{"id":"https://openalex.org/W1993674836","doi":"https://doi.org/10.1117/12.2018051","title":"Development of a versatile lab-on-a-chip enzyme assay platform for pathogen detection in CBRNE scenarios","display_name":"Development of a versatile lab-on-a-chip enzyme assay platform for pathogen detection in CBRNE scenarios","publication_year":2013,"publication_date":"2013-05-29","ids":{"openalex":"https://openalex.org/W1993674836","doi":"https://doi.org/10.1117/12.2018051","mag":"1993674836"},"language":"en","primary_location":{"id":"doi:10.1117/12.2018051","doi":"https://doi.org/10.1117/12.2018051","is_oa":false,"landing_page_url":"https://doi.org/10.1117/12.2018051","pdf_url":null,"source":{"id":"https://openalex.org/S183492911","display_name":"Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE","issn_l":"0277-786X","issn":["0277-786X","1996-756X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1"],"host_organization":"https://openalex.org/P4310315543","host_organization_name":"SPIE","host_organization_lineage":["https://openalex.org/P4310315543"],"host_organization_lineage_names":["SPIE"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"SPIE Proceedings","raw_type":"proceedings-article"},"volume":null,"type":"conference-paper","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Richard Klemm","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210143711","display_name":"Microfluidic ChipShop (Germany)","ror":"https://ror.org/045kvge53","country_code":"DE","type":"company","lineage":["https://openalex.org/I4210143711"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Richard Klemm","raw_affiliation_strings":["microfluidic ChipShop GmbH (Germany)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"microfluidic ChipShop GmbH (Germany)","institution_ids":["https://openalex.org/I4210143711"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045458548","display_name":"Sebastian Schattschneider","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210143711","display_name":"Microfluidic ChipShop (Germany)","ror":"https://ror.org/045kvge53","country_code":"DE","type":"company","lineage":["https://openalex.org/I4210143711"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Sebastian Schattschneider","raw_affiliation_strings":["microfluidic ChipShop GmbH (Germany)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"microfluidic ChipShop GmbH (Germany)","institution_ids":["https://openalex.org/I4210143711"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083804748","display_name":"Tobias Jahn","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210143711","display_name":"Microfluidic ChipShop (Germany)","ror":"https://ror.org/045kvge53","country_code":"DE","type":"company","lineage":["https://openalex.org/I4210143711"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Tobias Jahn","raw_affiliation_strings":["microfluidic ChipShop GmbH (Germany)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"microfluidic ChipShop GmbH (Germany)","institution_ids":["https://openalex.org/I4210143711"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044543400","display_name":"Nadine Hlawatsch","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210143711","display_name":"Microfluidic ChipShop (Germany)","ror":"https://ror.org/045kvge53","country_code":"DE","type":"company","lineage":["https://openalex.org/I4210143711"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Nadine Hlawatsch","raw_affiliation_strings":["microfluidic ChipShop GmbH (Germany)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"microfluidic ChipShop GmbH (Germany)","institution_ids":["https://openalex.org/I4210143711"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010525750","display_name":"Sandra Julich","orcid":"https://orcid.org/0000-0002-8570-6162","observed_orcids":["https://orcid.org/0000-0002-8570-6162"]},"institutions":[{"id":"https://openalex.org/I1310048521","display_name":"Friedrich-Loeffler-Institut","ror":"https://ror.org/025fw7a54","country_code":"DE","type":"government","lineage":["https://openalex.org/I1310048521","https://openalex.org/I2801963157"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Sandra Julich","raw_affiliation_strings":["Friedrich-Loeffler-Institut (Germany)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Friedrich-Loeffler-Institut (Germany)","institution_ids":["https://openalex.org/I1310048521"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052268204","display_name":"Holger