{"id":"https://openalex.org/W1993748422","doi":"https://doi.org/10.1016/j.mrgentox.2004.02.007","title":"Growth inhibition and mutagenesis induced in Escherichia coli by dihydropyrazines with DNA strand-cleaving activity","display_name":"Growth inhibition and mutagenesis induced in Escherichia coli by dihydropyrazines with DNA strand-cleaving activity","publication_year":2004,"publication_date":"2004-04-03","ids":{"openalex":"https://openalex.org/W1993748422","doi":"https://doi.org/10.1016/j.mrgentox.2004.02.007","mag":"1993748422","pmid":"https://pubmed.ncbi.nlm.nih.gov/15099824"},"language":"en","primary_location":{"id":"doi:10.1016/j.mrgentox.2004.02.007","doi":"https://doi.org/10.1016/j.mrgentox.2004.02.007","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.mrgentox.2004.02.007","pdf_url":null,"source":{"id":"https://openalex.org/S29775604","display_name":"Mutation Research/Genetic Toxicology and Environmental Mutagenesis","issn_l":"1383-5718","issn":["1383-5718","1879-3592"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mutation Research/Genetic Toxicology and Environmental Mutagenesis","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5010004241","display_name":"Shinji Takechi","orcid":"https://orcid.org/0000-0002-4397-9410","observed_orcids":["https://orcid.org/0000-0002-4397-9410"]},"institutions":[{"id":"https://openalex.org/I118574687","display_name":"University of Miyazaki","ror":"https://ror.org/0447kww10","country_code":"JP","type":"education","lineage":["https://openalex.org/I118574687"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Shinji Takechi","raw_affiliation_strings":["Department of Biochemistry, Miyazaki Medical College, Kihara, Kiyotake, Miyazaki 889-1692, Japan. stakechi@post.med.miyazaki-u.ac.jp","Department of Biochemistry, Miyazaki Medical College, Kihara, Kiyotake, Miyazaki 889-1692, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Miyazaki Medical College, Kihara, Kiyotake, Miyazaki 889-1692, Japan. stakechi@post.med.miyazaki-u.ac.jp","institution_ids":["https://openalex.org/I118574687"]},{"raw_affiliation_string":"Department of Biochemistry, Miyazaki Medical College, Kihara, Kiyotake, Miyazaki 889-1692, Japan","institution_ids":["https://openalex.org/I118574687"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112004995","display_name":"Tadatoshi Yamaguchi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I118574687","display_name":"University of Miyazaki","ror":"https://ror.org/0447kww10","country_code":"JP","type":"education","lineage":["https://openalex.org/I118574687"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tadatoshi Yamaguchi","raw_affiliation_strings":["Department of Hygiene, Miyazaki Medical College, Kihara, Kiyotake, Miyazaki 889-1692, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hygiene, Miyazaki Medical College, Kihara, Kiyotake, Miyazaki 889-1692, Japan","institution_ids":["https://openalex.org/I118574687"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074855937","display_name":"Hajime Nomura","orcid":"https://orcid.org/0000-0003-0811-6932","observed_orcids":["https://orcid.org/0000-0003-0811-6932"]},"institutions":[{"id":"https://openalex.org/I118574687","display_name":"University of Miyazaki","ror":"https://ror.org/0447kww10","country_code":"JP","type":"education","lineage":["https://openalex.org/I118574687"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hajime Nomura","raw_affiliation_strings":["Department of Laboratory Medicine, Miyazaki Medical College, Kihara, Kiyotake, Miyazaki 889-1692, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Laboratory Medicine, Miyazaki Medical College, Kihara, Kiyotake, Miyazaki 889-1692, Japan","institution_ids":["https://openalex.org/I118574687"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113820740","display_name":"Toshio Minematsu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Toshio Minematsu","raw_affiliation_strings":["Institute of Disease Control, Aisenkai Nichinan Hospital, Kazeta, Nichinan, Miyazaki 887-0034, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Disease Control, Aisenkai Nichinan Hospital, Kazeta, Nichinan, Miyazaki 887-0034, Japan","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5057910880","display_name":"Tatsuo Nakayama","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I118574687","display_name":"University of Miyazaki","ror":"https://ror.org/0447kww10","country_code":"JP","type":"education","lineage":["https://openalex.org/I118574687"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tatsuo Nakayama","raw_affiliation_strings":["Department of Biochemistry, Miyazaki Medical College, Kihara, Kiyotake, Miyazaki 889-1692, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Miyazaki Medical College, Kihara, Kiyotake, Miyazaki 889-1692, Japan","institution_ids":["https://openalex.org/I118574687"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5010004241"],"corresponding_institution_ids":["https://openalex.org/I118574687"],"apc_list":{"value":3350,"currency":"USD","value_usd":3350},"apc_paid":null,"fwci":0.9312,"has_fulltext":false,"cited_by_count":22,"citation_normalized_percentile":{"value":0.70838168,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":95},"biblio":{"volume":"560","issue":"1","first_page":"49","last_page":"55"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.0017999999690800905,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12356","display_name":"Bioactive Compounds and Antitumor Agents","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dihydropyrazines","display_name":"dihydropyrazines","score":0.9819999933242798},{"id":"https://openalex.org/keywords/dna-strand-breaks","display_name":"DNA strand