{"id":"https://openalex.org/W1993785932","doi":"https://doi.org/10.1002/hep.510250315","title":"Difference in Gene Expression for Matrix Metalloproteinase\u20131 Between Early and Advanced Hepatocellular Carcinomas","display_name":"Difference in Gene Expression for Matrix Metalloproteinase\u20131 Between Early and Advanced Hepatocellular Carcinomas","publication_year":1997,"publication_date":"1997-03-01","ids":{"openalex":"https://openalex.org/W1993785932","doi":"https://doi.org/10.1002/hep.510250315","mag":"1993785932","pmid":"https://pubmed.ncbi.nlm.nih.gov/9049202"},"language":"en","primary_location":{"id":"doi:10.1002/hep.510250315","doi":"https://doi.org/10.1002/hep.510250315","is_oa":false,"landing_page_url":"https://doi.org/10.1002/hep.510250315","pdf_url":null,"source":{"id":"https://openalex.org/S156174673","display_name":"Hepatology","issn_l":"0270-9139","issn":["0270-9139","1527-3350"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hepatology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5040381217","display_name":"Isao Okazaki","orcid":"https://orcid.org/0000-0002-9825-496X","observed_orcids":["https://orcid.org/0000-0002-9825-496X"]},"institutions":[{"id":"https://openalex.org/I1314466530","display_name":"Tokai University","ror":"https://ror.org/01p7qe739","country_code":"JP","type":"education","lineage":["https://openalex.org/I1314466530"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"I Okazaki","raw_affiliation_strings":["Department of Community Health, School of Medicine, Tokai University, Isehara City, Kanagawa, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Community Health, School of Medicine, Tokai University, Isehara City, Kanagawa, Japan","institution_ids":["https://openalex.org/I1314466530"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008461685","display_name":"Norihito Wada","orcid":"https://orcid.org/0000-0003-4857-8453","observed_orcids":["https://orcid.org/0000-0003-4857-8453"]},"institutions":[{"id":"https://openalex.org/I1314466530","display_name":"Tokai University","ror":"https://ror.org/01p7qe739","country_code":"JP","type":"education","lineage":["https://openalex.org/I1314466530"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"N Wada","raw_affiliation_strings":["Department of Community Health, School of Medicine, Tokai University, Isehara City, Kanagawa, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Community Health, School of Medicine, Tokai University, Isehara City, Kanagawa, Japan","institution_ids":["https://openalex.org/I1314466530"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102743834","display_name":"Masayuki Nakano","orcid":"https://orcid.org/0000-0002-5021-9313","observed_orcids":["https://orcid.org/0000-0002-5021-9313"]},"institutions":[{"id":"https://openalex.org/I1314466530","display_name":"Tokai University","ror":"https://ror.org/01p7qe739","country_code":"JP","type":"education","lineage":["https://openalex.org/I1314466530"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"M Nakano","raw_affiliation_strings":["Department of Community Health, School of Medicine, Tokai University, Isehara City, Kanagawa, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Community Health, School of Medicine, Tokai University, Isehara City, Kanagawa, Japan","institution_ids":["https://openalex.org/I1314466530"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016286590","display_name":"Akiko Saito","orcid":"https://orcid.org/0000-0002-8977-4533","observed_orcids":["https://orcid.org/0000-0002-8977-4533"]},"institutions":[{"id":"https://openalex.org/I1314466530","display_name":"Tokai University","ror":"https://ror.org/01p7qe739","country_code":"JP","type":"education","lineage":["https://openalex.org/I1314466530"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"A Saito","raw_affiliation_strings":["Department of Community Health, School of Medicine, Tokai University, Isehara City, Kanagawa, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Community Health, School of Medicine, Tokai University, Isehara City, Kanagawa, Japan","institution_ids":["https://openalex.org/I1314466530"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112136316","display_name":"Ken Takasaki","orcid":"https://orcid.org/0000-0001-8707-6654","observed_orcids":["https://orcid.org/0000-0001-8707-6654"]},"institutions":[{"id":"https://openalex.org/I1314466530","display_name":"Tokai