{"id":"https://openalex.org/W1993423819","doi":"https://doi.org/10.1186/1472-6874-10-28","title":"Risk-reducing strategies for women carrying brca1/2 mutations with a focus on prophylactic surgery","display_name":"Risk-reducing strategies for women carrying brca1/2 mutations with a focus on prophylactic surgery","publication_year":2010,"publication_date":"2010-10-20","ids":{"openalex":"https://openalex.org/W1993423819","doi":"https://doi.org/10.1186/1472-6874-10-28","mag":"1993423819","pmid":"https://pubmed.ncbi.nlm.nih.gov/20961453","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2987888"},"language":"en","primary_location":{"id":"doi:10.1186/1472-6874-10-28","doi":"https://doi.org/10.1186/1472-6874-10-28","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1472-6874-10-28","pdf_url":"https://bmcwomenshealth.biomedcentral.com/counter/pdf/10.1186/1472-6874-10-28","source":{"id":"https://openalex.org/S94788606","display_name":"BMC Women s Health","issn_l":"1472-6874","issn":["1472-6874"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Women's Health","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcwomenshealth.biomedcentral.com/counter/pdf/10.1186/1472-6874-10-28","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111647292","display_name":"Mohamed Salhab","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165862685","display_name":"St George's, University of London","ror":"https://ror.org/040f08y74","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I165862685","https://openalex.org/I4401726869"]},{"id":"https://openalex.org/I4210124280","display_name":"The Princess Grace Hospital","ror":"https://ror.org/024tpjw43","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I4210124280"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Mohamed Salhab","raw_affiliation_strings":["London Breast Institute, The Princess Grace Hospital, 45 Nottingham Place, London W1U 5NY, UK","St. George\u2019s, University of London, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"London Breast Institute, The Princess Grace Hospital, 45 Nottingham Place, London W1U 5NY, UK","institution_ids":["https://openalex.org/I4210124280"]},{"raw_affiliation_string":"St. George\u2019s, University of London, London, UK","institution_ids":["https://openalex.org/I165862685"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033693267","display_name":"Selina Bismohun","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165862685","display_name":"St George's, University of London","ror":"https://ror.org/040f08y74","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I165862685","https://openalex.org/I4401726869"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Selina Bismohun","raw_affiliation_strings":["St. George\u2019s, University of London, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"St. George\u2019s, University of London, London, UK","institution_ids":["https://openalex.org/I165862685"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5006935581","display_name":"Kefah Mokbel","orcid":"https://orcid.org/0000-0001-7255-7850","observed_orcids":["https://orcid.org/0000-0001-7255-7850"]},"institutions":[{"id":"https://openalex.org/I4210124280","display_name":"The Princess Grace Hospital","ror":"https://ror.org/024tpjw43","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I4210124280"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Kefah Mokbel","raw_affiliation_strings":["London Breast Institute, The Princess Grace Hospital, 45 Nottingham Place, London, W1U 5NY, UK","London Breast Institute, The Princess Grace Hospital, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"London Breast Institute, The Princess Grace Hospital, 45 Nottingham Place, London, W1U 5NY, UK","institution_ids":["https://openalex.org/I4210124280"]},{"raw_affiliation_string":"London Breast Institute, The Princess Grace Hospital, London, UK","institution_ids":["https://openalex.org/I4210124280"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5006935581"],"corresponding_institution_ids":["https://openalex.org/I4210124280"],"apc_list":{"value":2890,"currency":"USD","value_usd":2890},"apc_paid":{"value":2890,"currency":"USD","value_usd":2890},"fwci":0.5114,"has_fulltext":true,"cited_by_count":73,"citation_normalized_percentile":{"value":0.42965779,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"10","issue":"1","first_page":"28","last_page":"28"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10769","display_name":"BRCA gene mutations in cancer","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10769","display_name":"BRCA gene mutations in