breaks","score":0.9700000286102295},{"id":"https://openalex.org/keywords/genotoxicity","display_name":"genotoxicity","score":0.8339999914169312},{"id":"https://openalex.org/keywords/cytotoxicity","display_name":"cytotoxicity","score":0.9760000109672546},{"id":"https://openalex.org/keywords/escherichia-coli","display_name":"Escherichia coli","score":0.8429999947547913},{"id":"https://openalex.org/keywords/cell-growth-inhibition","display_name":"cell growth inhibition","score":0.7429999709129333},{"id":"https://openalex.org/keywords/mutation-frequency","display_name":"mutation frequency","score":0.8199999928474426},{"id":"https://openalex.org/keywords/reca","display_name":"RecA","score":0.8980000019073486},{"id":"https://openalex.org/keywords/uvrb","display_name":"UvrB","score":0.996999979019165},{"id":"https://openalex.org/keywords/dna-repair","display_name":"DNA repair","score":0.6340000033378601},{"id":"https://openalex.org/keywords/mutagenesis","display_name":"mutagenesis","score":0.492000013589859}],"concepts":[{"id":"https://openalex.org/C547475151","wikidata":"https://www.wikidata.org/wiki/Q25419","display_name":"Escherichia coli","level":3,"score":0.8661431074142456},{"id":"https://openalex.org/C16318435","wikidata":"https://www.wikidata.org/wiki/Q149299","display_name":"Mutagenesis","level":4,"score":0.7256788015365601},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.6956256628036499},{"id":"https://openalex.org/C143425029","wikidata":"https://www.wikidata.org/wiki/Q5205747","display_name":"DNA damage","level":3,"score":0.6263250708580017},{"id":"https://openalex.org/C2780852648","wikidata":"https://www.wikidata.org/wiki/Q143584","display_name":"SOS response","level":4,"score":0.5814381837844849},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5050066113471985},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.4991466999053955},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4901772141456604},{"id":"https://openalex.org/C2778022156","wikidata":"https://www.wikidata.org/wiki/Q576145","display_name":"Strain (injury)","level":2,"score":0.4773849844932556},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.44355663657188416},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.4292737543582916},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4190337657928467},{"id":"https://openalex.org/C102306862","wikidata":"https://www.wikidata.org/wiki/Q6943735","display_name":"Mutation frequency","level":4,"score":0.4130796492099762},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3437744975090027},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2423597276210785},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.14695772528648376},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D004249","descriptor_name":"DNA Damage","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004269","descriptor_name":"DNA, Bacterial","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":false},{"descriptor_ui":"D011719","descriptor_name":"Pyrazines","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D016296","descriptor_name":"Mutagenesis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.mrgentox.2004.02.007","doi":"https://doi.org/10.1016/j.mrgentox.2004.02.007","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.mrgentox.2004.02.007","pdf_url":null,"source":{"id":"https://openalex.org/S29775604","display_name":"Mutation Research/Genetic Toxicology and Environmental Mutagenesis","issn_l":"1383-5718","issn":["1383-5718","1879-3592"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mutation Research/Genetic Toxicology and Environmental Mutagenesis","raw_type":"journal-article"},{"id":"pmid:15099824","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15099824","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mutation research","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.6000000238418579,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320320912","display_name":"Ministry of Education, Culture, Sports, Science and Technology","ror":"https://ror.org/048rj2z13"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":34,"referenced_works":["https://openalex.org/W1509038183","https://openalex.org/W1555021163","https://openalex.org/W1582285433","https://openalex.org/W1595824689","https://openalex.org/W1601195700","https://openalex.org/W1716100151","https://openalex.org/W1878196482","https://openalex.org/W1878364547","https://openalex.org/W1975908101","https://openalex.org/W1981800376","https://openalex.org/W1986289016","https://openalex.org/W1989977749","https://openalex.org/W1994331558","https://openalex.org/W1996718531","https://openalex.org/W2002003641","https://openalex.org/W2014573324","https://openalex.org/W2028622989","https://openalex.org/W2031010426","https://openalex.org/W2044455364","https://openalex.org/W2061970910","https://openalex.org/W2064381147","https://openalex.org/W2065719103","https://openalex.org/W2071636061","https://openalex.org/W2074939150","https://openalex.org/W2076398524","https://openalex.org/W2086379488","https://openalex.org/W2090737357","https://openalex.org/W2101994201","https://openalex.org/W2130663998","https://openalex.org/W2139367105","https://openalex.org/W2289907862","https://openalex.org/W2312271248","https://openalex.org/W2408575276","https://openalex.org/W2949260850"],"related_works":["https://openalex.org/W2036083744","https://openalex.org/W1994133917","https://openalex.org/W2030608863","https://openalex.org/W2187774775","https://openalex.org/W2503523724","https://openalex.org/W2040559562","https://openalex.org/W2044455364","https://openalex.org/W2049062098","https://openalex.org/W7064639642","https://openalex.org/W2070144419"],"abstract_inverted_index":null,"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
