{"id":"https://openalex.org/W1993495644","doi":"https://doi.org/10.1093/ndt/15.5.574","title":"Blood monocyte phenotypes and soluble endotoxin receptor CD14 in systemic inflammatory diseases and patients with chronic renal failure","display_name":"Blood monocyte phenotypes and soluble endotoxin receptor CD14 in systemic inflammatory diseases and patients with chronic renal failure","publication_year":2000,"publication_date":"2000-05-01","ids":{"openalex":"https://openalex.org/W1993495644","doi":"https://doi.org/10.1093/ndt/15.5.574","mag":"1993495644","pmid":"https://pubmed.ncbi.nlm.nih.gov/10809793"},"language":"en","primary_location":{"id":"doi:10.1093/ndt/15.5.574","doi":"https://doi.org/10.1093/ndt/15.5.574","is_oa":false,"landing_page_url":"https://doi.org/10.1093/ndt/15.5.574","pdf_url":null,"source":{"id":"https://openalex.org/S186113128","display_name":"Nephrology Dialysis Transplantation","issn_l":"0931-0509","issn":["0931-0509","1460-2385"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nephrology Dialysis Transplantation","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111572868","display_name":"Juergen E. Scherberich","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Juergen E. Scherberich","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5000301339","display_name":"Wolfgang Andreas Nockher","orcid":"https://orcid.org/0000-0001-8761-095X","observed_orcids":["https://orcid.org/0000-0001-8761-095X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Wolfgang A. Nockher","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3474,"currency":"EUR","value_usd":3926},"apc_paid":null,"fwci":0.5221,"has_fulltext":false,"cited_by_count":26,"citation_normalized_percentile":{"value":0.68088666,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"15","issue":"5","first_page":"574","last_page":"578"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10291","display_name":"Dialysis and Renal Disease Management","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10291","display_name":"Dialysis and Renal Disease Management","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.0034000000450760126,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10218","display_name":"Sepsis Diagnosis and Treatment","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/monocyte-phenotype","display_name":"monocyte phenotype","score":0.8500000238418579},{"id":"https://openalex.org/keywords/cd14","display_name":"CD14","score":0.9549999833106995},{"id":"https://openalex.org/keywords/end-stage-renal-disease","display_name":"end-stage renal disease","score":0.8220000267028809},{"id":"https://openalex.org/keywords/chronic-renal-replacement-therapy","display_name":"chronic renal replacement therapy","score":0.7950000166893005},{"id":"https://openalex.org/keywords/uremia","display_name":"uremia","score":0.7739999890327454},{"id":"https://openalex.org/keywords/systemic-inflammation","display_name":"systemic inflammation","score":0.675000011920929},{"id":"https://openalex.org/keywords/secondary-immunodeficiency","display_name":"secondary immunodeficiency","score":0.8240000009536743},{"id":"https://openalex.org/keywords/pro-inflammatory-cytokines","display_name":"inflammatory cytokines","score":0.7620000243186951},{"id":"https://openalex.org/keywords/atherosclerosis","display_name":"atherosclerosis","score":0.6759999990463257},{"id":"https://openalex.org/keywords/cardiovascular-risk","display_name":"cardiovascular risk","score":0.8080000281333923},{"id":"https://openalex.org/keywords/phagocytosis","display_name":"phagocytosis","score":0.7390000224113464}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9544587135314941},{"id":"https://openalex.org/C2778513237","wikidata":"https://www.wikidata.org/wiki/Q419553","display_name":"CD14","level":3,"score":0.7792540788650513},{"id":"https://openalex.org/C2781184567","wikidata":"https://www.wikidata.org/wiki/Q107244","display_name":"Monocyte","level":2,"score":0.7132818698883057},{"id":"https://openalex.org/C2993356106","wikidata":"https://www.wikidata.org/wiki/Q736715","display_name":"Chronic renal failure","level":2,"score":0.5763580203056335},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4809764623641968},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.46129998564720154},{"id":"https://openalex.org/C2778653478","wikidata":"https://www.wikidata.org/wiki/Q1054718","display_name":"Kidney disease","level":2,"score":0.41203194856643677},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.34810954332351685},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.33968856930732727},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D007676","descriptor_name":"Kidney