{"id":"https://openalex.org/W1993321728","doi":"https://doi.org/10.3109/09537104.2012.693991","title":"Platelets from WAS patients show an increased susceptibility toex vivophagocytosis","display_name":"Platelets from WAS patients show an increased susceptibility toex vivophagocytosis","publication_year":2012,"publication_date":"2012-07-19","ids":{"openalex":"https://openalex.org/W1993321728","doi":"https://doi.org/10.3109/09537104.2012.693991","mag":"1993321728","pmid":"https://pubmed.ncbi.nlm.nih.gov/22812495","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3529772"},"language":"en","primary_location":{"id":"doi:10.3109/09537104.2012.693991","doi":"https://doi.org/10.3109/09537104.2012.693991","is_oa":false,"landing_page_url":"https://doi.org/10.3109/09537104.2012.693991","pdf_url":null,"source":{"id":"https://openalex.org/S103305516","display_name":"Platelets","issn_l":"0953-7104","issn":["0953-7104","1369-1635"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320449","host_organization_name":"Informa","host_organization_lineage":["https://openalex.org/P4310320449"],"host_organization_lineage_names":["Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Platelets","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3529772","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5018431271","display_name":"Amanda Prislovsky","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210086422","display_name":"Memphis VA Medical Center","ror":"https://ror.org/000vjzq57","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210086422","https://openalex.org/I4210112672"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Amanda Prislovsky","raw_affiliation_strings":["Department of Pathology and Laboratory Medicine, Memphis VA Medical Center, Memphis, TN 38104, USA","Department of Pathology and Laboratory Medicine, Memphis VA Medical Center, Memphis, TN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology and Laboratory Medicine, Memphis VA Medical Center, Memphis, TN 38104, USA","institution_ids":["https://openalex.org/I4210086422"]},{"raw_affiliation_string":"Department of Pathology and Laboratory Medicine, Memphis VA Medical Center, Memphis, TN, USA","institution_ids":["https://openalex.org/I4210086422"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066932465","display_name":"Xueying Zeng","orcid":"https://orcid.org/0000-0001-6346-365X","observed_orcids":["https://orcid.org/0000-0001-6346-365X"]},"institutions":[{"id":"https://openalex.org/I160606119","display_name":"University of Tennessee Health Science Center","ror":"https://ror.org/0011qv509","country_code":"US","type":"education","lineage":["https://openalex.org/I160606119"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xueying Zeng","raw_affiliation_strings":["Department of Pathology and Laboratory Medicine, University of Tennessee Health Science Center, Memphis, TN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology and Laboratory Medicine, University of Tennessee Health Science Center, Memphis, TN, USA","institution_ids":["https://openalex.org/I160606119"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002793183","display_name":"Robert A. Sokolic","orcid":"https://orcid.org/0000-0002-3399-7893","observed_orcids":["https://orcid.org/0000-0002-3399-7893","https://orcid.org/0009-0007-2366-3690"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210090236","display_name":"National Human Genome Research Institute","ror":"https://ror.org/00baak391","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210090236"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert A. Sokolic","raw_affiliation_strings":["National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210090236"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084179048","display_name":"Elizabeth Garabedian","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210090236","display_name":"National Human Genome Research Institute","ror":"https://ror.org/00baak391","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210090236"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Elizabeth N. Garabedian","raw_affiliation_strings":["National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210090236"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069249031","display_name":"Praveen Anur","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Praveen Anur","raw_affiliation_strings":["Oregon