{"id":"https://openalex.org/W1993633758","doi":"https://doi.org/10.1210/jc.2014-1065","title":"Advances in Target-Specific Therapy for Osteoporosis","display_name":"Advances in Target-Specific Therapy for Osteoporosis","publication_year":2014,"publication_date":"2014-01-21","ids":{"openalex":"https://openalex.org/W1993633758","doi":"https://doi.org/10.1210/jc.2014-1065","mag":"1993633758","pmid":"https://pubmed.ncbi.nlm.nih.gov/24446660"},"language":"en","primary_location":{"id":"doi:10.1210/jc.2014-1065","doi":"https://doi.org/10.1210/jc.2014-1065","is_oa":false,"landing_page_url":"https://doi.org/10.1210/jc.2014-1065","pdf_url":null,"source":{"id":"https://openalex.org/S205775358","display_name":"The Journal of Clinical Endocrinology & Metabolism","issn_l":"0021-972X","issn":["0021-972X","1945-7197"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Clinical Endocrinology & Metabolism","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5090665248","display_name":"Nelson B. Watts","orcid":"https://orcid.org/0000-0003-0719-9801","observed_orcids":["https://orcid.org/0000-0003-0719-9801"]},"institutions":[{"id":"https://openalex.org/I4210165260","display_name":"Mercy Health","ror":"https://ror.org/054bs2v13","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210165260"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Nelson B. Watts","raw_affiliation_strings":["Mercy Health Osteoporosis and Bone Health Services (N.B.W.), Cincinnati, Ohio 45236;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mercy Health Osteoporosis and Bone Health Services (N.B.W.), Cincinnati, Ohio 45236;","institution_ids":["https://openalex.org/I4210165260"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5013126573","display_name":"John Paul Bilezikian","orcid":"https://orcid.org/0000-0002-1570-2617","observed_orcids":["https://orcid.org/0000-0002-1570-2617"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"John P. Bilezikian","raw_affiliation_strings":["Metabolic Bone Diseases Unit (J.P.B.), Endocrinology Division, College of Physicians and Surgeons, New York, New York 10032"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Metabolic Bone Diseases Unit (J.P.B.), Endocrinology Division, College of Physicians and Surgeons, New York, New York 10032","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5013126573","https://openalex.org/A5090665248"],"corresponding_institution_ids":["https://openalex.org/I4210165260"],"apc_list":{"value":3750,"currency":"USD","value_usd":3750},"apc_paid":null,"fwci":2.0686,"has_fulltext":true,"cited_by_count":9,"citation_normalized_percentile":{"value":0.84573776,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"99","issue":"4","first_page":"1149","last_page":"1151"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10071","display_name":"Bone health and osteoporosis research","score":0.9297000169754028,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10071","display_name":"Bone health and osteoporosis research","score":0.9297000169754028,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11221","display_name":"Bone health and treatments","score":0.03180000185966492,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11219","display_name":"Bone Metabolism and Diseases","score":0.03099999949336052,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/osteoporosis","display_name":"osteoporosis","score":0.9739999771118164},{"id":"https://openalex.org/keywords/bisphosphonates","display_name":"bisphosphonates","score":0.8259999752044678},{"id":"https://openalex.org/keywords/alendronate","display_name":"alendronate","score":0.9380000233650208},{"id":"https://openalex.org/keywords/risedronate","display_name":"risedronate","score":0.9929999709129333},{"id":"https://openalex.org/keywords/zoledronic-acid","display_name":"zoledronic acid","score":0.9819999933242798},{"id":"https://openalex.org/keywords/antiresorptive-therapy","display_name":"antiresorptive therapy","score":0.7770000100135803},{"id":"https://openalex.org/keywords/bone-remodeling","display_name":"bone