{"id":"https://openalex.org/W1993045641","doi":"https://doi.org/10.1371/journal.pone.0036804","title":"Ischemia-Reperfusion Injury and Pregnancy Initiate Time-Dependent and Robust Signs of Up-Regulation of Cardiac Progenitor Cells","display_name":"Ischemia-Reperfusion Injury and Pregnancy Initiate Time-Dependent and Robust Signs of Up-Regulation of Cardiac Progenitor Cells","publication_year":2012,"publication_date":"2012-05-09","ids":{"openalex":"https://openalex.org/W1993045641","doi":"https://doi.org/10.1371/journal.pone.0036804","mag":"1993045641","pmid":"https://pubmed.ncbi.nlm.nih.gov/22590612","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3348899"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pone.0036804","doi":"https://doi.org/10.1371/journal.pone.0036804","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0036804","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0036804&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0036804&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5041116482","display_name":"Rami Genead","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":true,"raw_author_name":"Rami Genead","raw_affiliation_strings":["Division of Cardiology, Department of Medicine, Karolinska Institutet, Stockholm, Sweden. rami.genead@ki.se","Division of Cardiology, Department of Medicine, Karolinska Institutet, Stockholm, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cardiology, Department of Medicine, Karolinska Institutet, Stockholm, Sweden. rami.genead@ki.se","institution_ids":["https://openalex.org/I28166907"]},{"raw_affiliation_string":"Division of Cardiology, Department of Medicine, Karolinska Institutet, Stockholm, Sweden","institution_ids":["https://openalex.org/I28166907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103097447","display_name":"Hel\u00e9ne Fischer","orcid":"https://orcid.org/0000-0002-5583-2088","observed_orcids":["https://orcid.org/0000-0002-5583-2088"]},"institutions":[{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Helene Fischer","raw_affiliation_strings":["Department of Physiology, Karolinska Institutet, Stockholm, Sweden","Dept of Physiology, Karolinska Institutet, Stockholm, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, Karolinska Institutet, Stockholm, Sweden","institution_ids":["https://openalex.org/I28166907"]},{"raw_affiliation_string":"Dept of Physiology, Karolinska Institutet, Stockholm, Sweden","institution_ids":["https://openalex.org/I28166907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102991981","display_name":"Alamdar Hussain","orcid":"https://orcid.org/0000-0003-4888-7280","observed_orcids":["https://orcid.org/0000-0003-4888-7280"]},"institutions":[{"id":"https://openalex.org/I16076960","display_name":"COMSATS University Islamabad","ror":"https://ror.org/00nqqvk19","country_code":"PK","type":"education","lineage":["https://openalex.org/I16076960"]},{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["PK","SE"],"is_corresponding":false,"raw_author_name":"Alamdar Hussain","raw_affiliation_strings":["Department of Biosciences, COMSATS Institute of Information Technology, Chak Shahzad Campus, Islamabad, Pakistan","Department of Laboratory Medicine, Clinical Research Center, Karolinska Institutet, Stockholm, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biosciences, COMSATS Institute of Information Technology, Chak Shahzad Campus, Islamabad, Pakistan","institution_ids":["https://openalex.org/I16076960"]},{"raw_affiliation_string":"Department of Laboratory Medicine, Clinical Research Center, Karolinska Institutet, Stockholm, Sweden","institution_ids":["https://openalex.org/I28166907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027390678","display_name":"Marie Jaksch","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1335113835","display_name":"Karolinska University Hospital","ror":"https://ror.org/00m8d6786","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I1335113835"]},{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Marie Jaksch","raw_affiliation_strings":["Division of Cardiothoracic Surgery and Anaesthesiology, Department of Molecular Medicine and Surgery, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cardiothoracic Surgery and Anaesthesiology, Department of Molecular Medicine and Surgery, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden","institution_ids":["https://openalex.org/I1335113835","https://openalex.org/I28166907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060350356","display_name":"Agneta Andersson","orcid":"https://orcid.org/0000-0001-9795-0624","observed_orcids":["https://orcid.org/0000-0001-9795-0624"]},"institutions":[{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Agneta