{"id":"https://openalex.org/W1993465897","doi":"https://doi.org/10.1523/jneurosci.3501-06.2007","title":"A\u03b2 Oligomer-Induced Aberrations in Synapse Composition, Shape, and Density Provide a Molecular Basis for Loss of Connectivity in Alzheimer's Disease","display_name":"A\u03b2 Oligomer-Induced Aberrations in Synapse Composition, Shape, and Density Provide a Molecular Basis for Loss of Connectivity in Alzheimer's Disease","publication_year":2007,"publication_date":"2007-01-24","ids":{"openalex":"https://openalex.org/W1993465897","doi":"https://doi.org/10.1523/jneurosci.3501-06.2007","mag":"1993465897","pmid":"https://pubmed.ncbi.nlm.nih.gov/17251419","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6672917"},"language":"en","primary_location":{"id":"doi:10.1523/jneurosci.3501-06.2007","doi":"https://doi.org/10.1523/jneurosci.3501-06.2007","is_oa":true,"landing_page_url":"https://doi.org/10.1523/jneurosci.3501-06.2007","pdf_url":"https://www.jneurosci.org/content/jneuro/27/4/796.full.pdf","source":{"id":"https://openalex.org/S5555990","display_name":"Journal of Neuroscience","issn_l":"0270-6474","issn":["0270-6474","1529-2401"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319739","host_organization_name":"Society for Neuroscience","host_organization_lineage":["https://openalex.org/P4310319739"],"host_organization_lineage_names":["Society for Neuroscience"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Neuroscience","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://www.jneurosci.org/content/jneuro/27/4/796.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108505001","display_name":"Pascale N. Lacor","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Pascale N. Lacor","raw_affiliation_strings":["Department of Neurobiology and Physiology, Northwestern University, Evanston, Illinois 60208, USA. p-lacor@northwestern.edu","Department of Neurobiology and Physiology, Northwestern University, Evanston, Illinois, 60208, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurobiology and Physiology, Northwestern University, Evanston, Illinois 60208, USA. p-lacor@northwestern.edu","institution_ids":["https://openalex.org/I111979921"]},{"raw_affiliation_string":"Department of Neurobiology and Physiology, Northwestern University, Evanston, Illinois, 60208, USA","institution_ids":["https://openalex.org/I111979921"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002408091","display_name":"Maria C. F. Buniel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Maria C. Buniel","raw_affiliation_strings":["Department of Neurobiology and Physiology , Northwestern University , Evanston , Illinois 60208","Northwestern University****"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurobiology and Physiology , Northwestern University , Evanston , Illinois 60208","institution_ids":["https://openalex.org/I111979921"]},{"raw_affiliation_string":"Northwestern University****","institution_ids":["https://openalex.org/I111979921"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059902785","display_name":"Paul W. Furlow","orcid":"https://orcid.org/0000-0002-0754-4962","observed_orcids":["https://orcid.org/0000-0002-0754-4962"]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Paul W. Furlow","raw_affiliation_strings":["Department of Neurobiology and Physiology , Northwestern University , Evanston , Illinois 60208","Northwestern University****"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurobiology and Physiology , Northwestern University , Evanston , Illinois 60208","institution_ids":["https://openalex.org/I111979921"]},{"raw_affiliation_string":"Northwestern University****","institution_ids":["https://openalex.org/I111979921"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036478363","display_name":"Antonio Sanz-Clemente","orcid":"https://orcid.org/0000-0002-1256-4722","observed_orcids":["https://orcid.org/0000-0002-1256-4722"]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Antonio Sanz Clemente","raw_affiliation_strings":["Department of Neurobiology and Physiology, Northwestern University, Evanston, Illinois 60208"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurobiology and Physiology, Northwestern University, Evanston, Illinois 60208","institution_ids":["https://openalex.org/I111979921"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068395362","display_name":"Pauline T. Velasco","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Pauline