{"id":"https://openalex.org/W1993553086","doi":"https://doi.org/10.1530/acta.0.1090320","title":"Sexual differences in the effect of serotonin on LH secretion in rats","display_name":"Sexual differences in the effect of serotonin on LH secretion in rats","publication_year":1985,"publication_date":"1985-07-01","ids":{"openalex":"https://openalex.org/W1993553086","doi":"https://doi.org/10.1530/acta.0.1090320","mag":"1993553086","pmid":"https://pubmed.ncbi.nlm.nih.gov/3161263"},"language":"en","primary_location":{"id":"doi:10.1530/acta.0.1090320","doi":"https://doi.org/10.1530/acta.0.1090320","is_oa":false,"landing_page_url":"https://doi.org/10.1530/acta.0.1090320","pdf_url":null,"source":{"id":"https://openalex.org/S4210218062","display_name":"European Journal of Endocrinology","issn_l":"0804-4643","issn":["0804-4643","1479-683X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta Endocrinologica","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109933247","display_name":"Jaime A. Moguilevsky","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I24354313","display_name":"Universidad de Buenos Aires","ror":"https://ror.org/0081fs513","country_code":"AR","type":"education","lineage":["https://openalex.org/I24354313"]}],"countries":["AR"],"is_corresponding":false,"raw_author_name":"Jaime A. Moguilevsky","raw_affiliation_strings":["Instituto de Fisiolog\u00eda \u2018Prof. Dr. Bernardo A. Houssay\u2019, Facultad de Medicina, Universidad de Buenos Aires, Paraguay 2155, 1121 Buenos Aires"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto de Fisiolog\u00eda \u2018Prof. Dr. Bernardo A. Houssay\u2019, Facultad de Medicina, Universidad de Buenos Aires, Paraguay 2155, 1121 Buenos Aires","institution_ids":["https://openalex.org/I24354313"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040554341","display_name":"Mar\u00eda R. Faig\u00f3n","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I24354313","display_name":"Universidad de Buenos Aires","ror":"https://ror.org/0081fs513","country_code":"AR","type":"education","lineage":["https://openalex.org/I24354313"]}],"countries":["AR"],"is_corresponding":false,"raw_author_name":"Mar\u00eda R. Faig\u00f3n","raw_affiliation_strings":["Instituto de Fisiolog\u00eda \u2018Prof. Dr. Bernardo A. Houssay\u2019, Facultad de Medicina, Universidad de Buenos Aires, Paraguay 2155, 1121 Buenos Aires"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto de Fisiolog\u00eda \u2018Prof. Dr. Bernardo A. Houssay\u2019, Facultad de Medicina, Universidad de Buenos Aires, Paraguay 2155, 1121 Buenos Aires","institution_ids":["https://openalex.org/I24354313"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001536726","display_name":"Carlos Rubio\u2010Terres","orcid":"https://orcid.org/0000-0001-5106-2912","observed_orcids":["https://orcid.org/0000-0001-5106-2912","https://orcid.org/0009-0004-7959-0863"]},"institutions":[{"id":"https://openalex.org/I24354313","display_name":"Universidad de Buenos Aires","ror":"https://ror.org/0081fs513","country_code":"AR","type":"education","lineage":["https://openalex.org/I24354313"]}],"countries":["AR"],"is_corresponding":false,"raw_author_name":"Modesto C. Rubio","raw_affiliation_strings":["Instituto de Fisiolog\u00eda \u2018Prof. Dr. Bernardo A. Houssay\u2019, Facultad de Medicina, Universidad de Buenos Aires, Paraguay 2155, 1121 Buenos Aires"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto de Fisiolog\u00eda \u2018Prof. Dr. Bernardo A. Houssay\u2019, Facultad de Medicina, Universidad de Buenos Aires, Paraguay 2155, 1121 Buenos Aires","institution_ids":["https://openalex.org/I24354313"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113529769","display_name":"Pablo A. Scacchi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I24354313","display_name":"Universidad de Buenos Aires","ror":"https://ror.org/0081fs513","country_code":"AR","type":"education","lineage":["https://openalex.org/I24354313"]}],"countries":["AR"],"is_corresponding":false,"raw_author_name":"Pablo Scacchi","raw_affiliation_strings":["Instituto de Fisiolog\u00eda \u2018Prof. Dr. Bernardo A. Houssay\u2019, Facultad de Medicina, Universidad de Buenos Aires, Paraguay 2155, 1121 Buenos Aires"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto de Fisiolog\u00eda \u2018Prof. Dr. Bernardo A. Houssay\u2019, Facultad de Medicina, Universidad de Buenos Aires, Paraguay 2155, 1121 Buenos Aires","institution_ids":["https://openalex.org/I24354313"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5052174977","display_name":"Berta