Failure, Chronic","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007676","descriptor_name":"Kidney Failure, Chronic","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D009000","descriptor_name":"Monocytes","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012995","descriptor_name":"Solubility","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018950","descriptor_name":"Lipopolysaccharide Receptors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1093/ndt/15.5.574","doi":"https://doi.org/10.1093/ndt/15.5.574","is_oa":false,"landing_page_url":"https://doi.org/10.1093/ndt/15.5.574","pdf_url":null,"source":{"id":"https://openalex.org/S186113128","display_name":"Nephrology Dialysis Transplantation","issn_l":"0931-0509","issn":["0931-0509","1460-2385"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nephrology Dialysis Transplantation","raw_type":"journal-article"},{"id":"pmid:10809793","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10809793","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association","raw_type":"Editorial"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":22,"referenced_works":["https://openalex.org/W237733484","https://openalex.org/W1602907103","https://openalex.org/W1942388374","https://openalex.org/W1974749956","https://openalex.org/W1977472135","https://openalex.org/W1984281931","https://openalex.org/W1992961556","https://openalex.org/W2003927611","https://openalex.org/W2013480262","https://openalex.org/W2018840055","https://openalex.org/W2036518009","https://openalex.org/W2038523160","https://openalex.org/W2063691541","https://openalex.org/W2069880944","https://openalex.org/W2080631148","https://openalex.org/W2101767905","https://openalex.org/W2112117215","https://openalex.org/W2122769143","https://openalex.org/W2186699960","https://openalex.org/W2271688629","https://openalex.org/W2313010005","https://openalex.org/W2413428127"],"related_works":["https://openalex.org/W3026546556","https://openalex.org/W2001693594","https://openalex.org/W2744168289","https://openalex.org/W2961096346","https://openalex.org/W2989586692","https://openalex.org/W2012456254","https://openalex.org/W2023413772","https://openalex.org/W237733484","https://openalex.org/W2414213082","https://openalex.org/W2617404027"],"abstract_inverted_index":{"Patients":[0],"with":[1],"end\u2010stage":[2],"renal":[3,7],"failure":[4],"undergoing":[5],"chronic":[6,61,71],"replacement":[8],"therapy":[9],"reveal":[10],"several":[11],"signs":[12,72],"of":[13,73,123,146],"an":[14],"impaired":[15],"humoral":[16],"and":[17,37,49,75,85,90,105,118,121,126,143],"cellular":[18],"immune":[19,148],"response":[20,43],"[1,2].":[21],"As":[22],"a":[23,128],"consequence":[24],"patients":[25,154],"are":[26,111,138],"more":[27],"susceptible":[28],"to":[29,45,101],"bacterial":[30],"infections,":[31],"exhibit":[32],"defective":[33],"phagocytosis,":[34],"altered":[35],"B\u2010/T\u2010cell":[36],"disturbed":[38],"killer":[39],"cell":[40],"activity,":[41],"low":[42],"rate":[44],"hepatitis":[46],"B":[47],"vaccine,":[48],"increased":[50,106],"risk":[51],"for":[52,141],"cancer.":[53],"On":[54],"the":[55,144,147],"other":[56],"hand,":[57],"secondary":[58],"immunodeficiency":[59],"in":[60,81,92,114,135,151],"uraemia":[62],"is":[63],"masked":[64],"by":[65],"dialysis\u2010related":[66],"blood\u2010membrane":[67],"interactions":[68],"which":[69],"show":[70],"complement":[74],"monocyte":[76],"activation.":[77],"In":[78],"addition,":[79],"changes":[80],"proinflammatory":[82],"cytokine":[83],"synthesis":[84],"secretion":[86,122],"(IL1,":[87],"IL6,":[88],"TNF\u2010\u03b1)":[89],"rise":[91],"acute":[93],"phase":[94],"reactants":[95],"revealing":[96],"inadequate":[97],"\u2018immunostimulation\u2019":[98],"apparently":[99],"contribute":[100],"progressive":[102],"atherosclerotic":[103],"lesions":[104],"cardiovascular":[107],"events":[108],"[3,4].":[109],"Monocytes":[110],"closely":[112],"involved":[113],"antigen":[115],"presentation,":[116],"T\u2010":[117],"B\u2010cell":[119],"cooperation":[120],"various":[124],"monokines,":[125],"play":[127],"pivotal":[129],"role":[130],"not":[131],"only":[132],"as":[133],"targets":[134],"biocompatibility":[136],"but":[137],"also":[139],"responsible":[140],"microinflammation":[142],"dysbalance":[145],"system":[149],"observed":[150],"chronically":[152],"uraemic":[153],"[5,6].":[155]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}