{"id":"https://openalex.org/W1993781652","doi":"https://doi.org/10.1158/1538-7445.am10-lb-203","title":"Abstract LB-203: Aromatase expression promotes breast cancer tumorigenesis and bone metastasis","display_name":"Abstract LB-203: Aromatase expression promotes breast cancer tumorigenesis and bone metastasis","publication_year":2010,"publication_date":"2010-04-01","ids":{"openalex":"https://openalex.org/W1993781652","doi":"https://doi.org/10.1158/1538-7445.am10-lb-203","mag":"1993781652"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.am10-lb-203","doi":"https://doi.org/10.1158/1538-7445.am10-lb-203","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am10-lb-203","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112070194","display_name":"Keya De","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165951966","display_name":"The University of Texas at San Antonio Health Science Center","ror":"https://ror.org/02f6dcw23","country_code":"US","type":"education","lineage":["https://openalex.org/I165951966","https://openalex.org/I45438204"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Keya De","raw_affiliation_strings":["1UT Health Science Center San Antonio, San Antonio, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1UT Health Science Center San Antonio, San Antonio, TX","institution_ids":["https://openalex.org/I165951966"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100364732","display_name":"Zhao Liu","orcid":"https://orcid.org/0009-0000-5103-9923","observed_orcids":["https://orcid.org/0009-0000-5103-9923"]},"institutions":[{"id":"https://openalex.org/I165951966","display_name":"The University of Texas at San Antonio Health Science Center","ror":"https://ror.org/02f6dcw23","country_code":"US","type":"education","lineage":["https://openalex.org/I165951966","https://openalex.org/I45438204"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zhao Liu","raw_affiliation_strings":["1UT Health Science Center San Antonio, San Antonio, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1UT Health Science Center San Antonio, San Antonio, TX","institution_ids":["https://openalex.org/I165951966"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069261325","display_name":"Lan Yu","orcid":"https://orcid.org/0000-0002-8693-5987","observed_orcids":["https://orcid.org/0000-0002-8693-5987"]},"institutions":[{"id":"https://openalex.org/I165951966","display_name":"The University of Texas at San Antonio Health Science Center","ror":"https://ror.org/02f6dcw23","country_code":"US","type":"education","lineage":["https://openalex.org/I165951966","https://openalex.org/I45438204"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lan Yu","raw_affiliation_strings":["1UT Health Science Center San Antonio, San Antonio, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1UT Health Science Center San Antonio, San Antonio, TX","institution_ids":["https://openalex.org/I165951966"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5056931880","display_name":"Lu\u2010Zhe Sun","orcid":"https://orcid.org/0000-0001-7117-4559","observed_orcids":["https://orcid.org/0000-0001-7117-4559"]},"institutions":[{"id":"https://openalex.org/I165951966","display_name":"The University of Texas at San Antonio Health Science Center","ror":"https://ror.org/02f6dcw23","country_code":"US","type":"education","lineage":["https://openalex.org/I165951966","https://openalex.org/I45438204"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Luzhe Sun","raw_affiliation_strings":["1UT Health Science Center San Antonio, San Antonio, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1UT Health Science Center San Antonio, San Antonio, TX","institution_ids":["https://openalex.org/I165951966"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I165951966"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"70","issue":"8_Supplement","first_page":"LB","last_page":"203"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12465","display_name":"Cancer, Lipids, and