{"id":"https://openalex.org/W1993037570","doi":"https://doi.org/10.1093/carcin/15.4.763","title":"Inhibition of 2-amino-3-methylimidazo[4,5-f]quinoline (IQ)-DNA binding in rats given chlorophyllin: dose-response and time-course studies in the liver and colon","display_name":"Inhibition of 2-amino-3-methylimidazo[4,5-f]quinoline (IQ)-DNA binding in rats given chlorophyllin: dose-response and time-course studies in the liver and colon","publication_year":1994,"publication_date":"1994-01-01","ids":{"openalex":"https://openalex.org/W1993037570","doi":"https://doi.org/10.1093/carcin/15.4.763","mag":"1993037570","pmid":"https://pubmed.ncbi.nlm.nih.gov/8149493"},"language":"en","primary_location":{"id":"doi:10.1093/carcin/15.4.763","doi":"https://doi.org/10.1093/carcin/15.4.763","is_oa":false,"landing_page_url":"https://doi.org/10.1093/carcin/15.4.763","pdf_url":null,"source":{"id":"https://openalex.org/S184620562","display_name":"Carcinogenesis","issn_l":"0143-3334","issn":["0143-3334","1460-2180"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Carcinogenesis","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5053880845","display_name":"Dexin Guo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I117965899","display_name":"University of Hawai\u02bbi at M\u0101noa","ror":"https://ror.org/01wspgy28","country_code":"US","type":"education","lineage":["https://openalex.org/I117965899"]},{"id":"https://openalex.org/I1331384533","display_name":"University of Hawaii System","ror":"https://ror.org/03tzaeb71","country_code":"US","type":"education","lineage":["https://openalex.org/I1331384533"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dexin Guo","raw_affiliation_strings":["Department of Environmental Biochemistry, University of Hawaii, Honolulu 96822","Department of Environmental Biochemistry, University of HawaiiHonolulu, HI 96822, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Environmental Biochemistry, University of Hawaii, Honolulu 96822","institution_ids":["https://openalex.org/I117965899","https://openalex.org/I1331384533"]},{"raw_affiliation_string":"Department of Environmental Biochemistry, University of HawaiiHonolulu, HI 96822, USA","institution_ids":["https://openalex.org/I117965899","https://openalex.org/I1331384533"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5082820494","display_name":"Roderick H. Dashwood","orcid":"https://orcid.org/0000-0003-0351-4034","observed_orcids":["https://orcid.org/0000-0003-0351-4034"]},"institutions":[{"id":"https://openalex.org/I117965899","display_name":"University of Hawai\u02bbi at M\u0101noa","ror":"https://ror.org/01wspgy28","country_code":"US","type":"education","lineage":["https://openalex.org/I117965899"]},{"id":"https://openalex.org/I1331384533","display_name":"University of Hawaii System","ror":"https://ror.org/03tzaeb71","country_code":"US","type":"education","lineage":["https://openalex.org/I1331384533"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Roderick Dashwood","raw_affiliation_strings":["Department of Environmental Biochemistry, University of Hawaii Honolulu, HI 96822, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Environmental Biochemistry, University of Hawaii Honolulu, HI 96822, USA","institution_ids":["https://openalex.org/I117965899","https://openalex.org/I1331384533"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4835,"currency":"USD","value_usd":4835},"apc_paid":null,"fwci":1.1807,"has_fulltext":false,"cited_by_count":35,"citation_normalized_percentile":{"value":0.76535088,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"15","issue":"4","first_page":"763","last_page":"766"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment","score":0.9628999829292297,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment","score":0.9628999829292297,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10122","display_name":"Toxic Organic Pollutants Impact","score":0.0027000000700354576,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12756","display_name":"Plant Toxicity and Pharmacological Properties","score":0.002400000113993883,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chlorophyllin","display_name":"chlorophyllin","score":0.9980000257492065},{"id":"https://openalex.org/keywords/2-amino-3-methylimidazo-4-5-f-quinoline","display_name":"2-amino-3-methylimidazo[4,5-f]quinoline","score":0.9819999933242798},{"id":"https://openalex.org/keywords/dna-adducts","display_name":"DNA adducts","score":0.628000020980835},{"id":"https://openalex.org/keywords/chemoprevention","display_name":"chemoprevention","score":0.7059999704360962},{"id":"https://openalex.org/keywords/molecular-complex-formation","display_name":"molecular complex formation","score":0.765999972820282},{"id":"https://openalex.org/keywords/small-intestine","display_name":"small intestine","score":0.734000027179718},{"id":"https://openalex.org/keywords/liver","display_name":"liver","score":0.8370000123977661},{"id":"https://openalex.org/keywords/colon","display_name":"colon","score":0.996999979019165},{"id":"https://openalex.org/keywords/dose-response-relationship","display_name":"dose-response relationship","score":0.8399999737739563},{"id":"https://openalex.org/keywords/time-course","display_name":"time