University","ror":"https://ror.org/01p7qe739","country_code":"JP","type":"education","lineage":["https://openalex.org/I1314466530"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"K Takasaki","raw_affiliation_strings":["Department of Community Health, School of Medicine, Tokai University, Isehara City, Kanagawa, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Community Health, School of Medicine, Tokai University, Isehara City, Kanagawa, Japan","institution_ids":["https://openalex.org/I1314466530"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086866950","display_name":"Mikio Doi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1314466530","display_name":"Tokai University","ror":"https://ror.org/01p7qe739","country_code":"JP","type":"education","lineage":["https://openalex.org/I1314466530"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"M Doi","raw_affiliation_strings":["Department of Community Health, School of Medicine, Tokai University, Isehara City, Kanagawa, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Community Health, School of Medicine, Tokai University, Isehara City, Kanagawa, Japan","institution_ids":["https://openalex.org/I1314466530"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084143917","display_name":"Kaori Kameyama","orcid":"https://orcid.org/0000-0003-2069-3249","observed_orcids":["https://orcid.org/0000-0003-2069-3249"]},"institutions":[{"id":"https://openalex.org/I1314466530","display_name":"Tokai University","ror":"https://ror.org/01p7qe739","country_code":"JP","type":"education","lineage":["https://openalex.org/I1314466530"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"K Kameyama","raw_affiliation_strings":["Department of Community Health, School of Medicine, Tokai University, Isehara City, Kanagawa, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Community Health, School of Medicine, Tokai University, Isehara City, Kanagawa, Japan","institution_ids":["https://openalex.org/I1314466530"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045197572","display_name":"Y Otani","orcid":"https://orcid.org/0009-0008-6049-1135","observed_orcids":["https://orcid.org/0009-0008-6049-1135"]},"institutions":[{"id":"https://openalex.org/I1314466530","display_name":"Tokai University","ror":"https://ror.org/01p7qe739","country_code":"JP","type":"education","lineage":["https://openalex.org/I1314466530"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Y Otani","raw_affiliation_strings":["Department of Community Health, School of Medicine, Tokai University, Isehara City, Kanagawa, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Community Health, School of Medicine, Tokai University, Isehara City, Kanagawa, Japan","institution_ids":["https://openalex.org/I1314466530"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028210669","display_name":"Kiyoshi Kubochi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1314466530","display_name":"Tokai University","ror":"https://ror.org/01p7qe739","country_code":"JP","type":"education","lineage":["https://openalex.org/I1314466530"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"K Kubochi","raw_affiliation_strings":["Department of Community Health, School of Medicine, Tokai University, Isehara City, Kanagawa, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Community Health, School of Medicine, Tokai University, Isehara City, Kanagawa, Japan","institution_ids":["https://openalex.org/I1314466530"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014845190","display_name":"Maki Niioka","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1314466530","display_name":"Tokai University","ror":"https://ror.org/01p7qe739","country_code":"JP","type":"education","lineage":["https://openalex.org/I1314466530"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"M Niioka","raw_affiliation_strings":["Department of Community Health, School of Medicine, Tokai University, Isehara City, Kanagawa, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Community Health, School of Medicine, Tokai University, Isehara City, Kanagawa, Japan","institution_ids":["https://openalex.org/I1314466530"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082402683","display_name":"Takuya Watanabe","orcid":"https://orcid.org/0000-0003-3820-0262","observed_orcids":["https://orcid.org/0000-0003-3820-0262"]},"institutions":[{"id":"https://openalex.org/I1314466530","display_name":"Tokai University","ror":"https://ror.org/01p7qe739","country_code":"JP","type":"education","lineage":["https://openalex.org/I1314466530"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"T