{"id":"https://openalex.org/W1993795103","doi":"https://doi.org/10.1159/000326268","title":"Noninvasive Evaluation of Retinal Leakage Using Optical Coherence Tomography","display_name":"Noninvasive Evaluation of Retinal Leakage Using Optical Coherence Tomography","publication_year":2011,"publication_date":"2011-01-01","ids":{"openalex":"https://openalex.org/W1993795103","doi":"https://doi.org/10.1159/000326268","mag":"1993795103","pmid":"https://pubmed.ncbi.nlm.nih.gov/21508651"},"language":"en","primary_location":{"id":"doi:10.1159/000326268","doi":"https://doi.org/10.1159/000326268","is_oa":false,"landing_page_url":"https://doi.org/10.1159/000326268","pdf_url":null,"source":{"id":"https://openalex.org/S204308127","display_name":"Ophthalmologica","issn_l":"0030-3755","issn":["0030-3755","1423-0267"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310317820","host_organization_name":"Karger Publishers","host_organization_lineage":["https://openalex.org/P4310317820"],"host_organization_lineage_names":["Karger Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Ophthalmologica","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/10400.2/1955","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5064063105","display_name":"Rui Bernardes","orcid":"https://orcid.org/0000-0002-6677-2754","observed_orcids":["https://orcid.org/0000-0002-6677-2754"]},"institutions":[{"id":"https://openalex.org/I4210141142","display_name":"Association for Innovation and Biomedical Research on Light and Image","ror":"https://ror.org/03j96wp44","country_code":"PT","type":"nonprofit","lineage":["https://openalex.org/I4210141142"]},{"id":"https://openalex.org/I76903346","display_name":"University of Coimbra","ror":"https://ror.org/04z8k9a98","country_code":"PT","type":"education","lineage":["https://openalex.org/I76903346"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Rui Bernardes","raw_affiliation_strings":["Center of New Technologies for Medicine, Association for Innovation and Biomedical Research on Light and Image (AIBILI), Coimbra, Portugal. rcb@aibilli.pt","Center of New Technologies for Medicine, Association for Innovation and Biomedical Research on Light and Image (AIBILI),","Institute of Biomedical Research on Light and Image, Faculty of Medicine, University of Coimbra, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center of New Technologies for Medicine, Association for Innovation and Biomedical Research on Light and Image (AIBILI), Coimbra, Portugal. rcb@aibilli.pt","institution_ids":["https://openalex.org/I4210141142"]},{"raw_affiliation_string":"Center of New Technologies for Medicine, Association for Innovation and Biomedical Research on Light and Image (AIBILI),","institution_ids":["https://openalex.org/I4210141142"]},{"raw_affiliation_string":"Institute of Biomedical Research on Light and Image, Faculty of Medicine, University of Coimbra, and","institution_ids":["https://openalex.org/I76903346"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076515187","display_name":"Torcato Santos","orcid":"https://orcid.org/0000-0003-1873-4320","observed_orcids":["https://orcid.org/0000-0003-1873-4320"]},"institutions":[{"id":"https://openalex.org/I4210141142","display_name":"Association for Innovation and Biomedical Research on Light and Image","ror":"https://ror.org/03j96wp44","country_code":"PT","type":"nonprofit","lineage":["https://openalex.org/I4210141142"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Torcato Santos","raw_affiliation_strings":["Center of New Technologies for Medicine, Association for Innovation and Biomedical Research on Light and Image (AIBILI),"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center of New Technologies for Medicine, Association for Innovation and Biomedical Research on Light and Image (AIBILI),","institution_ids":["https://openalex.org/I4210141142"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003891187","display_name":"Pedro Serranho","orcid":"https://orcid.org/0000-0003-2176-3923","observed_orcids":["https://orcid.org/0000-0003-2176-3923"]},"institutions":[{"id":"https://openalex.org/I76903346","display_name":"University of Coimbra","ror":"https://ror.org/04z8k9a98","country_code":"PT","type":"education","lineage":["https://openalex.org/I76903346"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Pedro