiliation_strings":["On-site Sensing and Diagnosis Research Laboratory, National Institute for Advanced Industrial Science and Technology (AIST) Kyushu, 807-1 Shuku-machi, Tosu, Saga 841-0052, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"On-site Sensing and Diagnosis Research Laboratory, National Institute for Advanced Industrial Science and Technology (AIST) Kyushu, 807-1 Shuku-machi, Tosu, Saga 841-0052, Japan","institution_ids":["https://openalex.org/I73613424"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103111310","display_name":"Hideki Ohba","orcid":"https://orcid.org/0000-0003-2925-3696","observed_orcids":["https://orcid.org/0000-0003-2925-3696"]},"institutions":[{"id":"https://openalex.org/I73613424","display_name":"National Institute of Advanced Industrial Science and Technology","ror":"https://ror.org/01703db54","country_code":"JP","type":"government","lineage":["https://openalex.org/I73613424"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hideki Ohba","raw_affiliation_strings":["On-site Sensing and Diagnosis Research Laboratory, National Institute for Advanced Industrial Science and Technology (AIST) Kyushu, 807-1 Shuku-machi, Tosu, Saga 841-0052, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"On-site Sensing and Diagnosis Research Laboratory, National Institute for Advanced Industrial Science and Technology (AIST) Kyushu, 807-1 Shuku-machi, Tosu, Saga 841-0052, Japan","institution_ids":["https://openalex.org/I73613424"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012744077","display_name":"Keiko Doi","orcid":"https://orcid.org/0000-0003-4485-4510","observed_orcids":["https://orcid.org/0000-0003-4485-4510"]},"institutions":[{"id":"https://openalex.org/I4210086780","display_name":"Japan Science and Technology Agency","ror":"https://ror.org/00097mb19","country_code":"JP","type":"government","lineage":["https://openalex.org/I1319490839","https://openalex.org/I4210086780"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Keiko Doi","raw_affiliation_strings":["Innovation Plaza Fukuoka, Japan Science and Technology Agency (JST), 3-8-34 Momochihama, Sawara-ku, Fukuoka 814-0001, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Innovation Plaza Fukuoka, Japan Science and Technology Agency (JST), 3-8-34 Momochihama, Sawara-ku, Fukuoka 814-0001, Japan","institution_ids":["https://openalex.org/I4210086780"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5063543498","display_name":"Masayuki Fujii","orcid":"https://orcid.org/0000-0002-9633-0906","observed_orcids":["https://orcid.org/0000-0002-9633-0906"]},"institutions":[{"id":"https://openalex.org/I916559398","display_name":"Kindai University","ror":"https://ror.org/05kt9ap64","country_code":"JP","type":"education","lineage":["https://openalex.org/I916559398"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Masayuki Fujii","raw_affiliation_strings":["Department of Biological and Environmental Chemistry, School of Humanity-Oriented Science and Engineering, Kinki University, 11-6 Kayanomori, Iizuka, Fukuoka 820-8555, Japan","Molecular Engineering Institute, Kinki University, 11-6 Kayanomori, Iizuka, Fukuoka 820-8555, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological and Environmental Chemistry, School of Humanity-Oriented Science and Engineering, Kinki University, 11-6 Kayanomori, Iizuka, Fukuoka 820-8555, Japan","institution_ids":["https://openalex.org/I916559398"]},{"raw_affiliation_string":"Molecular Engineering Institute, Kinki University, 11-6 Kayanomori, Iizuka, Fukuoka 820-8555, Japan","institution_ids":["https://openalex.org/I916559398"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5063543498"],"corresponding_institution_ids":["https://openalex.org/I916559398"],"apc_list":null,"apc_paid":null,"fwci":1.1536,"has_fulltext":false,"cited_by_count":32,"citation_normalized_percentile":{"value":0.74403456,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"3","issue":"18","first_page":"3257","last_page":"3257"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.9721999764442444,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.9721999764442444,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10432","display_name":"DNA