Health Science University, Portland, OR, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oregon Health Science University, Portland, OR, USA","institution_ids":["https://openalex.org/I165690674"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062385004","display_name":"Fabio Candotti","orcid":"https://orcid.org/0000-0001-6399-6042","observed_orcids":["https://orcid.org/0000-0001-6399-6042"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210090236","display_name":"National Human Genome Research Institute","ror":"https://ror.org/00baak391","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210090236"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Fabio Candotti","raw_affiliation_strings":["National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210090236"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5002935249","display_name":"Ted S. Strom","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I160606119","display_name":"University of Tennessee Health Science Center","ror":"https://ror.org/0011qv509","country_code":"US","type":"education","lineage":["https://openalex.org/I160606119"]},{"id":"https://openalex.org/I4210086422","display_name":"Memphis VA Medical Center","ror":"https://ror.org/000vjzq57","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210086422","https://openalex.org/I4210112672"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Ted S. Strom","raw_affiliation_strings":["Department of Pathology and Laboratory Medicine, Memphis VA Medical Center, Memphis, TN, USA; Department of Pathology and Laboratory Medicine, University of Tennessee Health Science Center, Memphis, TN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology and Laboratory Medicine, Memphis VA Medical Center, Memphis, TN, USA; Department of Pathology and Laboratory Medicine, University of Tennessee Health Science Center, Memphis, TN, USA","institution_ids":["https://openalex.org/I160606119","https://openalex.org/I4210086422"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5002935249"],"corresponding_institution_ids":["https://openalex.org/I160606119","https://openalex.org/I4210086422"],"apc_list":{"value":4055,"currency":"AUD","value_usd":2970},"apc_paid":null,"fwci":1.2776,"has_fulltext":false,"cited_by_count":22,"citation_normalized_percentile":{"value":0.80917719,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"24","issue":"4","first_page":"288","last_page":"296"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10746","display_name":"Platelet Disorders and Treatments","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10746","display_name":"Platelet Disorders and Treatments","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11725","display_name":"Immunodeficiency and Autoimmune Disorders","score":0.005200000014156103,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10993","display_name":"Complement system in diseases","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/wiskott-aldrich-syndrome","display_name":"Wiskott-Aldrich syndrome","score":1.0},{"id":"https://openalex.org/keywords/platelet-phagocytosis","display_name":"platelet phagocytosis","score":0.9139999747276306},{"id":"https://openalex.org/keywords/platelet-consumption","display_name":"platelet consumption","score":0.7990000247955322},{"id":"https://openalex.org/keywords/thrombocytopenia","display_name":"thrombocytopenia","score":0.9700000286102295},{"id":"https://openalex.org/keywords/opsonization","display_name":"opsonization","score":0.7929999828338623},{"id":"https://openalex.org/keywords/reticulated-platelets","display_name":"reticulated platelets","score":0.8029999732971191},{"id":"https://openalex.org/keywords/thp-1-macrophages","display_name":"THP-1 macrophages","score":0.8159999847412109},{"id":"https://openalex.org/keywords/x-linked-thrombocytopenia","display_name":"X-linked thrombocytopenia","score":0.7699999809265137}],"concepts":[{"id":"https://openalex.org/C89560881","wikidata":"https://www.wikidata.org/wiki/Q101026","display_name":"Platelet","level":2,"score":0.9384841918945312},{"id":"https://openalex.org/C168507396","wikidata":"https://www.wikidata.org/wiki/Q14859847","display_name":"Antibody opsonization","level":4,"score":0.8651795983314514},{"id":"https://openalex.org/C26291073","wikidata":"https://www.wikidata.org/wiki/Q310484","display_name":"Ex