{"id":"https://openalex.org/W1993353735","doi":"https://doi.org/10.1212/wnl.55.11.1748","title":"A placebo-controlled crossover trial of creatine in mitochondrial diseases","display_name":"A placebo-controlled crossover trial of creatine in mitochondrial diseases","publication_year":2000,"publication_date":"2000-12-12","ids":{"openalex":"https://openalex.org/W1993353735","doi":"https://doi.org/10.1212/wnl.55.11.1748","mag":"1993353735","pmid":"https://pubmed.ncbi.nlm.nih.gov/11113239"},"language":"en","primary_location":{"id":"doi:10.1212/wnl.55.11.1748","doi":"https://doi.org/10.1212/wnl.55.11.1748","is_oa":false,"landing_page_url":"https://doi.org/10.1212/wnl.55.11.1748","pdf_url":null,"source":{"id":"https://openalex.org/S79704628","display_name":"Neurology","issn_l":"0028-3878","issn":["0028-3878","1526-632X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5026565602","display_name":"Thomas Klopstock","orcid":"https://orcid.org/0000-0003-2805-4652","observed_orcids":["https://orcid.org/0000-0003-2805-4652"]},"institutions":[{"id":"https://openalex.org/I62916508","display_name":"Technical University of Munich","ror":"https://ror.org/02kkvpp62","country_code":"DE","type":"education","lineage":["https://openalex.org/I62916508"]},{"id":"https://openalex.org/I8204097","display_name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen","ror":"https://ror.org/05591te55","country_code":"DE","type":"education","lineage":["https://openalex.org/I8204097"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"T. Klopstock","raw_affiliation_strings":["From the Department of Neurology (Drs. Klopstock, Querner, Gekeler, Gasser, Straube, and Dieterich, and F. Schmidt) and the Friedrich-Baur-Institut (Drs. Walter, Pongratz, and Mu\u0308ller\u2013Felber), Ludwig-Maximilians-Universita\u0308t Mu\u0308nchen; and the Department of Sports Medicine (Dr. Hartard) and the Institute for Medical Statistics and Epidemiology (M. Hennig), Technische Universita\u0308t Mu\u0308nchen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Neurology (Drs. Klopstock, Querner, Gekeler, Gasser, Straube, and Dieterich, and F. Schmidt) and the Friedrich-Baur-Institut (Drs. Walter, Pongratz, and Mu\u0308ller\u2013Felber), Ludwig-Maximilians-Universita\u0308t Mu\u0308nchen; and the Department of Sports Medicine (Dr. Hartard) and the Institute for Medical Statistics and Epidemiology (M. Hennig), Technische Universita\u0308t Mu\u0308nchen, Germany","institution_ids":["https://openalex.org/I62916508","https://openalex.org/I8204097"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029948697","display_name":"Veronika Querner","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I62916508","display_name":"Technical University of Munich","ror":"https://ror.org/02kkvpp62","country_code":"DE","type":"education","lineage":["https://openalex.org/I62916508"]},{"id":"https://openalex.org/I8204097","display_name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen","ror":"https://ror.org/05591te55","country_code":"DE","type":"education","lineage":["https://openalex.org/I8204097"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"V. Querner","raw_affiliation_strings":["From the Department of Neurology (Drs. Klopstock, Querner, Gekeler, Gasser, Straube, and Dieterich, and F. Schmidt) and the Friedrich-Baur-Institut (Drs. Walter, Pongratz, and Mu\u0308ller\u2013Felber), Ludwig-Maximilians-Universita\u0308t Mu\u0308nchen; and the Department of Sports Medicine (Dr. Hartard) and the Institute for Medical Statistics and Epidemiology (M. Hennig), Technische Universita\u0308t Mu\u0308nchen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Neurology (Drs. Klopstock, Querner, Gekeler, Gasser, Straube, and Dieterich, and F. Schmidt) and the Friedrich-Baur-Institut (Drs. Walter, Pongratz, and Mu\u0308ller\u2013Felber), Ludwig-Maximilians-Universita\u0308t Mu\u0308nchen; and the Department of Sports Medicine (Dr. Hartard) and the Institute for Medical Statistics and Epidemiology (M. Hennig), Technische Universita\u0308t Mu\u0308nchen, Germany","institution_ids":["https://openalex.org/I62916508","https://openalex.org/I8204097"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057543478","display_name":"Frank-Peter Schmidt","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I62916508","display_name":"Technical University of