T. Velasco","raw_affiliation_strings":["Department of Neurobiology and Physiology , Northwestern University , Evanston , Illinois 60208","Northwestern University****"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurobiology and Physiology , Northwestern University , Evanston , Illinois 60208","institution_ids":["https://openalex.org/I111979921"]},{"raw_affiliation_string":"Northwestern University****","institution_ids":["https://openalex.org/I111979921"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Margaret Wood","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Margaret Wood","raw_affiliation_strings":["Department of Neurobiology and Physiology , Northwestern University , Evanston , Illinois 60208","Northwestern University****"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurobiology and Physiology , Northwestern University , Evanston , Illinois 60208","institution_ids":["https://openalex.org/I111979921"]},{"raw_affiliation_string":"Northwestern University****","institution_ids":["https://openalex.org/I111979921"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033839136","display_name":"Kirsten L. Viola","orcid":"https://orcid.org/0000-0002-9862-6436","observed_orcids":["https://orcid.org/0000-0002-9862-6436"]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kirsten L. Viola","raw_affiliation_strings":["Department of Neurobiology and Physiology , Northwestern University , Evanston , Illinois 60208","Northwestern University****"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurobiology and Physiology , Northwestern University , Evanston , Illinois 60208","institution_ids":["https://openalex.org/I111979921"]},{"raw_affiliation_string":"Northwestern University****","institution_ids":["https://openalex.org/I111979921"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5054687151","display_name":"William L. Klein","orcid":"https://orcid.org/0000-0002-3047-9978","observed_orcids":["https://orcid.org/0000-0002-3047-9978"]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"William L. Klein","raw_affiliation_strings":["Department of Neurobiology and Physiology , Northwestern University , Evanston , Illinois 60208","Neurobiology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurobiology and Physiology , Northwestern University , Evanston , Illinois 60208","institution_ids":["https://openalex.org/I111979921"]},{"raw_affiliation_string":"Neurobiology","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I111979921"],"apc_list":null,"apc_paid":null,"fwci":50.5851,"has_fulltext":true,"cited_by_count":1188,"citation_normalized_percentile":{"value":0.99968748,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"27","issue":"4","first_page":"796","last_page":"807"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.0017000000225380063,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.9350000023841858},{"id":"https://openalex.org/keywords/amyloid-beta-oligomers","display_name":"amyloid-beta oligomers","score":0.875},{"id":"https://openalex.org/keywords/synaptic-dysfunction","display_name":"synaptic dysfunction","score":0.6480000019073486},{"id":"https://openalex.org/keywords/dendritic-spines","display_name":"dendritic spines","score":0.9380000233650208},{"id":"https://openalex.org/keywords/spine-morphology","display_name":"dendritic spine morphology","score":0.8230000138282776},{"id":"https://openalex.org/keywords/postsynaptic-density","display_name":"postsynaptic density","score":0.7860000133514404},{"id":"https://openalex.org/keywords/nmda-receptor","display_name":"NMDA receptor","score":0.9700000286102295},{"id":"https://openalex.org/keywords/ephb2","display_name":"EphB2","score":0.9710000157356262},{"id":"https://openalex.org/keywords/drebrin","display_name":"drebrin","score":0.9620000123977661},{"id":"https://openalex.org/keywords/hippocampal-neurons","display_name":"hippocampal neurons","score":0.8169999718666077},{"id":"https://openalex.org/keywords/synaptosomes","display_name":"synaptosomes","score":0.6970000267028809},{"id":"https://openalex.org/keywords/synapse-loss","display_name":"synaptic loss","score":0.5210000276565552},{"id":"https://openalex.org/keywords/memory-loss","display_name":"memory loss","score":0.5}],"concepts":[{"id":"https://openalex.org/C174884520","wikidata":"https://www.wikidata.org/wiki/Q902079","display_name":"Dendritic