{"id":"https://openalex.org/W1993576110","doi":"https://doi.org/10.1371/journal.pone.0011070","title":"Neuronal MicroRNA Deregulation in Response to Alzheimer's Disease Amyloid-\u03b2","display_name":"Neuronal MicroRNA Deregulation in Response to Alzheimer's Disease Amyloid-\u03b2","publication_year":2010,"publication_date":"2010-06-11","ids":{"openalex":"https://openalex.org/W1993576110","doi":"https://doi.org/10.1371/journal.pone.0011070","mag":"1993576110","pmid":"https://pubmed.ncbi.nlm.nih.gov/20552018","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2884018"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pone.0011070","doi":"https://doi.org/10.1371/journal.pone.0011070","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0011070","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0011070&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0011070&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5021245416","display_name":"Nicole Sch\u00f6nrock","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129604602","display_name":"The University of Sydney","ror":"https://ror.org/0384j8v12","country_code":"AU","type":"education","lineage":["https://openalex.org/I129604602"]}],"countries":["AU"],"is_corresponding":true,"raw_author_name":"Nicole Schonrock","raw_affiliation_strings":["Alzheimer's and Parkinson's Disease Laboratory, Brain and Mind Research Institute, University of Sydney, Sydney, New South Wales, Australia. nschonrock@med.usyd.edu.au","Alzheimer's and Parkinson's Disease Laboratory, Brain and Mind Research Institute, University of Sydney, Sydney, New South Wales, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Alzheimer's and Parkinson's Disease Laboratory, Brain and Mind Research Institute, University of Sydney, Sydney, New South Wales, Australia. nschonrock@med.usyd.edu.au","institution_ids":["https://openalex.org/I129604602"]},{"raw_affiliation_string":"Alzheimer's and Parkinson's Disease Laboratory, Brain and Mind Research Institute, University of Sydney, Sydney, New South Wales, Australia","institution_ids":["https://openalex.org/I129604602"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030210067","display_name":"Yazi Diana Ke","orcid":"https://orcid.org/0000-0002-1423-0451","observed_orcids":["https://orcid.org/0000-0002-1423-0451"]},"institutions":[{"id":"https://openalex.org/I129604602","display_name":"The University of Sydney","ror":"https://ror.org/0384j8v12","country_code":"AU","type":"education","lineage":["https://openalex.org/I129604602"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Yazi D. Ke","raw_affiliation_strings":["Alzheimer's and Parkinson's Disease Laboratory, Brain and Mind Research Institute, University of Sydney, Sydney, New South Wales, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Alzheimer's and Parkinson's Disease Laboratory, Brain and Mind Research Institute, University of Sydney, Sydney, New South Wales, Australia","institution_ids":["https://openalex.org/I129604602"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030539741","display_name":"David T. Humphreys","orcid":"https://orcid.org/0000-0003-4140-0089","observed_orcids":["https://orcid.org/0000-0003-4140-0089"]},"institutions":[{"id":"https://openalex.org/I19514445","display_name":"Victor Chang Cardiac Research Institute","ror":"https://ror.org/03trvqr13","country_code":"AU","type":"nonprofit","lineage":["https://openalex.org/I19514445"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"David Humphreys","raw_affiliation_strings":["Molecular Genetics Division, Victor Chang Cardiac Research Institute (VCCRI), Darlinghurst, Sydney, New South Wales, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Genetics Division, Victor Chang Cardiac Research Institute (VCCRI), Darlinghurst, Sydney, New South Wales, Australia","institution_ids":["https://openalex.org/I19514445"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047542970","display_name":"Matthias Staufenbiel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1283582996","display_name":"Novartis (Switzerland)","ror":"https://ror.org/02f9zrr09","country_code":"CH","type":"company","lineage":["https://openalex.org/I1283582996"]},{"id":"https://openalex.org/I4400600974","display_name":"Novartis