and Nucleic Acid Chemistry","score":0.02669999934732914,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10207","display_name":"Advanced biosensing and bioanalysis techniques","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/antisense-oligonucleotides","display_name":"antisense oligonucleotides","score":0.9409999847412109},{"id":"https://openalex.org/keywords/peptide-oligonucleotide-conjugates","display_name":"peptide-oligonucleotide conjugates","score":0.9120000004768372},{"id":"https://openalex.org/keywords/nuclear-export-signal","display_name":"nuclear export signal","score":0.9959999918937683},{"id":"https://openalex.org/keywords/cellular-uptake","display_name":"cellular uptake","score":0.5320000052452087},{"id":"https://openalex.org/keywords/subcellular-localization","display_name":"subcellular localization","score":0.8220000267028809},{"id":"https://openalex.org/keywords/nuclease-resistance","display_name":"nuclease resistance","score":0.8309999704360962},{"id":"https://openalex.org/keywords/leukemia-cells","display_name":"leukemia cells","score":0.890999972820282},{"id":"https://openalex.org/keywords/amphiphilic-peptides","display_name":"peptide amphiphiles","score":0.8259999752044678}],"concepts":[{"id":"https://openalex.org/C129312508","wikidata":"https://www.wikidata.org/wiki/Q133686","display_name":"Oligonucleotide","level":3,"score":0.8035057187080383},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7810699343681335},{"id":"https://openalex.org/C197336794","wikidata":"https://www.wikidata.org/wiki/Q5161150","display_name":"Conjugate","level":2,"score":0.6863963007926941},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.5497334003448486},{"id":"https://openalex.org/C49805395","wikidata":"https://www.wikidata.org/wiki/Q910966","display_name":"Nuclear localization sequence","level":3,"score":0.5484779477119446},{"id":"https://openalex.org/C2777271071","wikidata":"https://www.wikidata.org/wiki/Q422529","display_name":"Nuclease","level":3,"score":0.5441287159919739},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.5436628460884094},{"id":"https://openalex.org/C2779281246","wikidata":"https://www.wikidata.org/wiki/Q172847","display_name":"Peptide","level":2,"score":0.540803074836731},{"id":"https://openalex.org/C186435350","wikidata":"https://www.wikidata.org/wiki/Q1050365","display_name":"NLS","level":4,"score":0.5250653624534607},{"id":"https://openalex.org/C10879258","wikidata":"https://www.wikidata.org/wiki/Q76826611","display_name":"RNase P","level":4,"score":0.4950055480003357},{"id":"https://openalex.org/C190062978","wikidata":"https://www.wikidata.org/wiki/Q79899","display_name":"Cytoplasm","level":2,"score":0.4680604040622711},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.44980281591415405},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1010485589504242},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.0},{"id":"https://openalex.org/C134306372","wikidata":"https://www.wikidata.org/wiki/Q7754","display_name":"Mathematical analysis","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016376","descriptor_name":"Oligonucleotides, Antisense","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016376","descriptor_name":"Oligonucleotides, Antisense","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016376","descriptor_name":"Oligonucleotides, Antisense","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016376","descriptor_name":"Oligonucleotides, Antisense","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D016376","descriptor_name":"Oligonucleotides, Antisense","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D016376","descriptor_name":"Oligonucleotides, Antisense","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D016376","descriptor_name":"Oligonucleotides, Antisense","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D016376","descriptor_name":"Oligonucleotides, Antisense","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D016376","descriptor_name":"Oligonucleotides, Antisense","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D019098","descriptor_name":"Telomerase","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D019098","descriptor_name":"Telomerase","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D019098","descriptor_name":"Telomerase","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1039/b507691a","doi":"https://doi.org/10.1039/b507691a","is_oa":false,"landing_page_url":"https://doi.org/10.1039/b507691a","pdf_url":null,"source":{"id":"https://openalex.org/S179810352","display_name":"Organic & Biomolecular Chemistry","issn_l":"1477-0520","issn":["1477-0520","1477-0539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-2","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310320556","host_organization_name":"Royal Society of Chemistry","host_organization_lineage":["https://openalex.org/P4310320556"],"host_organization_lineage_names":["Royal Society of Chemistry"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Organic &amp; Biomolecular Chemistry","raw_type":"journal-article"},{"id":"pmid:16132084","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16132084","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Organic & biomolecular chemistry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":24,"referenced_works":["https://openalex.org/W1968866064","https://openalex.org/W1977643768","https://openalex.org/W1986882083","https://openalex.org/W1997660008","https://openalex.org/W1998745896","https://openalex.org/W2016455999","https://openalex.org/W2024735180","https://openalex.org/W2036326817","https://openalex.org/W2036425276","https://openalex.org/W2044286897","https://openalex.org/W2049944281","https://openalex.org/W2052973382","https://openalex.org/W2053327612","https://openalex.org/W2057658284","https://openalex.org/W2058975342","https://openalex.org/W2060606238","https://openalex.org/W2089408908","https://openalex.org/W2091716703","https://openalex.org/W2110419228","https://openalex.org/W2122675272","https://openalex.org/W2123377969","https://openalex.org/W2138668121","https://openalex.org/W2173844423","https://openalex.org/W2249249956"],"related_works":["https://openalex.org/W3175810710","https://openalex.org/W2343044156","https://openalex.org/W2377326938","https://openalex.org/W2040933678","https://openalex.org/W1984446732","https://openalex.org/W2884371102","https://openalex.org/W2014289053","https://openalex.org/W3135240534","https://openalex.org/W2381230116","https://openalex.org/W2048130209"],"abstract_inverted_index":{"Oligonucleotides":[0],"can":[1],"be":[2,110,123],"covalently":[3],"linked":[4],"to":[5,62,76],"peptides":[6,20,44,98],"composed":[7],"of":[8,11,37,49,52],"any":[9],"sequence":[10],"amino":[12],"acids":[13],"by":[14],"solid":[15],"phase":[16],"fragment":[17],"condensation.":[18],"The":[19],"incorporated":[21],"into":[22,113],"the":[23,58,71,81,94,105,114,118,126],"conjugates":[24,54,59,72,95,106,119],"include":[25],"nuclear":[26,30],"localizing":[27],"signals":[28,32],"(NLS),":[29],"export":[31],"(NES),":[33],"membrane":[34],"fusion":[35,97],"domain":[36],"some":[38,42],"viral":[39],"proteins":[40],"and":[41,65],"designed":[43],"with":[45,67,96,107,120,134],"amphipathic":[46],"character.":[47],"Evaluation":[48],"biological":[50],"properties":[51],"DNA-peptide":[53],"indicated":[55],"that":[56],"(a)":[57],"could":[60,84,109,122,136],"bind":[61],"target":[63],"RNA":[64],"dsDNA":[66],"increased":[68],"affinity,":[69],"(b)":[70],"were":[73],"more":[74,145],"resistant":[75],"cellular":[77,102],"nuclease":[78],"degradation,":[79],"(c)":[80],"conjugate-RNA":[82],"hybrids":[83],"activate":[85],"RNase":[86],"H":[87],"as":[88,90],"effectively":[89],"native":[91],"oligonucleotides,":[92],"(d)":[93],"showed":[99],"largely":[100],"enhanced":[101],"uptake,":[103],"(e)":[104],"NLS":[108,135],"predominantly":[111],"delivered":[112],"cell":[115],"nucleus,":[116],"(f)":[117],"NES":[121],"localized":[124],"in":[125,140],"cytoplasm.":[127],"As":[128],"a":[129],"result,":[130],"antisense":[131],"oligonucleotides":[132],"conjugated":[133],"inhibit":[137],"human":[138,141],"telomerase":[139],"leukemia":[142],"cells":[143],"much":[144],"strongly":[146],"than":[147],"phosphorothioate":[148],"oligonucleotides.":[149]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-08-21T09:56:20.448147","created_date":"2025-10-10T00:00:00"}
