{"id":"https://openalex.org/W1993636631","doi":"https://doi.org/10.1136/jnnp.57.10.1212","title":"Tenascin in cerebrospinal fluid is a useful biomarker for the diagnosis of brain tumour.","display_name":"Tenascin in cerebrospinal fluid is a useful biomarker for the diagnosis of brain tumour.","publication_year":1994,"publication_date":"1994-10-01","ids":{"openalex":"https://openalex.org/W1993636631","doi":"https://doi.org/10.1136/jnnp.57.10.1212","mag":"1993636631","pmid":"https://pubmed.ncbi.nlm.nih.gov/7523604","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/485489"},"language":"en","primary_location":{"id":"doi:10.1136/jnnp.57.10.1212","doi":"https://doi.org/10.1136/jnnp.57.10.1212","is_oa":true,"landing_page_url":"https://doi.org/10.1136/jnnp.57.10.1212","pdf_url":"https://jnnp.bmj.com/content/jnnp/57/10/1212.full.pdf","source":{"id":"https://openalex.org/S134773490","display_name":"Journal of Neurology Neurosurgery & Psychiatry","issn_l":"0022-3050","issn":["0022-3050","1468-330X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neurology, Neurosurgery &amp; Psychiatry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://jnnp.bmj.com/content/jnnp/57/10/1212.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5105654707","display_name":"Junji Yoshida","orcid":"https://orcid.org/0000-0002-1433-9297","observed_orcids":["https://orcid.org/0000-0002-1433-9297"]},"institutions":[{"id":"https://openalex.org/I60134161","display_name":"Nagoya University","ror":"https://ror.org/04chrp450","country_code":"JP","type":"education","lineage":["https://openalex.org/I60134161"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"J Yoshida","raw_affiliation_strings":["Department of Neurosurgery, Nagoya University School of Medicine, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, Nagoya University School of Medicine, Japan","institution_ids":["https://openalex.org/I60134161"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016645141","display_name":"Takashi Wakabayashi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I60134161","display_name":"Nagoya University","ror":"https://ror.org/04chrp450","country_code":"JP","type":"education","lineage":["https://openalex.org/I60134161"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"T Wakabayashi","raw_affiliation_strings":["Department of Neurosurgery, Nagoya University School of Medicine, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, Nagoya University School of Medicine, Japan","institution_ids":["https://openalex.org/I60134161"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031314236","display_name":"Sho Okamoto","orcid":"https://orcid.org/0000-0002-4997-6042","observed_orcids":["https://orcid.org/0000-0002-4997-6042"]},"institutions":[{"id":"https://openalex.org/I60134161","display_name":"Nagoya University","ror":"https://ror.org/04chrp450","country_code":"JP","type":"education","lineage":["https://openalex.org/I60134161"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"S Okamoto","raw_affiliation_strings":["Department of Neurosurgery, Nagoya University School of Medicine, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, Nagoya University School of Medicine, Japan","institution_ids":["https://openalex.org/I60134161"]}]},{"author_position":"middle","author":{"id":null,"display_name":"S Kimura","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I60134161","display_name":"Nagoya University","ror":"https://ror.org/04chrp450","country_code":"JP","type":"education","lineage":["https://openalex.org/I60134161"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"S Kimura","raw_affiliation_strings":["Department of Neurosurgery, Nagoya University School of Medicine, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, Nagoya University School of Medicine, Japan","institution_ids":["https://openalex.org/I60134161"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088216950","display_name":"Kinya Washizu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I60134161","display_name":"Nagoya University","ror":"https://ror.org/04chrp450","country_code":"JP","type":"education","lineage":["https://openalex.org/I60134161"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"K Washizu","raw_affiliation_strings":["Department of Neurosurgery, Nagoya University School of Medicine, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, Nagoya University School of Medicine, Japan","institution_ids":["https://openalex.org/I60134161"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063941260","display_name":"Kazuhiro Kiyosawa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I60134161","display_name":"Nagoya University","ror":"https://ror.org/04chrp450","country_code":"JP","type":"education","lineage":["https://openalex.org/I60134161"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"K Kiyosawa","raw_affiliation_strings":["Department of Neurosurgery, Nagoya University School of Medicine, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, Nagoya