Institutes for BioMedical Research","ror":"https://ror.org/053gv2m95","country_code":"CH","type":"funder","lineage":["https://openalex.org/I1283582996","https://openalex.org/I4400600974"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Matthias Staufenbiel","raw_affiliation_strings":["Novartis Institute for BioMedical Research, Basel, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Novartis Institute for BioMedical Research, Basel, Switzerland","institution_ids":["https://openalex.org/I1283582996","https://openalex.org/I4400600974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073763982","display_name":"Lars Matthias Ittner","orcid":"https://orcid.org/0000-0001-6738-3825","observed_orcids":["https://orcid.org/0000-0001-6738-3825"]},"institutions":[{"id":"https://openalex.org/I129604602","display_name":"The University of Sydney","ror":"https://ror.org/0384j8v12","country_code":"AU","type":"education","lineage":["https://openalex.org/I129604602"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Lars M. Ittner","raw_affiliation_strings":["Alzheimer's and Parkinson's Disease Laboratory, Brain and Mind Research Institute, University of Sydney, Sydney, New South Wales, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Alzheimer's and Parkinson's Disease Laboratory, Brain and Mind Research Institute, University of Sydney, Sydney, New South Wales, Australia","institution_ids":["https://openalex.org/I129604602"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086052856","display_name":"Thomas Prei\u00df","orcid":"https://orcid.org/0000-0001-6273-784X","observed_orcids":["https://orcid.org/0000-0001-6273-784X"]},"institutions":[{"id":"https://openalex.org/I19514445","display_name":"Victor Chang Cardiac Research Institute","ror":"https://ror.org/03trvqr13","country_code":"AU","type":"nonprofit","lineage":["https://openalex.org/I19514445"]},{"id":"https://openalex.org/I31746571","display_name":"UNSW Sydney","ror":"https://ror.org/03r8z3t63","country_code":"AU","type":"education","lineage":["https://openalex.org/I31746571"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Thomas Preiss","raw_affiliation_strings":["Molecular Genetics Division, Victor Chang Cardiac Research Institute (VCCRI), Darlinghurst, Sydney, New South Wales, Australia","School of Biotechnology and Biomolecular Sciences and St. Vincent's Clinical School, University of New South Wales, Sydney, New South Wales, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Genetics Division, Victor Chang Cardiac Research Institute (VCCRI), Darlinghurst, Sydney, New South Wales, Australia","institution_ids":["https://openalex.org/I19514445"]},{"raw_affiliation_string":"School of Biotechnology and Biomolecular Sciences and St. Vincent's Clinical School, University of New South Wales, Sydney, New South Wales, Australia","institution_ids":["https://openalex.org/I31746571"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5045325665","display_name":"J\u00fcrgen G\u00f6tz","orcid":"https://orcid.org/0000-0001-8501-7896","observed_orcids":["https://orcid.org/0000-0001-8501-7896","https://orcid.org/0000-0002-2003-9135"]},"institutions":[{"id":"https://openalex.org/I129604602","display_name":"The University of Sydney","ror":"https://ror.org/0384j8v12","country_code":"AU","type":"education","lineage":["https://openalex.org/I129604602"]}],"countries":["AU"],"is_corresponding":true,"raw_author_name":"J\u00fcrgen G\u00f6tz","raw_affiliation_strings":["Alzheimer's and Parkinson's Disease Laboratory, Brain and Mind Research Institute, University of Sydney, Sydney, New South Wales, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Alzheimer's and Parkinson's Disease Laboratory, Brain and Mind Research Institute, University of Sydney, Sydney, New South