remodeling","score":0.8870000243186951},{"id":"https://openalex.org/keywords/bone-resorption","display_name":"bone resorption","score":0.8820000290870667},{"id":"https://openalex.org/keywords/estrogen-deficiency","display_name":"estrogen deficiency","score":0.6330000162124634},{"id":"https://openalex.org/keywords/menopause","display_name":"menopause","score":0.9509999752044678},{"id":"https://openalex.org/keywords/raloxifene","display_name":"raloxifene","score":0.878000020980835},{"id":"https://openalex.org/keywords/calcitonin","display_name":"calcitonin","score":0.9959999918937683},{"id":"https://openalex.org/keywords/bone-mineral-density","display_name":"bone mineral density","score":0.8560000061988831},{"id":"https://openalex.org/keywords/fracture-prevention","display_name":"fracture prevention","score":0.7139999866485596},{"id":"https://openalex.org/keywords/farnesyl-pyrophosphate-synthase","display_name":"farnesyl diphosphate synthase","score":0.8309999704360962},{"id":"https://openalex.org/keywords/mevalonate-pathway","display_name":"mevalonate pathway","score":0.7609999775886536},{"id":"https://openalex.org/keywords/drug-safety-and-tolerability","display_name":"drug safety and tolerability","score":0.7039999961853027}],"concepts":[{"id":"https://openalex.org/C2776541429","wikidata":"https://www.wikidata.org/wiki/Q165328","display_name":"Osteoporosis","level":2,"score":0.7219949960708618},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.654794454574585},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.650393545627594},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6022020578384399}],"mesh":[{"descriptor_ui":"D002986","descriptor_name":"Clinical Trials as Topic","qualifier_ui":"Q000639","qualifier_name":"trends","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010024","descriptor_name":"Osteoporosis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D013379","descriptor_name":"Substrate Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015663","descriptor_name":"Osteoporosis, Postmenopausal","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D050071","descriptor_name":"Bone Density Conservation Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D058990","descriptor_name":"Molecular Targeted Therapy","qualifier_ui":"Q000639","qualifier_name":"trends","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1210/jc.2014-1065","doi":"https://doi.org/10.1210/jc.2014-1065","is_oa":false,"landing_page_url":"https://doi.org/10.1210/jc.2014-1065","pdf_url":null,"source":{"id":"https://openalex.org/S205775358","display_name":"The Journal of Clinical Endocrinology & Metabolism","issn_l":"0021-972X","issn":["0021-972X","1945-7197"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Clinical Endocrinology & Metabolism","raw_type":"journal-article"},{"id":"pmid:24446660","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24446660","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of clinical endocrinology and metabolism","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320307105","display_name":"Amgen","ror":"https://ror.org/03g03ge92"},{"id":"https://openalex.org/F4320307758","display_name":"Eli Lilly and Company","ror":"https://ror.org/01qat3289"},{"id":"https://openalex.org/F4320307765","display_name":"Pfizer","ror":"https://ror.org/01xdqrp08"},{"id":"https://openalex.org/F4320307781","display_name":"Sanofi","ror":"https://ror.org/027vj4x92"},{"id":"https://openalex.org/F4320315027","display_name":"Amarin Corporation","ror":"https://ror.org/02fccce66"},{"id":"https://openalex.org/F4320322436","display_name":"Novo