spine","level":3,"score":0.8655710220336914},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.7254987955093384},{"id":"https://openalex.org/C127445978","wikidata":"https://www.wikidata.org/wiki/Q187181","display_name":"Synapse","level":2,"score":0.6486002206802368},{"id":"https://openalex.org/C197341189","wikidata":"https://www.wikidata.org/wiki/Q863533","display_name":"Postsynaptic potential","level":3,"score":0.5746241807937622},{"id":"https://openalex.org/C98229152","wikidata":"https://www.wikidata.org/wiki/Q1551556","display_name":"Synaptic plasticity","level":3,"score":0.5223594903945923},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.48701387643814087},{"id":"https://openalex.org/C148762608","wikidata":"https://www.wikidata.org/wiki/Q3748185","display_name":"Hippocampal formation","level":2,"score":0.477977454662323},{"id":"https://openalex.org/C187541742","wikidata":"https://www.wikidata.org/wiki/Q4374336","display_name":"Postsynaptic density","level":4,"score":0.47474366426467896},{"id":"https://openalex.org/C2779715522","wikidata":"https://www.wikidata.org/wiki/Q507027","display_name":"Forebrain","level":3,"score":0.4496413767337799},{"id":"https://openalex.org/C99223954","wikidata":"https://www.wikidata.org/wiki/Q5419646","display_name":"Excitatory synapse","level":4,"score":0.44598519802093506},{"id":"https://openalex.org/C67018056","wikidata":"https://www.wikidata.org/wiki/Q414896","display_name":"NMDA receptor","level":3,"score":0.4118984341621399},{"id":"https://openalex.org/C112592302","wikidata":"https://www.wikidata.org/wiki/Q1207387","display_name":"Excitatory postsynaptic potential","level":3,"score":0.4044424295425415},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.24784252047538757},{"id":"https://openalex.org/C17077164","wikidata":"https://www.wikidata.org/wiki/Q1185869","display_name":"Inhibitory postsynaptic potential","level":2,"score":0.19944360852241516},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.1310352385044098},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0769105851650238}],"mesh":[{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002452","descriptor_name":"Cell Count","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009434","descriptor_name":"Neural Pathways","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009434","descriptor_name":"Neural Pathways","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D013569","descriptor_name":"Synapses","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D013569","descriptor_name":"Synapses","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D013569","descriptor_name":"Synapses","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D016229","descriptor_name":"Amyloid beta-Peptides","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D016229","descriptor_name":"Amyloid beta-Peptides","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D048430","descriptor_name":"Cell Shape","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D048430","descriptor_name":"Cell Shape","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1523/jneurosci.3501-06.2007","doi":"https://doi.org/10.1523/jneurosci.3501-06.2007","is_oa":true,"landing_page_url":"https://doi.org/10.1523/jneurosci.3501-06.2007","pdf_url":"https://www.jneurosci.org/content/jneuro/27/4/796.full.pdf","source":{"id":"https://openalex.org/S5555990","display_name":"Journal of Neuroscience","issn_l":"0270-6474","issn":["0270-6474","1529-2401"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319739","host_organization_name":"Society for Neuroscience","host_organization_lineage":["https://openalex.org/P4310319739"],"host_organization_lineage_names":["Society for Neuroscience"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Neuroscience","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6672917","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6672917","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Neurosci","raw_type":"Text"},{"id":"pmid:17251419","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17251419","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of neuroscience : the official journal of the Society for Neuroscience","raw_type":"Comparative Study"}],"best_oa_location":{"id":"doi:10.1523/jneurosci.3501-06.2007","doi":"https://doi.org/10.1523/jneurosci.3501-06.2007","is_oa":true,"landing_page_url":"https://doi.org/10.1523/jneurosci.3501-06.2007","pdf_url":"https://www.jneurosci.org/content/jneuro/27/4/796.full.pdf","source":{"id":"https://openalex.org/S5555990","display_name":"Journal