Metabolism","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/aromatase","display_name":"aromatase","score":0.972000002861023},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.9490000009536743},{"id":"https://openalex.org/keywords/bone-metastases","display_name":"bone metastasis","score":0.8650000095367432},{"id":"https://openalex.org/keywords/estrogen-biosynthesis","display_name":"estrogen synthesis","score":0.7620000243186951},{"id":"https://openalex.org/keywords/estrogen-receptor-positive-breast-cancer","display_name":"estrogen receptor-positive breast cancer","score":0.7289999723434448},{"id":"https://openalex.org/keywords/zr-75-1-cells","display_name":"ZR-75-1 cells","score":0.8870000243186951},{"id":"https://openalex.org/keywords/intracardiac-injection","display_name":"intracardiac injection","score":0.5709999799728394},{"id":"https://openalex.org/keywords/orthotopic-xenograft-model","display_name":"orthotopic xenograft","score":0.6650000214576721},{"id":"https://openalex.org/keywords/tumor-cell-survival","display_name":"tumor cell survival","score":0.3610000014305115},{"id":"https://openalex.org/keywords/mammary-fat-pad","display_name":"mammary fat pad","score":0.46299999952316284}],"concepts":[{"id":"https://openalex.org/C2776166826","wikidata":"https://www.wikidata.org/wiki/Q415287","display_name":"Aromatase","level":4,"score":0.9288090467453003},{"id":"https://openalex.org/C2777164284","wikidata":"https://www.wikidata.org/wiki/Q277954","display_name":"Estrogen","level":2,"score":0.7391484975814819},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.6350200176239014},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.630907416343689},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.600531816482544},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5528504252433777},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.47474199533462524},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4044649600982666},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.34977149963378906}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.am10-lb-203","doi":"https://doi.org/10.1158/1538-7445.am10-lb-203","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am10-lb-203","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2315007525","https://openalex.org/W2321514483","https://openalex.org/W2016343876","https://openalex.org/W54069900","https://openalex.org/W2125788271","https://openalex.org/W2075019139","https://openalex.org/W2042157811","https://openalex.org/W2045275262","https://openalex.org/W2410309122","https://openalex.org/W2043879831"],"abstract_inverted_index":{"Abstract":[0],"Aromatase":[1],"P450":[2],"(CYP19)":[3],"is":[4,60,379,396],"the":[5,9,32,66,86,108,113,142,148,179,189,206,209,220,233,238,259,268,280,311,359,447,452],"rate-limiting":[6],"enzyme":[7],"catalyzing":[8],"final":[10],"step":[11],"in":[12,19,43,57,72,93,106,139,242,273,323,392,409,432],"estrogen":[13,51,55,70,92,198,253,272,302],"biosynthesis,":[14],"and":[15,47,63,127,211,224,276,282,286,325,337,349,362,375,403,406,434],"an":[16,122,372],"important":[17],"target":[18],"breast":[20,35,44,76,94,117,247,393,411,426],"cancer":[21,36,77,95,118,248,394,412,427],"therapy.":[22],"In":[23],"post-menopausal":[24],"women,":[25],"ovaries":[26],"cease":[27],"to":[28,82,159,167,321,398],"make":[29],"estrogen,":[30],"yet":[31],"incidence":[33],"of":[34,68,91,137,147,184,194,201,208,230,270,307,330,358,371,390,446,451],"increases":[37],"with":[38,121,141,300,313,346,368],"age":[39],"as":[40,340],"aromatase":[41,84,124,138,234,373,391,430],"present":[42],"adipose":[45,261],"stroma":[46,262],"epithelium":[48],"catalyzes":[49],"local":[50,69],"formation.":[52],"The":[53,170],"circulating":[54,245],"level":[56,136],"postmenopausal":[58],"women":[59],"very":[61],"low":[62],"it":[64],"reflects":[65],"sum":[67],"biosynthesis":[71],"various":[73],"sites.":[74