Watanabe","raw_affiliation_strings":["Department of Community Health, School of Medicine, Tokai University, Isehara City, Kanagawa, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Community Health, School of Medicine, Tokai University, Isehara City, Kanagawa, Japan","institution_ids":["https://openalex.org/I1314466530"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5070143024","display_name":"Katsuya Maruyama","orcid":"https://orcid.org/0000-0003-0662-5987","observed_orcids":["https://orcid.org/0000-0003-0662-5987"]},"institutions":[{"id":"https://openalex.org/I1314466530","display_name":"Tokai University","ror":"https://ror.org/01p7qe739","country_code":"JP","type":"education","lineage":["https://openalex.org/I1314466530"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"K Maruyama","raw_affiliation_strings":["Department of Community Health, School of Medicine, Tokai University, Isehara City, Kanagawa, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Community Health, School of Medicine, Tokai University, Isehara City, Kanagawa, Japan","institution_ids":["https://openalex.org/I1314466530"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I1314466530"],"apc_list":{"value":2900,"currency":"USD","value_usd":2900},"apc_paid":null,"fwci":0.9907,"has_fulltext":false,"cited_by_count":42,"citation_normalized_percentile":{"value":0.74661364,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"25","issue":"3","first_page":"580","last_page":"584"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.9901999831199646,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.9901999831199646,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10073","display_name":"Hepatocellular Carcinoma Treatment and Prognosis","score":0.006000000052154064,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.0026000000070780516,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mmp-1","display_name":"MMP-1","score":0.9459999799728394},{"id":"https://openalex.org/keywords/hepatocellular-carcinoma","display_name":"hepatocellular carcinoma","score":0.9980000257492065},{"id":"https://openalex.org/keywords/tumor-differentiation","display_name":"tumor differentiation","score":0.7480000257492065},{"id":"https://openalex.org/keywords/tumor-invasion","display_name":"tumor invasion","score":0.6639999747276306},{"id":"https://openalex.org/keywords/extracellular-matrix-degradation","display_name":"extracellular matrix degradation","score":0.8190000057220459},{"id":"https://openalex.org/keywords/liver-cirrhosis","display_name":"liver cirrhosis","score":0.7379999756813049},{"id":"https://openalex.org/keywords/fibrous-bands","display_name":"fibrous bands","score":0.5009999871253967},{"id":"https://openalex.org/keywords/gene-expression","display_name":"gene expression","score":0.6600000262260437}],"concepts":[{"id":"https://openalex.org/C2778019345","wikidata":"https://www.wikidata.org/wiki/Q1148337","display_name":"Hepatocellular carcinoma","level":2,"score":0.7472831010818481},{"id":"https://openalex.org/C2779314089","wikidata":"https://www.wikidata.org/wiki/Q18026830","display_name":"HCCS","level":3,"score":0.7280898690223694},{"id":"https://openalex.org/C81439078","wikidata":"https://www.wikidata.org/wiki/Q2304142","display_name":"In situ hybridization","level":4,"score":0.7246773838996887},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.6101874113082886},{"id":"https://openalex.org/C2777214474","wikidata":"https://www.wikidata.org/wiki/Q147778","display_name":"Cirrhosis","level":2,"score":0.5843204855918884},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5526280999183655},{"id":"https://openalex.org/C109523444","wikidata":"https://www.wikidata.org/wiki/Q424216","display_name":"Matrix metalloproteinase","level":2,"score":0.5219773054122925},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.5031115412712097},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.5017015933990479},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4976489841938019},{"id":"https://openalex.org/C2776231280","wikidata":"https://www.wikidata.org/wiki/Q623031","display_name":"Liver