Munich","ror":"https://ror.org/02kkvpp62","country_code":"DE","type":"education","lineage":["https://openalex.org/I62916508"]},{"id":"https://openalex.org/I8204097","display_name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen","ror":"https://ror.org/05591te55","country_code":"DE","type":"education","lineage":["https://openalex.org/I8204097"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"F. Schmidt","raw_affiliation_strings":["From the Department of Neurology (Drs. Klopstock, Querner, Gekeler, Gasser, Straube, and Dieterich, and F. Schmidt) and the Friedrich-Baur-Institut (Drs. Walter, Pongratz, and Mu\u0308ller\u2013Felber), Ludwig-Maximilians-Universita\u0308t Mu\u0308nchen; and the Department of Sports Medicine (Dr. Hartard) and the Institute for Medical Statistics and Epidemiology (M. Hennig), Technische Universita\u0308t Mu\u0308nchen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Neurology (Drs. Klopstock, Querner, Gekeler, Gasser, Straube, and Dieterich, and F. Schmidt) and the Friedrich-Baur-Institut (Drs. Walter, Pongratz, and Mu\u0308ller\u2013Felber), Ludwig-Maximilians-Universita\u0308t Mu\u0308nchen; and the Department of Sports Medicine (Dr. Hartard) and the Institute for Medical Statistics and Epidemiology (M. Hennig), Technische Universita\u0308t Mu\u0308nchen, Germany","institution_ids":["https://openalex.org/I62916508","https://openalex.org/I8204097"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038379742","display_name":"Florian Gekeler","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I62916508","display_name":"Technical University of Munich","ror":"https://ror.org/02kkvpp62","country_code":"DE","type":"education","lineage":["https://openalex.org/I62916508"]},{"id":"https://openalex.org/I8204097","display_name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen","ror":"https://ror.org/05591te55","country_code":"DE","type":"education","lineage":["https://openalex.org/I8204097"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"F. Gekeler","raw_affiliation_strings":["From the Department of Neurology (Drs. Klopstock, Querner, Gekeler, Gasser, Straube, and Dieterich, and F. Schmidt) and the Friedrich-Baur-Institut (Drs. Walter, Pongratz, and Mu\u0308ller\u2013Felber), Ludwig-Maximilians-Universita\u0308t Mu\u0308nchen; and the Department of Sports Medicine (Dr. Hartard) and the Institute for Medical Statistics and Epidemiology (M. Hennig), Technische Universita\u0308t Mu\u0308nchen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Neurology (Drs. Klopstock, Querner, Gekeler, Gasser, Straube, and Dieterich, and F. Schmidt) and the Friedrich-Baur-Institut (Drs. Walter, Pongratz, and Mu\u0308ller\u2013Felber), Ludwig-Maximilians-Universita\u0308t Mu\u0308nchen; and the Department of Sports Medicine (Dr. Hartard) and the Institute for Medical Statistics and Epidemiology (M. Hennig), Technische Universita\u0308t Mu\u0308nchen, Germany","institution_ids":["https://openalex.org/I62916508","https://openalex.org/I8204097"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110666855","display_name":"M. Walter","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I62916508","display_name":"Technical University of Munich","ror":"https://ror.org/02kkvpp62","country_code":"DE","type":"education","lineage":["https://openalex.org/I62916508"]},{"id":"https://openalex.org/I8204097","display_name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen","ror":"https://ror.org/05591te55","country_code":"DE","type":"education","lineage":["https://openalex.org/I8204097"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"M. Walter","raw_affiliation_strings":["From the Department of Neurology (Drs. Klopstock, Querner, Gekeler, Gasser, Straube, and Dieterich, and F. Schmidt) and the Friedrich-Baur-Institut (Drs. Walter, Pongratz, and Mu\u0308ller\u2013Felber), Ludwig-Maximilians-Universita\u0308t Mu\u0308nchen; and the Department of Sports Medicine (Dr. Hartard) and the Institute for Medical Statistics and Epidemiology (M. Hennig), Technische Universita\u0308t Mu\u0308nchen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Neurology (Drs. Klopstock, Querner, Gekeler, Gasser, Straube, and Dieterich, and F. Schmidt) and the Friedrich-Baur-Institut (Drs. Walter, Pongratz, and Mu\u0308ller\u2013Felber), Ludwig-Maximilians-Universita\u0308t Mu\u0308nchen; and the Department of Sports Medicine (Dr. Hartard) and the Institute for Medical Statistics and Epidemiology (M. Hennig), Technische Universita\u0308t Mu\u0308nchen, Germany","institution_ids":["https://openalex.org/I62916508","https://openalex.org/I8204097"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073570143","display_name":"Manfred