University School of Medicine, Japan","institution_ids":["https://openalex.org/I60134161"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110047563","display_name":"Kenji Mokuno","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I60134161","display_name":"Nagoya University","ror":"https://ror.org/04chrp450","country_code":"JP","type":"education","lineage":["https://openalex.org/I60134161"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"K Mokuno","raw_affiliation_strings":["Department of Neurosurgery, Nagoya University School of Medicine, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, Nagoya University School of Medicine, Japan","institution_ids":["https://openalex.org/I60134161"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I60134161"],"apc_list":null,"apc_paid":null,"fwci":0.9997,"has_fulltext":true,"cited_by_count":38,"citation_normalized_percentile":{"value":0.77688143,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"57","issue":"10","first_page":"1212","last_page":"1215"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11406","display_name":"Cerebrospinal fluid and hydrocephalus","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13779","display_name":"Cancer Mechanisms and Therapy","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tenascin","display_name":"tenascin","score":1.0},{"id":"https://openalex.org/keywords/cerebrospinal-fluid-biomarkers","display_name":"cerebrospinal fluid biomarkers","score":0.9110000133514404},{"id":"https://openalex.org/keywords/brain-tumor-diagnosis","display_name":"brain tumor diagnosis","score":0.8880000114440918},{"id":"https://openalex.org/keywords/astrocytic-tumors","display_name":"astrocytic tumors","score":0.8100000023841858},{"id":"https://openalex.org/keywords/glioma","display_name":"glioma","score":0.6060000061988831},{"id":"https://openalex.org/keywords/anaplastic-astrocytoma","display_name":"anaplastic astrocytoma","score":0.8830000162124634},{"id":"https://openalex.org/keywords/glioblastoma","display_name":"glioblastoma","score":0.9990000128746033},{"id":"https://openalex.org/keywords/tumour-dissemination","display_name":"tumour dissemination","score":0.7540000081062317},{"id":"https://openalex.org/keywords/extracellular-matrix-glycoprotein","display_name":"extracellular matrix glycoprotein","score":0.9049999713897705},{"id":"https://openalex.org/keywords/differential-diagnosis","display_name":"differential diagnosis","score":0.7039999961853027},{"id":"https://openalex.org/keywords/treatment-monitoring","display_name":"treatment monitoring","score":0.5360000133514404}],"concepts":[{"id":"https://openalex.org/C2777738151","wikidata":"https://www.wikidata.org/wiki/Q1903925","display_name":"Tenascin","level":4,"score":0.8148502111434937},{"id":"https://openalex.org/C2779651940","wikidata":"https://www.wikidata.org/wiki/Q54196","display_name":"Cerebrospinal fluid","level":2,"score":0.7433587312698364},{"id":"https://openalex.org/C2778880634","wikidata":"https://www.wikidata.org/wiki/Q177755","display_name":"Astrocytoma","level":3,"score":0.7025627493858337},{"id":"https://openalex.org/C2779083369","wikidata":"https://www.wikidata.org/wiki/Q486092","display_name":"Anaplastic astrocytoma","level":4,"score":0.6818691492080688},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.6623732447624207},{"id":"https://openalex.org/C2778227246","wikidata":"https://www.wikidata.org/wiki/Q1365309","display_name":"Glioma","level":2,"score":0.58628249168396},{"id":"https://openalex.org/C117961784","wikidata":"https://www.wikidata.org/wiki/Q18027461","display_name":"Tenascin C","level":3,"score":0.5778064131736755},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5643482208251953},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.5021762847900391},{"id":"https://openalex.org/C2780813603","wikidata":"https://www.wikidata.org/wiki/Q268930","display_name":"Subarachnoid space","level":3,"score":0.48428887128829956},{"id":"https://openalex.org/C189165786","wikidata":"https://www.wikidata.org/wiki/Q193825","display_name":"Extracellular matrix","level":2,"score":0.45024773478507996},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.22976332902908325},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.22923988103866577},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.1869315505027771},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C86492073","wikidata":"https://www.wikidata.org/wiki/Q413766","display_name":"Fibronectin","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000134","qualifier_name":"cerebrospinal fluid","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007124","descriptor_name":"Immunoenzyme Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000134","qualifier_name":"cerebrospinal fluid","is_major_topic":true},{"descriptor_ui":"D015816","descriptor_name":"Cell Adhesion Molecules, Neuronal","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D015816","descriptor_name":"Cell