cancer","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13544","display_name":"Women's cancer prevention and management","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14078","display_name":"Multiple and Secondary Primary Cancers","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/brca1-mutation","display_name":"BRCA1 mutation","score":0.7829999923706055},{"id":"https://openalex.org/keywords/brca2-mutation","display_name":"BRCA2 mutation","score":1.0},{"id":"https://openalex.org/keywords/hereditary-breast-cancer","display_name":"hereditary breast cancer","score":0.8119999766349792},{"id":"https://openalex.org/keywords/hereditary-ovarian-cancer","display_name":"hereditary ovarian cancer","score":0.9900000095367432},{"id":"https://openalex.org/keywords/prophylactic-surgery","display_name":"prophylactic surgery","score":0.8169999718666077},{"id":"https://openalex.org/keywords/bilateral-prophylactic-mastectomy","display_name":"bilateral prophylactic mastectomy","score":0.8510000109672546},{"id":"https://openalex.org/keywords/salpingo-oophorectomy","display_name":"salpingo-oophorectomy","score":0.9520000219345093},{"id":"https://openalex.org/keywords/breast-cancer-surveillance","display_name":"breast cancer surveillance","score":0.7099999785423279},{"id":"https://openalex.org/keywords/chemoprevention","display_name":"chemoprevention","score":0.9860000014305115},{"id":"https://openalex.org/keywords/antiestrogen-therapy","display_name":"antiestrogen therapy","score":0.7919999957084656},{"id":"https://openalex.org/keywords/risk-mitigation-strategies","display_name":"risk mitigation strategies","score":0.8700000047683716},{"id":"https://openalex.org/keywords/mutation-carriers","display_name":"mutation carriers","score":0.4569999873638153}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8304581642150879},{"id":"https://openalex.org/C2910584544","wikidata":"https://www.wikidata.org/wiki/Q65042430","display_name":"Prophylactic Surgery","level":4,"score":0.80463707447052},{"id":"https://openalex.org/C2910039337","wikidata":"https://www.wikidata.org/wiki/Q16394661","display_name":"Prophylactic Mastectomy","level":5,"score":0.7474606037139893},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.608453631401062},{"id":"https://openalex.org/C2777757722","wikidata":"https://www.wikidata.org/wiki/Q848318","display_name":"Mastectomy","level":4,"score":0.5530121922492981},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.4900011122226715},{"id":"https://openalex.org/C2779473830","wikidata":"https://www.wikidata.org/wiki/Q1540899","display_name":"MEDLINE","level":2,"score":0.4431447684764862},{"id":"https://openalex.org/C2777696064","wikidata":"https://www.wikidata.org/wiki/Q1751597","display_name":"Oophorectomy","level":3,"score":0.42519450187683105},{"id":"https://openalex.org/C2780194787","wikidata":"https://www.wikidata.org/wiki/Q4836333","display_name":"BRCA mutation","level":4,"score":0.4179357886314392},{"id":"https://openalex.org/C29456083","wikidata":"https://www.wikidata.org/wiki/Q1221899","display_name":"Gynecology","level":1,"score":0.40037864446640015},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.385286808013916},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3452007472515106},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.322541207075119},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.24085447192192078},{"id":"https://openalex.org/C2779494336","wikidata":"https://www.wikidata.org/wiki/Q550675","display_name":"Hysterectomy","level":2,"score":0.19696027040481567},{"id":"https://openalex.org/C17744445","wikidata":"https://www.wikidata.org/wiki/Q36442","display_name":"Political science","level":0,"score":0.0},{"id":"https://openalex.org/C199539241","wikidata":"https://www.wikidata.org/wiki/Q7748","display_name":"Law","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008408","descriptor_name":"Mastectomy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D010051","descriptor_name":"Ovarian Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D010051","descriptor_name":"Ovarian Neoplasms","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D010052","descriptor_name":"Ovariectomy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012306","descriptor_name":"Risk","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017558","descriptor_name":"Elective Surgical