Szwarcfarb","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I151201029","display_name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas","ror":"https://ror.org/03cqe8w59","country_code":"AR","type":"government","lineage":["https://openalex.org/I151201029","https://openalex.org/I4210123736","https://openalex.org/I4387155568"]}],"countries":["AR"],"is_corresponding":false,"raw_author_name":"Berta Szwarcfarb","raw_affiliation_strings":["Instituto de Investigaciones Farmacol\u00f3gicas, Consejo Nacional de Investigationes Cient\u00edficas y T\u00e9cnicas (CONICET), Buenos Aires"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto de Investigaciones Farmacol\u00f3gicas, Consejo Nacional de Investigationes Cient\u00edficas y T\u00e9cnicas (CONICET), Buenos Aires","institution_ids":["https://openalex.org/I151201029"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3798,"currency":"EUR","value_usd":4292},"apc_paid":null,"fwci":0.2724,"has_fulltext":false,"cited_by_count":20,"citation_normalized_percentile":{"value":0.45836124,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"109","issue":"3","first_page":"320","last_page":"325"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10960","display_name":"Hypothalamic control of reproductive hormones","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10960","display_name":"Hypothalamic control of reproductive hormones","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11541","display_name":"Neuroendocrine regulation and behavior","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10364","display_name":"Reproductive Biology and Fertility","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/serotonin","display_name":"serotonin","score":0.9879999756813049},{"id":"https://openalex.org/keywords/luteinizing-hormone-secretion","display_name":"luteinizing hormone secretion","score":0.9819999933242798},{"id":"https://openalex.org/keywords/5-hydroxytryptophan","display_name":"5-hydroxytryptophan","score":0.9480000138282776},{"id":"https://openalex.org/keywords/sexual-difference","display_name":"sexual difference","score":0.7879999876022339},{"id":"https://openalex.org/keywords/prepubertal-rats","display_name":"prepubertal rats","score":0.9210000038146973},{"id":"https://openalex.org/keywords/ovariectomy","display_name":"ovariectomy","score":0.7419999837875366},{"id":"https://openalex.org/keywords/p-chloroamphetamine","display_name":"p-chloroamphetamine","score":0.8560000061988831},{"id":"https://openalex.org/keywords/lh-release","display_name":"LH release","score":0.4180000126361847},{"id":"https://openalex.org/keywords/pituitary-gland","display_name":"pituitary gland","score":0.734000027179718},{"id":"https://openalex.org/keywords/gonadotropin-secretion","display_name":"gonadotropin secretion","score":0.609000027179718}],"concepts":[{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.9323804974555969},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.9290030002593994},{"id":"https://openalex.org/C37000724","wikidata":"https://www.wikidata.org/wiki/Q50430226","display_name":"Serotonergic","level":4,"score":0.7117233276367188},{"id":"https://openalex.org/C2775864247","wikidata":"https://www.wikidata.org/wiki/Q167934","display_name":"Serotonin","level":3,"score":0.6418087482452393},{"id":"https://openalex.org/C2778575703","wikidata":"https://www.wikidata.org/wiki/Q50265477","display_name":"Luteinizing hormone","level":3,"score":0.5788320899009705},{"id":"https://openalex.org/C8264082","wikidata":"https://www.wikidata.org/wiki/Q7113259","display_name":"Ovariectomized rat","level":3,"score":0.5323479771614075},{"id":"https://openalex.org/C2910820727","wikidata":"https://www.wikidata.org/wiki/Q719723","display_name":"Prepuberty","level":3,"score":0.521273136138916},{"id":"https://openalex.org/C2779399491","wikidata":"https://www.wikidata.org/wiki/Q238544","display_name":"5-Hydroxytryptophan","level":4,"score":0.5138850212097168},{"id":"https://openalex.org/C192536144","wikidata":"https://www.wikidata.org/wiki/Q609370","display_name":"Sexual