{"id":"https://openalex.org/W1992967175","doi":"https://doi.org/10.5732/cjc.012.10236","title":"Enhanced MGMT expression contributes to temozolomide resistance in glioma stem-like cells","display_name":"Enhanced MGMT expression contributes to temozolomide resistance in glioma stem-like cells","publication_year":2013,"publication_date":"2013-08-20","ids":{"openalex":"https://openalex.org/W1992967175","doi":"https://doi.org/10.5732/cjc.012.10236","mag":"1992967175","pmid":"https://pubmed.ncbi.nlm.nih.gov/23958055","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3935013"},"language":"en","primary_location":{"id":"doi:10.5732/cjc.012.10236","doi":"https://doi.org/10.5732/cjc.012.10236","is_oa":true,"landing_page_url":"https://doi.org/10.5732/cjc.012.10236","pdf_url":"http://www.cancercommun.com/cn/entopdf.asp?ly=CJC&idno=20344","source":{"id":"https://openalex.org/S4306555428","display_name":"\u764c\u75c7\uff1a\u82f1\u6587\u7248","issn_l":"1000-467X","issn":["1000-467X","1944-446X","2523-3548"],"is_oa":false,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","dongbi-b","ki-jl-1","medline","norway-2","poland-20","russia-white-list-1"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chinese Journal of Cancer","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"http://www.cancercommun.com/cn/entopdf.asp?ly=CJC&idno=20344","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5019979066","display_name":"Zhi-kun Qiu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210146711","display_name":"Sun Yat-sen University Cancer Center","ror":"https://ror.org/0400g8r85","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210146711"]},{"id":"https://openalex.org/I4391768007","display_name":"State Key Laboratory of Oncology in South China","ror":"https://ror.org/04dn2ax39","country_code":"CN","type":"facility","lineage":["https://openalex.org/I157773358","https://openalex.org/I4391768007"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhi-Kun Qiu","raw_affiliation_strings":["State Key Laboratory of Oncology in South China; Department of Neurosurgery/Neuro-oncology, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong 510060, P. R. China. chenzhp@sysucc.org.cn","State Key Laboratory of Oncology in South China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Oncology in South China; Department of Neurosurgery/Neuro-oncology, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong 510060, P. R. China. chenzhp@sysucc.org.cn","institution_ids":["https://openalex.org/I4210146711","https://openalex.org/I4391768007"]},{"raw_affiliation_string":"State Key Laboratory of Oncology in South China","institution_ids":["https://openalex.org/I4391768007"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Dong Shen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]},{"id":"https://openalex.org/I4391768007","display_name":"State Key Laboratory of Oncology in South China","ror":"https://ror.org/04dn2ax39","country_code":"CN","type":"facility","lineage":["https://openalex.org/I157773358","https://openalex.org/I4391768007"]},{"id":"https://openalex.org/I76569877","display_name":"Southeast University","ror":"https://ror.org/04ct4d772","country_code":"CN","type":"education","lineage":["https://openalex.org/I76569877"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Dong Shen","raw_affiliation_strings":["Department of Oncology , The Affiliated Jiangyin Hospital of Southeast University Medical College , Jiangyin , Jiangsu 214400 , P. R. China","State Key Laboratory of Oncology in South China , Guangzhou , Guangdong 510060 , P. R. China;","Sun Yat-Sen University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology , The Affiliated Jiangyin Hospital of Southeast University Medical College , Jiangyin , Jiangsu 214400 , P. R. China","institution_ids":["https://openalex.org/I76569877"]},{"raw_affiliation_string":"State Key Laboratory of Oncology in South China , Guangzhou , Guangdong 510060 , P. R. China;","institution_ids":["https://openalex.org/I4391768007"]},{"raw_affiliation_string":"Sun Yat-Sen University","institution_ids":["https://openalex.org/I157773358"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110530855","display_name":"Yin-Sheng Chen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]},{"id":"https://openalex.org/I4210146711","display_name":"Sun Yat-sen University Cancer