Becker","orcid":"https://orcid.org/0000-0002-7678-2518","observed_orcids":["https://orcid.org/0000-0002-7678-2518"]},"institutions":[{"id":"https://openalex.org/I4210143711","display_name":"Microfluidic ChipShop (Germany)","ror":"https://ror.org/045kvge53","country_code":"DE","type":"company","lineage":["https://openalex.org/I4210143711"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Holger Becker","raw_affiliation_strings":["microfluidic ChipShop GmbH (Germany)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"microfluidic ChipShop GmbH (Germany)","institution_ids":["https://openalex.org/I4210143711"]}]},{"author_position":"last","author":{"id":null,"display_name":"Claudia G\u00e4rtner","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210143711","display_name":"Microfluidic ChipShop (Germany)","ror":"https://ror.org/045kvge53","country_code":"DE","type":"company","lineage":["https://openalex.org/I4210143711"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Claudia G\u00e4rtner","raw_affiliation_strings":["microfluidic ChipShop GmbH (Germany)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"microfluidic ChipShop GmbH (Germany)","institution_ids":["https://openalex.org/I4210143711"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.1641,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.73549379,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"8725","issue":null,"first_page":"87252K","last_page":"87252K"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10412","display_name":"Microfluidic and Capillary Electrophoresis Applications","score":0.6215999722480774,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10412","display_name":"Microfluidic and Capillary Electrophoresis Applications","score":0.6215999722480774,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11393","display_name":"Biosensors and Analytical Detection","score":0.37209999561309814,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12867","display_name":"Advanced Biosensing Techniques and Applications","score":0.0017000000225380063,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lab-on-a-chip","display_name":"lab-on-a-chip","score":0.9980000257492065},{"id":"https://openalex.org/keywords/enzyme-activity-assay","display_name":"enzyme activity assay","score":0.7799999713897705},{"id":"https://openalex.org/keywords/pathogen-detection","display_name":"pathogen detection","score":0.9829999804496765},{"id":"https://openalex.org/keywords/cbrne","display_name":"CBRNE","score":0.9490000009536743},{"id":"https://openalex.org/keywords/microfluidic-device-design","display_name":"microfluidic device design","score":0.8420000076293945}],"concepts":[{"id":"https://openalex.org/C8673954","wikidata":"https://www.wikidata.org/wiki/Q138845","display_name":"Microfluidics","level":2,"score":0.6980607509613037},{"id":"https://openalex.org/C165005293","wikidata":"https://www.wikidata.org/wiki/Q1074500","display_name":"Chip","level":2,"score":0.6682209372520447},{"id":"https://openalex.org/C113843644","wikidata":"https://www.wikidata.org/wiki/Q901882","display_name":"Interface (matter)","level":4,"score":0.5683966279029846},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.555791974067688},{"id":"https://openalex.org/C2988198817","wikidata":"https://www.wikidata.org/wiki/Q633261","display_name":"Microfluidic chip","level":3,"score":0.5429527163505554},{"id":"https://openalex.org/C138942068","wikidata":"https://www.wikidata.org/wiki/Q633261","display_name":"Lab-on-a-chip","level":3,"score":0.5259618759155273},{"id":"https://openalex.org/C132651336","wikidata":"https://www.wikidata.org/wiki/Q185571","display_name":"Fluidics","level":2,"score":0.45675477385520935},{"id":"https://openalex.org/C149635348","wikidata":"https://www.wikidata.org/wiki/Q193040","display_name":"Embedded system","level":1,"score":0.35751256346702576},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.33057883381843567},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.3107548654079437},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.17801493406295776},{"id":"https://openalex.org/C119599485","wikidata":"https://www.wikidata.org/wiki/Q43035","display_name":"Electrical engineering","level":1,"score":0.15204942226409912},{"id":"https://openalex.org/C76155785","wikidata":"https://www.wikidata.org/wiki/Q418","display_name":"Telecommunications","level":1,"score":0.10942906141281128},{"id":"https://openalex.org/C173608175","wikidata":"https://www.wikidata.org/wiki/Q232661","display_name":"Parallel