vivo","level":3,"score":0.7083833813667297},{"id":"https://openalex.org/C160448771","wikidata":"https://www.wikidata.org/wiki/Q184726","display_name":"Phagocytosis","level":2,"score":0.6821447610855103},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.6400467753410339},{"id":"https://openalex.org/C2776958478","wikidata":"https://www.wikidata.org/wiki/Q14914622","display_name":"Thrombopoiesis","level":5,"score":0.5612354874610901},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4894920587539673},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4751155972480774},{"id":"https://openalex.org/C3018697912","wikidata":"https://www.wikidata.org/wiki/Q179217","display_name":"Platelet activation","level":3,"score":0.4289247393608093},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3181517720222473},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.27519991993904114},{"id":"https://openalex.org/C89372155","wikidata":"https://www.wikidata.org/wiki/Q420107","display_name":"Opsonin","level":3,"score":0.1938459277153015},{"id":"https://openalex.org/C2779705218","wikidata":"https://www.wikidata.org/wiki/Q821701","display_name":"Megakaryocyte","level":4,"score":0.11907699704170227},{"id":"https://openalex.org/C109159458","wikidata":"https://www.wikidata.org/wiki/Q919283","display_name":"Haematopoiesis","level":3,"score":0.09069541096687317},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.05156424641609192},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D001792","descriptor_name":"Blood Platelets","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D001792","descriptor_name":"Blood Platelets","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010587","descriptor_name":"Phagocytosis","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D010976","descriptor_name":"Platelet Count","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014923","descriptor_name":"Wiskott-Aldrich Syndrome","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D014923","descriptor_name":"Wiskott-Aldrich Syndrome","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D051316","descriptor_name":"Wiskott-Aldrich Syndrome Protein","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.3109/09537104.2012.693991","doi":"https://doi.org/10.3109/09537104.2012.693991","is_oa":false,"landing_page_url":"https://doi.org/10.3109/09537104.2012.693991","pdf_url":null,"source":{"id":"https://openalex.org/S103305516","display_name":"Platelets","issn_l":"0953-7104","issn":["0953-7104","1369-1635"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320449","host_organization_name":"Informa","host_organization_lineage":["https://openalex.org/P4310320449"],"host_organization_lineage_names":["Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Platelets","raw_type":"journal-article"},{"id":"pmid:22812495","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22812495","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Platelets","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3529772","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3529772","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Platelets","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:3529772","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3529772","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Platelets","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G3729397424","display_name":"Determination of a Mechanism for the Thrombocytopenia of WAS","funder_award_id":"R21AI079757","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G4422253776","display_name":"Gene Therapy Approaches for Primary Immunodeficiencies","funder_award_id":"Z01HG000122","funder_id":"https://openalex.org/F4320337348","funder_display_name":"National Human Genome Research Institute"},{"id":"https://openalex.org/G4705346009","display_name":null,"funder_award_id":"Z99 HL999999","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G4712338446","display_name":null,"funder_award_id":"Z99 MH999999","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G5294359063","display_name":null,"funder_award_id":"Z99 HG999999","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320306127","display_name":"U.S. Department of Veterans Affairs","ror":"https://ror.org/05rsv9s98"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337348","display_name":"National Human Genome Research