Center","ror":"https://ror.org/0400g8r85","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210146711"]},{"id":"https://openalex.org/I4391768007","display_name":"State Key Laboratory of Oncology in South China","ror":"https://ror.org/04dn2ax39","country_code":"CN","type":"facility","lineage":["https://openalex.org/I157773358","https://openalex.org/I4391768007"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yin-Sheng Chen","raw_affiliation_strings":["Department of Neurosurgery/Neuro-oncology , Sun Yat-sen University Cancer Center , Guangzhou , Guangdong 510060 , P. R. China;","State Key Laboratory of Oncology in South China , Guangzhou , Guangdong 510060 , P. R. China;","Sun Yat-Sen University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery/Neuro-oncology , Sun Yat-sen University Cancer Center , Guangzhou , Guangdong 510060 , P. R. China;","institution_ids":["https://openalex.org/I4210146711"]},{"raw_affiliation_string":"State Key Laboratory of Oncology in South China , Guangzhou , Guangdong 510060 , P. R. China;","institution_ids":["https://openalex.org/I4391768007"]},{"raw_affiliation_string":"Sun Yat-Sen University","institution_ids":["https://openalex.org/I157773358"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109977181","display_name":"Qun-Ying Yang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]},{"id":"https://openalex.org/I4210146711","display_name":"Sun Yat-sen University Cancer Center","ror":"https://ror.org/0400g8r85","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210146711"]},{"id":"https://openalex.org/I4391768007","display_name":"State Key Laboratory of Oncology in South China","ror":"https://ror.org/04dn2ax39","country_code":"CN","type":"facility","lineage":["https://openalex.org/I157773358","https://openalex.org/I4391768007"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qun-Ying Yang","raw_affiliation_strings":["Department of Neurosurgery/Neuro-oncology , Sun Yat-sen University Cancer Center , Guangzhou , Guangdong 510060 , P. R. China;","State Key Laboratory of Oncology in South China , Guangzhou , Guangdong 510060 , P. R. China;","Sun Yat-Sen University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery/Neuro-oncology , Sun Yat-sen University Cancer Center , Guangzhou , Guangdong 510060 , P. R. China;","institution_ids":["https://openalex.org/I4210146711"]},{"raw_affiliation_string":"State Key Laboratory of Oncology in South China , Guangzhou , Guangdong 510060 , P. R. China;","institution_ids":["https://openalex.org/I4391768007"]},{"raw_affiliation_string":"Sun Yat-Sen University","institution_ids":["https://openalex.org/I157773358"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109977182","display_name":"Cheng-Cheng Guo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]},{"id":"https://openalex.org/I4210146711","display_name":"Sun Yat-sen University Cancer Center","ror":"https://ror.org/0400g8r85","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210146711"]},{"id":"https://openalex.org/I4391768007","display_name":"State Key Laboratory of Oncology in South China","ror":"https://ror.org/04dn2ax39","country_code":"CN","type":"facility","lineage":["https://openalex.org/I157773358","https://openalex.org/I4391768007"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Cheng-Cheng Guo","raw_affiliation_strings":["Department of Neurosurgery/Neuro-oncology , Sun Yat-sen University Cancer Center , Guangzhou , Guangdong 510060 , P. R. China;","State Key Laboratory of Oncology in South China , Guangzhou , Guangdong 510060 , P. R. China;","Sun Yat-Sen University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery/Neuro-oncology , Sun Yat-sen University Cancer Center , Guangzhou , Guangdong 510060 , P. R. China;","institution_ids":["https://openalex.org/I4210146711"]},{"raw_affiliation_string":"State Key Laboratory of Oncology in South China , Guangzhou , Guangdong 510060 , P. R. China;","institution_ids":["https://openalex.org/I4391768007"]},{"raw_affiliation_string":"Sun Yat-Sen University","institution_ids":["https://openalex.org/I157773358"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Bing-Hong Feng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I190242452","display_name":"Guangdong Pharmaceutical University","ror":"https://ror.org/02vg7mz57","country_code":"CN","type":"education","lineage":["https://openalex.org/I190242452"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Bing-Hong