{"id":"https://openalex.org/W1992964095","doi":"https://doi.org/10.1073/pnas.86.13.4833","title":"Deletions of bases in one strand of duplex DNA, in contrast to single-base mismatches, produce highly kinked molecules: possible relevance to the folding of single-stranded nucleic acids.","display_name":"Deletions of bases in one strand of duplex DNA, in contrast to single-base mismatches, produce highly kinked molecules: possible relevance to the folding of single-stranded nucleic acids.","publication_year":1989,"publication_date":"1989-07-01","ids":{"openalex":"https://openalex.org/W1992964095","doi":"https://doi.org/10.1073/pnas.86.13.4833","mag":"1992964095","pmid":"https://pubmed.ncbi.nlm.nih.gov/2740330","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/297509"},"language":"en","primary_location":{"id":"doi:10.1073/pnas.86.13.4833","doi":"https://doi.org/10.1073/pnas.86.13.4833","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.86.13.4833","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","datacite","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/297509","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"C H Hsieh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]},{"id":"https://openalex.org/I4390039329","display_name":"UNC Lineberger Comprehensive Cancer Center","ror":"https://ror.org/043ehm030","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I114027177","https://openalex.org/I4390039329"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"C H Hsieh","raw_affiliation_strings":["Lineberger Cancer Research Center, University of North Carolina, Chapel Hill 27514"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lineberger Cancer Research Center, University of North Carolina, Chapel Hill 27514","institution_ids":["https://openalex.org/I114027177","https://openalex.org/I4390039329"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5061660001","display_name":"Jack D. Griffith","orcid":"https://orcid.org/0000-0002-8357-8689","observed_orcids":["https://orcid.org/0000-0002-8357-8689"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]},{"id":"https://openalex.org/I4390039329","display_name":"UNC Lineberger Comprehensive Cancer Center","ror":"https://ror.org/043ehm030","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I114027177","https://openalex.org/I4390039329"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J D Griffith","raw_affiliation_strings":["Lineberger Cancer Research Center, University of North Carolina, Chapel Hill 27514","Microbiology and Immunology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lineberger Cancer Research Center, University of North Carolina, Chapel Hill 27514","institution_ids":["https://openalex.org/I114027177","https://openalex.org/I4390039329"]},{"raw_affiliation_string":"Microbiology and Immunology","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.8642,"has_fulltext":true,"cited_by_count":101,"citation_normalized_percentile":{"value":0.92366749,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"86","issue":"13","first_page":"4833","last_page":"4837"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10432","display_name":"DNA and Nucleic Acid Chemistry","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10432","display_name":"DNA and Nucleic Acid Chemistry","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10207","display_name":"Advanced biosensing and bioanalysis techniques","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dna-duplex-structure","display_name":"DNA duplex structure","score":0.4869999885559082},{"id":"https://openalex.org/keywords/base-pair-mismatch","display_name":"mismatched base pairs","score":0.703000009059906},{"id":"https://openalex.org/keywords/dna-conformation","display_name":"DNA conformation","score":0.5709999799728394}],"concepts":[{"id":"https://openalex.org/C99611785","wikidata":"https://www.wikidata.org/wiki/Q6453233","display_name":"Duplex (building)","level":3,"score":0.8370344638824463},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.7353830337524414},{"id":"https://openalex.org/C24107716","wikidata":"https://www.wikidata.org/wiki/Q123619","display_name":"Nucleic acid","level":2,"score":0.687225878238678},{"id":"https://openalex.org/C185581394","wikidata":"https://www.wikidata.org/wiki/Q145911","display_name":"Base pair","level":3,"score":0.6538209915161133},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.5055334568023682},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.46174484491348267},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4486513137817383},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.4481486678123474},{"id":"https://openalex.org/C129312508","wikidata":"https://www.wikidata.org/wiki/Q133686","display_name":"Oligonucleotide","level":3,"score":0.44047629833221436},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3557239770889282},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2962031960487366},{"id":"https://openalex.org/C149923435","wikidata":"https://www.wikidata.org/wiki/Q37732","display_name":"Demography","level":1,"score":0.0},{"id":"https://openalex.org/C144024400","wikidata":"https://www.wikidata.org/wiki/Q21201","display_name":"Sociology","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D001482","descriptor_name":"Base