Institute","ror":"https://ror.org/00baak391"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":22,"referenced_works":["https://openalex.org/W77948366","https://openalex.org/W1520402351","https://openalex.org/W1976245524","https://openalex.org/W1989192113","https://openalex.org/W1993238790","https://openalex.org/W1994657930","https://openalex.org/W2010949326","https://openalex.org/W2038979180","https://openalex.org/W2048340817","https://openalex.org/W2060891467","https://openalex.org/W2083164757","https://openalex.org/W2083197627","https://openalex.org/W2086642580","https://openalex.org/W2087792204","https://openalex.org/W2103771488","https://openalex.org/W2104475366","https://openalex.org/W2135369362","https://openalex.org/W2143791165","https://openalex.org/W2154311360","https://openalex.org/W2158369873","https://openalex.org/W2168613117","https://openalex.org/W2171068060"],"related_works":["https://openalex.org/W2979872568","https://openalex.org/W2087792204","https://openalex.org/W2586694359","https://openalex.org/W2144140866","https://openalex.org/W2583497405","https://openalex.org/W2590589078","https://openalex.org/W2484006480","https://openalex.org/W1969172568","https://openalex.org/W2010949326","https://openalex.org/W2083197627"],"abstract_inverted_index":{"The":[0],"thrombocytopenia":[1,267,304],"of":[2,55,79,85,96,116,163,171,180,190,201,209,222,225,247,268,275,280,282,285,300,303],"Wiskott-Aldrich":[3],"syndrome":[4],"(WAS)":[5],"is":[6,90,133,151,218],"thought":[7],"to":[8,11,94,121,158,251,265,297],"be":[9,141,295],"due":[10],"both":[12],"reduced":[13,134],"platelet":[14,18,136,185,238,261],"production":[15,246],"and":[16,39],"accelerated":[17],"consumption.":[19],"We":[20,69,127,155,196],"have":[21],"previously":[22],"demonstrated":[23],"that":[24,40,54,71,95,129,214,244,257],"platelets":[25,62,81,150,249,286],"from":[26,63,82,109,147,203],"WASP-deficient":[27],"mice":[28],"are":[29,36,156],"consumed":[30],"more":[31,50,152],"rapidly":[32,153],"in":[33,92,193,215,235,240,259],"vivo":[34,73,216,260],"than":[35,51],"WT":[37,56,174],"platelets,":[38,212],"opsonization":[41,164,217],"accelerates":[42],"their":[43],"uptake":[44,170,208,224],"by":[45,75,135],"bone":[46],"marrow-":[47],"derived":[48],"macrophages":[49],"it":[52],"does":[53],"platelets.":[57,99,175,227],"Here":[58],"we":[59,105,229],"asked":[60],"whether":[61],"WAS":[64,86,204,241],"patients":[65,89,205],"show":[66,70,128,230],"similar":[67],"features.":[68],"ex":[72],"phagocytosis":[74,181,281],"activated":[76],"THP-1":[77],"cells":[78],"DIO-labeled":[80],"a":[83,101,110,160,291],"series":[84],"or":[87],"XLT":[88],"increased":[91,223],"comparison":[93],"normal":[97,210],"control":[98,211],"Using":[100],"numerical":[102],"analysis":[103],"method,":[104],"distinguish":[106],"this":[107,194],"effect":[108,112,162,200],"concurrent":[111],"on":[113,168,206],"the":[114,122,130,144,169,177,188,191,207,220,236,252,266,273,298],"amount":[115],"detectable":[117],"fluorescent":[118],"signal":[119],"transferred":[120,146],"macrophage":[123],"per":[124,182],"phagocytosed":[125],"platelet.":[126],"latter":[131],"quantity":[132],"WASP":[137],"deficiency,":[138],"as":[139,306],"might":[140],"expected":[142],"if":[143,232],"fluorescence":[145],"these":[148],"smaller":[149],"quenched.":[154],"unable":[157],"detect":[159],"differential":[161],"with":[165],"anti-CD61":[166],"antibody":[167],"WASP(-)":[172,184,226],"vs.":[173],"However,":[176],"high":[178],"probability":[179],"adsorbed":[183],"could":[186],"limit":[187],"sensitivity":[189],"assay":[192],"case.":[195],"also":[197,271],"see":[198],"no":[199],"sera":[202],"suggesting":[213,243],"not":[219],"cause":[221],"Finally,":[228],"little,":[231],"any,":[233],"increase":[234],"reticulated":[237,248],"fraction":[239],"patients,":[242],"impaired":[245],"contributes":[250,263],"thrombocytopenia.":[253],"Our":[254],"findings":[255],"suggest":[256],"rapid":[258],"consumption":[262],"significantly":[264],"WAS.":[269],"They":[270],"demonstrate":[272],"feasibility":[274],"routinely":[276],"performing":[277],"functional":[278],"assays":[279],"small":[283],"numbers":[284],"obtained":[287],"at":[288],"remote":[289],"locations,":[290],"method":[292],"which":[293],"should":[294],"applicable":[296],"study":[299],"other":[301],"types":[302],"such":[305],"ITP.":[307]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2013,"cited_by_count":5}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}