],"Although":[75],"cells":[78,96,120,172,191,226,239,249,284,317,342,395,428],"have":[79],"been":[80,103],"shown":[81],"express":[83],"prompting":[85],"hypothesis":[87],"that":[88,386],"intracrine":[89,252,271,400],"action":[90,402],"may":[97,250],"drive":[98],"tumor":[99,210],"progression,":[100],"there":[101],"has":[102],"little":[104],"evidence":[105],"addressing":[107],"hypothesis.":[109],"We":[110,353],"stably":[111,344],"transfected":[112,345],"ER":[114],"positive":[115],"(ER+)":[116],"ZR-75-1":[119],"human":[123],"expression":[125,235,351,389,431],"vector":[126],"obtained":[128],"a":[129,133,212,347,387],"few":[130],"clones":[131,149],"expressing":[132],"moderately":[134],"higher":[135],"comparison":[140],"control":[143,190],"vector-transfected":[144],"cells.":[145,413],"One":[146],"called":[150],"ZR-75-1/Aro/Clone10":[151],"(Cl10)":[152],"was":[153,217],"selected":[154],"for":[155,255,420,455],"further":[156,204],"study":[157],"due":[158],"its":[160],"increased":[161,236],"intracellular":[162],"estradiol":[163],"(E2)":[164],"concentration":[165],"compared":[166],"other":[168],"clones.":[169],"Cl10":[171,223,281],"formed":[173],"tumors":[174,196,299,361],"after":[175,257,304,327],"being":[176],"xenografted":[177],"into":[178,289],"inguinal":[180],"mammary":[181],"fat":[182],"pad":[183],"female":[185,290],"athymic":[186,291],"mice":[187,312],"while":[188],"were":[192,240,343],"incapable":[193],"forming":[195],"without":[197],"supplementation.":[199],"Implantation":[200],"testosterone":[202],"pellet":[203],"stimulated":[205],"growth":[207,357],"cell":[213,295],"line,":[214],"ZR-75-1/Aro/Clone10/TT1":[215],"(TT1)":[216],"established":[218],"from":[219],"tumor.":[221],"Both":[222],"TT1":[225,283],"expressed":[227],"similar":[228],"levels":[229],"aromatase.":[231],"Interestingly,":[232],"when":[237],"cultured":[241],"suspension":[243,433],"suggesting":[244],"ER+":[246,410,425],"up-regulate":[251,429],"activity":[254],"survival":[256],"leaving":[258],"estrogen-rich":[260],"at":[263],"primary":[264],"site.":[265],"To":[266],"investigate":[267],"importance":[269],"promoting":[274],"tumorigenesis":[275,405],"metastasis,":[277],"we":[278],"implanted":[279],"orthotopically":[285],"intracardiacally":[287],"(I.C.)":[288],"mice.":[292],"Notably,":[293],"both":[294,341],"lines":[296],"generated":[297],"orthotopic":[298,360],"no":[301],"supplementation":[303],"three":[305],"weeks":[306,329],"inoculation.":[308],"More":[309],"interestingly,":[310],"I.C.":[314],"inoculated":[315],"aromatase-expressing":[316,415],"presented":[318],"distant":[319],"metastasis":[320,378,408],"bones":[322],"mandible":[324],"legs":[326],"two":[328],"inoculation":[331],"detected":[332],"by":[333],"whole":[334],"mouse":[335],"fluorescence":[336],"bioluminescence":[338],"imaging":[339],"luciferase":[348],"GFP":[350],"vector.":[352],"will":[354],"determine":[355],"whether":[356,376],"bone":[363,377,436],"metastases":[364],"can":[365],"be":[366,418],"inhibited":[367],"systemic":[369],"administration":[370],"inhibitor":[374],"osteoclastic":[380],"or":[381],"osteoblastic.":[382],"Our":[383],"studies":[384],"show":[385],"moderate":[388],"sufficient":[397],"generate":[399],"estrogenic":[401],"promote":[404],"skeletal":[407],"These":[414],"models":[416],"should":[417],"useful":[419],"future":[421],"investigation":[422],"on":[423],"how":[424],"induces":[435],"remodeling.":[437],"Citation":[438],"Format:":[439],"{Authors}.":[440],"{Abstract":[441],"title}":[442],"[abstract].":[443],"In:":[444],"Proceedings":[445],"101st":[448],"Annual":[449],"Meeting":[450],"American":[453],"Association":[454],"Cancer":[456,466],"Research;":[457],"2010":[458],"Apr":[459],"17-21;":[460],"Washington,":[461],"DC.":[462],"Philadelphia":[463],"(PA):":[464],"AACR;":[465],"Res":[467],"2010;70(8":[468],"Suppl):Abstract":[469],"nr":[470],"LB-203.":[471]},"counts_by_year":[],"updated_date":"2026-07-14T23:27:15.235271","created_date":"2016-06-24T00:00:00"}