Procedures","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019398","descriptor_name":"Genes, BRCA1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D024522","descriptor_name":"Genes, BRCA2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1186/1472-6874-10-28","doi":"https://doi.org/10.1186/1472-6874-10-28","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1472-6874-10-28","pdf_url":"https://bmcwomenshealth.biomedcentral.com/counter/pdf/10.1186/1472-6874-10-28","source":{"id":"https://openalex.org/S94788606","display_name":"BMC Women s Health","issn_l":"1472-6874","issn":["1472-6874"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Women's Health","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2987888","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2987888","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Womens Health","raw_type":"Text"},{"id":"pmid:20961453","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20961453","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC women's health","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:a7bbf7a985eb48c28d68cdf19fda530c","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/a7bbf7a985eb48c28d68cdf19fda530c","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Women's Health, Vol 10, Iss 1, p 28 (2010)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1186/1472-6874-10-28","doi":"https://doi.org/10.1186/1472-6874-10-28","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1472-6874-10-28","pdf_url":"https://bmcwomenshealth.biomedcentral.com/counter/pdf/10.1186/1472-6874-10-28","source":{"id":"https://openalex.org/S94788606","display_name":"BMC Women s Health","issn_l":"1472-6874","issn":["1472-6874"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Women's Health","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1993423819.pdf","grobid_xml":"https://content.openalex.org/works/W1993423819.grobid-xml"},"referenced_works_count":98,"referenced_works":["https://openalex.org/W108280640","https://openalex.org/W1242630251","https://openalex.org/W1518015545","https://openalex.org/W1536810585","https://openalex.org/W1819988664","https://openalex.org/W1873998261","https://openalex.org/W1881645183","https://openalex.org/W1944723793","https://openalex.org/W1966928100","https://openalex.org/W1972606816","https://openalex.org/W1974305968","https://openalex.org/W1979900434","https://openalex.org/W1982457346","https://openalex.org/W1982603317","https://openalex.org/W1985450164","https://openalex.org/W1987365087","https://openalex.org/W1991555835","https://openalex.org/W1994789648","https://openalex.org/W2004310491","https://openalex.org/W2010295180","https://openalex.org/W2014085551","https://openalex.org/W2017777816","https://openalex.org/W2018022325","https://openalex.org/W2022253294","https://openalex.org/W2026362521","https://openalex.org/W2030093162","https://openalex.org/W2033556486","https://openalex.org/W2038793520","https://openalex.org/W2045733577","https://openalex.org/W2045986910","https://openalex.org/W2046809735","https://openalex.org/W2051102205","https://openalex.org/W2051797600","https://openalex.org/W2064100589","https://openalex.org/W2065597586","https://openalex.org/W2066509456","https://openalex.org/W2070876263","https://openalex.org/W2074846736","https://openalex.org/W2077324625","https://openalex.org/W2081401566","https://openalex.org/W2085682959","https://openalex.org/W2087145961","https://openalex.org/W2089454614","https://openalex.org/W2097205092","https://openalex.org/W2097243677","https://openalex.org/W2097419638","https://openalex.org/W2098383175","https://openalex.org/W2100397190","https://openalex.org/W2101699473","https://openalex.org/W2103970959","https://openalex.org/W2105722841","https://openalex.org/W2106080156","https://openalex.org/W2107700706","https://openalex.org/W2108830626","https://openalex.org/W2109465247","https://openalex.org/W2109764430","https://openalex.org/W2112187879","https://openalex.org/W2112510101","https://openalex.org/W2116554987","https://openalex.org/W2126728040","https://openalex.org/W2128784131","https://openalex.org/W2131241397","https://openalex.org/W2132266605","https://openalex.org/W2134999121","https://openalex.org/W2136589637","https://openalex.org/W2137086763","https://openalex.org/W2137167442","https://openalex.org/W2138250010","https://openalex.org/W2139882858","https://openalex.org/W2142795777","https://openalex.org/W2143698296","https://openalex.org/W2143934748","https://openalex.org/W2144624092","https://openalex.org/W2145703637","https://openalex.org/W2147058464","https://openalex.org/W2147782334","https://openalex.org/W2149597080","https://openalex.org/W2150111967","https://openalex.org/W2151323006","https://openalex.org/W2152217620","https://openalex.org/W2160324074","https://openalex.org/W2161032558","https://openalex.org/W2161764786","https