Feng","raw_affiliation_strings":["Department of Pharmacology , Guangdong Pharmaceutical University , Guangzhou , Guangdong 510006 , P. R. China;","Guangdong College of Pharmacy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology , Guangdong Pharmaceutical University , Guangzhou , Guangdong 510006 , P. R. China;","institution_ids":["https://openalex.org/I190242452"]},{"raw_affiliation_string":"Guangdong College of Pharmacy","institution_ids":["https://openalex.org/I190242452"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5108578418","display_name":"Zhong Ping Chen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210146711","display_name":"Sun Yat-sen University Cancer Center","ror":"https://ror.org/0400g8r85","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210146711"]},{"id":"https://openalex.org/I4391768007","display_name":"State Key Laboratory of Oncology in South China","ror":"https://ror.org/04dn2ax39","country_code":"CN","type":"facility","lineage":["https://openalex.org/I157773358","https://openalex.org/I4391768007"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhong-Ping Chen","raw_affiliation_strings":["Department of Neurosurgery/Neuro-oncology, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong 510060, P. R. China","State Key Laboratory of Oncology in South China, Guangzhou, Guangdong 510060, P. R. China","Neurosurgery"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery/Neuro-oncology, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong 510060, P. R. China","institution_ids":["https://openalex.org/I4210146711"]},{"raw_affiliation_string":"State Key Laboratory of Oncology in South China, Guangzhou, Guangdong 510060, P. R. China","institution_ids":["https://openalex.org/I4391768007"]},{"raw_affiliation_string":"Neurosurgery","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3080,"currency":"USD","value_usd":3080},"apc_paid":null,"fwci":3.4735,"has_fulltext":true,"cited_by_count":83,"citation_normalized_percentile":{"value":0.93319747,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":96,"max":99},"biblio":{"volume":"33","issue":"2","first_page":"115","last_page":"122"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mgmt","display_name":"MGMT","score":0.8930000066757202},{"id":"https://openalex.org/keywords/o6-methylguanine-dna-methyltransferase","display_name":"O6-methylguanine-DNA methyltransferase","score":0.902999997138977},{"id":"https://openalex.org/keywords/temozolomide-resistance","display_name":"temozolomide resistance","score":0.9739999771118164},{"id":"https://openalex.org/keywords/glioma-stem-cells","display_name":"glioma stem cells","score":0.996999979019165},{"id":"https://openalex.org/keywords/nf-kappab","display_name":"NF-\u03baB","score":0.8659999966621399},{"id":"https://openalex.org/keywords/mg132","display_name":"MG132","score":0.9919999837875366},{"id":"https://openalex.org/keywords/alkylating-agent-resistance","display_name":"alkylating agent resistance","score":0.8510000109672546},{"id":"https://openalex.org/keywords/dna-alkylation-repair","display_name":"DNA alkylation repair","score":0.8029999732971191},{"id":"https://openalex.org/keywords/recurrent-glioma","display_name":"recurrent glioma","score":0.5759999752044678},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.5049999952316284}],"concepts":[{"id":"https://openalex.org/C2777389519","wikidata":"https://www.wikidata.org/wiki/Q425088","display_name":"Temozolomide","level":3,"score":0.9398664236068726},{"id":"https://openalex.org/C91965660","wikidata":"https://www.wikidata.org/wiki/Q415875","display_name":"Methyltransferase","level":4,"score":0.6989364624023438},{"id":"https://openalex.org/C2778227246","wikidata":"https://www.wikidata.org/wiki/Q1365309","display_name":"Glioma","level":2,"score":0.6859305500984192},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6331396102905273},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.5182885527610779},{"id":"https://openalex.org/C2779527866","wikidata":"https://www.wikidata.org/wiki/Q21118735","display_name":"O-6-methylguanine-DNA methyltransferase","level":5,"score":0.5077796578407288},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.493068665266037},{"id":"https://openalex.org/C81089528","wikidata":"https://www.wikidata.org/wiki/Q5134986","display_name":"clone (Java