Wales, Australia","institution_ids":["https://openalex.org/I129604602"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5021245416","https://openalex.org/A5045325665"],"corresponding_institution_ids":["https://openalex.org/I129604602"],"apc_list":{"value":2382,"currency":"USD","value_usd":2382},"apc_paid":{"value":2382,"currency":"USD","value_usd":2382},"fwci":7.5847,"has_fulltext":true,"cited_by_count":217,"citation_normalized_percentile":{"value":0.98509652,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":100},"biblio":{"volume":"5","issue":"6","first_page":"e11070","last_page":"e11070"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.6723999977111816,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.6723999977111816,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.3176000118255615,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.004999999888241291,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.9210000038146973},{"id":"https://openalex.org/keywords/amyloid-beta","display_name":"amyloid-beta","score":0.9789999723434448},{"id":"https://openalex.org/keywords/mirna-dysregulation","display_name":"microRNA dysregulation","score":0.9620000123977661},{"id":"https://openalex.org/keywords/hippocampus","display_name":"hippocampus","score":0.6899999976158142},{"id":"https://openalex.org/keywords/app23-mice","display_name":"APP23 mice","score":0.9649999737739563},{"id":"https://openalex.org/keywords/amyloid-plaques","display_name":"amyloid plaques","score":0.7870000004768372},{"id":"https://openalex.org/keywords/microrna-target-genes","display_name":"miRNA target genes","score":0.6570000052452087},{"id":"https://openalex.org/keywords/neurodegeneration","display_name":"neurodegeneration","score":0.8650000095367432},{"id":"https://openalex.org/keywords/non-coding-rna-regulation","display_name":"non-coding RNA regulation","score":0.5860000252723694}],"concepts":[{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.7299160957336426},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7111616134643555},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.5756155252456665},{"id":"https://openalex.org/C148762608","wikidata":"https://www.wikidata.org/wiki/Q3748185","display_name":"Hippocampal formation","level":2,"score":0.538640558719635},{"id":"https://openalex.org/C2776925932","wikidata":"https://www.wikidata.org/wiki/Q1755122","display_name":"Neurodegeneration","level":3,"score":0.5217857360839844},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.5163156390190125},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3203381597995758},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.2944710850715637},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.24650341272354126},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.21578049659729004},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.20324522256851196},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.10979241132736206},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.10452708601951599}],"mesh":[{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008822","descriptor_name":"Mice, Transgenic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016133","descriptor_name":"Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016229","descriptor_name":"Amyloid beta-Peptides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":8,"locations":[{"id":"doi:10.1371/journal.pone.0011070","doi":"https://doi.org/10.1371/journal.pone.0011070","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0011070","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0011070&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2884018","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2884018","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS One","raw_type":"Text"},{"id":"pmid:20552018","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20552018","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PloS one","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.354.2881","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.354.2881","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/eb/7c/PLoS_One_2010_Jun_11_5(6)_e11070.tar.gz","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:3cf4161601604376a398ba936a98b7fe","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/3cf4161601604376a398ba936a98b7fe","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE, Vol 5, Iss 6, p e11070 (2010)","raw_type":"article"},{"id":"pmh:oai:openresearch-repository.anu.edu.au:1885/16093","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1885/16093","pdf_url":null,"source":{"id":"https://openalex.org/S4306402539","display_name":"ANU Open Research (Australian National University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I118347636","host_organization_name":"Australian National University","host_organization_lineage":["https://openalex.org/I118347636"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE","raw_type":"Journal article"},{"id":"pmh:oai:unsworks.library.unsw.edu.au:1959.4/unsworks_53694","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1959.4/unsworks_53694","pdf_url":null,"source":{"id":"https://openalex.org/S4377196481","display_name":"UNSWorks (UNSW Sydney)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I31746571","host_organization_name":"UNSW Sydney","host_organization_lineage":["https://openalex.org/I31746571"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS One, 5, 6, e11070","raw_type":"http://purl.org/coar/resource_type/c_6501"},{"id":"mag:3216369360","doi":null,"is_oa":false,"landing_page_url":"https://openresearch-repository.anu.edu.au/bitstream/1885/16093/1/01_Schonrock_Neuronal_microRNA_eeregulation_2010.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"doi:10.1371/journal.pone.0011070","doi":"https://doi.org/10.1371/journal.pone.0011070","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0011070","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0011070&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320307773","display_name":"GlaxoSmithKline","ror":"https://ror.org/01xsqw823"},{"id":"https://openalex.org/F4320320966","display_name":"University of Sydney","ror":"https://ror.org/0384j8v12"},{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"},{"id":"https://openalex.org/F4320334704","display_name":"Australian Research Council","ror":"https://ror.org/05mmh0f86"},{"id":"https://openalex.org/F4320334705","display_name":"National Health and Medical Research Council","ror":"https://ror.org/011kf5r70"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1993576110.pdf","grobid_xml":"https://content.openalex.org/works/W1993576110.grobid-xml"},"referenced_works_count":71,"referenced_works":["https://openalex.org/W32204808","https://openalex.org/W62972292","https://openalex.org/W123030052","https://openalex.org/W1589357319","https://openalex.org/W1600812038","https://openalex.org/W1823703999","https://openalex.org/W1886575365","https://openalex.org/W1964622632","https://openalex.org/W1964822121","https://openalex.org/W1968008181","https://openalex.org/W1969104747","https://openalex.org/W1969271586","https://openalex.org/W1970998345","https://openalex.org/W1979481666","https://openalex.org/W1981458288","https://openalex.org/W1982250275","https://openalex.org/W1985051759","https://openalex.org/W1987248329","https://openalex.org/W1988163167","https://openalex.org/W1990589261","https://openalex.org/W1995344309","https://openalex.org/W1996132904","https://openalex.org/W1998837829","https://openalex.org/W2000418014","https://openalex.org/W2001003536","https://openalex.org/W2001210466","https://openalex.org/W2007759608","https://openalex.org/W2013706950","https://openalex.org/W2019028138","https://openalex.org/W2027633665","https://openalex.org/W2030001972","https://openalex.org/W2035470211","https://openalex.org/W2038603404","https://openalex.org/W2039029682","https://openalex.org/W2041945875","https://openalex.org/W2042794149","https://openalex.org/W2044510533","https://openalex.org/W2065566217","https://openalex.org/W2070705691","https://openalex.org/W2072484559","https://openalex.org/W2072636314","https://openalex.org/W2072810552","https://openalex.org/W2074602692","https://openalex.org/W2075141112","https://openalex.org/W2080718047","https://openalex.org/W2083381199","https://openalex.org/W2090183355","https://openalex.org/W2090778647","https://openalex.org/W2091934374","https://openalex.org/W2102609766","https://openalex.org/W2102753200","https://openalex.org/W2102991194","https://openalex.org/W2107444074","https://openalex.org/W2110612472","https://openalex.org/W2114570899","https://openalex.org/W2115441328","https://openalex.org/W2120522615","https://openalex.org/W2122683221","https