://openalex.org/W2162096542","https://openalex.org/W2162485927","https://openalex.org/W2163492706","https://openalex.org/W2164654252","https://openalex.org/W2166969772","https://openalex.org/W2167618573","https://openalex.org/W2169394417","https://openalex.org/W2170878671","https://openalex.org/W2185443161","https://openalex.org/W2262508003","https://openalex.org/W2332006577","https://openalex.org/W2338185498","https://openalex.org/W2406947676","https://openalex.org/W2735861455","https://openalex.org/W4231105422"],"related_works":["https://openalex.org/W2415146411","https://openalex.org/W2087331960","https://openalex.org/W2077992695","https://openalex.org/W2480199247","https://openalex.org/W2126236396","https://openalex.org/W2981952281","https://openalex.org/W2502290981","https://openalex.org/W2051102205","https://openalex.org/W2045986910","https://openalex.org/W2148213360"],"abstract_inverted_index":{"BACKGROUND:":[0],"Women":[1],"who":[2],"have":[3,12,23],"inherited":[4],"mutations":[5],"in":[6,53,141,168,275],"the":[7,50,79,106,120,129,148,172,186,206,231,272,278,296],"BRCA1":[8,159],"or":[9,96,123,160],"BRCA2":[10,161],"genes":[11],"substantially":[13],"elevated":[14],"risks":[15],"of":[16,37,78,99,125,174,188,197,205,218,228,258,283],"breast":[17,176,190],"and":[18,28,32,46,73,136,177,225,260,263,281,291],"ovarian":[19,178],"cancer.":[20,179],"Mutation":[21],"carriers":[22,163,196],"various":[24,238,273],"options,":[25],"including":[26],"extensive":[27],"regular":[29],"surveillance,":[30,191],"chemoprevention":[31,192],"risk-reducing":[33,56,109,209,219],"surgery.":[34,64],"The":[35,66,76,203,216],"aim":[36],"this":[38],"review":[39,68],"is":[40,69,152,166,211,288],"to":[41,47,55,84,104,118,143,154,170,277],"provide":[42],"an":[43],"up-to-date":[44],"analysis":[45],"subsequently":[48],"summarise":[49],"available":[51,298],"literature":[52,67],"relation":[54,276],"strategies,":[57],"with":[58,193,270],"a":[59,97,213],"keen":[60],"focus":[61],"on":[62,147,221],"prophylactic":[63,126,156,200],"METHODS:":[65],"facilitated":[70],"by":[71],"Medline":[72],"PubMed":[74],"databases.":[75],"cross-referencing":[77],"obtained":[80],"articles":[81],"was":[82],"used":[83],"identify":[85],"other":[86,239],"relevant":[87],"studies.":[88,302],"RESULTS:":[89],"Prophylactic":[90],"surgery":[91],"(bilateral":[92],"mastectomy,":[93],"bilateral":[94,199],"salpingo-oophorectomy":[95],"combination":[98],"both":[100],"procedures)":[101],"has":[102,131],"proved":[103],"be":[105,184,242],"most":[107,207],"effective":[108],"strategy.":[110],"There":[111],"are":[112,230,285],"no":[113],"randomised":[114,266],"controlled":[115,267],"trials":[116,268],"able":[117],"demonstrate":[119],"potential":[121],"benefits":[122],"harms":[124],"surgery;":[127],"therefore,":[128],"evidence":[130,299],"been":[132],"derived":[133],"from":[134,300],"retrospective":[135,301],"short":[137],"follow-up":[138],"prospective":[139,265],"studies,":[140],"addition":[142],"hypothetical":[144],"mathematical":[145],"models.Based":[146],"current":[149,297],"knowledge,":[150],"it":[151],"reasonable":[153],"recommend":[155],"oophorectomy":[157],"for":[158,195,235],"mutation":[162,249,284],"when":[164,246],"childbearing":[165],"completed":[167],"order":[169],"reduce":[171],"risk":[173],"developing":[175],"In":[180],"addition,":[181],"women":[182],"should":[183,241],"offered":[185],"options":[187],"rigorous":[189],"anti-oestrogens--especially":[194],"BRCA2--or":[198],"mastectomy.":[201],"CONCLUSION:":[202],"selection":[204],"appropriate":[208],"strategy":[210],"not":[212],"straightforward":[214],"task.":[215],"impact":[217],"strategies":[220],"cancer":[222],"risk,":[223],"survival,":[224],"overall":[226],"quality":[227],"life":[229],"key":[232],"criteria":[233],"considered":[234],"decision-making.":[236],"Notably,":[237],"factors":[240],"taken":[243],"into":[244],"consideration":[245],"evaluating":[247],"individual":[248,251,261],"carriers'":[250],"circumstances,":[252],"namely":[253],"woman's":[254,279],"age,":[255],"morbidity,":[256],"type":[257,282],"mutation,":[259],"preferences":[262],"expectations.Although":[264],"concerned":[269],"examining":[271],"interventions":[274],"age":[280],"needed,":[286],"randomisation":[287],"extremely":[289],"difficult":[290],"rather":[292],"deemed":[293],"unethical":[294],"given":[295]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":2},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":11},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":7},{"year":2013,"cited_by_count":7},{"year":2012,"cited_by_count":6}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}