B. Andersson","raw_affiliation_strings":["Division of Cardiology, Department of Medicine, Karolinska Institutet, Stockholm, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cardiology, Department of Medicine, Karolinska Institutet, Stockholm, Sweden","institution_ids":["https://openalex.org/I28166907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101612063","display_name":"Karin Ljung","orcid":"https://orcid.org/0009-0004-0787-9254","observed_orcids":["https://orcid.org/0009-0004-0787-9254"]},"institutions":[{"id":"https://openalex.org/I1335113835","display_name":"Karolinska University Hospital","ror":"https://ror.org/00m8d6786","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I1335113835"]},{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Karin Ljung","raw_affiliation_strings":["Division of Cardiothoracic Surgery and Anaesthesiology, Department of Molecular Medicine and Surgery, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cardiothoracic Surgery and Anaesthesiology, Department of Molecular Medicine and Surgery, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden","institution_ids":["https://openalex.org/I1335113835","https://openalex.org/I28166907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076760329","display_name":"Ivana Bulatovi\u0107","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1335113835","display_name":"Karolinska University Hospital","ror":"https://ror.org/00m8d6786","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I1335113835"]},{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Ivana Bulatovic","raw_affiliation_strings":["Division of Cardiothoracic Surgery and Anaesthesiology, Department of Molecular Medicine and Surgery, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cardiothoracic Surgery and Anaesthesiology, Department of Molecular Medicine and Surgery, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden","institution_ids":["https://openalex.org/I1335113835","https://openalex.org/I28166907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047897533","display_name":"Anders Franco\u2010Cereceda","orcid":"https://orcid.org/0000-0002-3427-9455","observed_orcids":["https://orcid.org/0000-0002-3427-9455"]},"institutions":[{"id":"https://openalex.org/I1335113835","display_name":"Karolinska University Hospital","ror":"https://ror.org/00m8d6786","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I1335113835"]},{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Anders Franco-Cereceda","raw_affiliation_strings":["Division of Cardiothoracic Surgery and Anaesthesiology, Department of Molecular Medicine and Surgery, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cardiothoracic Surgery and Anaesthesiology, Department of Molecular Medicine and Surgery, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden","institution_ids":["https://openalex.org/I1335113835","https://openalex.org/I28166907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110748842","display_name":"Elzafir B. Elsheikh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Elzafir Elsheikh","raw_affiliation_strings":["Division of Cardiology, Department of Medicine, Karolinska Institutet, Stockholm, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cardiology, Department of Medicine, Karolinska Institutet, Stockholm, Sweden","institution_ids":["https://openalex.org/I28166907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052764346","display_name":"Matthias Corbascio","orcid":"https://orcid.org/0000-0003-3544-6689","observed_orcids":["https://orcid.org/0000-0003-3544-6689"]},"institutions":[{"id":"https://openalex.org/I1335113835","display_name":"Karolinska University Hospital","ror":"https://ror.org/00m8d6786","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I1335113835"]},{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Matthias Corbascio","raw_affiliation_strings":["Division of Cardiothoracic Surgery and Anaesthesiology, Department of Molecular Medicine and Surgery, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cardiothoracic Surgery and Anaesthesiology, Department of Molecular Medicine and Surgery, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden","institution_ids":["https://openalex.org/I1335113835","https://openalex.org/I28166907"]}]},{"author_position":"middle","author":{"id":null,"display_name":"C. I. Edvard Smith","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"C. I. Edvard Smith","raw_affiliation_strings":["Department of Laboratory Medicine, Clinical Research Center, Karolinska Institutet, Stockholm, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Laboratory Medicine, Clinical Research