Hartard","orcid":"https://orcid.org/0000-0001-7247-0931","observed_orcids":["https://orcid.org/0000-0001-7247-0931"]},"institutions":[{"id":"https://openalex.org/I62916508","display_name":"Technical University of Munich","ror":"https://ror.org/02kkvpp62","country_code":"DE","type":"education","lineage":["https://openalex.org/I62916508"]},{"id":"https://openalex.org/I8204097","display_name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen","ror":"https://ror.org/05591te55","country_code":"DE","type":"education","lineage":["https://openalex.org/I8204097"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"M. Hartard","raw_affiliation_strings":["From the Department of Neurology (Drs. Klopstock, Querner, Gekeler, Gasser, Straube, and Dieterich, and F. Schmidt) and the Friedrich-Baur-Institut (Drs. Walter, Pongratz, and Mu\u0308ller\u2013Felber), Ludwig-Maximilians-Universita\u0308t Mu\u0308nchen; and the Department of Sports Medicine (Dr. Hartard) and the Institute for Medical Statistics and Epidemiology (M. Hennig), Technische Universita\u0308t Mu\u0308nchen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Neurology (Drs. Klopstock, Querner, Gekeler, Gasser, Straube, and Dieterich, and F. Schmidt) and the Friedrich-Baur-Institut (Drs. Walter, Pongratz, and Mu\u0308ller\u2013Felber), Ludwig-Maximilians-Universita\u0308t Mu\u0308nchen; and the Department of Sports Medicine (Dr. Hartard) and the Institute for Medical Statistics and Epidemiology (M. Hennig), Technische Universita\u0308t Mu\u0308nchen, Germany","institution_ids":["https://openalex.org/I62916508","https://openalex.org/I8204097"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014734892","display_name":"M. Hennig","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I62916508","display_name":"Technical University of Munich","ror":"https://ror.org/02kkvpp62","country_code":"DE","type":"education","lineage":["https://openalex.org/I62916508"]},{"id":"https://openalex.org/I8204097","display_name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen","ror":"https://ror.org/05591te55","country_code":"DE","type":"education","lineage":["https://openalex.org/I8204097"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"M. Hennig Dipl-Stat","raw_affiliation_strings":["From the Department of Neurology (Drs. Klopstock, Querner, Gekeler, Gasser, Straube, and Dieterich, and F. Schmidt) and the Friedrich-Baur-Institut (Drs. Walter, Pongratz, and Mu\u0308ller\u2013Felber), Ludwig-Maximilians-Universita\u0308t Mu\u0308nchen; and the Department of Sports Medicine (Dr. Hartard) and the Institute for Medical Statistics and Epidemiology (M. Hennig), Technische Universita\u0308t Mu\u0308nchen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Neurology (Drs. Klopstock, Querner, Gekeler, Gasser, Straube, and Dieterich, and F. Schmidt) and the Friedrich-Baur-Institut (Drs. Walter, Pongratz, and Mu\u0308ller\u2013Felber), Ludwig-Maximilians-Universita\u0308t Mu\u0308nchen; and the Department of Sports Medicine (Dr. Hartard) and the Institute for Medical Statistics and Epidemiology (M. Hennig), Technische Universita\u0308t Mu\u0308nchen, Germany","institution_ids":["https://openalex.org/I62916508","https://openalex.org/I8204097"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067744605","display_name":"Thomas Gasser","orcid":"https://orcid.org/0000-0002-1069-1146","observed_orcids":["https://orcid.org/0000-0002-1069-1146"]},"institutions":[{"id":"https://openalex.org/I62916508","display_name":"Technical University of Munich","ror":"https://ror.org/02kkvpp62","country_code":"DE","type":"education","lineage":["https://openalex.org/I62916508"]},{"id":"https://openalex.org/I8204097","display_name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen","ror":"https://ror.org/05591te55","country_code":"DE","type":"education","lineage":["https://openalex.org/I8204097"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"T. Gasser","raw_affiliation_strings":["From the Department of Neurology (Drs. Klopstock, Querner, Gekeler, Gasser, Straube, and Dieterich, and F. Schmidt) and the Friedrich-Baur-Institut (Drs. Walter, Pongratz, and Mu\u0308ller\u2013Felber), Ludwig-Maximilians-Universita\u0308t Mu\u0308nchen; and the Department of Sports Medicine (Dr. Hartard) and the Institute for Medical Statistics and Epidemiology (M. Hennig), Technische Universita\u0308t Mu\u0308nchen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Neurology (Drs. Klopstock, Querner, Gekeler, Gasser, Straube, and Dieterich, and F. Schmidt) and the Friedrich-Baur-Institut (Drs. Walter, Pongratz, and Mu\u0308ller\u2013Felber), Ludwig-Maximilians-Universita\u0308t Mu\u0308nchen; and the Department of Sports Medicine (Dr. Hartard) and the Institute for Medical Statistics and Epidemiology (M. Hennig), Technische Universita\u0308t Mu\u0308nchen, Germany","institution_ids":["https://openalex.org/I62916508","https://openalex.org/I8204097"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058140723","display_name":"Dieter E. Pongratz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I62916508","display_name":"Technical University of Munich","ror":"https://ror.org/02kkvpp62","country_code":"DE","type":"education","lineage":["https://openalex.org/I62916508"]},{"id":"https://openalex.org/I8204097","display_name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen","ror":"https://ror.org/05591te55","country_code":"DE","type":"education","lineage":["https://openalex.org/I8204097"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"D. Pongratz","raw_affiliation_strings":["From the Department of Neurology (Drs. Klopstock, Querner, Gekeler, Gasser, Straube, and Dieterich, and F. Schmidt) and the Friedrich-Baur-Institut (Drs. Walter, Pongratz, and Mu\u0308ller\u2013Felber), Ludwig-Maximilians-Universita\u0308t Mu\u0308nchen; and the Department of Sports Medicine (Dr. Hartard) and the Institute for Medical Statistics and Epidemiology (M. Hennig), Technische Universita\u0308t Mu\u0308nchen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Neurology (Drs. Klopstock, Querner, Gekeler, Gasser, Straube, and Dieterich, and F. Schmidt) and the Friedrich-Baur-Institut (Drs. Walter, Pongratz, and Mu\u0308ller\u2013Felber), Ludwig-Maximilians-Universita\u0308t Mu\u0308nchen; and the Department of Sports Medicine (Dr. Hartard) and the Institute for Medical Statistics and Epidemiology (M. Hennig), Technische Universita\u0308t Mu\u0308nchen, Germany","institution_ids":["https://openalex.org/I62916508","https://openalex.org/I8204097"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002693055","display_name":"A. Straube","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I62916508","display_name":"Technical University of Munich","ror":"https://ror.org/02kkvpp62","country_code":"DE","type":"education","lineage":["https://openalex.org/I62916508"]},{"id":"https://openalex.org/I8204097","display_name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen","ror":"https://ror.org/05591te55","country_code":"DE","type":"education","lineage":["https://openalex.org/I8204097"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"A. Straube","raw_affiliation_strings":["From the Department of Neurology (Drs. Klopstock, Querner, Gekeler, Gasser, Straube, and Dieterich, and F. Schmidt) and the Friedrich-Baur-Institut (Drs. Walter, Pongratz, and Mu\u0308ller\u2013Felber), Ludwig-Maximilians-Universita\u0308t Mu\u0308nchen; and the Department of Sports Medicine (Dr. Hartard) and the Institute for Medical Statistics and Epidemiology (M. Hennig), Technische Universita\u0308t Mu\u0308nchen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Neurology (Drs. Klopstock, Querner, Gekeler, Gasser, Straube, and Dieterich, and F. Schmidt) and the Friedrich-Baur-Institut (Drs. Walter, Pongratz, and Mu\u0308ller\u2013Felber), Ludwig-Maximilians-Universita\u0308t Mu\u0308nchen; and the Department of Sports Medicine (Dr. Hartard) and the Institute for Medical Statistics and Epidemiology (M. Hennig), Technische Universita\u0308t Mu\u0308nchen, Germany","institution_ids":["https://openalex.org/I62916508","https://openalex.org/I8204097"]}]},{"author_position":"middle","author":{"id":null,"display_name":"M. Dieterich","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I62916508","display_name":"Technical University of Munich","ror":"https://ror.org/02kkvpp62","country_code":"DE","type":"education","lineage":["https://openalex.org/I62916508"]},{"id":"https://openalex.org/I8204097","display_name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen","ror":"https://ror.org/05591te55","country_code":"DE","type":"education","lineage":["https://openalex.org/I8204097"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"M. Dieterich","raw_affiliation_strings":["From the Department of Neurology (Drs. Klopstock, Querner, Gekeler, Gasser, Straube, and Dieterich, and F. Schmidt) and the Friedrich-Baur-Institut (Drs. Walter, Pongratz, and Mu\u0308ller\u2013Felber), Ludwig-Maximilians-Universita\u0308t Mu\u0308nchen; and the Department of Sports Medicine (Dr. Hartard) and the Institute