{"id":"https://openalex.org/W1993766933","doi":"https://doi.org/10.1007/bf00512468","title":"Effects of clonidine on the rate of noradrenaline turnover in discrete areas of the rat central nervous system","display_name":"Effects of clonidine on the rate of noradrenaline turnover in discrete areas of the rat central nervous system","publication_year":1983,"publication_date":"1983-08-01","ids":{"openalex":"https://openalex.org/W1993766933","doi":"https://doi.org/10.1007/bf00512468","mag":"1993766933","pmid":"https://pubmed.ncbi.nlm.nih.gov/6633671"},"language":"en","primary_location":{"id":"doi:10.1007/bf00512468","doi":"https://doi.org/10.1007/bf00512468","is_oa":false,"landing_page_url":"https://doi.org/10.1007/bf00512468","pdf_url":null,"source":{"id":"https://openalex.org/S159534381","display_name":"Naunyn-Schmiedeberg s Archives of Pharmacology","issn_l":"0028-1298","issn":["0028-1298","0340-5249","1432-1912"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Naunyn-Schmiedeberg's Archives of Pharmacology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113698219","display_name":"H.P. Lorez","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I118019719","display_name":"F. Hoffmann-La Roche AG","ror":"https://ror.org/00by1q217","country_code":"CH","type":"company","lineage":["https://openalex.org/I118019719"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"H. P. Lorez","raw_affiliation_strings":["Pharmaceutical Research Department of F. Hoffmann-La Roche & Co., Ltd., Basel, Switzerland","Pharmaceutical Research Department of F. Hoffmann-La Roche and Co. Ltd, Basel, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharmaceutical Research Department of F. Hoffmann-La Roche & Co., Ltd., Basel, Switzerland","institution_ids":["https://openalex.org/I118019719"]},{"raw_affiliation_string":"Pharmaceutical Research Department of F. Hoffmann-La Roche and Co. Ltd, Basel, Switzerland","institution_ids":["https://openalex.org/I118019719"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019320962","display_name":"D\u00e9nes Zsolt Kiss","orcid":"https://orcid.org/0000-0002-8521-5152","observed_orcids":["https://orcid.org/0000-0002-8521-5152"]},"institutions":[{"id":"https://openalex.org/I118019719","display_name":"F. Hoffmann-La Roche AG","ror":"https://ror.org/00by1q217","country_code":"CH","type":"company","lineage":["https://openalex.org/I118019719"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"D. Kiss","raw_affiliation_strings":["Pharmaceutical Research Department of F. Hoffmann-La Roche & Co., Ltd., Basel, Switzerland","Pharmaceutical Research Department of F. Hoffmann-La Roche and Co. Ltd, Basel, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharmaceutical Research Department of F. Hoffmann-La Roche & Co., Ltd., Basel, Switzerland","institution_ids":["https://openalex.org/I118019719"]},{"raw_affiliation_string":"Pharmaceutical Research Department of F. Hoffmann-La Roche and Co. Ltd, Basel, Switzerland","institution_ids":["https://openalex.org/I118019719"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110437442","display_name":"M. Da Prada","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I118019719","display_name":"F. Hoffmann-La Roche AG","ror":"https://ror.org/00by1q217","country_code":"CH","type":"company","lineage":["https://openalex.org/I118019719"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"M. Da Prada","raw_affiliation_strings":["Pharmaceutical Research Department of F. Hoffmann-La Roche & Co., Ltd., Basel, Switzerland","Pharmaceutical Research Department of F. Hoffmann-La Roche and Co. Ltd, Basel, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharmaceutical Research Department of F. Hoffmann-La Roche & Co., Ltd., Basel, Switzerland","institution_ids":["https://openalex.org/I118019719"]},{"raw_affiliation_string":"Pharmaceutical Research Department of F. Hoffmann-La Roche and Co. Ltd, Basel, Switzerland","institution_ids":["https://openalex.org/I118019719"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110450690","display_name":"Gabriele Haeusler","orcid":"https://orcid.org/0000-0001-7919-3447","observed_orcids":["https://orcid.org/0000-0001-7919-3447"]},"institutions":[{"id":"https://openalex.org/I118019719","display_name":"F. Hoffmann-La Roche AG","ror":"https://ror.org/00by1q217","country_code":"CH","type":"company","lineage":["https://openalex.org/I118019719"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"G. Haeusler","raw_affiliation_strings":["Pharmaceutical Research Department of F. Hoffmann-La Roche & Co., Ltd., Basel, Switzerland","Pharmaceutical Research Department of F. Hoffmann-La Roche and Co. Ltd, Basel, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharmaceutical Research Department of F. Hoffmann-La Roche & Co., Ltd., Basel, Switzerland","institution_ids":["https://openalex.org/I118019719"]},{"raw_affiliation_string":"Pharmaceutical Research Department of F. Hoffmann-La Roche and Co. Ltd, Basel, Switzerland","institution_ids":["https://openalex.org/I118019719"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I118019719"],"apc_list":{"value":4790,"currency":"USD","value_usd":4790},"apc_paid":null,"fwci":1.2016,"has_fulltext":false,"cited_by_count":33,"citation_normalized_percentile":{"value":0.74200136,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":93},"biblio":{"volume":"323","issue":"4","first_page":"307","last_page":"314"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.8223000168800354,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.8223000168800354,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.12039999663829803,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.031300000846385956,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/clonidine","display_name":"clonidine","score":1.0},{"id":"https://openalex.org/keywords/noradrenaline-turnover","display_name":"noradrenaline turnover","score":0.9990000128746033},{"id":"https://openalex.org/keywords/alpha2-adrenergic-receptors","display_name":"alpha2-adrenoceptors","score":0.7549999952316284},{"id":"https://openalex.org/keywords/locus-coeruleus","display_name":"locus