of Neuroscience","issn_l":"0270-6474","issn":["0270-6474","1529-2401"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319739","host_organization_name":"Society for Neuroscience","host_organization_lineage":["https://openalex.org/P4310319739"],"host_organization_lineage_names":["Society for Neuroscience"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Neuroscience","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8048999905586243,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3196972107","display_name":null,"funder_award_id":"AG022237","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G5494874922","display_name":"Abeta oligomers (ADDLs) in Alzheimer's Disease pathology","funder_award_id":"R01AG022547","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G7040499787","display_name":"Loss of synapses in physiological and pathological aging","funder_award_id":"R03AG022237","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G7044419332","display_name":null,"funder_award_id":"AG022547","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G8778916289","display_name":"NEUROLOGICAL DEFICITS DUE TO TOXIC A BETA OLIGOMERS","funder_award_id":"R01AG018877","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G8870181497","display_name":null,"funder_award_id":"AG018877","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"}],"funders":[{"id":"https://openalex.org/F4320306229","display_name":"American Health Assistance Foundation","ror":"https://ror.org/03cvfxv40"},{"id":"https://openalex.org/F4320308102","display_name":"Illinois Department of Public Health","ror":"https://ror.org/027bk5v43"},{"id":"https://openalex.org/F4320309475","display_name":"Northwestern University","ror":"https://ror.org/000e0be47"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1993465897.pdf","grobid_xml":"https://content.openalex.org/works/W1993465897.grobid-xml"},"referenced_works_count":87,"referenced_works":["https://openalex.org/W69341822","https://openalex.org/W81005182","https://openalex.org/W255871888","https://openalex.org/W1514559719","https://openalex.org/W1532542691","https://openalex.org/W1584834830","https://openalex.org/W1637989849","https://openalex.org/W1647836033","https://openalex.org/W1648265574","https://openalex.org/W1705725530","https://openalex.org/W1825797577","https://openalex.org/W1857351893","https://openalex.org/W1964741226","https://openalex.org/W1967917932","https://openalex.org/W1972567838","https://openalex.org/W1975642312","https://openalex.org/W1976568654","https://openalex.org/W1980750700","https://openalex.org/W1981238903","https://openalex.org/W1986295281","https://openalex.org/W1990752558","https://openalex.org/W1993759415","https://openalex.org/W1995691453","https://openalex.org/W1995946234","https://openalex.org/W2004968757","https://openalex.org/W2008767130","https://openalex.org/W2009174342","https://openalex.org/W2013553668","https://openalex.org/W2014581806","https://openalex.org/W2015588918","https://openalex.org/W2020497815","https://openalex.org/W2024849224","https://openalex.org/W2025018124","https://openalex.org/W2025563134","https://openalex.org/W2030910483","https://openalex.org/W2033087539","https://openalex.org/W2040721710","https://openalex.org/W2043006474","https://openalex.org/W2046228107","https://openalex.org/W2049494624","https://openalex.org/W2055361873","https://openalex.org/W2057877784","https://openalex.org/W2058495283","https://openalex.org/W2061619331","https://openalex.org/W2063236931","https://openalex.org/W2066848236","https://openalex.org/W2070881916","https://openalex.org/W2072480165","https://openalex.org/W2075481535","https://openalex.org/W2075930760","https://openalex.org/W2076936216","https://openalex.org/W2078212921","https://openalex.org/W2082429191","https://openalex.org/W2082600620","https://openalex.org/W2086717125","https://openalex.org/W2091612053","https://openalex.org/W2093419961","https://openalex.org/W2093807579","https://openalex.org/W2098655420","https://openalex.org/W2101473364","https://openalex.org/W2103960901","https://openalex.org/W2106492868","https://openalex.org/W2108215229","https://openalex.org/W2110998913","https://openalex.org/W2118891894","https://openalex.org/W2121963977","https://openalex.org/W2122065036","https://openalex.org/W2123176475","https://openalex.org/W2131897