course","score":0.7699999809265137}],"concepts":[{"id":"https://openalex.org/C2780679280","wikidata":"https://www.wikidata.org/wiki/Q379123","display_name":"Chlorophyllin","level":3,"score":0.7838828563690186},{"id":"https://openalex.org/C2776309666","wikidata":"https://www.wikidata.org/wiki/Q408384","display_name":"Quinoline","level":2,"score":0.7032531499862671},{"id":"https://openalex.org/C114246631","wikidata":"https://www.wikidata.org/wiki/Q187661","display_name":"Carcinogen","level":2,"score":0.6647371649742126},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5189290046691895},{"id":"https://openalex.org/C2779107934","wikidata":"https://www.wikidata.org/wiki/Q4774590","display_name":"Anticarcinogen","level":4,"score":0.5142468810081482},{"id":"https://openalex.org/C2776639595","wikidata":"https://www.wikidata.org/wiki/Q221696","display_name":"Mutagen","level":3,"score":0.47500789165496826},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.4435604214668274},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4177986979484558},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3222564160823822},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.26639848947525024},{"id":"https://openalex.org/C116073593","wikidata":"https://www.wikidata.org/wiki/Q864491","display_name":"Biological activity","level":3,"score":0.18820986151695251},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.18561047315597534},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.183077871799469},{"id":"https://openalex.org/C2776373379","wikidata":"https://www.wikidata.org/wiki/Q43177","display_name":"Chlorophyll","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001692","descriptor_name":"Biological Transport","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002735","descriptor_name":"Chlorophyllides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D003106","descriptor_name":"Colon","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004249","descriptor_name":"DNA Damage","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007408","descriptor_name":"Intestinal Absorption","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011804","descriptor_name":"Quinolines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1093/carcin/15.4.763","doi":"https://doi.org/10.1093/carcin/15.4.763","is_oa":false,"landing_page_url":"https://doi.org/10.1093/carcin/15.4.763","pdf_url":null,"source":{"id":"https://openalex.org/S184620562","display_name":"Carcinogenesis","issn_l":"0143-3334","issn":["0143-3334","1460-2180"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Carcinogenesis","raw_type":"journal-article"},{"id":"pmid:8149493","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8149493","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Carcinogenesis","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.912.9524","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.912.9524","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://carcin.oxfordjournals.org/content/15/4/763.full.pdf","raw_type":"text"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7098039581","https://openalex.org/W2120423700","https://openalex.org/W2037278432","https://openalex.org/W2408785176","https://openalex.org/W2083378088","https://openalex.org/W2057290105","https://openalex.org/W2090232149","https://openalex.org/W2016843393","https://openalex.org/W2011284050","https://openalex.org/W2137811870"],"abstract_inverted_index":{"Chlorophyllin":[0],"(CHL),":[1],"a":[2,18,130,228],"water-soluble":[3],"salt":[4],"of":[5,65,111,114,121,127,138],"chlorophyll,":[6],"has":[7],"been":[8],"shown":[9],"to":[10,107,246],"inhibit":[11],"2-amino-3-methylimidazo[4,5-f]quinoline":[12],"(IQ)-DNA":[13],"binding":[14,67,99,165,187],"in":[15,68,101,129,169,198,216,237],"vitro":[16],"by":[17,53,149,188,202,222],"mechanism":[19,229],"that":[20,134,241],"involves":[21],"molecular":[22],"complex":[23,231],"formation":[24,232],"with":[25,157,180,253],"the":[26,75,83,92,102,109,125,135,170,199,217,242,254],"carcinogen.":[27,255],"Based":[28],"on":[29],"this":[30],"mechanism,":[31],"rats":[32,146],"weighing":[33],"approximately":[34],"160":[35],"g":[36],"were":[37,105,155,167],"given":[38,147,182],"10":[39],"mumol":[40,51],"(100":[41],"microCi)":[42],"IQ":[43,45,117,128,158,183,236],"or":[44,49],"plus":[46],"20,":[47],"200":[48],"1000":[50],"CHL":[52,61,94,115,139,148,185,234],"single":[54],"oral":[55],"gavage.":[56],"Six":[57],"hours":[58],"after":[59,176],"dosing,":[60],"produced":[62],"dose-related":[63,131],"inhibition":[64,88],"IQ-DNA":[66,98,164],"three":[69],"target":[70],"organs":[71],"for":[72],"carcinogenesis,":[73],"namely,":[74],"small":[76,103,122],"intestine,":[77],"large":[78],"intestine":[79,104,123],"and":[80,116,163,172,193,201,211,235,239],"liver.":[81],"In":[82],"latter":[84],"tissues,":[85],">":[86],"80%":[87],"was":[89],"detected":[90],"at":[91,151,159,190,195,204,208,213],"highest":[93,136],"dose":[95,137],"tested,":[96],"while":[97],"levels":[100,166],"reduced":[106],"below":[108],"limit":[110],"detection.":[112],"Co-injection":[113],"into":[118],"ligated":[119],"sections":[120],"inhibited":[124,186],"absorption":[126],"manner,":[132],"such":[133],"almost":[140],"completely":[141],"blocked":[142],"carcinogen":[143,177],"uptake.":[144],"Finally,":[145],"gavage":[150],"time":[152],"0":[153,191,205],"h":[154,175,192,197,210,215],"treated":[156],"various":[160],"times":[161],"thereafter":[162],"measured":[168],"liver":[171],"colon":[173,218],"6":[174],"exposure.":[178],"Compared":[179],"controls":[181],"alone,":[184],"79%":[189],"40%":[194],"1":[196,209],"liver,":[200],"63%":[203],"h,":[206],"38%":[207],"58%":[212],"24":[214],"(P":[219],"<":[220],"0.05":[221],"Student's":[223],"t-test).":[224],"These":[225],"results":[226],"support":[227],"involving":[230],"between":[233],"vivo":[238],"suggest":[240],"inhibitor":[243],"is":[244],"likely":[245],"be":[247],"most":[248],"effective":[249],"when":[250],"ingested":[251],"simultaneously":[252]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
