{"id":"https://openalex.org/W1993338136","doi":"https://doi.org/10.1016/j.bmc.2009.01.019","title":"Design, synthesis and structure\u2013activity relationships of 1,3,4-oxadiazole derivatives as novel inhibitors of glycogen synthase kinase-3\u03b2","display_name":"Design, synthesis and structure\u2013activity relationships of 1,3,4-oxadiazole derivatives as novel inhibitors of glycogen synthase kinase-3\u03b2","publication_year":2009,"publication_date":"2009-01-16","ids":{"openalex":"https://openalex.org/W1993338136","doi":"https://doi.org/10.1016/j.bmc.2009.01.019","mag":"1993338136","pmid":"https://pubmed.ncbi.nlm.nih.gov/19200745"},"language":"en","primary_location":{"id":"doi:10.1016/j.bmc.2009.01.019","doi":"https://doi.org/10.1016/j.bmc.2009.01.019","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.bmc.2009.01.019","pdf_url":null,"source":{"id":"https://openalex.org/S10422866","display_name":"Bioorganic & Medicinal Chemistry","issn_l":"0968-0896","issn":["0968-0896","1464-3391"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioorganic &amp; Medicinal Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5060924397","display_name":"Morihisa Saitoh","orcid":"https://orcid.org/0009-0006-3573-4970","observed_orcids":["https://orcid.org/0009-0006-3573-4970"]},"institutions":[{"id":"https://openalex.org/I44892455","display_name":"Takeda (Japan)","ror":"https://ror.org/04hjbmv12","country_code":"JP","type":"company","lineage":["https://openalex.org/I44892455"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Morihisa Saitoh","raw_affiliation_strings":["Pharmaceutical Research Division, Medicinal Chemistry Research Laboratories, Takeda Pharmaceutical Company, Ltd, Osaka, Japan. Saitoh_Morihisa@takeda.co.jp","Medicinal Chemistry Research Laboratories, Pharmaceutical Research Division, Takeda Pharmaceutical Company, Ltd, 17-85, Jusohonmachi 2-chome, Yodogawa-ku, Osaka 532-8686, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharmaceutical Research Division, Medicinal Chemistry Research Laboratories, Takeda Pharmaceutical Company, Ltd, Osaka, Japan. Saitoh_Morihisa@takeda.co.jp","institution_ids":["https://openalex.org/I44892455"]},{"raw_affiliation_string":"Medicinal Chemistry Research Laboratories, Pharmaceutical Research Division, Takeda Pharmaceutical Company, Ltd, 17-85, Jusohonmachi 2-chome, Yodogawa-ku, Osaka 532-8686, Japan","institution_ids":["https://openalex.org/I44892455"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031002036","display_name":"Jun Kunitomo","orcid":"https://orcid.org/0000-0002-9999-8151","observed_orcids":["https://orcid.org/0000-0002-9999-8151"]},"institutions":[{"id":"https://openalex.org/I44892455","display_name":"Takeda (Japan)","ror":"https://ror.org/04hjbmv12","country_code":"JP","type":"company","lineage":["https://openalex.org/I44892455"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Jun Kunitomo","raw_affiliation_strings":["Medicinal Chemistry Research Laboratories, Pharmaceutical Research Division, Takeda Pharmaceutical Company, Ltd, 17-85, Jusohonmachi 2-Chome, Yodogawa-ku, Osaka 532-8686, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medicinal Chemistry Research Laboratories, Pharmaceutical Research Division, Takeda Pharmaceutical Company, Ltd, 17-85, Jusohonmachi 2-Chome, Yodogawa-ku, Osaka 532-8686, Japan","institution_ids":["https://openalex.org/I44892455"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109841326","display_name":"Eiji Kimura","orcid":"https://orcid.org/0000-0002-9832-5422","observed_orcids":["https://orcid.org/0000-0002-9832-5422"]},"institutions":[{"id":"https://openalex.org/I44892455","display_name":"Takeda (Japan)","ror":"https://ror.org/04hjbmv12","country_code":"JP","type":"company","lineage":["https://openalex.org/I44892455"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Eiji Kimura","raw_affiliation_strings":["Medicinal Chemistry Research Laboratories, Pharmaceutical Research Division, Takeda Pharmaceutical Company, Ltd, 17-85, Jusohonmachi 2-Chome, Yodogawa-ku, Osaka 532-8686, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medicinal Chemistry Research Laboratories, Pharmaceutical Research Division, Takeda Pharmaceutical Company, Ltd, 17-85, Jusohonmachi 2-Chome, Yodogawa-ku, Osaka 532-8686, Japan","institution_ids":["https://openalex.org/I44892455"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069592176","display_name":"Yoji Hayase","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I44892455","display_name":"Takeda (Japan)","ror":"https://ror.org/04hjbmv12","country_code":"JP","type":"company","lineage":["https://openalex.org/I44892455"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yoji