Serranho","raw_affiliation_strings":["Institute of Biomedical Research on Light and Image, Faculty of Medicine, University of Coimbra, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Biomedical Research on Light and Image, Faculty of Medicine, University of Coimbra, and","institution_ids":["https://openalex.org/I76903346"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068843811","display_name":"Concei\u00e7\u00e3o Lopes Lobo","orcid":"https://orcid.org/0000-0001-5831-7711","observed_orcids":["https://orcid.org/0000-0001-5831-7711"]},"institutions":[{"id":"https://openalex.org/I2802025818","display_name":"Unidade Local de Sa\u00fade de Coimbra","ror":"https://ror.org/04032fz76","country_code":"PT","type":"healthcare","lineage":["https://openalex.org/I2802025818"]},{"id":"https://openalex.org/I4210141142","display_name":"Association for Innovation and Biomedical Research on Light and Image","ror":"https://ror.org/03j96wp44","country_code":"PT","type":"nonprofit","lineage":["https://openalex.org/I4210141142"]},{"id":"https://openalex.org/I76903346","display_name":"University of Coimbra","ror":"https://ror.org/04z8k9a98","country_code":"PT","type":"education","lineage":["https://openalex.org/I76903346"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Concei\u00e7\u00e3o Lobo","raw_affiliation_strings":["Center of New Technologies for Medicine, Association for Innovation and Biomedical Research on Light and Image (AIBILI),","Coimbra University Hospital, Coimbra, Portugal","Institute of Biomedical Research on Light and Image, Faculty of Medicine, University of Coimbra, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center of New Technologies for Medicine, Association for Innovation and Biomedical Research on Light and Image (AIBILI),","institution_ids":["https://openalex.org/I4210141142"]},{"raw_affiliation_string":"Coimbra University Hospital, Coimbra, Portugal","institution_ids":["https://openalex.org/I2802025818"]},{"raw_affiliation_string":"Institute of Biomedical Research on Light and Image, Faculty of Medicine, University of Coimbra, and","institution_ids":["https://openalex.org/I76903346"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5064272918","display_name":"Jos\u00e9 Guilherme Cunha-Vaz","orcid":"https://orcid.org/0000-0002-0947-9850","observed_orcids":["https://orcid.org/0000-0002-0947-9850"]},"institutions":[{"id":"https://openalex.org/I4210141142","display_name":"Association for Innovation and Biomedical Research on Light and Image","ror":"https://ror.org/03j96wp44","country_code":"PT","type":"nonprofit","lineage":["https://openalex.org/I4210141142"]},{"id":"https://openalex.org/I76903346","display_name":"University of Coimbra","ror":"https://ror.org/04z8k9a98","country_code":"PT","type":"education","lineage":["https://openalex.org/I76903346"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Jos\u00e9 Cunha-Vaz","raw_affiliation_strings":["Center of New Technologies for Medicine, Association for Innovation and Biomedical Research on Light and Image (AIBILI),","Institute of Biomedical Research on Light and Image, Faculty of Medicine, University of Coimbra, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center of New Technologies for Medicine, Association for Innovation and Biomedical Research on Light and Image (AIBILI),","institution_ids":["https://openalex.org/I4210141142"]},{"raw_affiliation_string":"Institute of Biomedical Research on Light and Image, Faculty of Medicine, University of Coimbra, and","institution_ids":["https://openalex.org/I76903346"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.1648,"has_fulltext":false,"cited_by_count":21,"citation_normalized_percentile":{"value":0.85034504,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"226","issue":"2","first_page":"29","last_page":"36"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11569","display_name":"Optical Coherence Tomography Applications","score":0.6859999895095825,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11569","display_name":"Optical Coherence Tomography Applications","score":0.6859999895095825,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11438","display_name":"Retinal Imaging and Analysis","score":0.19300000369548798,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10170","display_name":"Retinal Diseases and