method)","level":3,"score":0.4619849622249603},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.4571222960948944},{"id":"https://openalex.org/C134935766","wikidata":"https://www.wikidata.org/wiki/Q210538","display_name":"DNA repair","level":3,"score":0.4247412085533142},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3263733386993408},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.1709507405757904},{"id":"https://openalex.org/C33288867","wikidata":"https://www.wikidata.org/wiki/Q518328","display_name":"Methylation","level":3,"score":0.15212076902389526},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.13768717646598816}],"mesh":[{"descriptor_ui":"D000077204","descriptor_name":"Temozolomide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003606","descriptor_name":"Dacarbazine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D003606","descriptor_name":"Dacarbazine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004357","descriptor_name":"Drug Synergism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005910","descriptor_name":"Glioma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005910","descriptor_name":"Glioma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007976","descriptor_name":"Leupeptins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D014411","descriptor_name":"Neoplastic Stem Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016328","descriptor_name":"NF-kappa B","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D016328","descriptor_name":"NF-kappa B","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018906","descriptor_name":"Antineoplastic Agents, Alkylating","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D019008","descriptor_name":"Drug Resistance, Neoplasm","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019853","descriptor_name":"O(6)-Methylguanine-DNA Methyltransferase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.5732/cjc.012.10236","doi":"https://doi.org/10.5732/cjc.012.10236","is_oa":true,"landing_page_url":"https://doi.org/10.5732/cjc.012.10236","pdf_url":"http://www.cancercommun.com/cn/entopdf.asp?ly=CJC&idno=20344","source":{"id":"https://openalex.org/S4306555428","display_name":"\u764c\u75c7\uff1a\u82f1\u6587\u7248","issn_l":"1000-467X","issn":["1000-467X","1944-446X","2523-3548"],"is_oa":false,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","dongbi-b","ki-jl-1","medline","norway-2","poland-20","russia-white-list-1"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chinese Journal of Cancer","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2916505","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/articles/PMC3935013","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3935013","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3935013","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chin J Cancer","raw_type":"Text"},{"id":"pmid:23958055","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23958055","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chinese journal of cancer","raw_type":"Journal Article"},{"id":"mag:3150460318","doi":null,"is_oa":true,"landing_page_url":"http://www.cqvip.com/QK/90720X/201402/49438541.html","pdf_url":null,"source":{"id":"https://openalex.org/S4306555428","display_name":"\u764c\u75c7\uff1a\u82f1\u6587\u7248","issn_l":"1000-467X","issn":["1000-467X","1944-446X","2523-3548"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","dongbi-b","ki-jl-1","medline","norway-2","poland-20","russia-white-list-1"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":"\u764c\u75c7\uff1a\u82f1\u6587\u7248","raw_type":null}],"best_oa_location":{"id":"doi:10.5732/cjc.012.10236","doi":"https://doi.org/10.5732/cjc.012.10236","is_oa":true,"landing_page_url":"https://doi.org/10.5732/cjc.012.10236","pdf_url":"http://www.cancercommun.com/cn/entopdf.asp?ly=CJC&idno=20344","source":{"id":"https://openalex.org/S4306555428","display_name":"\u764c\u75c7\uff1a\u82f1\u6587\u7248","issn_l":"1000-467X","issn":["1000-467X","1944-446X","2523-3548"],"is_oa":false,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","dongbi-b","ki-jl-1","medline","norway-2","poland-20","russia-white-list-1"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chinese Journal of