for Medical Statistics and Epidemiology (M. Hennig), Technische Universita\u0308t Mu\u0308nchen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Neurology (Drs. Klopstock, Querner, Gekeler, Gasser, Straube, and Dieterich, and F. Schmidt) and the Friedrich-Baur-Institut (Drs. Walter, Pongratz, and Mu\u0308ller\u2013Felber), Ludwig-Maximilians-Universita\u0308t Mu\u0308nchen; and the Department of Sports Medicine (Dr. Hartard) and the Institute for Medical Statistics and Epidemiology (M. Hennig), Technische Universita\u0308t Mu\u0308nchen, Germany","institution_ids":["https://openalex.org/I62916508","https://openalex.org/I8204097"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5029637170","display_name":"Wolfgang M\u00fcller\u2010Felber","orcid":"https://orcid.org/0000-0001-9916-5048","observed_orcids":["https://orcid.org/0000-0001-9916-5048"]},"institutions":[{"id":"https://openalex.org/I62916508","display_name":"Technical University of Munich","ror":"https://ror.org/02kkvpp62","country_code":"DE","type":"education","lineage":["https://openalex.org/I62916508"]},{"id":"https://openalex.org/I8204097","display_name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen","ror":"https://ror.org/05591te55","country_code":"DE","type":"education","lineage":["https://openalex.org/I8204097"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"W. Mu\u0308ller\u2013Felber","raw_affiliation_strings":["From the Department of Neurology (Drs. Klopstock, Querner, Gekeler, Gasser, Straube, and Dieterich, and F. Schmidt) and the Friedrich-Baur-Institut (Drs. Walter, Pongratz, and Mu\u0308ller\u2013Felber), Ludwig-Maximilians-Universita\u0308t Mu\u0308nchen; and the Department of Sports Medicine (Dr. Hartard) and the Institute for Medical Statistics and Epidemiology (M. Hennig), Technische Universita\u0308t Mu\u0308nchen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Neurology (Drs. Klopstock, Querner, Gekeler, Gasser, Straube, and Dieterich, and F. Schmidt) and the Friedrich-Baur-Institut (Drs. Walter, Pongratz, and Mu\u0308ller\u2013Felber), Ludwig-Maximilians-Universita\u0308t Mu\u0308nchen; and the Department of Sports Medicine (Dr. Hartard) and the Institute for Medical Statistics and Epidemiology (M. Hennig), Technische Universita\u0308t Mu\u0308nchen, Germany","institution_ids":["https://openalex.org/I62916508","https://openalex.org/I8204097"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.1661,"has_fulltext":false,"cited_by_count":87,"citation_normalized_percentile":{"value":0.87061954,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"55","issue":"11","first_page":"1748","last_page":"1751"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.5625,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.5625,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11399","display_name":"Muscle metabolism and nutrition","score":0.263700008392334,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11027","display_name":"Metabolism and Genetic Disorders","score":0.09700000286102295,"subfield":{"id":"https://openalex.org/subfields/1308","display_name":"Clinical Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/creatine-monohydrate","display_name":"creatine monohydrate","score":0.9800000190734863},{"id":"https://openalex.org/keywords/mitochondrial-disease","display_name":"mitochondrial disease","score":0.9440000057220459},{"id":"https://openalex.org/keywords/chronic-progressive-external-ophthalmoplegia","display_name":"chronic progressive external ophthalmoplegia","score":0.984000027179718},{"id":"https://openalex.org/keywords/mitochondrial-myopathy","display_name":"mitochondrial myopathy","score":1.0},{"id":"https://openalex.org/keywords/exercise-performance","display_name":"exercise performance","score":0.9129999876022339},{"id":"https://openalex.org/keywords/eye-movements","display_name":"eye movements","score":0.972000002861023},{"id":"https://openalex.org/keywords/activities-of-daily-living","display_name":"activities of daily living","score":0.8420000076293945},{"id":"https://openalex.org/keywords/drug-safety","display_name":"drug safety","score":0.6060000061988831}],"concepts":[{"id":"https://openalex.org/C87813604","wikidata":"https://www.wikidata.org/wiki/Q1242899","display_name":"Crossover study","level":4,"score":0.853820264339447},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.7769885063171387},{"id":"https://openalex.org/C2779896295","wikidata":"https://www.wikidata.org/wiki/Q223600","display_name":"Creatine","level":2,"score":0.7496222257614136},{"id":"https://openalex.org/C2775833069","wikidata":"https://www.wikidata.org/wiki/Q6881881","display_name":"Mitochondrial