cancer","level":3,"score":0.45131683349609375},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.43600353598594666},{"id":"https://openalex.org/C55728118","wikidata":"https://www.wikidata.org/wiki/Q425402","display_name":"Metalloproteinase","level":3,"score":0.4281717538833618},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4049120545387268},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.36041367053985596},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2846892178058624},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.1283542811870575},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.06369206309318542}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009363","descriptor_name":"Neoplasm Proteins","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D009363","descriptor_name":"Neoplasm Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009367","descriptor_name":"Neoplasm Staging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D015971","descriptor_name":"Gene Expression Regulation, Enzymologic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017364","descriptor_name":"Collagenases","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D017364","descriptor_name":"Collagenases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020781","descriptor_name":"Matrix Metalloproteinase 1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/hep.510250315","doi":"https://doi.org/10.1002/hep.510250315","is_oa":false,"landing_page_url":"https://doi.org/10.1002/hep.510250315","pdf_url":null,"source":{"id":"https://openalex.org/S156174673","display_name":"Hepatology","issn_l":"0270-9139","issn":["0270-9139","1527-3350"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hepatology","raw_type":"journal-article"},{"id":"pmid:9049202","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9049202","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hepatology (Baltimore, Md.)","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9476000070571899,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":18,"referenced_works":["https://openalex.org/W1277373232","https://openalex.org/W1491598928","https://openalex.org/W1970082102","https://openalex.org/W1990905621","https://openalex.org/W2015116198","https://openalex.org/W2015361704","https://openalex.org/W2020494144","https://openalex.org/W2030958462","https://openalex.org/W2031717125","https://openalex.org/W2041760911","https://openalex.org/W2049859945","https://openalex.org/W2057410099","https://openalex.org/W2102773032","https://openalex.org/W2136873073","https://openalex.org/W2253298865","https://openalex.org/W2290670539","https://openalex.org/W2315123663","https://openalex.org/W2415704076"],"related_works":["https://openalex.org/W2348257747","https://openalex.org/W2079655998","https://openalex.org/W89357927","https://openalex.org/W3029905982","https://openalex.org/W2412011651","https://openalex.org/W1751278600","https://openalex.org/W4210591057","https://openalex.org/W2008346295","https://openalex.org/W4232741423","https://openalex.org/W2349070812"],"abstract_inverted_index":{"The":[0],"histological":[1],"observation":[2],"that":[3,19],"well-differentiated":[4,94],"cancer":[5,95,107,110,126,146],"cells":[6,96,111],"in":[7,32,57,63,83,93,102,114,142],"early":[8,58,98,115,151],"hepatocellular":[9],"carcinoma":[10],"(HCC)":[11],"invade":[12],"portal":[13,120],"tracts":[14],"and/or":[15,128],"fibrous":[16,21,36,130],"bands":[17],"and":[18,52,61,70,89,148,152],"these":[20],"tissues":[22],"then":[23,77],"disappear":[24],"suggests":[25],"the":[26,33,42,45,49,79,119,125,129,143],"participation":[27],"of":[28,35,47,74,97,132,145],"matrix":[29],"metalloproteinase-1":[30],"(MMP-1)":[31],"degradation":[34],"tissue.":[37],"To":[38],"confirm":[39],"this":[40],"hypothesis,":[41],"authors":[43],"investigated":[44],"localization":[46],"both":[48],"MMP-1":[50,86,113],"protein":[51,90],"its":[53],"messenger":[54],"RNA":[55],"(mRNA)":[56],"HCC":[59,99,116],"immunohistochemically":[60],"by":[62],"situ":[64],"hybridization":[65],"using":[66],"complementary":[67],"DNA":[68],"(cDNA)":[69],"synthetic":[71],"antisense":[72],"probe":[73],"MMP-1;":[75],"they":[76],"compared":[78],"results":[80,135],"with":[81],"those":[82],"advanced":[84,153],"HCC.":[85],"gene":[87],"transcripts":[88],"were":[91],"observed":[92],"but":[100],"not":[101],"moderately":[103],"or":[104],"poorly":[105],"differentiated":[106],"cells.":[108],"Thus,":[109],"producing":[112],"may":[117],"destroy":[118],"tract":[121],"tissue":[122],"adjacent":[123],"to":[124,137],"lesion":[127],"band":[131],"cirrhosis.":[133],"These":[134],"seem":[136],"have":[138],"demonstrated":[139],"a":[140],"difference":[141],"mechanism":[144],"growth":[147],"invasion":[149],"between":[150],"HCCs.":[154]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