Cancer","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1992967175.pdf","grobid_xml":"https://content.openalex.org/works/W1992967175.grobid-xml"},"referenced_works_count":28,"referenced_works":["https://openalex.org/W58655401","https://openalex.org/W1968226383","https://openalex.org/W1971344938","https://openalex.org/W1975372331","https://openalex.org/W1975992482","https://openalex.org/W1976488065","https://openalex.org/W1983596157","https://openalex.org/W1990757263","https://openalex.org/W1991800191","https://openalex.org/W1999549596","https://openalex.org/W2000468534","https://openalex.org/W2001544973","https://openalex.org/W2051994734","https://openalex.org/W2060551076","https://openalex.org/W2081447858","https://openalex.org/W2090185653","https://openalex.org/W2096287682","https://openalex.org/W2121560055","https://openalex.org/W2133175627","https://openalex.org/W2138964047","https://openalex.org/W2151891352","https://openalex.org/W2153903134","https://openalex.org/W2154450774","https://openalex.org/W2157069447","https://openalex.org/W2167414381","https://openalex.org/W2167650288","https://openalex.org/W2328946792","https://openalex.org/W2363744459"],"related_works":["https://openalex.org/W2793271304","https://openalex.org/W2885328228","https://openalex.org/W2147500079","https://openalex.org/W2158751879","https://openalex.org/W2158088774","https://openalex.org/W2884785743","https://openalex.org/W2600576384","https://openalex.org/W2031461112","https://openalex.org/W1968601707","https://openalex.org/W2202848214"],"abstract_inverted_index":{"O6-methylguanine":[0],"DNA":[1,6,12],"methyltransferase":[2],"(MGMT)":[3],"can":[4],"remove":[5],"alkylation":[7],"adducts,":[8],"thereby":[9],"repairing":[10],"damaged":[11],"and":[13,39,53,58,76,87,99,111,121,166,226],"contributing":[14],"to":[15,21,33,49,139,192,247],"the":[16,37,59,95,108,119,157,175,185,210],"drug":[17],"resistance":[18,41,249],"of":[19,42,61,162,194,212],"gliomas":[20],"alkylating":[22],"agents.":[23],"In":[24,44,133],"addition,":[25,134],"glioma":[26,124,144],"stem-like":[27],"cells":[28],"(GSCs)":[29],"have":[30],"been":[31],"demonstrated":[32],"be":[34],"involved":[35],"in":[36,56,156,232,250],"recurrence":[38],"treatment":[40],"gliomas.":[43],"this":[45],"study,":[46],"we":[47,173,203],"aimed":[48],"investigate":[50],"MGMT":[51,62,206,229,244],"expression":[52,207,214,225,245],"regulatory":[54],"mechanisms":[55],"GSCs":[57,67,93,120,135,168,177,195],"association":[60],"with":[63,178,197],"temozolomide":[64],"(TMZ)":[65],"sensitivity.":[66],"were":[68,127,136],"enriched":[69],"from":[70,94,107],"one":[71],"MGMT-positive":[72,165,176,237,251],"cell":[73,79,101,113,125,145],"line":[74],"(SF-767)":[75],"7":[77],"MGMT-negative":[78,167],"lines":[80,102,114,126,146],"(U251,":[81],"SKMG-4,":[82],"SKMG-1,":[83],"SF295,":[84],"U87,":[85],"MGR1,":[86],"MGR2)":[88],"through":[89,209],"serum-free":[90],"clone":[91],"culture.":[92],"U251G,":[96],"SKMG-4G,":[97],"SF295G,":[98],"SKMG-1G":[100],"became":[103],"MGMT-positive,":[104],"but":[105],"those":[106],"U87G,":[109],"MGR1G,":[110],"MGR2G":[112],"remained":[115],"MGMT-negative.":[116],"However,":[117,150],"all":[118],"their":[122,142],"parental":[123,143],"positive":[128],"for":[129],"nuclear":[130],"factor-\u03baB":[131],"(NF-\u03baB).":[132],"more":[137],"resistant":[138],"TMZ":[140,163,179,198,248],"than":[141],"(P":[147,169,200],"<":[148],"0.05).":[149,171],"there":[151],"was":[152,188],"no":[153],"significant":[154],"difference":[155],"50%":[158],"inhibition":[159],"concentration":[160],"(IC50)":[161],"between":[164],">":[170],"When":[172],"treated":[174,196],"plus":[180],"MG-132":[181,221],"(an":[182],"NF-\u03baB":[183,213,224],"inhibitor),":[184],"antitumor":[186],"activity":[187],"significantly":[189],"enhanced":[190,243],"compared":[191],"that":[193,205,220,242],"alone":[199],"<0.05).":[201],"Furthermore,":[202],"found":[204],"decreased":[208],"down-regulation":[211],"by":[215],"MG-132.":[216],"Our":[217],"results":[218,240],"show":[219],"may":[222],"inhibit":[223],"further":[227],"decrease":[228],"expression,":[230],"resulting":[231],"a":[233],"synergistic":[234],"effect":[235],"on":[236],"GSCs.":[238,252],"These":[239],"indicate":[241],"contributes":[246]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":8},{"year":2019,"cited_by_count":9},{"year":2018,"cited_by_count":10},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":10},{"year":2015,"cited_by_count":7},{"year":2014,"cited_by_count":4}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}