{"id":"https://openalex.org/W1993519656","doi":"https://doi.org/10.1289/ehp.001081219","title":"A 4-Year-Old Girl with Manifestations of Multiple Chemical Sensitivities","display_name":"A 4-Year-Old Girl with Manifestations of Multiple Chemical Sensitivities","publication_year":2000,"publication_date":"2000-12-01","ids":{"openalex":"https://openalex.org/W1993519656","doi":"https://doi.org/10.1289/ehp.001081219","mag":"1993519656","pmid":"https://pubmed.ncbi.nlm.nih.gov/11133405","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1240206"},"language":"en","primary_location":{"id":"doi:10.1289/ehp.001081219","doi":"https://doi.org/10.1289/ehp.001081219","is_oa":true,"landing_page_url":"https://doi.org/10.1289/ehp.001081219","pdf_url":null,"source":{"id":"https://openalex.org/S10446503","display_name":"Environmental Health Perspectives","issn_l":"0091-6765","issn":["0091-6765","1552-9924"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319799","host_organization_name":"National Institute of Environmental Health Sciences","host_organization_lineage":["https://openalex.org/P4310319799","https://openalex.org/P4310316754"],"host_organization_lineage_names":["National Institute of Environmental Health Sciences","National Institutes of Health"],"type":"journal"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Environmental Health Perspectives","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1289/ehp.001081219","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5011009043","display_name":"Alan D. Woolf","orcid":"https://orcid.org/0000-0002-6793-2676","observed_orcids":["https://orcid.org/0000-0002-6793-2676"]},"institutions":[{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"A Woolf","raw_affiliation_strings":["Pediatric Environmental Health Subspecialty Unit and Clinical Toxicology Program, Children's Hospital Boston, MA 02115, USA. woolf@a1.tch.harvard.edu"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pediatric Environmental Health Subspecialty Unit and Clinical Toxicology Program, Children's Hospital Boston, MA 02115, USA. woolf@a1.tch.harvard.edu","institution_ids":["https://openalex.org/I1288882113","https://openalex.org/I136199984"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5011009043"],"corresponding_institution_ids":["https://openalex.org/I1288882113","https://openalex.org/I136199984"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":{"value":4500,"currency":"USD","value_usd":4500},"fwci":0.8706,"has_fulltext":false,"cited_by_count":15,"citation_normalized_percentile":{"value":0.6924305,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"108","issue":"12","first_page":"1219","last_page":"1219"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11002","display_name":"Indoor Air Quality and Microbial Exposure","score":0.4214000105857849,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11002","display_name":"Indoor Air Quality and Microbial Exposure","score":0.4214000105857849,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11334","display_name":"Psychosomatic Disorders and Their Treatments","score":0.3310999870300293,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14393","display_name":"Health, Environment, Cognitive Aging","score":0.024700000882148743,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/multiple-chemical-sensitivity","display_name":"multiple chemical sensitivity","score":0.9750000238418579},{"id":"https://openalex.org/keywords/pediatric-patients","display_name":"pediatric patients","score":0.7039999961853027},{"id":"https://openalex.org/keywords/preschool-children","display_name":"preschool children","score":0.5199999809265137},{"id":"https://openalex.org/keywords/cow-s-milk-allergy","display_name":"cow's milk allergy","score":0.6470000147819519},{"id":"https://openalex.org/keywords/asthma","display_name":"asthma","score":0.7580000162124634},{"id":"https://openalex.org/keywords/sinusitis","display_name":"sinusitis","score":0.7139999866485596},{"id":"https://openalex.org/keywords/food-allergy","display_name":"food allergy","score":0.41600000858306885},{"id":"https://openalex.org/keywords/environmental-allergens","display_name":"environmental allergens","score":0.5049999952316284},{"id":"https://openalex.org/keywords/psychosomatic-disorders","display_name":"psychosomatic disorders","score":0.6930000185966492},{"id":"https://openalex.org/keywords/diagnostic-strategy","display_name":"diagnostic approach","score":0.6460000276565552}],"concepts":[{"id":"https://openalex.org/C2780642338","wikidata":"https://www.wikidata.org/wiki/Q7632042","display_name":"Subspecialty","level":2,"score":0.7750242948532104},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7586569786071777},{"id":"https://openalex.org/C2779013996","wikidata":"https://www.wikidata.org/wiki/Q674461","display_name":"Multiple