Hayase","raw_affiliation_strings":["Frontier Research Laboratories, Pharmaceutical Research Division, Takeda Pharmaceutical Company, Ltd, 10 Wadai, Tsukuba-shi, Ibaraki 300-4293, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Frontier Research Laboratories, Pharmaceutical Research Division, Takeda Pharmaceutical Company, Ltd, 10 Wadai, Tsukuba-shi, Ibaraki 300-4293, Japan","institution_ids":["https://openalex.org/I44892455"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112256135","display_name":"Hiromi Kobayashi","orcid":"https://orcid.org/0000-0003-0138-5363","observed_orcids":["https://orcid.org/0000-0003-0138-5363"]},"institutions":[{"id":"https://openalex.org/I44892455","display_name":"Takeda (Japan)","ror":"https://ror.org/04hjbmv12","country_code":"JP","type":"company","lineage":["https://openalex.org/I44892455"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiromi Kobayashi","raw_affiliation_strings":["Medicinal Chemistry Research Laboratories, Pharmaceutical Research Division, Takeda Pharmaceutical Company, Ltd, 17-85, Jusohonmachi 2-Chome, Yodogawa-ku, Osaka 532-8686, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medicinal Chemistry Research Laboratories, Pharmaceutical Research Division, Takeda Pharmaceutical Company, Ltd, 17-85, Jusohonmachi 2-Chome, Yodogawa-ku, Osaka 532-8686, Japan","institution_ids":["https://openalex.org/I44892455"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029180206","display_name":"Noriko Uchiyama","orcid":"https://orcid.org/0000-0003-4042-1574","observed_orcids":["https://orcid.org/0000-0003-4042-1574"]},"institutions":[{"id":"https://openalex.org/I44892455","display_name":"Takeda (Japan)","ror":"https://ror.org/04hjbmv12","country_code":"JP","type":"company","lineage":["https://openalex.org/I44892455"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Noriko Uchiyama","raw_affiliation_strings":["Discovery Research Center, Pharmaceutical Research Division, Takeda Pharmaceutical Company, Ltd, 17-85, Jusohonmachi 2-Chome, Yodogawa-ku, Osaka 532-8686, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Discovery Research Center, Pharmaceutical Research Division, Takeda Pharmaceutical Company, Ltd, 17-85, Jusohonmachi 2-Chome, Yodogawa-ku, Osaka 532-8686, Japan","institution_ids":["https://openalex.org/I44892455"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084346121","display_name":"Tomohiro Kawamoto","orcid":"https://orcid.org/0000-0002-2985-5948","observed_orcids":["https://orcid.org/0000-0002-2985-5948"]},"institutions":[{"id":"https://openalex.org/I44892455","display_name":"Takeda (Japan)","ror":"https://ror.org/04hjbmv12","country_code":"JP","type":"company","lineage":["https://openalex.org/I44892455"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tomohiro Kawamoto","raw_affiliation_strings":["Discovery Research Center, Pharmaceutical Research Division, Takeda Pharmaceutical Company, Ltd, 17-85, Jusohonmachi 2-Chome, Yodogawa-ku, Osaka 532-8686, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Discovery Research Center, Pharmaceutical Research Division, Takeda Pharmaceutical Company, Ltd, 17-85, Jusohonmachi 2-Chome, Yodogawa-ku, Osaka 532-8686, Japan","institution_ids":["https://openalex.org/I44892455"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007116662","display_name":"Toshimasa Tanaka","orcid":"https://orcid.org/0000-0002-4988-8536","observed_orcids":["https://orcid.org/0000-0002-4988-8536"]},"institutions":[{"id":"https://openalex.org/I44892455","display_name":"Takeda (Japan)","ror":"https://ror.org/04hjbmv12","country_code":"JP","type":"company","lineage":["https://openalex.org/I44892455"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Toshimasa Tanaka","raw_affiliation_strings":["Discovery Research Center, Pharmaceutical Research Division, Takeda Pharmaceutical Company, Ltd, 17-85, Jusohonmachi 2-Chome, Yodogawa-ku, Osaka 532-8686, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Discovery Research Center, Pharmaceutical Research Division, Takeda Pharmaceutical Company, Ltd, 17-85, Jusohonmachi 2-Chome, Yodogawa-ku, Osaka 532-8686, Japan","institution_ids":["https://openalex.org/I44892455"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112793062","display_name":"Clifford D. Mol","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Clifford D. Mol","raw_affiliation_strings":["Takeda San Diego, Inc., 10410, Science Center Drive, San Diego, CA 92121, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Takeda San Diego, Inc., 10410, Science Center Drive, San Diego, CA 92121, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053685220","display_name":"Douglas