Center, Karolinska Institutet, Stockholm, Sweden","institution_ids":["https://openalex.org/I28166907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002207055","display_name":"Christer Sylv\u00e9n","orcid":"https://orcid.org/0000-0003-1017-7849","observed_orcids":["https://orcid.org/0000-0003-1017-7849"]},"institutions":[{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Christer Sylv\u00e9n","raw_affiliation_strings":["Division of Cardiology, Department of Medicine, Karolinska Institutet, Stockholm, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cardiology, Department of Medicine, Karolinska Institutet, Stockholm, Sweden","institution_ids":["https://openalex.org/I28166907"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5024114707","display_name":"Karl\u2010Henrik Grinnemo","orcid":"https://orcid.org/0000-0002-6100-6209","observed_orcids":["https://orcid.org/0000-0002-6100-6209","https://orcid.org/0000-0001-6717-3393"]},"institutions":[{"id":"https://openalex.org/I1335113835","display_name":"Karolinska University Hospital","ror":"https://ror.org/00m8d6786","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I1335113835"]},{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Karl-Henrik Grinnemo","raw_affiliation_strings":["Division of Cardiothoracic Surgery and Anaesthesiology, Department of Molecular Medicine and Surgery, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cardiothoracic Surgery and Anaesthesiology, Department of Molecular Medicine and Surgery, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden","institution_ids":["https://openalex.org/I1335113835","https://openalex.org/I28166907"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5041116482"],"corresponding_institution_ids":["https://openalex.org/I28166907"],"apc_list":{"value":2382,"currency":"USD","value_usd":2382},"apc_paid":{"value":2382,"currency":"USD","value_usd":2382},"fwci":1.3649,"has_fulltext":true,"cited_by_count":25,"citation_normalized_percentile":{"value":0.78733045,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":98},"biblio":{"volume":"7","issue":"5","first_page":"e36804","last_page":"e36804"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11677","display_name":"Congenital heart defects research","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11677","display_name":"Congenital heart defects research","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10176","display_name":"Mesenchymal stem cell research","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11962","display_name":"Cardiac Fibrosis and Remodeling","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ischemia-reperfusion-injury","display_name":"ischemia-reperfusion injury","score":0.9369999766349792},{"id":"https://openalex.org/keywords/cardiac-progenitor-cells","display_name":"cardiac progenitor cells","score":0.9229999780654907},{"id":"https://openalex.org/keywords/pregnancy","display_name":"pregnancy","score":0.7950000166893005},{"id":"https://openalex.org/keywords/myocardial-infarction","display_name":"myocardial infarction","score":0.9909999966621399},{"id":"https://openalex.org/keywords/c-kit","display_name":"CD117","score":0.8600000143051147},{"id":"https://openalex.org/keywords/isl1","display_name":"Isl1","score":0.9879999756813049},{"id":"https://openalex.org/keywords/nkx2-5","display_name":"Nkx2.5","score":0.9990000128746033},{"id":"https://openalex.org/keywords/mast-cells","display_name":"mast cells","score":0.8730000257492065},{"id":"https://openalex.org/keywords/insulin-like-growth-factor-i","display_name":"insulin-like growth factor I","score":0.9440000057220459},{"id":"https://openalex.org/keywords/hepatocyte-growth-factor","display_name":"hepatocyte growth factor","score":1.0},{"id":"https://openalex.org/keywords/cardiomyocyte-regeneration","display_name":"cardiomyocyte regeneration","score":0.7200000286102295},{"id":"https://openalex.org/keywords/growth-factor-signaling","display_name":"growth factor signaling","score":0.5360000133514404}],"concepts":[{"id":"https://openalex.org/C2776996007","wikidata":"https://www.wikidata.org/wiki/Q2399112","display_name":"Hepatocyte growth factor","level":3,"score":0.7345152497291565},{"id":"https://openalex.org/C2780114680","wikidata":"https://www.wikidata.org/wiki/Q1413991","display_name":"Reperfusion injury","level":3,"score":0.6625393629074097},{"id":"https://openalex.org/C541997718","wikidata":"https://www.wikidata.org/wiki/Q188151","display_name":"Ischemia","level":2,"score":0.6482126116752625},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.616709291934967},{"id":"https://openalex.org/C201750760","wikidata":"https://www.wikidata.org/wiki/Q1896218","display_name":"Progenitor