{"id":"https://openalex.org/W1993465636","doi":"https://doi.org/10.1097/00000441-198909000-00002","title":"Normalization of LDL Receptor Function by Lymphocytes of Patients with Heterozygous Familial Hypercholesterolemia After Treatment with Plasma Cholesterol Lowering Agents","display_name":"Normalization of LDL Receptor Function by Lymphocytes of Patients with Heterozygous Familial Hypercholesterolemia After Treatment with Plasma Cholesterol Lowering Agents","publication_year":1989,"publication_date":"1989-09-01","ids":{"openalex":"https://openalex.org/W1993465636","doi":"https://doi.org/10.1097/00000441-198909000-00002","mag":"1993465636","pmid":"https://pubmed.ncbi.nlm.nih.gov/2552800"},"language":"en","primary_location":{"id":"doi:10.1097/00000441-198909000-00002","doi":"https://doi.org/10.1097/00000441-198909000-00002","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00000441-198909000-00002","pdf_url":null,"source":{"id":"https://openalex.org/S109361689","display_name":"The American Journal of the Medical Sciences","issn_l":"0002-9629","issn":["0002-9629","1538-2990"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American Journal of the Medical Sciences","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5007342242","display_name":"Jennifer A. Cuthbert","orcid":"https://orcid.org/0000-0002-8413-2128","observed_orcids":["https://orcid.org/0000-0002-8413-2128"]},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jennifer A. Cuthbert","raw_affiliation_strings":["Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas","Internal Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas","institution_ids":["https://openalex.org/I867280407"]},{"raw_affiliation_string":"Internal Medicine","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5106668439","display_name":"Cara A. East","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Cara A. East","raw_affiliation_strings":["Liver, Rheumatic Diseases, and Lipid Metabolism Units, Department of Internal Medicine, The University of Texas Southwestern Medical Center at Dallas, Dallas, Texas","University of Texas, Southwestern Medical Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Liver, Rheumatic Diseases, and Lipid Metabolism Units, Department of Internal Medicine, The University of Texas Southwestern Medical Center at Dallas, Dallas, Texas","institution_ids":["https://openalex.org/I867280407"]},{"raw_affiliation_string":"University of Texas, Southwestern Medical Center","institution_ids":["https://openalex.org/I867280407"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5043874873","display_name":"Peter E. Lipsky","orcid":"https://orcid.org/0000-0002-9287-1676","observed_orcids":["https://orcid.org/0000-0002-9287-1676"]},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Peter E. Lipsky","raw_affiliation_strings":["Liver, Rheumatic Diseases, and Lipid Metabolism Units, Department of Internal Medicine, The University of Texas Southwestern Medical Center at Dallas, Dallas, Texas","University of Texas, Southwestern Medical Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Liver, Rheumatic Diseases, and Lipid Metabolism Units, Department of Internal Medicine, The University of Texas Southwestern Medical Center at Dallas, Dallas, Texas","institution_ids":["https://openalex.org/I867280407"]},{"raw_affiliation_string":"University of Texas, Southwestern Medical Center","institution_ids":["https://openalex.org/I867280407"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5007342242"],"corresponding_institution_ids":["https://openalex.org/I867280407"],"apc_list":{"value":2940,"currency":"USD","value_usd":2940},"apc_paid":null,"fwci":0.5785,"has_fulltext":false,"cited_by_count":6,"citation_normalized_percentile":{"value":0.68051151,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"298","issue":"3","first_page":"152","last_page":"160"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10394","display_name":"Lipoproteins and Cardiovascular Health","score":0.9096999764442444,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10394","display_name":"Lipoproteins and Cardiovascular Health","score":0.9096999764442444,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11618","display_name":"Cholesterol and Lipid Metabolism","score":0.08810000121593475,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13430","display_name":"Lipid metabolism and disorders","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/heterozygous-familial-hypercholesterolemia","display_name":"heterozygous familial hypercholesterolemia","score":0.9760000109672546},{"id":"https://openalex.org/keywords/lymphocytes","display_name":"lymphocytes","score":0.9409999847412109},{"id":"https://openalex.org/keywords/lovastatin","display_name":"lovastatin","score":0.8939999938011169},{"id":"https://openalex.org/keywords/bile-acid-sequestrants","display_name":"bile acid sequestrants","score":0.9570000171661377},{"id":"https://openalex.org/keywords/cholesterol-synthesis-inhibition","display_name":"cholesterol synthesis inhibition","score":0.7540000081062317},{"id":"https://openalex.org/keywords/ldl-lowering-therapy","display_name":"LDL-C lowering therapy","score":0.7580000162124634},{"id":"https://openalex.org/keywords/serum-cholesterol","display_name":"serum cholesterol","score":0.37700000405311584},{"id":"https://openalex.org/keywords/receptor-expression","display_name":"receptor expression","score":0.3700000047683716},{"id":"https://openalex.org/keywords/mitogen-activated-lymphocytes","display_name":"mitogen-activated