chemical sensitivity","level":2,"score":0.6971490383148193},{"id":"https://openalex.org/C2780966972","wikidata":"https://www.wikidata.org/wiki/Q86","display_name":"Headaches","level":2,"score":0.610081672668457},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.5558772087097168},{"id":"https://openalex.org/C2776042228","wikidata":"https://www.wikidata.org/wiki/Q35869","display_name":"Asthma","level":2,"score":0.46606141328811646},{"id":"https://openalex.org/C207480886","wikidata":"https://www.wikidata.org/wiki/Q42982","display_name":"Allergy","level":2,"score":0.4430635869503021},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.3922986388206482},{"id":"https://openalex.org/C16005928","wikidata":"https://www.wikidata.org/wiki/Q171171","display_name":"Dermatology","level":1,"score":0.34542346000671387},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.23851832747459412},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.12227457761764526}],"mesh":[{"descriptor_ui":"D000223","descriptor_name":"Adaptation, Psychological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002675","descriptor_name":"Child, Preschool","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003937","descriptor_name":"Diagnosis, Differential","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004032","descriptor_name":"Diet","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004781","descriptor_name":"Environmental Exposure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005192","descriptor_name":"Family Health","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005512","descriptor_name":"Food Hypersensitivity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018777","descriptor_name":"Multiple Chemical Sensitivity","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D018777","descriptor_name":"Multiple Chemical Sensitivity","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D018777","descriptor_name":"Multiple Chemical Sensitivity","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1289/ehp.001081219","doi":"https://doi.org/10.1289/ehp.001081219","is_oa":true,"landing_page_url":"https://doi.org/10.1289/ehp.001081219","pdf_url":null,"source":{"id":"https://openalex.org/S10446503","display_name":"Environmental Health Perspectives","issn_l":"0091-6765","issn":["0091-6765","1552-9924"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319799","host_organization_name":"National Institute of Environmental Health Sciences","host_organization_lineage":["https://openalex.org/P4310319799","https://openalex.org/P4310316754"],"host_organization_lineage_names":["National Institute of Environmental Health Sciences","National Institutes of Health"],"type":"journal"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Environmental Health Perspectives","raw_type":"journal-article"},{"id":"doi:10.2307/3434837","doi":"https://doi.org/10.2307/3434837","is_oa":true,"landing_page_url":"https://doi.org/10.2307/3434837","pdf_url":null,"source":{"id":"https://openalex.org/S10446503","display_name":"Environmental Health Perspectives","issn_l":"0091-6765","issn":["0091-6765","1552-9924"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319799","host_organization_name":"National Institute of Environmental Health Sciences","host_organization_lineage":["https://openalex.org/P4310319799","https://openalex.org/P4310316754"],"host_organization_lineage_names":["National Institute of Environmental Health Sciences","National Institutes of Health"],"type":"journal"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Environmental Health Perspectives","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:216783","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1240206","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:1240206","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1240206","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Environ Health Perspect","raw_type":"Text"},{"id":"pmid:11133405","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11133405","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Environmental health perspectives","raw_type":"Case Reports"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.280.7339","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.280.7339","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/de/63/Environ_Health_Perspect_2000_Dec_108(12)_1219-1223.tar.gz","raw_type":"text"}],"best_oa_location":{"id":"doi:10.1289/ehp.001081219","doi":"https://doi.org/10.1289/ehp.001081219","is_oa":true,"landing_page_url":"https://doi.org/10.1289/ehp.001081219","pdf_url":null,"source":{"id":"https://openalex.org/S10446503","display_name":"Environmental