453","https://openalex.org/W2136901555","https://openalex.org/W2138910339","https://openalex.org/W2139925126","https://openalex.org/W2142186280","https://openalex.org/W2148256023","https://openalex.org/W2149086197","https://openalex.org/W2150746478","https://openalex.org/W2156326104","https://openalex.org/W2157069791","https://openalex.org/W2158226583","https://openalex.org/W2158676848","https://openalex.org/W2162807572","https://openalex.org/W2163916825","https://openalex.org/W2165021720","https://openalex.org/W2167768159","https://openalex.org/W2168334242","https://openalex.org/W2483419956","https://openalex.org/W4296154147"],"related_works":["https://openalex.org/W24364968","https://openalex.org/W1973552295","https://openalex.org/W81005182","https://openalex.org/W1984924722","https://openalex.org/W2088639812","https://openalex.org/W1966771395","https://openalex.org/W2162807572","https://openalex.org/W2090377179","https://openalex.org/W2040721710","https://openalex.org/W2157069791"],"abstract_inverted_index":{"The":[0,213],"basis":[1],"for":[2,89],"memory":[3],"loss":[4],"in":[5,29,149,161,176,188,233],"early":[6],"Alzheimer's":[7,209],"disease":[8],"(AD)":[9],"seems":[10],"likely":[11],"to":[12,26,40,53,72,100,105,118,136,141,221,240],"involve":[13],"synaptic":[14,45,63],"damage":[15,238],"caused":[16,184],"by":[17,196,207],"soluble":[18],"Abeta-derived":[19],"oligomers":[20],"(ADDLs).":[21],"ADDLs":[22,71,98,116,135,144,183,220,232],"have":[23],"been":[24],"shown":[25],"build":[27],"up":[28],"the":[30,57,68,173,200,208],"brain":[31,235],"and":[32,37,62,77,156,180],"CSF":[33],"of":[34,44,56,70,83,91,115,134,152,167,172,199,216,225],"AD":[35,60,226,234],"patients":[36],"are":[38],"known":[39],"interfere":[41],"with":[42,102,123,131,165],"mechanisms":[43],"plasticity,":[46],"acting":[47],"as":[48],"gain-of-function":[49],"ligands":[50],"that":[51,97,231],"attach":[52],"synapses.":[54],"Because":[55],"correlation":[58],"between":[59],"dementia":[61],"degeneration,":[64],"we":[65,95],"investigated":[66],"here":[67],"ability":[69],"affect":[73],"synapse":[74,92],"composition,":[75],"structure,":[76],"abundance.":[78],"Using":[79],"highly":[80],"differentiated":[81],"cultures":[82],"hippocampal":[84,142],"neurons,":[85,143],"a":[86,146,185,222],"preferred":[87],"model":[88],"studies":[90],"cell":[93],"biology,":[94],"found":[96,175],"bound":[99,117],"neurons":[101,109],"specificity,":[103],"attaching":[104],"presumed":[106],"excitatory":[107],"pyramidal":[108],"but":[110],"not":[111],"GABAergic":[112],"neurons.":[113],"Fractionation":[114],"forebrain":[119],"synaptosomes":[120],"showed":[121],"association":[122],"postsynaptic":[124],"density":[125],"complexes":[126],"containing":[127],"NMDA":[128],"receptors,":[129],"consistent":[130],"observed":[132,214],"attachment":[133],"dendritic":[137,217],"spines.":[138],"During":[139],"binding":[140],"promoted":[145],"rapid":[147],"decrease":[148,187],"membrane":[150],"expression":[151],"memory-related":[153],"receptors":[154],"(NMDA":[155],"EphB2).":[157],"Continued":[158],"exposure":[159],"resulted":[160],"abnormal":[162],"spine":[163,189,201],"morphology,":[164],"induction":[166],"long":[168],"thin":[169],"spines":[170,218],"reminiscent":[171],"morphology":[174],"mental":[177],"retardation,":[178],"deafferentation,":[179],"prionoses.":[181],"Ultimately,":[182],"significant":[186],"density.":[190],"Synaptic":[191],"deterioration,":[192],"which":[193],"was":[194,205],"accompanied":[195],"decreased":[197],"levels":[198],"cytoskeletal":[202],"protein":[203],"drebrin,":[204],"blocked":[206],"therapeutic":[210],"drug":[211],"Namenda.":[212],"disruption":[215],"links":[219],"major":[223],"facet":[224],"pathology,":[227],"providing":[228],"strong":[229],"evidence":[230],"cause":[236],"neuropil":[237],"believed":[239],"underlie":[241],"dementia.":[242]},"counts_by_year":[{"year":2026,"cited_by_count":21},{"year":2025,"cited_by_count":40},{"year":2024,"cited_by_count":48},{"year":2023,"cited_by_count":48},{"year":2022,"cited_by_count":51},{"year":2021,"cited_by_count":46},{"year":2020,"cited_by_count":77},{"year":2019,"cited_by_count":43},{"year":2018,"cited_by_count":60},{"year":2017,"cited_by_count":73},{"year":2016,"cited_by_count":58},{"year":2015,"cited_by_count":64},{"year":2014,"cited_by_count":75},{"year":2013,"cited_by_count":84},{"year":2012,"cited_by_count":85}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}