{"id":"https://openalex.org/W1993698518","doi":"https://doi.org/10.1371/journal.ppat.1003992","title":"Pernicious Pathogens or Expedient Elements of Inheritance: The Significance of Yeast Prions","display_name":"Pernicious Pathogens or Expedient Elements of Inheritance: The Significance of Yeast Prions","publication_year":2014,"publication_date":"2014-04-10","ids":{"openalex":"https://openalex.org/W1993698518","doi":"https://doi.org/10.1371/journal.ppat.1003992","mag":"1993698518","pmid":"https://pubmed.ncbi.nlm.nih.gov/24722628","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3983059"},"language":"en","primary_location":{"id":"doi:10.1371/journal.ppat.1003992","doi":"https://doi.org/10.1371/journal.ppat.1003992","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.ppat.1003992","pdf_url":"https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1003992&type=printable","source":{"id":"https://openalex.org/S2004986","display_name":"PLoS Pathogens","issn_l":"1553-7366","issn":["1553-7366","1553-7374"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Pathogens","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1003992&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5053169078","display_name":"James S. Byers","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James S. Byers","raw_affiliation_strings":["Departments of Chemical and Systems Biology and of Developmental Biology, Stanford University School of Medicine, Stanford, California, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Chemical and Systems Biology and of Developmental Biology, Stanford University School of Medicine, Stanford, California, United States of America","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5066860900","display_name":"Daniel F. Jarosz","orcid":"https://orcid.org/0000-0003-3497-5888","observed_orcids":["https://orcid.org/0000-0003-3497-5888"]},"institutions":[{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Daniel F. Jarosz","raw_affiliation_strings":["Departments of Chemical and Systems Biology and of Developmental Biology, Stanford University School of Medicine, Stanford, California, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Chemical and Systems Biology and of Developmental Biology, Stanford University School of Medicine, Stanford, California, United States of America","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5066860900"],"corresponding_institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"],"apc_list":{"value":3043,"currency":"USD","value_usd":3043},"apc_paid":{"value":3043,"currency":"USD","value_usd":3043},"fwci":0.284,"has_fulltext":true,"cited_by_count":17,"citation_normalized_percentile":{"value":0.23253884,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"10","issue":"4","first_page":"e1003992","last_page":"e1003992"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11335","display_name":"Prion Diseases and Protein Misfolding","score":0.9887999892234802,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11335","display_name":"Prion Diseases and Protein Misfolding","score":0.9887999892234802,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10676","display_name":"Genetics, Aging, and Longevity in Model Organisms","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/1302","display_name":"Aging"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/yeast-prions","display_name":"yeast prions","score":0.9940000176429749},{"id":"https://openalex.org/keywords/prion-protein","display_name":"prion protein","score":0.6100000143051147},{"id":"https://openalex.org/keywords/heredity-biology","display_name":"heredity (biology)","score":0.4699999988079071},{"id":"https://openalex.org/keywords/pathogenicity","display_name":"pathogenicity","score":0.5550000071525574},{"id":"https://openalex.org/keywords/protein-folding","display_name":"protein folding","score":0.3970000147819519},{"id":"https://openalex.org/keywords/saccharomyces-cerevisiae","display_name":"Saccharomyces cerevisiae","score":0.7710000276565552}],"concepts":[{"id":"https://openalex.org/C2779222958","wikidata":"https://www.wikidata.org/wiki/Q45422","display_name":"Yeast","level":2,"score":0.6656481027603149},{"id":"https://openalex.org/C2780902518","wikidata":"https://www.wikidata.org/wiki/Q6033780","display_name":"Inheritance (genetic algorithm)","level":3,"score":0.6024202704429626},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5237362384796143},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.4494086802005768},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.444301038980484},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.11887577176094055}],"mesh":[{"descriptor_ui":"D010454","descriptor_name":"Peptide Termination Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D010454","descriptor_name":"Peptide Termination Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011328","descriptor_name":"Prions","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D011328","descriptor_name":"Prions","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D029701","descriptor_name":"Saccharomyces cerevisiae Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D029701","descriptor_name":"Saccharomyces cerevisiae Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D048468","descriptor_name":"Podospora","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D048468","descriptor_name":"Podospora","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":6,"locations":[{"id":"doi:10.1371/journal.ppat.1003992","doi":"https://doi.org/10.1371/journal.ppat.1003992","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.ppat.1003992","pdf_url":"https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1003992&type=printable","source":{"id":"https://openalex.org/S2004986","display_name":"PLoS