{"id":"https://openalex.org/W1993743949","doi":"https://doi.org/10.1111/j.1527-3466.2005.tb00158.x","title":"Pharmacological Mechanisms Contributing to the Clinical Efficacy of Levosimendan","display_name":"Pharmacological Mechanisms Contributing to the Clinical Efficacy of Levosimendan","publication_year":2005,"publication_date":"2005-03-01","ids":{"openalex":"https://openalex.org/W1993743949","doi":"https://doi.org/10.1111/j.1527-3466.2005.tb00158.x","mag":"1993743949","pmid":"https://pubmed.ncbi.nlm.nih.gov/15867949"},"language":"en","primary_location":{"id":"doi:10.1111/j.1527-3466.2005.tb00158.x","doi":"https://doi.org/10.1111/j.1527-3466.2005.tb00158.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1527-3466.2005.tb00158.x","pdf_url":null,"source":{"id":"https://openalex.org/S200652724","display_name":"Cardiovascular Drug Reviews","issn_l":"0897-5957","issn":["0897-5957","1527-3466"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cardiovascular Drug Reviews","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5044635006","display_name":"Zolt\u00e1n Papp","orcid":"https://orcid.org/0000-0002-4675-1542","observed_orcids":["https://orcid.org/0000-0002-4675-1542"]},"institutions":[{"id":"https://openalex.org/I132735039","display_name":"University of Debrecen","ror":"https://ror.org/02xf66n48","country_code":"HU","type":"education","lineage":["https://openalex.org/I132735039"]}],"countries":["HU"],"is_corresponding":true,"raw_author_name":"Zolt\u00e1n Papp","raw_affiliation_strings":["Division of Clinical Physiology, Institute of Cardiology, University of Debrecen, Medical and Health Science Center, Medical School, P.O. BOX 1, H-4004 Debrecen, Hungary. pappz@jaguar.unideb.hu","Division of Clinical Physiology, Institute of Cardiology, University of Debrecen, Medical and Health Science Center, Medical School, P.O. BOX 1, H-4004 Debrecen, Hungary"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Clinical Physiology, Institute of Cardiology, University of Debrecen, Medical and Health Science Center, Medical School, P.O. BOX 1, H-4004 Debrecen, Hungary. pappz@jaguar.unideb.hu","institution_ids":["https://openalex.org/I132735039"]},{"raw_affiliation_string":"Division of Clinical Physiology, Institute of Cardiology, University of Debrecen, Medical and Health Science Center, Medical School, P.O. BOX 1, H-4004 Debrecen, Hungary","institution_ids":["https://openalex.org/I132735039"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056385874","display_name":"K\u00e1lm\u00e1n Csap\u00f3","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I132735039","display_name":"University of Debrecen","ror":"https://ror.org/02xf66n48","country_code":"HU","type":"education","lineage":["https://openalex.org/I132735039"]}],"countries":["HU"],"is_corresponding":false,"raw_author_name":"K\u00e1lm\u00e1n Csap\u00f3","raw_affiliation_strings":["Division of Clinical Physiology, Institute of Cardiology, University of Debrecen, Medical and Health Science Center, Debrecen, Hungary"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Clinical Physiology, Institute of Cardiology, University of Debrecen, Medical and Health Science Center, Debrecen, Hungary","institution_ids":["https://openalex.org/I132735039"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032946611","display_name":"Piero Pollesello","orcid":"https://orcid.org/0000-0001-6994-768X","observed_orcids":["https://orcid.org/0000-0001-6994-768X"]},"institutions":[{"id":"https://openalex.org/I4210118237","display_name":"Orion Corporation (Finland)","ror":"https://ror.org/0296s4x19","country_code":"FI","type":"company","lineage":["https://openalex.org/I4210118237"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Piero Pollesello","raw_affiliation_strings":["Orion Pharma, Espoo, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Orion Pharma, Espoo, Finland","institution_ids":["https://openalex.org/I4210118237"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108559982","display_name":"Heimo Haikala","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210118237","display_name":"Orion Corporation (Finland)","ror":"https://ror.org/0296s4x19","country_code":"FI","type":"company","lineage":["https://openalex.org/I4210118237"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Heimo Haikala","raw_affiliation_strings":["Orion Pharma, Espoo, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Orion Pharma, Espoo, Finland","institution_ids":["https://openalex.org/I4210118237"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5060727278","display_name":"Istvan Ferenc Edes","orcid":"https://orcid.org/0000-0001-8062-825X","observed_orcids":["https://orcid.org/0000-0001-8062-825X"]},"institutions":[{"id":"https://openalex.org/I132735039","display_name":"University