://openalex.org/W2127582027","https://openalex.org/W2131293603","https://openalex.org/W2141792156","https://openalex.org/W2152114580","https://openalex.org/W2153273744","https://openalex.org/W2158217645","https://openalex.org/W2159270639","https://openalex.org/W2159482845","https://openalex.org/W2162423616","https://openalex.org/W2171520215","https://openalex.org/W4294216483","https://openalex.org/W4297846234","https://openalex.org/W4298014089"],"related_works":["https://openalex.org/W7099638973","https://openalex.org/W3216369360","https://openalex.org/W2897379107","https://openalex.org/W2083615113","https://openalex.org/W2036556087","https://openalex.org/W4286717546","https://openalex.org/W2019127856","https://openalex.org/W3139466802","https://openalex.org/W1917905880","https://openalex.org/W2147495042"],"abstract_inverted_index":{"Normal":[0],"brain":[1,32,52],"development":[2],"and":[3,18,42,65,79,227],"function":[4],"depends":[5],"on":[6,114],"microRNA":[7],"(miRNA)":[8],"networks":[9],"to":[10,100,119,132,172,182,249,260,266],"fine":[11],"tune":[12],"the":[13,16,21,73,81,101,154,167,192,206,213,221,261],"balance":[14],"between":[15],"transcriptome":[17],"proteome":[19],"of":[20,68,75,91,103,124,137,150,156,208,215,263],"cell.":[22],"These":[23],"small":[24],"non-coding":[25],"RNA":[26],"regulators":[27],"are":[28,55,170],"highly":[29],"enriched":[30],"in":[31,38,130,145,177,185,195,200,205,224,234,247],"where":[33],"they":[34],"play":[35],"key":[36],"roles":[37],"neuronal":[39,94,138,179,244],"development,":[40],"plasticity":[41],"disease.":[43,69],"In":[44,219],"neurodegenerative":[45],"disorders":[46],"such":[47],"as":[48,153],"Alzheimer's":[49],"disease":[50],"(AD),":[51],"miRNA":[53,58,95,111,151,193,222,245],"profiles":[54],"altered;":[56],"thus":[57],"dysfunction":[59],"could":[60,98],"be":[61,183,255],"both":[62],"a":[63,66,87,147,203],"cause":[64],"consequence":[67],"Our":[70],"study":[71],"dissects":[72],"complexity":[74],"human":[76,235],"AD":[77,236],"pathology,":[78],"addresses":[80],"hypothesis":[82],"that":[83,121,142,166,191,243],"amyloid-beta":[84],"(Abeta)":[85],"itself,":[86],"known":[88,181],"causative":[89],"factor":[90,258],"AD,":[92],"causes":[93],"deregulation,":[96],"which":[97],"contribute":[99],"pathomechanisms":[102],"AD.":[104,186,267],"We":[105],"used":[106],"sensitive":[107],"TaqMan":[108],"low":[109],"density":[110],"arrays":[112],"(TLDA)":[113],"murine":[115],"primary":[116],"hippocampal":[117,196,225],"cultures":[118,197,226],"show":[120,141],"about":[122],"half":[123],"all":[125],"miRNAs":[126,159,169],"tested":[127],"were":[128],"down-regulated":[129],"response":[131,155,248],"Abeta":[133,139,143,216,253],"peptides.":[134],"Time-course":[135],"assays":[136],"treatments":[140],"is":[144,160],"fact":[146],"powerful":[148],"regulator":[149],"levels":[152],"certain":[157],"mature":[158],"extremely":[161],"rapid.":[162],"Bioinformatic":[163],"analysis":[164],"predicts":[165],"deregulated":[168],"likely":[171],"affect":[173],"target":[174],"genes":[175],"present":[176],"prominent":[178],"pathways":[180],"disrupted":[184],"Remarkably,":[187],"we":[188],"also":[189],"found":[190],"deregulation":[194,204,223,246],"was":[198],"paralleled":[199],"vivo":[201],"by":[202,252],"hippocampus":[207,229],"Abeta42-depositing":[209],"APP23":[210,228],"mice,":[211],"at":[212],"onset":[214],"plaque":[217],"formation.":[218],"addition,":[220],"overlaps":[230],"with":[231],"those":[232],"obtained":[233],"studies.":[237],"Taken":[238],"together,":[239],"our":[240],"findings":[241],"suggest":[242],"an":[250,256],"insult":[251],"may":[254],"important":[257],"contributing":[259],"cascade":[262],"events":[264],"leading":[265]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":17},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":10},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":17},{"year":2019,"cited_by_count":14},{"year":2018,"cited_by_count":9},{"year":2017,"cited_by_count":12},{"year":2016,"cited_by_count":11},{"year":2015,"cited_by_count":18},{"year":2014,"cited_by_count":21},{"year":2013,"cited_by_count":20},{"year":2012,"cited_by_count":26}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}