R. Dougan","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Douglas R. Dougan","raw_affiliation_strings":["Takeda San Diego, Inc., 10410, Science Center Drive, San Diego, CA 92121, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Takeda San Diego, Inc., 10410, Science Center Drive, San Diego, CA 92121, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082726942","display_name":"Garret P. Textor","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Garret S. Textor","raw_affiliation_strings":["Takeda San Diego, Inc., 10410, Science Center Drive, San Diego, CA 92121, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Takeda San Diego, Inc., 10410, Science Center Drive, San Diego, CA 92121, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066925303","display_name":"G. Snell","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gyorgy P. Snell","raw_affiliation_strings":["Takeda San Diego, Inc., 10410, Science Center Drive, San Diego, CA 92121, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Takeda San Diego, Inc., 10410, Science Center Drive, San Diego, CA 92121, USA","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109325065","display_name":"Fumio Itoh","orcid":"https://orcid.org/0000-0003-3411-0278","observed_orcids":["https://orcid.org/0000-0003-3411-0278"]},"institutions":[{"id":"https://openalex.org/I44892455","display_name":"Takeda (Japan)","ror":"https://ror.org/04hjbmv12","country_code":"JP","type":"company","lineage":["https://openalex.org/I44892455"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Fumio Itoh","raw_affiliation_strings":["Medicinal Chemistry Research Laboratories, Pharmaceutical Research Division, Takeda Pharmaceutical Company, Ltd, 17-85, Jusohonmachi 2-Chome, Yodogawa-ku, Osaka 532-8686, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medicinal Chemistry Research Laboratories, Pharmaceutical Research Division, Takeda Pharmaceutical Company, Ltd, 17-85, Jusohonmachi 2-Chome, Yodogawa-ku, Osaka 532-8686, Japan","institution_ids":["https://openalex.org/I44892455"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5060924397"],"corresponding_institution_ids":["https://openalex.org/I44892455"],"apc_list":{"value":3960,"currency":"USD","value_usd":3960},"apc_paid":null,"fwci":6.6274,"has_fulltext":false,"cited_by_count":113,"citation_normalized_percentile":{"value":0.96940012,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":96,"max":99},"biblio":{"volume":"17","issue":"5","first_page":"2017","last_page":"2029"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.6395999789237976,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.6395999789237976,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10274","display_name":"Synthesis and biological activity","score":0.14030000567436218,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12410","display_name":"Structural and Chemical Analysis of Organic and Inorganic Compounds","score":0.04320000112056732,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glycogen-synthase-kinase-3beta","display_name":"glycogen synthase kinase-3\u03b2","score":0.8569999933242798},{"id":"https://openalex.org/keywords/gsk-3beta-inhibitors","display_name":"GSK-3\u03b2 inhibitors","score":0.9179999828338623},{"id":"https://openalex.org/keywords/1-3-4-oxadiazole-derivatives","display_name":"1,3,4-oxadiazole derivatives","score":0.9919999837875366},{"id":"https://openalex.org/keywords/structure-activity-relationship","display_name":"structure-activity relationship","score":0.9580000042915344},{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.9520000219345093},{"id":"https://openalex.org/keywords/tau-hyperphosphorylation","display_name":"tau hyperphosphorylation","score":0.9480000138282776},{"id":"https://openalex.org/keywords/kinase-inhibitors","display_name":"kinase inhibitors","score":0.40700000524520874}],"concepts":[{"id":"https://openalex.org/C182996813","wikidata":"https://www.wikidata.org/wiki/Q910847","display_name":"GSK-3","level":3,"score":0.9251512289047241},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.8603459000587463},{"id":"https://openalex.org/C192118531","wikidata":"https://www.wikidata.org/wiki/Q86360001","display_name":"Glycogen synthase","level":3,"score":0.7213897109031677},{"id":"https://openalex.org/C2779448499","wikidata":"https://www.wikidata.org/wiki/Q1227206","display_name":"Oxadiazole","level":2,"score":0.6588647961616516},{"id":"https://openalex.org/C193042331","wikidata":"https://www.wikidata.org/wiki/Q1772003","display_name":"Structure\u2013activity