Treatments","score":0.11020000278949738,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/blood-retinal-barrier","display_name":"blood-retinal barrier","score":0.9559999704360962},{"id":"https://openalex.org/keywords/retinal-vascular-leakage","display_name":"retinal vascular leakage","score":0.9909999966621399},{"id":"https://openalex.org/keywords/optical-coherence-tomography","display_name":"optical coherence tomography","score":0.8640000224113464},{"id":"https://openalex.org/keywords/fluorescein-leakage","display_name":"fluorescein leakage","score":0.8889999985694885},{"id":"https://openalex.org/keywords/refractive-index-change","display_name":"refractive index change","score":0.7760000228881836},{"id":"https://openalex.org/keywords/nonproliferative-diabetic-retinopathy","display_name":"non-proliferative diabetic retinopathy","score":0.8830000162124634},{"id":"https://openalex.org/keywords/neovascular-age-related-macular-degeneration","display_name":"neovascular age-related macular degeneration","score":0.9819999933242798},{"id":"https://openalex.org/keywords/extracellular-space","display_name":"extracellular space","score":0.8069999814033508},{"id":"https://openalex.org/keywords/retinal-disease","display_name":"retinal disease","score":0.47699999809265137}],"concepts":[{"id":"https://openalex.org/C2778818243","wikidata":"https://www.wikidata.org/wiki/Q899552","display_name":"Optical coherence tomography","level":2,"score":0.8344107270240784},{"id":"https://openalex.org/C2780827179","wikidata":"https://www.wikidata.org/wiki/Q422001","display_name":"Retinal","level":2,"score":0.6117168068885803},{"id":"https://openalex.org/C2777042071","wikidata":"https://www.wikidata.org/wiki/Q6509304","display_name":"Leakage (economics)","level":2,"score":0.5404620170593262},{"id":"https://openalex.org/C163716698","wikidata":"https://www.wikidata.org/wiki/Q841267","display_name":"Tomography","level":2,"score":0.4851270616054535},{"id":"https://openalex.org/C118487528","wikidata":"https://www.wikidata.org/wiki/Q161437","display_name":"Ophthalmology","level":1,"score":0.4406152367591858},{"id":"https://openalex.org/C119767625","wikidata":"https://www.wikidata.org/wiki/Q618211","display_name":"Optometry","level":1,"score":0.42579153180122375},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.4091419577598572},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3869154751300812},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.21459123492240906},{"id":"https://openalex.org/C162324750","wikidata":"https://www.wikidata.org/wiki/Q8134","display_name":"Economics","level":0,"score":0.0},{"id":"https://openalex.org/C139719470","wikidata":"https://www.wikidata.org/wiki/Q39680","display_name":"Macroeconomics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001813","descriptor_name":"Blood-Retinal Barrier","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002199","descriptor_name":"Capillary Permeability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003930","descriptor_name":"Diabetic Retinopathy","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D005240","descriptor_name":"Feasibility Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005451","descriptor_name":"Fluorescein Angiography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012171","descriptor_name":"Retinal Vessels","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D041623","descriptor_name":"Tomography, Optical Coherence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D057135","descriptor_name":"Wet Macular Degeneration","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1159/000326268","doi":"https://doi.org/10.1159/000326268","is_oa":false,"landing_page_url":"https://doi.org/10.1159/000326268","pdf_url":null,"source":{"id":"https://openalex.org/S204308127","display_name":"Ophthalmologica","issn_l":"0030-3755","issn":["0030-3755","1423-0267"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310317820","host_organization_name":"Karger Publishers","host_organization_lineage":["https://openalex.org/P4310317820"],"host_organization_lineage_names":["Karger Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Ophthalmologica","raw_type":"journal-article"},{"id":"pmid:21508651","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21508651","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift fur