lymphocytes","score":0.7080000042915344}],"concepts":[{"id":"https://openalex.org/C2779120738","wikidata":"https://www.wikidata.org/wiki/Q2711291","display_name":"Familial hypercholesterolemia","level":3,"score":0.7789034843444824},{"id":"https://openalex.org/C43554185","wikidata":"https://www.wikidata.org/wiki/Q425649","display_name":"LDL receptor","level":4,"score":0.744022786617279},{"id":"https://openalex.org/C2780940807","wikidata":"https://www.wikidata.org/wiki/Q417740","display_name":"Lovastatin","level":3,"score":0.7080615758895874},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7056134939193726},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.6899957060813904},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6810235977172852},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6569387912750244},{"id":"https://openalex.org/C2777761686","wikidata":"https://www.wikidata.org/wiki/Q715347","display_name":"Lymphocyte","level":2,"score":0.6399549245834351},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.6294901371002197},{"id":"https://openalex.org/C2779620165","wikidata":"https://www.wikidata.org/wiki/Q28749","display_name":"Low-density lipoprotein","level":3,"score":0.4879555106163025},{"id":"https://openalex.org/C2780072125","wikidata":"https://www.wikidata.org/wiki/Q28350","display_name":"Lipoprotein","level":3,"score":0.46640104055404663},{"id":"https://openalex.org/C2779399885","wikidata":"https://www.wikidata.org/wiki/Q413288","display_name":"Bile acid","level":2,"score":0.4347556233406067}],"mesh":[{"descriptor_ui":"D000924","descriptor_name":"Anticholesteremic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D002792","descriptor_name":"Cholestyramine Resin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D003084","descriptor_name":"Colestipol","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D004338","descriptor_name":"Drug Combinations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006579","descriptor_name":"Heterozygote","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006938","descriptor_name":"Hyperlipoproteinemia Type II","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D006938","descriptor_name":"Hyperlipoproteinemia Type II","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006938","descriptor_name":"Hyperlipoproteinemia Type II","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D008074","descriptor_name":"Lipoproteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008077","descriptor_name":"Lipoproteins, LDL","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008148","descriptor_name":"Lovastatin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D008214","descriptor_name":"Lymphocytes","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D011956","descriptor_name":"Receptors, Cell Surface","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D012016","descriptor_name":"Reference Values","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018110","descriptor_name":"Receptors, Lipoprotein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1097/00000441-198909000-00002","doi":"https://doi.org/10.1097/00000441-198909000-00002","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00000441-198909000-00002","pdf_url":null,"source":{"id":"https://openalex.org/S109361689","display_name":"The American Journal of the Medical Sciences","issn_l":"0002-9629","issn":["0002-9629","1538-2990"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American Journal of the Medical Sciences","raw_type":"journal-article"},{"id":"pmid:2552800","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2552800","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American journal of the medical sciences","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[{"id":"https://openalex.org/G1867400065","display_name":"GENERAL CLINICAL RESEARCH CENTER","funder_award_id":"M01RR000633","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G26165529","display_name":null,"funder_award_id":"MO-1 RR-00633","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G5222145888","display_name":null,"funder_award_id":"AI-17653","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G718925254","display_name":null,"funder_award_id":"HL-292-52","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"},{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":18,"referenced_works":["https://openalex.org/W614336952","https://openalex.org/W1570501116","https://openalex.org/W1775749144","https://openalex.org/W1966012268","https://openalex.org/W1972968384","https://openalex.org/W1989432650","https://openalex.org/W2028115524","https://openalex.org/W2055134345","https://openalex.org/W2067635119","https://openalex.org/W2084744450","https://openalex.org/W2088132089","https://openalex.org/W2121767872","https://openalex.org/W2142362392","https://openalex.org/W2169904273","https://openalex.org/W2336778665","https://openalex.org/W4206267791","https://openalex.org/W4210612282","https://openalex.org/W6607828777"],"related_works":["https://openalex.org/W2394578812","https://openalex.org/W2468898988","https://openalex.org/W2605546628","https://openalex.org/W2336778665","https://openalex.org/W2060075539","https://openalex.org/W7128508975","https://openalex.org/W2605525678","https://openalex.org/W2142362392","https://openalex.org/W2012080462","https://openalex.org/W2070666962"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