Health Perspectives","issn_l":"0091-6765","issn":["0091-6765","1552-9924"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319799","host_organization_name":"National Institute of Environmental Health Sciences","host_organization_lineage":["https://openalex.org/P4310319799","https://openalex.org/P4310316754"],"host_organization_lineage_names":["National Institute of Environmental Health Sciences","National Institutes of Health"],"type":"journal"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Environmental Health Perspectives","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9763000011444092,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/case-report","display_name":"Case Report"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":39,"referenced_works":["https://openalex.org/W161755725","https://openalex.org/W1607624071","https://openalex.org/W1966251797","https://openalex.org/W1978110278","https://openalex.org/W1978156279","https://openalex.org/W1982523212","https://openalex.org/W2013809223","https://openalex.org/W2027758809","https://openalex.org/W2041375531","https://openalex.org/W2053022502","https://openalex.org/W2054868037","https://openalex.org/W2055950647","https://openalex.org/W2057461690","https://openalex.org/W2062564426","https://openalex.org/W2063844422","https://openalex.org/W2063879536","https://openalex.org/W2071213390","https://openalex.org/W2082836085","https://openalex.org/W2083372681","https://openalex.org/W2085314575","https://openalex.org/W2109859396","https://openalex.org/W2116352376","https://openalex.org/W2118310407","https://openalex.org/W2122368751","https://openalex.org/W2126955732","https://openalex.org/W2132751574","https://openalex.org/W2135704807","https://openalex.org/W2154695707","https://openalex.org/W2160684164","https://openalex.org/W2313814626","https://openalex.org/W2332944719","https://openalex.org/W2398162849","https://openalex.org/W2399407082","https://openalex.org/W2403218711","https://openalex.org/W2410725819","https://openalex.org/W2464143008","https://openalex.org/W2587292901","https://openalex.org/W4230563404","https://openalex.org/W4245052430"],"related_works":["https://openalex.org/W7098016625","https://openalex.org/W2325646694","https://openalex.org/W4390232426","https://openalex.org/W1992578370","https://openalex.org/W3141253098","https://openalex.org/W4310995728","https://openalex.org/W3128747149","https://openalex.org/W2170570224","https://openalex.org/W1207958783","https://openalex.org/W7166834602"],"abstract_inverted_index":{"Multiple":[0],"chemical":[1],"sensitivities":[2],"(MCS)":[3],"syndrome,":[4],"also":[5],"known":[6],"as":[7,67,127,168],"idiopathic":[8],"environmental":[9],"intolerance,":[10],"is":[11,80,85],"a":[12,17,55,71,114],"controversial":[13],"diagnosis":[14],"that":[15],"encompasses":[16],"wide":[18],"range":[19],"of":[20,40,113,147,166],"waxing":[21],"and":[22,33,63,123,130,140,150,158,160],"waning,":[23],"subjective":[24],"symptoms":[25],"referable":[26],"to":[27,37,68,88],"more":[28],"than":[29],"one":[30],"body":[31],"system":[32],"provoked":[34],"by":[35,143,170],"exposure":[36],"low":[38],"levels":[39],"chemicals,":[41,148],"foods,":[42,149],"or":[43],"other":[44],"agents":[45],"in":[46,91],"the":[47,59,92,99,111],"environment.":[48],"Although":[49],"MCS":[50,79,167],"has":[51],"been":[52],"studied":[53],"extensively,":[54],"unifying":[56],"mechanism":[57],"explaining":[58],"illness":[60],"remains":[61],"obscure,":[62],"clinicians":[64],"are":[65],"divided":[66],"whether":[69],"such":[70],"medical":[72],"entity":[73],"exists":[74],"separately":[75],"from":[76,98,120],"psychosomatic":[77],"syndromes.":[78],"an":[81,128,144],"adult":[82],"diagnosis;":[83],"there":[84],"little":[86],"reference":[87],"pediatric":[89,164],"cases":[90],"scientific":[93],"literature.":[94],"In":[95],"this":[96,171],"case":[97,112],"Pediatric":[100],"Environmental":[101],"Health":[102],"Subspecialty":[103],"Unit":[104],"at":[105],"Boston's":[106],"Children's":[107],"Hospital,":[108],"I":[109,152],"present":[110],"preschool":[115],"child":[116],"who":[117],"had":[118],"suffered":[119],"milk":[121],"allergy":[122],"poor":[124],"weight":[125],"gain":[126],"infant,":[129],"then":[131],"later":[132],"developed":[133],"asthma,":[134],"allergic":[135],"symptoms,":[136],"sinusitis,":[137],"headaches,":[138],"fatigue,":[139],"rashes":[141],"precipitated":[142],"expanding":[145],"variety":[146],"allergens.":[151],"review":[153],"definitions,":[154],"mechanisms,":[155],"diagnostic":[156],"strategies,":[157],"management,":[159],"discuss":[161],"some":[162],"uniquely":[163],"features":[165],"illustrated":[169],"case.":[172]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}