Augenheilkunde","raw_type":"Journal Article"},{"id":"pmh:oai:repositorioaberto.uab.pt:10400.2/1955","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10400.2/1955","pdf_url":null,"source":{"id":"https://openalex.org/S4306402433","display_name":"Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"journal article"}],"best_oa_location":{"id":"pmh:oai:repositorioaberto.uab.pt:10400.2/1955","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10400.2/1955","pdf_url":null,"source":{"id":"https://openalex.org/S4306402433","display_name":"Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"journal article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320309762","display_name":"Clinical Trial Center, China Medical University Hospital","ror":"https://ror.org/0368s4g32"},{"id":"https://openalex.org/F4320321502","display_name":"Carl Zeiss Meditec AG","ror":"https://ror.org/02mp31p96"},{"id":"https://openalex.org/F4320337376","display_name":"NIH Clinical Center","ror":"https://ror.org/04vfsmv21"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":5,"referenced_works":["https://openalex.org/W1546955364","https://openalex.org/W1574975037","https://openalex.org/W2026545142","https://openalex.org/W2092367552","https://openalex.org/W2114712003"],"related_works":["https://openalex.org/W2058307280","https://openalex.org/W4390414041","https://openalex.org/W2171548487","https://openalex.org/W2032944344","https://openalex.org/W2598977718","https://openalex.org/W2569044496","https://openalex.org/W2087849319","https://openalex.org/W2121546163","https://openalex.org/W2440288898","https://openalex.org/W974694932"],"abstract_inverted_index":{"PURPOSE:":[0],"To":[1],"demonstrate":[2,220],"the":[3,8,19,23,45,53,74,78,96,133,149,169,175,201,212,221,227],"association":[4],"between":[5,91,105,138],"changes":[6,36,72],"in":[7,18,174,200,204],"blood-retinal":[9],"barrier":[10],"(BRB)":[11],"identified":[12,43,147],"by":[13,27,148],"fluorescein":[14],"leakage":[15,55,151],"and":[16,32,40,66,103,122,142,155,209],"those":[17],"optical":[20,28],"properties":[21],"of":[22,85,93,107,135,140,144,211,223],"human":[24,79],"retina":[25,176],"determined":[26],"coherence":[29],"tomography":[30],"(OCT)":[31],"show":[33],"how":[34],"these":[35],"can":[37],"be":[38,172,195],"quantified":[39,154],"their":[41],"location":[42],"within":[44,77,230],"retina.":[46],"METHODS:":[47],"Two":[48],"imaging":[49],"techniques":[50],"were":[51,88],"applied:":[52],"retinal":[54,150,207],"analyzer,":[56,152],"to":[57,68,177,186,197],"map":[58],"BRB":[59,228],"function":[60],"into":[61],"intact":[62,141],"or":[63,100],"disrupted":[64,101,145],"regions,":[65],"OCT,":[67],"measure":[69],"refractive":[70],"index":[71],"along":[73],"light":[75],"path":[76],"ocular":[80],"fundus.":[81],"RESULTS:":[82],"A":[83],"total":[84],"140":[86],"comparisons":[87],"made,":[89],"77":[90],"areas":[92,106],"regions":[94,108,139,143],"receiving":[95,109],"same":[97],"classification":[98],"(intact":[99],"BRB)":[102],"63":[104],"distinct":[110],"classifications,":[111],"from":[112],"4":[113],"pathological":[114],"cases:":[115],"2":[116,123],"eyes":[117,124,205],"with":[118,125,206],"nonproliferative":[119],"diabetic":[120],"retinopathy":[121],"wet":[126],"age-related":[127],"macular":[128],"degeneration.":[129],"In":[130,163],"all":[131],"cases,":[132],"distribution":[134],"OCT":[136,188,232],"data":[137],"BRB,":[146],"was":[153,156,166],"statistically":[157],"significantly":[158],"different":[159],"(p":[160],"<":[161],"0.001).":[162],"addition,":[164],"it":[165,193],"found":[167],"that":[168,192],"differences":[170,199],"could":[171],"localized":[173],"specific":[178],"structural":[179],"sequences.":[180],"CONCLUSIONS:":[181],"Using":[182],"a":[183],"novel":[184],"method":[185],"analyze":[187],"data,":[189],"we":[190],"showed":[191],"may":[194],"possible":[196],"quantify":[198],"extracellular":[202],"compartment":[203],"disease":[208],"alterations":[210],"BRB.":[213],"Based":[214],"on":[215,226],"quantitative":[216],"techniques,":[217],"our":[218],"findings":[219],"presence":[222],"indirect":[224],"information":[225],"status":[229],"noninvasive":[231],"data.":[233]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3},{"year":2023,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":7}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