maturity","level":2,"score":0.4134003818035126},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3518097996711731},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.3511752486228943},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3301011919975281},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3286830186843872},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.07338348031044006}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002369","descriptor_name":"Castration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004958","descriptor_name":"Estradiol","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006916","descriptor_name":"5-Hydroxytryptophan","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D007031","descriptor_name":"Hypothalamus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007986","descriptor_name":"Luteinizing Hormone","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007987","descriptor_name":"Gonadotropin-Releasing Hormone","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008694","descriptor_name":"Methamphetamine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D010902","descriptor_name":"Pituitary Gland","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011374","descriptor_name":"Progesterone","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D012701","descriptor_name":"Serotonin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D012737","descriptor_name":"Sex Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012741","descriptor_name":"Sexual Maturation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1530/acta.0.1090320","doi":"https://doi.org/10.1530/acta.0.1090320","is_oa":false,"landing_page_url":"https://doi.org/10.1530/acta.0.1090320","pdf_url":null,"source":{"id":"https://openalex.org/S4210218062","display_name":"European Journal of Endocrinology","issn_l":"0804-4643","issn":["0804-4643","1479-683X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta Endocrinologica","raw_type":"journal-article"},{"id":"pmid:3161263","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3161263","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta endocrinologica","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9476000070571899}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1970228122","https://openalex.org/W1984841954","https://openalex.org/W1987615033","https://openalex.org/W2087454008","https://openalex.org/W2084533142","https://openalex.org/W2052889702","https://openalex.org/W2134272465","https://openalex.org/W2022725540","https://openalex.org/W1972307648","https://openalex.org/W1989922909"],"abstract_inverted_index":{"The":[0,59],"effect":[1,133,180,211],"of":[2,22,46,50,63,134,147,206,212],"5-hydroxytryptophan":[3],"(5-HTP),":[4],"a":[5,150,165,187],"serotonin":[6,151],"(5-HT)":[7],"precursor,":[8],"on":[9,31,52,136,195],"luteinizing":[10],"hormone":[11],"(LH)":[12],"secretion":[13,197],"was":[14,77],"studied":[15,85],"in":[16,39,57,69,81,98,131,138,161,168,175,181,191,198,209,214],"prepubertal":[17,139],"male":[18],"and":[19,35,74,90],"female":[20,71],"rats":[21,41,140],"different":[23],"ages.":[24],"In":[25],"females":[26],"5-HTP":[27,51,80,102],"stimulated":[28],"LH":[29,53,109,116,137,170,196],"release":[30,117,171],"days":[32,45,92,144],"16,":[33],"18":[34],"20":[36,73],"but":[37,114,177],"not":[38,104],"older":[40],"(26,":[42,88],"30,":[43],"35":[44,91],"age).":[47],"No":[48],"effects":[49],"levels":[54,110,160],"were":[55],"observed":[56],"males.":[58,182],"positive":[60],"feed-back":[61],"mechanism":[62],"oestrogen-progesterone":[64],"(E-P),":[65],"that":[66,126,157],"normally":[67],"matures":[68],"the":[70,83,95,107,115,132,162,169,192,199,204,210],"between":[72],"26":[75,143],"days,":[76],"inhibited":[78],"by":[79,112],"all":[82],"ages":[84],"during":[86],"prepuberty":[87],"30":[89],"old).":[93],"On":[94],"other":[96],"hand,":[97],"adult":[99,215],"ovariectomized":[100],"rats,":[101],"administration":[103],"only":[105],"decreased":[106],"high":[108],"induced":[111,164],"ovariectomy,":[113],"response":[118,172],"to":[119,173,202],"E-P":[120],"as":[121],"well.":[122],"These":[123,183],"results":[124],"indicate":[125,203],"there":[127],"are":[128],"sexual":[129,207],"differences":[130,208],"5-HT":[135,159,193,213],"younger":[141],"than":[142],"old.":[145],"Administration":[146],"p-chloroamphetamine":[148],"(PCA)":[149],"neurotoxin":[152],"selective":[153],"for":[154],"serotoninergic":[155],"neurons":[156],"depletes":[158],"brain,":[163],"significant":[166],"increase":[167],"LRH":[174],"females,":[176],"had":[178],"no":[179],"results,":[184],"besides":[185],"suggesting":[186],"probable":[188],"pituitary":[189],"participation":[190],"action":[194],"female,":[200],"appear":[201],"existence":[205],"rats.":[216]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}