Nordisk","ror":"https://ror.org/0435rc536"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":12,"referenced_works":["https://openalex.org/W2004855713","https://openalex.org/W2024887507","https://openalex.org/W2040577562","https://openalex.org/W2096627331","https://openalex.org/W2113264234","https://openalex.org/W2119962765","https://openalex.org/W2124166505","https://openalex.org/W2153009489","https://openalex.org/W2160005424","https://openalex.org/W2161837912","https://openalex.org/W2321227665","https://openalex.org/W2335178464"],"related_works":["https://openalex.org/W1968925517","https://openalex.org/W29485186","https://openalex.org/W2070092125","https://openalex.org/W2288760711","https://openalex.org/W3047667821","https://openalex.org/W2004132578","https://openalex.org/W28337352","https://openalex.org/W2336565270","https://openalex.org/W2779114819","https://openalex.org/W2144220745"],"abstract_inverted_index":{"Bone":[0],"is":[1,13,20,52,177,184,218,228,246],"constantly":[2],"being":[3,204],"remodeled,":[4],"with":[5,22,55,160,261,272],"resorption":[6,57,203],"preceding":[7],"formation.":[8,194,209],"In":[9],"the":[10,23,26,36,40,50,83,98,116,127,149,155,200,211,242,283],"individual":[11],"who":[12],"not":[14,53,134,219,303],"losing":[15],"bone":[16,18,30,56,59,64,79,84,113,187,193,276],"mass,":[17],"remodeling":[19,85],"balanced,":[21,54],"osteoblast":[24],"forming":[25],"same":[27],"amount":[28],"of":[29,119,122,151,157,202,208,213,285],"that":[31,110,179,230,245],"has":[32],"been":[33],"resorbed":[34],"by":[35,46,97],"osteoclast.":[37],"Remodeling":[38],"in":[39,104,126,275,282],"aging":[41],"skeleton,":[42],"aided":[43],"and":[44,101,145,166,257,267,280,288,294],"abetted":[45],"estrogen":[47,164],"deficiency":[48],"after":[49],"menopause,":[51],"exceeding":[58],"formation;":[60],"as":[61,216,236],"a":[62,123],"result,":[63],"loss":[65],"ensues.":[66],"The":[67],"earliest":[68],"therapeutic":[69,196],"attempts":[70],"to":[71,185,253,264],"correct":[72,220],"this":[73],"imbalance":[74],"were":[75],"focused":[76],"on":[77,199],"inhibiting":[78],"resorption,":[80,114,188],"thus":[81],"bringing":[82],"unit":[86],"into":[87],"better":[88],"balance.":[89],"When":[90],"alendronate,":[91,265],"an":[92],"amino-containing":[93],"bisphosphonate,":[94],"was":[95,108,133],"approved":[96,152],"US":[99],"Food":[100],"Drug":[102],"Administration":[103],"1995":[105],"(1\u20133),":[106],"it":[107,111,176,227],"known":[109],"reduced":[112],"but":[115,301],"molecular":[117],"mechanism":[118],"action":[120],"(inhibition":[121],"key":[124],"enzyme":[125],"mevalonate":[128],"pathway,":[129],"farnesyl":[130],"pyrophosphate":[131],"synthase)":[132],"understood":[135],"until":[136],"later":[137],"(4,":[138],"5).":[139],"Subsequently,":[140],"other":[141,231],"bisphosphonates":[142,153],"(risedronate,":[143],"ibandronate,":[144],"zoledronic":[146,268],"acid)":[147],"joined":[148],"family":[150],"for":[154],"treatment":[156],"osteoporosis.":[158],"Along":[159],"estrogen,":[161],"raloxifene":[162],"(an":[163],"analog),":[165],"calcitonin,":[167],"these":[168,189,214,296],"agents":[169,251],"together":[170],"are":[171,223,270],"called":[172],"\u201cantiresorptive\u201d":[173],"drugs.":[174],"Although":[175,210],"true":[178],"their":[180,292],"initial":[181],"mechanistic":[182],"effect":[183,197],"reduce":[186,192],"drugs":[190,215,297],"also":[191],"Their":[195],"depends":[198],"inhibition":[201,207],"greater":[205],"than":[206],"classification":[212,244],"antiresorptives":[217],"because":[221],"they":[222],"general":[224],"antiremodeling":[225],"agents,":[226],"unlikely":[229],"more":[232],"accurate":[233],"terms":[234],"such":[235],"\u201canticatabolic\u201d":[237],"or":[238],"\u201cantiremodeling\u201d":[239],"will":[240],"replace":[241],"common":[243],"universally":[247],"used.":[248],"These":[249],"antiresorptive":[250],"appear":[252],"be":[254],"generally":[255],"safe":[256],"well":[258],"tolerated":[259],"and,":[260],"specific":[262],"reference":[263],"risedronate,":[266],"acid,":[269],"associated":[271],"significant":[273],"increases":[274],"mineral":[277],"density":[278],"(BMD)":[279],"reductions":[281],"incidence":[284],"vertebral,":[286],"hip,":[287],"nonvertebral":[289],"fractures.":[290],"Despite":[291],"safety":[293],"efficacy,":[295],"maintain":[298],"skeletal":[299],"microstructure":[300],"do":[302],"rebuild":[304],"it.":[305]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}