myopathy","level":4,"score":0.7398784160614014},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6641455888748169},{"id":"https://openalex.org/C2910054578","wikidata":"https://www.wikidata.org/wiki/Q223600","display_name":"Creatine Monohydrate","level":4,"score":0.5579695105552673},{"id":"https://openalex.org/C2781396761","wikidata":"https://www.wikidata.org/wiki/Q2026857","display_name":"Chronic progressive external ophthalmoplegia","level":5,"score":0.5347420573234558},{"id":"https://openalex.org/C2777300911","wikidata":"https://www.wikidata.org/wiki/Q692536","display_name":"Myopathy","level":2,"score":0.5005612373352051},{"id":"https://openalex.org/C2777614518","wikidata":"https://www.wikidata.org/wiki/Q935710","display_name":"Mitochondrial disease","level":4,"score":0.4634300172328949},{"id":"https://openalex.org/C1862650","wikidata":"https://www.wikidata.org/wiki/Q186005","display_name":"Physical therapy","level":1,"score":0.4338645935058594},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4251285493373871},{"id":"https://openalex.org/C24586158","wikidata":"https://www.wikidata.org/wiki/Q27075","display_name":"Mitochondrial DNA","level":3,"score":0.3626980185508728},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.15465879440307617},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.10130244493484497},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.059228479862213135},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003401","descriptor_name":"Creatine","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D004311","descriptor_name":"Double-Blind Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009132","descriptor_name":"Muscles","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D017240","descriptor_name":"Mitochondrial Myopathies","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D017240","descriptor_name":"Mitochondrial Myopathies","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1212/wnl.55.11.1748","doi":"https://doi.org/10.1212/wnl.55.11.1748","is_oa":false,"landing_page_url":"https://doi.org/10.1212/wnl.55.11.1748","pdf_url":null,"source":{"id":"https://openalex.org/S79704628","display_name":"Neurology","issn_l":"0028-3878","issn":["0028-3878","1526-632X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurology","raw_type":"journal-article"},{"id":"pmid:11113239","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11113239","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurology","raw_type":"Clinical Trial"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/randomized-controlled-trial","display_name":"Randomized Controlled Trial"},{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":9,"referenced_works":["https://openalex.org/W1573193689","https://openalex.org/W1968786774","https://openalex.org/W1977362203","https://openalex.org/W2011646422","https://openalex.org/W2042609760","https://openalex.org/W2053266431","https://openalex.org/W2096643396","https://openalex.org/W2129961360","https://openalex.org/W2216177017"],"related_works":["https://openalex.org/W2054478746","https://openalex.org/W310316151","https://openalex.org/W2291718914","https://openalex.org/W2096643396","https://openalex.org/W2042609760","https://openalex.org/W7206709884","https://openalex.org/W1979610489","https://openalex.org/W2077632383","https://openalex.org/W2595681657","https://openalex.org/W4230691655"],"abstract_inverted_index":{"To":[0],"test":[1],"the":[2],"efficacy":[3],"and":[4,70],"safety":[5],"of":[6,59,64],"creatine":[7],"(Cr)":[8],"monohydrate":[9],"in":[10,25],"mitochondrial":[11,21],"diseases,":[12],"16":[13],"patients":[14],"with":[15,50],"chronic":[16],"progressive":[17],"external":[18],"ophthalmoplegia":[19],"or":[20,33,57],"myopathy":[22],"were":[23,46],"randomized":[24],"a":[26],"crossover":[27],"design":[28],"to":[29,52],"receive":[30],"double-blind":[31],"placebo":[32],"20":[34],"g":[35],"Cr/day":[36],"for":[37],"4":[38],"weeks.":[39],"Cr":[40],"was":[41,68],"well":[42],"tolerated,":[43],"but":[44],"there":[45],"no":[47],"significant":[48],"effects":[49],"regard":[51],"exercise":[53],"performance,":[54],"eye":[55],"movements,":[56],"activities":[58],"daily":[60],"life.":[61],"The":[62],"power":[63],"this":[65],"pilot":[66],"study":[67],"limited":[69],"future":[71],"multicenter":[72],"trials":[73],"are":[74],"needed.":[75]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}