coeruleus","score":0.8830000162124634},{"id":"https://openalex.org/keywords/nucleus-tractus-solitarius","display_name":"nucleus tractus solitarius","score":0.9940000176429749},{"id":"https://openalex.org/keywords/intermediolateral-column","display_name":"intermediolateral cell column","score":0.9950000047683716},{"id":"https://openalex.org/keywords/thoracic-spinal-cord","display_name":"thoracic spinal cord","score":0.8029999732971191},{"id":"https://openalex.org/keywords/noradrenergic-terminals","display_name":"noradrenergic terminals","score":0.7929999828338623},{"id":"https://openalex.org/keywords/yohimbine","display_name":"yohimbine","score":0.8769999742507935},{"id":"https://openalex.org/keywords/phenoxybenzamine","display_name":"phenoxybenzamine","score":0.984000027179718},{"id":"https://openalex.org/keywords/alpha-methyl-p-tyrosine","display_name":"alpha-methyl-p-tyrosine","score":0.8289999961853027},{"id":"https://openalex.org/keywords/catecholamine-fluorescence","display_name":"catecholamine fluorescence","score":0.7310000061988831}],"concepts":[{"id":"https://openalex.org/C2778399450","wikidata":"https://www.wikidata.org/wiki/Q412221","display_name":"Clonidine","level":2,"score":0.9255939722061157},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.5097841620445251},{"id":"https://openalex.org/C26077564","wikidata":"https://www.wikidata.org/wiki/Q1910318","display_name":"Turnover","level":2,"score":0.48104193806648254},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.39292633533477783},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3101848363876343},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2901664078235626},{"id":"https://openalex.org/C162324750","wikidata":"https://www.wikidata.org/wiki/Q8134","display_name":"Economics","level":0,"score":0.22878709435462952},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.18711689114570618},{"id":"https://openalex.org/C187736073","wikidata":"https://www.wikidata.org/wiki/Q2920921","display_name":"Management","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002395","descriptor_name":"Catecholamines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002490","descriptor_name":"Central Nervous System","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D002490","descriptor_name":"Central Nervous System","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003000","descriptor_name":"Clonidine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D006651","descriptor_name":"Histocytochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008781","descriptor_name":"Methyltyrosines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D009638","descriptor_name":"Norepinephrine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010643","descriptor_name":"Phenoxybenzamine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011919","descriptor_name":"Rats, Inbred Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015016","descriptor_name":"Yohimbine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D019805","descriptor_name":"alpha-Methyltyrosine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1007/bf00512468","doi":"https://doi.org/10.1007/bf00512468","is_oa":false,"landing_page_url":"https://doi.org/10.1007/bf00512468","pdf_url":null,"source":{"id":"https://openalex.org/S159534381","display_name":"Naunyn-Schmiedeberg s Archives of Pharmacology","issn_l":"0028-1298","issn":["0028-1298","0340-5249","1432-1912"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Naunyn-Schmiedeberg's Archives of Pharmacology","raw_type":"journal-article"},{"id":"pmid:6633671","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6633671","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Naunyn-Schmiedeberg's archives of pharmacology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8560000061988831,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":45,"referenced_works":["https://openalex.org/W11560389","https://openalex.org/W74197732","https://openalex.org/W154893053","https://openalex.org/W996500346","https://openalex.org/W1488521817","https://openalex.org/W1775749144","https://openalex.org/W1972644473","https://openalex.org/W1973095106","https://openalex.org/W1976312594","https://openalex.org/W1984726871","https://openalex.org/W1989685757","https://openalex.org/W1996011703","https://openalex.org/W2001433408","https://openalex.org/W2001927191","https://openalex.org/W2002294075","https://openalex.org/W2008632370","https://openalex.org/W2018108226","https://openalex.org/W2020917603","https://openalex.org/W2023325653","https://openalex.org/W2023775324","https://openalex.org/W2026902857","https://openalex.org/W2031849897","https://openalex.org/W2041692227","https://openalex.org/W2041944228","https://openalex.org/W2051656343","https://openalex.org/W2058783800","https://openalex.org/W2061695248","https://openalex.org/W2064042245","https://openalex.org/W2077461364","https://openalex.org/W2080123448","https://openalex.org/W2080248872","https://openalex.org/W2088727446","https://openalex.org/W2091347681","https://openalex.org/W2092771620","https://openalex.org/W2113449040","https://openalex.org/W2164169061","https://openalex.org/W2296701411","https://openalex.org/W2311164852","https://openalex.org/W2323781365","https://openalex.org/W2399541528","https://openalex.org/W2399591959","https://openalex.org/W2412535727","https://openalex.org/W3082796960","https://openalex.org/W4300277006","https://openalex.org/W4406989315"],"related_works":["https://openalex.org/W2060704258","https://openalex.org/W1969817560","https://openalex.org/W2090914986","https://openalex.org/W2053743097","https://openalex.org/W2061695248","https://openalex.org/W2055104688","https://openalex.org/W2001251369","https://openalex.org/W1988221378","https://openalex.org/W1989792207","https://openalex.org/W2062340259"],"abstract_inverted_index":null,"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