of Debrecen","ror":"https://ror.org/02xf66n48","country_code":"HU","type":"education","lineage":["https://openalex.org/I132735039"]}],"countries":["HU"],"is_corresponding":false,"raw_author_name":"Istv\u00e1n \u00c9des","raw_affiliation_strings":["Division of Clinical Physiology, Institute of Cardiology, University of Debrecen, Medical and Health Science Center, Debrecen, Hungary"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Clinical Physiology, Institute of Cardiology, University of Debrecen, Medical and Health Science Center, Debrecen, Hungary","institution_ids":["https://openalex.org/I132735039"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5044635006"],"corresponding_institution_ids":["https://openalex.org/I132735039"],"apc_list":null,"apc_paid":null,"fwci":1.4025,"has_fulltext":false,"cited_by_count":113,"citation_normalized_percentile":{"value":0.80016863,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"23","issue":"1","first_page":"71","last_page":"98"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10198","display_name":"Heart Failure Treatment and Management","score":0.9911999702453613,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10198","display_name":"Heart Failure Treatment and Management","score":0.9911999702453613,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11962","display_name":"Cardiac Fibrosis and Remodeling","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12434","display_name":"Phosphodiesterase function and regulation","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/levosimendan","display_name":"levosimendan","score":1.0},{"id":"https://openalex.org/keywords/chronic-heart-failure","display_name":"chronic heart failure","score":0.6570000052452087},{"id":"https://openalex.org/keywords/acute-decompensation","display_name":"acute decompensation","score":0.7929999828338623},{"id":"https://openalex.org/keywords/calcium-sensitization","display_name":"calcium sensitization","score":0.8159999847412109},{"id":"https://openalex.org/keywords/troponin-c","display_name":"troponin C","score":0.9769999980926514},{"id":"https://openalex.org/keywords/atp-sensitive-potassium-channels","display_name":"ATP-sensitive potassium channels","score":0.9810000061988831},{"id":"https://openalex.org/keywords/positive-inotropic-effect","display_name":"positive inotropic effect","score":0.8960000276565552},{"id":"https://openalex.org/keywords/vasodilation","display_name":"vasodilation","score":0.9980000257492065},{"id":"https://openalex.org/keywords/myocardial-ischemia-protection","display_name":"myocardial ischemia protection","score":0.878000020980835},{"id":"https://openalex.org/keywords/cardiac-remodeling","display_name":"cardiac remodeling","score":0.8389999866485596},{"id":"https://openalex.org/keywords/cytokines","display_name":"cytokines","score":0.8539999723434448},{"id":"https://openalex.org/keywords/hemodynamics","display_name":"hemodynamics","score":0.578000009059906},{"id":"https://openalex.org/keywords/mortality","display_name":"mortality","score":0.5899999737739563}],"concepts":[{"id":"https://openalex.org/C2777335384","wikidata":"https://www.wikidata.org/wiki/Q162541","display_name":"Levosimendan","level":3,"score":0.8502457141876221},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6627662181854248},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5093956589698792},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.46272554993629456},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.34951692819595337},{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.2540673613548279}],"mesh":[{"descriptor_ui":"D000077464","descriptor_name":"Simendan","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002908","descriptor_name":"Chronic Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006333","descriptor_name":"Heart Failure","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006835","descriptor_name":"Hydrazones","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006835","descriptor_name":"Hydrazones","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D006835","descriptor_name":"Hydrazones","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D011724","descriptor_name":"Pyridazines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011724","descriptor_name":"Pyridazines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D011724","descriptor_name":"Pyridazines","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1111/j.1527-3466.2005.tb00158.x","doi":"https://doi.org/10.1111/j.1527-3466.2005.tb00158.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1527-3466.2005.tb00158.x","pdf_url":null,"source":{"id":"https://openalex.org/S200652724","display_name":"Cardiovascular Drug Reviews","issn_l":"0897-5957","issn":["0897-5957","1527-3466"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cardiovascular Drug Reviews","raw_type":"journal-article"},{"id":"pmid:15867949","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15867949","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cardiovascular drug reviews","raw_type":"Journal Article"},{"id":"pmh:oai:dea.lib.unideb.hu:2437/156463","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/2437/156463","pdf_url":null,"source":{"id":"https://openalex.org/S4306402089","display_name":"University of Debrecen Electronic Archive (University of Debrecen)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I132735039","host_organization_name":"University of Debrecen","host_organization_lineage":["https://openalex.org/I132735039"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"foly\u00f3iratcikk"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9907000064849854,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":133,"referenced_works":["https://openalex.org/W45001969","https://openalex.org/W171374847","https://openalex.org/W187129005","https://openalex.org/W1502532985","https://openalex.org/W1553263682","https://openalex.org/W1556535974","https://openalex.org/W1566590324","https://openalex.org/W1801814366","https://openalex.org/W1916712477","https://openalex.org/W1922700571","https://openalex.org/W1934572726","https://openalex.org/W1934994215","https://openalex.org/W1966561241","https://openalex.org/W1971467312","https://openalex.org/W1974256470","https://openalex.org/W1976305965","https://openalex.org/W1977637896","https://openalex.org/W1980129508","https://openalex.org/W1982871028","https://openalex.org/W1983435059","https://openalex.org/W1983477070","https://openalex.org/W1984690823","https://openalex.org/W1984765095","https://openalex.org/W1986373711","https://openalex.org/W1987152380","https://openalex.org/W1990049123","https://openalex.org/W1990189675","https://openalex.org/W1992993596","https://openalex.org/W1998133845","https://openalex.org/W1998213207","https://openalex.org/W1999005817","https://openalex.org/W1999065909","https://openalex.org/W1999706600","https://openalex.org/W1999967852","https://openalex.org/W2003001618","https://openalex.org/W2004169102","https://openalex.org/W2005170762","https://openalex.org/W2011231979","https://openalex.org/W2012006112","https://openalex.org/W2015078144","https://openalex.org/W2015441750","https://openalex.org/W2016543754","https://openalex.org/W2017397568","https://openalex.org/W2018155990","https://openalex.org/W2019057689","https://openalex.org/W2020088846","https://openalex.org/W2021967123","https://openalex.org/W2023358024","https://openalex.org/W2024222111","https://openalex.org/W2024881120","https://openalex.org/W2027898894","https://openalex.org/W2028055119","https://openalex.org/W2029152461","https://openalex.org/W2029377396","https://openalex.org/W2032520387","https://openalex.org/W2033804109","https://openalex.org/W2033971063","https://openalex.org/W2037166741","https://openalex.org/W2038229351","https://openalex.org/W2039266436","https://openalex.org/W2039562601","https://openalex.org/W2041543580","https://openalex.org/W2042524681","https://openalex.org/W2044848803","https://openalex.org/W2053645698","https://openalex.org/W2054874691","https://openalex.org/W2058823770","https://openalex.org/W2059309600","https://openalex.org/W2060904229","https://openalex.org/W2063399037","https://openalex.org/W2064301134","https://openalex.org/W2066118369","https://openalex.org/W2067361909","https://openalex.org/W2067839119","https://openalex.org/W2069491300","https://openalex.org/W2070518615","https://openalex.org/W2074904536","https://openalex.org/W2075455581","https://openalex.org/W2076331410","https://openalex.org/W2078046717","https://openalex.org/W2078176071","https://openalex.org/W2078213367","https://openalex.org/W2078671560","https://openalex.org/W2080591227","https://openalex.org/W2081071645","https://openalex.org/W2081403760","https://openalex.org/W2087126519","https://openalex.org/W2090815068","https://openalex.org/W2091575018","https://openalex.org/W2091953433","https://openalex.org/W2098740917","https://openalex.org/W2104481596","https://openalex.org/W2107442961","https://openalex.org/W2107651759","https://openalex.org/W2109121609","https://openalex.org/W2109146163","https://openalex.org/W2116963442","https://openalex.org/W2117229660","https://openalex.org/W2117483856","https://openalex.org/W2122001651","https://openalex.org/W2127139759","https://openalex.org/W2130310240","https://openalex.org/W2133981603","https://openalex.org/W2136822253","https://openalex.org/W2138301837","https://openalex.org/W2140827003","https://openalex.org/W2146830330","https://openalex.org/W2150724213","https://openalex.org/W2153995388","https://openalex.org/W2157204705","https://openalex.org/W2158256945","https://openalex.org/W2161035745","https://openalex.org/W2161421667","https://openalex.org/W2161726625","https://openalex.org/W2165392063","https://openalex.org/W2165516398","https://openalex.org/W2168037107","https://openalex.org/W2168299716","https://openalex.org/W2182151932","https://openalex.org/W2312185933","https://openalex.org/W2323986425","https://openalex.org/W2328292239","https://openalex.org/W2333295256","https://openalex.org/W2342869706","https://openalex.org/W2396113971","https://openalex.org/W2397481525","https://openalex.org/W2410746658","https://openalex.org/W2415530070","https://openalex.org/W2415705853","https://openalex.org/W2415978798","https://openalex.org/W2417968713","https://openalex.org/W3193261711","https://openalex.org/W4243192595"],"related_works":["https://openalex.org/W1801814366","https://openalex.org/W2071624230","https://openalex.org/W2395500818","https://openalex.org/W2103741220","https://openalex.org/W1982871028","https://openalex.org/W2052832524","https://openalex.org/W2003617335","https://openalex.org/W3160398088","https://openalex.org/W2029794453","https://openalex.org/W2133889186"],"abstract_inverted_index":{"Acute":[0],"decompensation":[1,37,63],"of":[2,18,30,50,64,93,107,154,157,166,183,195,202,217,220,237,243,250,263,267,276,283],"chronic":[3,31,65,286],"heart":[4,32,53,66,83,268,287],"failure":[5,33,54,67,84,269],"is":[6,43],"a":[7,44,89,196,207],"direct":[8],"life-threatening":[9],"situation":[10],"with":[11,285],"short-term":[12,132],"mortality":[13,130],"approaching":[14],"30%.":[15],"A":[16],"number":[17],"maladaptive":[19],"changes":[20,171],"are":[21,79,149],"amplified":[22],"within":[23],"the":[24,28,36,48,62,102,105,145,152,164,176,184,193,203,215,241,253,261,264,277],"cardiovascular":[25,146,255],"system":[26,147],"during":[27,61],"progression":[29],"that":[34,55,78,86,139,148,163],"makes":[35],"phase":[38],"difficult":[39],"to":[40,58,98,274],"handle.":[41],"Levosimendan":[42,72],"new":[45],"Ca2+-sensitizer":[46],"for":[47,81,151,192],"treatment":[49],"acutely":[51],"decompensated":[52],"has":[56,141,172],"proved":[57],"be":[59,137],"effective":[60],"and":[68,104,122,159,169,179,227,234,279],"acute":[69,82],"myocardial":[70,211,232,245],"infarction.":[71],"differs":[73],"from":[74],"other":[75],"cardiotonic":[76],"agents":[77],"used":[80],"in":[85,101,111,210],"it":[87],"utilizes":[88],"unique":[90],"dual":[91],"mechanism":[92],"action:":[94],"Ca2+-sensitization":[95,201],"through":[96,200],"binding":[97],"troponin":[99],"C":[100],"myocardium,":[103],"opening":[106],"ATP-sensitive":[108,221],"K+":[109,222],"channels":[110],"vascular":[112,170],"smooth":[113],"muscle.":[114],"In":[115],"general,":[116],"these":[117,248],"mechanisms":[118],"evoke":[119],"positive":[120,197],"inotropy":[121],"vasodilation.":[123],"Clinical":[124],"studies":[125],"suggested":[126],"long-term":[127],"benefits":[128],"on":[129,144,175,225],"following":[131],"administration.":[133],"It":[134],"may,":[135],"therefore,":[136],"inferred":[138],"levosimendan":[140,251],"additional":[142],"effects":[143,174,249],"responsible":[150],"prolongation":[153],"survival.":[155],"Results":[156],"preclinical":[158],"clinical":[160],"investigations":[161],"suggest":[162],"combination":[165],"levosimendan-induced":[167],"cardiac":[168],"favorable":[173],"coronary,":[177],"pulmonary":[178],"peripheral":[180],"circulations.":[181],"Redistribution":[182],"circulating":[185],"blood":[186],"offers":[187],"an":[188],"improved":[189,280],"hemodynamic":[190],"context":[191],"development":[194,216,242],"inotropic":[198],"effect":[199],"contractile":[204],"filaments,":[205],"without":[206],"proportionate":[208],"increase":[209],"oxygen":[212],"consumption":[213],"or":[214],"arrhythmias.":[218],"Activation":[219],"channels,":[223],"both":[224],"sarcolemma":[226],"mitochondria,":[228],"may":[229,239,272],"protect":[230],"against":[231],"ischemia,":[233],"decreased":[235],"levels":[236],"cytokines":[238],"prevent":[240],"further":[244],"remodeling.":[246],"Collectively,":[247],"shift":[252],"disturbed":[254],"parameters":[256],"towards":[257],"normalization,":[258],"thereby":[259],"halting":[260],"perpetuation":[262],"vicious":[265],"cycle":[266],"progression.":[270],"This":[271],"contribute":[273],"stabilization":[275],"circulation":[278],"life":[281],"expectancy":[282],"patients":[284],"failure.":[288]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":11},{"year":2017,"cited_by_count":8},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":9},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":7}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}