Adhesion Molecules, Neuronal","qualifier_ui":"Q000134","qualifier_name":"cerebrospinal fluid","is_major_topic":true},{"descriptor_ui":"D016326","descriptor_name":"Extracellular Matrix Proteins","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D016326","descriptor_name":"Extracellular Matrix Proteins","qualifier_ui":"Q000134","qualifier_name":"cerebrospinal fluid","is_major_topic":true},{"descriptor_ui":"D019063","descriptor_name":"Tenascin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1136/jnnp.57.10.1212","doi":"https://doi.org/10.1136/jnnp.57.10.1212","is_oa":true,"landing_page_url":"https://doi.org/10.1136/jnnp.57.10.1212","pdf_url":"https://jnnp.bmj.com/content/jnnp/57/10/1212.full.pdf","source":{"id":"https://openalex.org/S134773490","display_name":"Journal of Neurology Neurosurgery & Psychiatry","issn_l":"0022-3050","issn":["0022-3050","1468-330X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neurology, Neurosurgery &amp; Psychiatry","raw_type":"journal-article"},{"id":"pmid:7523604","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7523604","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of neurology, neurosurgery, and psychiatry","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:485489","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC485489/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Neurol Neurosurg Psychiatry","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1136/jnnp.57.10.1212","doi":"https://doi.org/10.1136/jnnp.57.10.1212","is_oa":true,"landing_page_url":"https://doi.org/10.1136/jnnp.57.10.1212","pdf_url":"https://jnnp.bmj.com/content/jnnp/57/10/1212.full.pdf","source":{"id":"https://openalex.org/S134773490","display_name":"Journal of Neurology Neurosurgery & Psychiatry","issn_l":"0022-3050","issn":["0022-3050","1468-330X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neurology, Neurosurgery &amp; Psychiatry","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1993636631.pdf","grobid_xml":"https://content.openalex.org/works/W1993636631.grobid-xml"},"referenced_works_count":15,"referenced_works":["https://openalex.org/W1493066666","https://openalex.org/W1678009046","https://openalex.org/W1978438935","https://openalex.org/W1981794076","https://openalex.org/W1988297300","https://openalex.org/W2005432934","https://openalex.org/W2016341390","https://openalex.org/W2026798810","https://openalex.org/W2037440587","https://openalex.org/W2084744044","https://openalex.org/W2089065997","https://openalex.org/W2119074990","https://openalex.org/W2151386979","https://openalex.org/W2168432310","https://openalex.org/W2408463275"],"related_works":["https://openalex.org/W2052556648","https://openalex.org/W2060950703","https://openalex.org/W4230447633","https://openalex.org/W2003850458","https://openalex.org/W1991572445","https://openalex.org/W2338368605","https://openalex.org/W1968648408","https://openalex.org/W1992361137","https://openalex.org/W2074851884","https://openalex.org/W2021624190"],"abstract_inverted_index":{"Tenascin,":[0],"an":[1,24,68],"extracellular":[2],"matrix":[3],"glycoprotein,":[4],"has":[5],"been":[6],"reported":[7],"to":[8],"be":[9],"expressed":[10],"predominantly":[11],"on":[12],"glioma":[13],"tissue":[14],"in":[15,19,50,58,65,79,96,116,141,149,156],"the":[16,43,46,106,150],"CNS,":[17],"both":[18],"a":[20,28,88],"cell":[21],"associated":[22],"and":[23,85,87,119,133,166],"excreted":[25],"form.":[26],"Recently,":[27],"highly":[29],"sensitive":[30],"sandwich":[31],"type":[32],"enzyme":[33],"immunoassay":[34],"for":[35,160],"quantitative":[36],"determination":[37],"of":[38,48,56,98,101,126,138,154,163,168],"tenascin":[39,49,57,109,143,155],"was":[40,52,63,73,94,144],"developed.":[41],"In":[42,136],"present":[44],"study,":[45],"amount":[47],"CSF":[51,59,99,157],"measured.":[53],"An":[54],"increase":[55,90],"(>":[60,76,91],"100":[61,114,147],"ng/ml)":[62,78,93,148],"found":[64,95],"patients":[66],"with":[67],"astrocytic":[69,169],"tumour.":[70],"The":[71,152],"concentration":[72],"significantly":[74],"higher":[75],"300":[77],"high":[80,102],"grade":[81,103],"astrocytoma":[82,84],"(anaplastic":[83],"glioblastoma)":[86],"further":[89],"1000":[92],"cases":[97,137],"dissemination":[100,125],"astrocytoma.":[104],"On":[105],"other":[107],"hand,":[108],"concentrations":[110],"were":[111],"less":[112],"than":[113],"ng/ml":[115],"non-astrocytic":[117],"tumours":[118,165],"non-neoplastic":[120],"neurological":[121],"diseases,":[122],"except":[123],"meningeal":[124,129],"tumour":[127],"cells,":[128],"stimulation":[130],"by":[131],"infection,":[132],"subarachnoid":[134],"haemorrhage.":[135],"treated":[139],"astrocytomas":[140],"remission,":[142],"negligible":[145],"(<":[146],"CSF.":[151],"measurement":[153],"is":[158],"useful":[159],"differential":[161],"diagnosis":[162],"brain":[164],"monitoring":[167],"tumours.":[170]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":3}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}