Pathogens","issn_l":"1553-7366","issn":["1553-7366","1553-7374"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Pathogens","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2966279","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3983059","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3983059","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3983059","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Pathog","raw_type":"Text"},{"id":"pmid:24722628","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24722628","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS pathogens","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.788.3014","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.788.3014","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/ab/d9/ppat.1003992.PMC3983059.pdf","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:9d08c5e57d654d85aa7c4158152a1847","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/9d08c5e57d654d85aa7c4158152a1847","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Pathogens, Vol 10, Iss 4, p e1003992 (2014)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1371/journal.ppat.1003992","doi":"https://doi.org/10.1371/journal.ppat.1003992","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.ppat.1003992","pdf_url":"https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1003992&type=printable","source":{"id":"https://openalex.org/S2004986","display_name":"PLoS Pathogens","issn_l":"1553-7366","issn":["1553-7366","1553-7374"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Pathogens","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G5275457478","display_name":"Genetics and Developmental Biology Training Program","funder_award_id":"T32GM007790","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G7421787314","display_name":"Quantitative analysis of the evolving genotype-to-phenotype map","funder_award_id":"R00GM098600","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1993698518.pdf","grobid_xml":"https://content.openalex.org/works/W1993698518.grobid-xml"},"referenced_works_count":34,"referenced_works":["https://openalex.org/W1503622815","https://openalex.org/W1978959047","https://openalex.org/W1979138426","https://openalex.org/W1981681091","https://openalex.org/W2000878370","https://openalex.org/W2006952692","https://openalex.org/W2009974909","https://openalex.org/W2010499900","https://openalex.org/W2011163535","https://openalex.org/W2012223842","https://openalex.org/W2025482639","https://openalex.org/W2046414350","https://openalex.org/W2063563543","https://openalex.org/W2066036014","https://openalex.org/W2068843220","https://openalex.org/W2070837478","https://openalex.org/W2073228699","https://openalex.org/W2073533352","https://openalex.org/W2077291291","https://openalex.org/W2078128181","https://openalex.org/W2086991973","https://openalex.org/W2095076518","https://openalex.org/W2097374545","https://openalex.org/W2106046434","https://openalex.org/W2118529378","https://openalex.org/W2127845878","https://openalex.org/W2130937633","https://openalex.org/W2136679442","https://openalex.org/W2138893131","https://openalex.org/W2155009058","https://openalex.org/W2163981524","https://openalex.org/W2165187711","https://openalex.org/W2169665392","https://openalex.org/W2171582839"],"related_works":["https://openalex.org/W7098230140","https://openalex.org/W2052228596","https://openalex.org/W2401974172","https://openalex.org/W2415859338","https://openalex.org/W2278366022","https://openalex.org/W3091620546","https://openalex.org/W7096080011","https://openalex.org/W2435103736","https://openalex.org/W4229585163","https://openalex.org/W2395612416"],"abstract_inverted_index":{"Prions":[0],"are":[1,72,103],"\u2018\u2018infectious\u2019":[2],"\u2019":[3],"misfolded":[4],"protein":[5,34,131],"states":[6],"that":[7,70],"can":[8,94],"template":[9],"their":[10],"self-perpetuating":[11],"conformations":[12],"onto":[13],"other":[14,84,109],"mole-cules":[15],"of":[16,28,53,101],"the":[17,50,67,120,133],"same":[18],"type.":[19],"This":[20,63],"unusual":[21],"folding":[22],"landscape":[23],"drives":[24],"a":[25],"paradigm-shifting":[26],"mechanism":[27],"inheritance":[29],"based":[30],"on":[31],"changes":[32,38],"in":[33,39,83,86,105],"conformation":[35],"rather":[36],"than":[37],"nucleic":[40],"acid.":[41],"The":[42,98,116],"first":[43],"prion":[44,118],"discovered,":[45],"Prion":[46],"Protein":[47],"(PrP),":[48],"is":[49,119],"causal":[51],"agent":[52],"several":[54],"human":[55],"neurodegenerative":[56],"diseases,":[57],"including":[58],"kuru":[59],"and":[60,93,108],"Creutz-feldt-Jakob":[61],"[1].":[62],"history":[64],"has":[65],"engendered":[66],"widespread":[68],"perception":[69],"prions":[71,78],"inherently":[73],"pathogenic.":[74],"However,":[75],"many":[76],"additional":[77],"have":[79],"now":[80],"been":[81],"found":[82,104],"eukaryotes":[85],"which":[87],"they":[88],"influence":[89],"diverse":[90],"biological":[91],"processes":[92],"produce":[95],"beneficial":[96],"traits.":[97],"most":[99],"well-characterized":[100],"these":[102],"Saccharomyces":[106],"cerevisiae":[107],"fungi,":[110],"such":[111],"as":[112],"Podospora":[113],"anserina":[114],"[2].":[115],"best-studied":[117],"yeast":[121],"translation":[122],"termination":[123],"factor":[124],"Sup35.":[125],"In":[126],"its":[127],"soluble":[128],"form,":[129],"this":[130],"promotes":[132],"faithful":[134]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