relationship","level":3,"score":0.5866940021514893},{"id":"https://openalex.org/C104629339","wikidata":"https://www.wikidata.org/wiki/Q18258585","display_name":"GSK3B","level":4,"score":0.5331864356994629},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.5268512964248657},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.5009145736694336},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.48527976870536804},{"id":"https://openalex.org/C2778198054","wikidata":"https://www.wikidata.org/wiki/Q15195154","display_name":"Hyperphosphorylation","level":3,"score":0.46310800313949585},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4279632568359375},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.32909709215164185},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.05359524488449097}],"mesh":[{"descriptor_ui":"D000071679","descriptor_name":"Glycogen Synthase Kinase 3 beta","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001562","descriptor_name":"Benzimidazoles","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":false},{"descriptor_ui":"D001562","descriptor_name":"Benzimidazoles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D001562","descriptor_name":"Benzimidazoles","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D009570","descriptor_name":"Nitriles","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":false},{"descriptor_ui":"D009570","descriptor_name":"Nitriles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D009570","descriptor_name":"Nitriles","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D010069","descriptor_name":"Oxadiazoles","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":false},{"descriptor_ui":"D010069","descriptor_name":"Oxadiazoles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D010069","descriptor_name":"Oxadiazoles","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015195","descriptor_name":"Drug Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018360","descriptor_name":"Crystallography, X-Ray","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D038362","descriptor_name":"Glycogen Synthase Kinase 3","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D038362","descriptor_name":"Glycogen Synthase Kinase 3","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.bmc.2009.01.019","doi":"https://doi.org/10.1016/j.bmc.2009.01.019","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.bmc.2009.01.019","pdf_url":null,"source":{"id":"https://openalex.org/S10422866","display_name":"Bioorganic & Medicinal Chemistry","issn_l":"0968-0896","issn":["0968-0896","1464-3391"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioorganic &amp; Medicinal Chemistry","raw_type":"journal-article"},{"id":"pmid:19200745","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19200745","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioorganic & medicinal chemistry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8048999905586243}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":28,"referenced_works":["https://openalex.org/W1483825698","https://openalex.org/W1496294957","https://openalex.org/W1562206355","https://openalex.org/W1970197612","https://openalex.org/W1976842203","https://openalex.org/W1977521133","https://openalex.org/W1993115135","https://openalex.org/W2004242265","https://openalex.org/W2022865784","https://openalex.org/W2031864556","https://openalex.org/W2034286717","https://openalex.org/W2037783340","https://openalex.org/W2038840577","https://openalex.org/W2046892908","https://openalex.org/W2047427096","https://openalex.org/W2049942764","https://openalex.org/W2061072280","https://openalex.org/W2063620211","https://openalex.org/W2080476827","https://openalex.org/W2081831345","https://openalex.org/W2091330155","https://openalex.org/W2091455801","https://openalex.org/W2114358785","https://openalex.org/W2130357785","https://openalex.org/W2142369061","https://openalex.org/W2144508375","https://openalex.org/W2161182074","https://openalex.org/W2168745901"],"related_works":["https://openalex.org/W2902117655","https://openalex.org/W1995377960","https://openalex.org/W2110089433","https://openalex.org/W2014686354","https://openalex.org/W2038474939","https://openalex.org/W4282840513","https://openalex.org/W2100654518","https://openalex.org/W2922026132","https://openalex.org/W2939098838","https://openalex.org/W1986317011"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":6},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":7},{"year":2016,"cited_by_count":8},{"year":2015,"cited_by_count":9},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":7},{"year":2012,"cited_by_count":12}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