cell","level":3,"score":0.5475233793258667},{"id":"https://openalex.org/C16613235","wikidata":"https://www.wikidata.org/wiki/Q285982","display_name":"Endogeny","level":2,"score":0.5081393718719482},{"id":"https://openalex.org/C500558357","wikidata":"https://www.wikidata.org/wiki/Q12152","display_name":"Myocardial infarction","level":2,"score":0.4327920377254486},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.418129026889801},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3629240393638611},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.3352643549442291},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2750396132469177},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.260733425617218},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.2019800841808319},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.13283619284629822}],"mesh":[{"descriptor_ui":"D000072576","descriptor_name":"Homeobox Protein Nkx-2.5","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000943","descriptor_name":"Antigens, Differentiation","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007334","descriptor_name":"Insulin-Like Growth Factor I","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D009203","descriptor_name":"Myocardial Infarction","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009203","descriptor_name":"Myocardial Infarction","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D011247","descriptor_name":"Pregnancy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011249","descriptor_name":"Pregnancy Complications, Cardiovascular","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011249","descriptor_name":"Pregnancy Complications, Cardiovascular","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D013234","descriptor_name":"Stem Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013234","descriptor_name":"Stem Cells","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D015428","descriptor_name":"Myocardial Reperfusion Injury","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015428","descriptor_name":"Myocardial Reperfusion Injury","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D015854","descriptor_name":"Up-Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017228","descriptor_name":"Hepatocyte Growth Factor","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D018398","descriptor_name":"Homeodomain Proteins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D019009","descriptor_name":"Proto-Oncogene Proteins c-kit","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D032383","descriptor_name":"Myocytes, Cardiac","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D032383","descriptor_name":"Myocytes, Cardiac","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1371/journal.pone.0036804","doi":"https://doi.org/10.1371/journal.pone.0036804","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0036804","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0036804&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3348899","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3348899","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS One","raw_type":"Text"},{"id":"pmid:22590612","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22590612","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PloS one","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.792.8300","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.792.8300","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/c1/a9/pone.0036804.PMC3348899.pdf","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:61a80349baad404cabc7050af14f045b","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/61a80349baad404cabc7050af14f045b","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE, Vol 7, Iss 5, p e36804 (2012)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1371/journal.pone.0036804","doi":"https://doi.org/10.1371/journal.pone.0036804","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0036804","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0036804&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.979200005531311}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320322581","display_name":"Vetenskapsr\u00e5det","ror":"https://ror.org/03zttf063"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1993045641.pdf","grobid_xml":"https://content.openalex.org/works/W1993045641.grobid-xml"},"referenced_works_count":46,"referenced_works":["https://openalex.org/W30639996","https://openalex.org/W198094151","https://openalex.org/W1508597447","https://openalex.org/W1916767456","https://openalex.org/W1963756072","https://openalex.org/W1966563415","https://openalex.org/W1968255930","https://openalex.org/W1971858639","https://openalex.org/W1981550662","https://openalex.org/W1983241347","https://openalex.org/W1983893679","https://openalex.org/W1988451304","https://openalex.org/W1990676827","https://openalex.org/W1991978261","https://openalex.org/W1993932646","https://openalex.org/W2010772462","https://openalex.org/W2020857408","https://openalex.org/W2028036560","https://openalex.org/W2031625536","https://openalex.org/W2033250271","https://openalex.org/W2036816705","https://openalex.org/W2038671576","https://openalex.org/W2044953345","https://openalex.org/W2045384140","https://openalex.org/W2057953361","https://openalex.org/W2065171831","https://openalex.org/W2070444361","https://openalex.org/W2078014987","https://openalex.org/W2081066133","https://openalex.org/W2083575511","https://openalex.org/W2088513836","https://openalex.org/W2101986300","https://openalex.org/W2104206289","https://openalex.org/W2105956218","https://openalex.org/W2107046090","https://openalex.org/W2110275581","https://openalex.org/W2113074426","https://openalex.org/W2115980362","https://openalex.org/W2119412946","https://openalex.org/W2122059700","https://openalex.org/W2129325840","https://openalex.org/W2138835306","https://openalex.org/W2148220540","https://openalex.org/W2154469193","https://openalex.org/W2406128100","https://openalex.org/W2438629221"],"related_works":["https://openalex.org/W2232930432","https://openalex.org/W2745530531","https://openalex.org/W1969055985","https://openalex.org/W2135338365","https://openalex.org/W2335463559","https://openalex.org/W2790376222","https://openalex.org/W1590712391","https://openalex.org/W72647562","https://openalex.org/W2018475606","https://openalex.org/W3046889901"],"abstract_inverted_index":{"To":[0],"explore":[1],"how":[2],"cardiac":[3,22,61,280],"regeneration":[4],"and":[5,27,34,47,55,67,75,80,85,105,126,155,172,181,213,216,234,251,261],"cell":[6,24,90,238],"turnover":[7],"adapts":[8],"to":[9,116,129,184,242],"disease,":[10],"different":[11],"forms":[12],"of":[13,111,124,165,170,179,187,246,259,269,279],"stress":[14],"were":[15,40,63],"studied":[16],"for":[17,88,276],"their":[18],"effects":[19],"on":[20,209,217],"the":[21,29,73,95,102,109,152,158,163,176,196,218,228,243,247,266,277],"progenitor":[23,237],"markers":[25],"c-Kit":[26,86,189,212,260],"Isl1,":[28],"early":[30,262],"cardiomyocyte":[31,236],"marker":[32,239],"Nkx2.5,":[33],"mast":[35,89],"cells.":[36],"Adult":[37],"female":[38],"rats":[39],"examined":[41],"during":[42],"pregnancy,":[43],"after":[44],"myocardial":[45,81,138],"infarction":[46,82,139],"ischemia-reperfusion":[48,92,141,225],"injury":[49,93,142,226],"with/out":[50],"insulin":[51],"like":[52],"growth":[53,57,198,248],"factor-1(IGF-1)":[54],"hepatocyte":[56],"factor":[58],"(HGF).":[59],"Different":[60],"sub-domains":[62],"analyzed":[64],"at":[65,72],"one":[66,210],"two":[68],"weeks":[69],"post-intervention,":[70],"both":[71,232],"mRNA":[74],"protein":[76],"levels.":[77],"While":[78],"pregnancy":[79,136,254],"up-regulated":[83,134],"Nkx2.5":[84,214],"(adjusted":[87],"activation),":[91],"induced":[94,143,255],"strongest":[96,229],"up-regulation":[97,150,164,186,245,258],"which":[98],"occurred":[99],"globally":[100],"throughout":[101,265],"entire":[103],"heart":[104],"not":[106,133,144,192],"just":[107],"around":[108],"site":[110],"injury.":[112],"This":[113,200],"response":[114],"seems":[115],"be":[117],"partly":[118],"mediated":[119],"by":[120,135,195],"increased":[121],"endogenous":[122,166,177,244],"production":[123],"IGF-1":[125,171,250],"HGF.":[127,252],"Contrary":[128],"c-Kit,":[130],"Isl1":[131,221],"was":[132,191,227],"or":[137],"while":[140],"a":[145,148,205,256],"global":[146,233],"but":[147],"focal":[149,185,235],"in":[151,157],"outflow":[153],"tract":[154],"also":[156],"peri-ischemic":[159],"region,":[160],"correlating":[161,183,241],"with":[162,231],"IGF-1.":[167],"The":[168],"addition":[169],"HGF":[173,182],"did":[174],"boost":[175],"expression":[178,190,215],"IGF":[180],"Isl1.":[188],"further":[193],"influenced":[194],"exogenous":[197],"factors.":[199],"indicates":[201],"that":[202],"there":[203],"is":[204],"spatial":[206],"mismatch":[207],"between":[208],"hand":[211,220],"other":[219],"expression.":[222],"In":[223],"conclusion,":[224],"stimulus":[230],"up-regulations,":[240],"factors":[249],"Also":[253],"general":[257],"Nkx2.5+":[263],"cardiomyocytes":[264],"heart.":[267],"Utilization":[268],"these":[270],"pathways":[271],"could":[272],"provide":[273],"new":[274],"strategies":[275],"treatment":[278],"disease.":[281]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":4}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}