computing","level":1,"score":0.0},{"id":"https://openalex.org/C129307140","wikidata":"https://www.wikidata.org/wiki/Q6795880","display_name":"Maximum bubble pressure method","level":3,"score":0.0},{"id":"https://openalex.org/C157915830","wikidata":"https://www.wikidata.org/wiki/Q2928001","display_name":"Bubble","level":2,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1117/12.2018051","doi":"https://doi.org/10.1117/12.2018051","is_oa":false,"landing_page_url":"https://doi.org/10.1117/12.2018051","pdf_url":null,"source":{"id":"https://openalex.org/S183492911","display_name":"Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE","issn_l":"0277-786X","issn":["0277-786X","1996-756X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1"],"host_organization":"https://openalex.org/P4310315543","host_organization_name":"SPIE","host_organization_lineage":["https://openalex.org/P4310315543"],"host_organization_lineage_names":["SPIE"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"SPIE Proceedings","raw_type":"proceedings-article"},{"id":"pmh:oai:www.openagrar.de:openagrar_mods_00002705","doi":null,"is_oa":false,"landing_page_url":"https://www.openagrar.de/receive/openagrar_mods_00002705","pdf_url":null,"source":{"id":"https://openalex.org/S7407055137","display_name":"OpenAgrar","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2035134353","https://openalex.org/W2526530665","https://openalex.org/W2024135805","https://openalex.org/W2519549973","https://openalex.org/W589637761","https://openalex.org/W1982357324","https://openalex.org/W2003664242","https://openalex.org/W1425375422","https://openalex.org/W2120820470","https://openalex.org/W2092340056"],"abstract_inverted_index":{"The":[0,179,209],"ability":[1],"to":[2,11,126,155,176],"integrate":[3],"complete":[4],"assays":[5,65,93],"on":[6,96],"a":[7,39,84,104,110,128,133,143,215],"microfluidic":[8,101,105],"chip":[9,106,166,180],"helps":[10],"greatly":[12],"simplify":[13],"instrument":[14],"requirements":[15],"and":[16,142,148,167,193,206],"allows":[17],"the":[18,24,34,61,74,92,122,159,165,177,230],"use":[19],"of":[20,36,46,112,121,130,151,158,171,187,201,229],"lab-on-a-chip":[21],"technology":[22],"in":[23,38,50,100,164,172],"field.":[25],"A":[26],"core":[27],"application":[28,90],"for":[29,60,119,132,146,198,240],"such":[30,42],"field-portable":[31],"systems":[32],"is":[33],"detection":[35,72,120],"pathogens":[37],"CBRNE":[40],"scenario":[41],"as":[43,83],"permanent":[44],"monitoring":[45],"airborne":[47],"pathogens,":[48],"e.g.":[49,202],"metro":[51],"stations":[52],"or":[53],"hospitals":[54],"etc.":[55],"As":[56],"one":[57,188],"assay":[58,78],"methodology":[59],"pathogen":[62],"identification,":[63],"enzymatic":[64],"were":[66],"chosen.":[67],"In":[68,88],"order":[69],"evaluate":[70],"different":[71],"strategies,":[73],"realized":[75,108],"on-chip":[76],"enzyme":[77,207],"module":[79],"has":[80],"been":[81],"designed":[82],"general":[85],"platform":[86],"chip.":[87,246],"all":[89],"cases,":[91],"are":[94,238],"based":[95],"immobilized":[97],"probes":[98],"located":[99],"channels.":[102],"Therefore":[103],"was":[107],"containing":[109],"set":[111,129],"three":[113,194],"individually":[114],"addressable":[115],"channels,":[116],"not":[117],"only":[118],"sample":[123,189,210],"itself":[124],"also":[125,226],"have":[127],"references":[131],"quantitative":[134],"analysis.":[135,178],"It":[136],"furthermore":[137],"includes":[138,182],"two":[139],"turning":[140],"valves":[141],"waste":[144],"container":[145],"clear":[147],"sealed":[149],"storage":[150],"potential":[152],"pathogenic":[153],"liquids":[154,162],"avoid":[156],"contamination":[157,228],"environment.":[160],"All":[161],"remain":[163],"can":[168,211,232],"be":[169,212,233,243],"disposed":[170],"proper":[173],"way":[174],"subsequently":[175],"design":[181],"four":[183],"inlet":[184],"ports":[185],"consisting":[186],"port":[190],"(Luer":[191],"interface)":[192],"mini":[195],"Luer":[196,223],"interfaces":[197],"fluidic":[199],"support":[200],"washing":[203],"buffer,":[204],"substrate":[205],"solution.":[208],"applied":[213],"via":[214],"special,":[216],"sealable":[217],"sampling":[218],"vessel":[219],"with":[220],"integrated":[221],"female":[222],"interface.":[224],"Thereby":[225],"pre-anaytical":[227],"environment":[231],"provided.":[234],"Other":[235],"reagents":[236],"that":[237],"required":[239],"analysis":[241],"will":[242],"stored":[244],"off":[245]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2014,"cited_by_count":2}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}