Composition","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002872","descriptor_name":"Chromosome Deletion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":true},{"descriptor_ui":"D004270","descriptor_name":"DNA, Circular","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D008854","descriptor_name":"Microscopy, Electron","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009838","descriptor_name":"Oligodeoxyribonucleotides","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":false},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1073/pnas.86.13.4833","doi":"https://doi.org/10.1073/pnas.86.13.4833","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.86.13.4833","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:297509","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/297509","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"},{"id":"pmid:2740330","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2740330","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences of the United States of America","raw_type":"Journal Article"},{"id":"pmh:cdr.lib.unc.edu:h989rb20j","doi":null,"is_oa":true,"landing_page_url":"https://doi.org/10.17615/kwzm-4862","pdf_url":"https://doi.org/10.17615/kwzm-4862","source":{"id":"https://openalex.org/S4306401075","display_name":"Carolina Digital Repository (University of North Carolina at Chapel Hill)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I114027177","host_organization_name":"University of North Carolina at Chapel Hill","host_organization_lineage":["https://openalex.org/I114027177"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Proceedings of the National Academy of Sciences of the United States of America, 86(13)","raw_type":"Article"},{"id":"doi:10.17615/kwzm-4862","doi":"https://doi.org/10.17615/kwzm-4862","is_oa":true,"landing_page_url":"https://doi.org/10.17615/kwzm-4862","pdf_url":null,"source":{"id":"https://openalex.org/S7407051488","display_name":"UNC Libraries","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article-journal"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:297509","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/297509","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G2774293502","display_name":null,"funder_award_id":"GM-31819","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G3518478496","display_name":"DNA-Protein Interactions at the Replication Fork","funder_award_id":"R01GM031819","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320306095","display_name":"American Cancer Society","ror":"https://ror.org/02e463172"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1992964095.pdf","grobid_xml":"https://content.openalex.org/works/W1992964095.grobid-xml"},"referenced_works_count":23,"referenced_works":["https://openalex.org/W1496033005","https://openalex.org/W1500213776","https://openalex.org/W1515974446","https://openalex.org/W1556339856","https://openalex.org/W1593931761","https://openalex.org/W1972753448","https://openalex.org/W1983727450","https://openalex.org/W1993748356","https://openalex.org/W2002957935","https://openalex.org/W2004219644","https://openalex.org/W2019288084","https://openalex.org/W2039134750","https://openalex.org/W2042932259","https://openalex.org/W2052116279","https://openalex.org/W2055663672","https://openalex.org/W2065740427","https://openalex.org/W2082208974","https://openalex.org/W2086855283","https://openalex.org/W2087960471","https://openalex.org/W2101812812","https://openalex.org/W2118337143","https://openalex.org/W2322672979","https://openalex.org/W2414010368"],"related_works":["https://openalex.org/W1521377667","https://openalex.org/W2013709527","https://openalex.org/W1995130130","https://openalex.org/W2036042382","https://openalex.org/W1967878422","https://openalex.org/W2077447943","https://openalex.org/W2084182950","https://openalex.org/W7096564051","https://openalex.org/W2055745964","https://openalex.org/W2128374781"],"abstract_inverted_index":{"A":[0,51],"32-base-pair":[1],"(bp)":[2],"DNA":[3,45,153,183],"duplex":[4,152,173],"with":[5,66],"deletions":[6,88,99,121,143],"in":[7,14,36,58,112,170,177,184,198],"one":[8],"strand,":[9,17],"and":[10,24,39,188],"thus":[11],"extra":[12],"bases":[13,146],"the":[15,31,40,43,59,62,67,81,90,105,127,137,171,185,200],"opposing":[16],"was":[18,34,46],"ligated":[19],"head-to-tail":[20],"to":[21,180],"produce":[22,154],"linear":[23,32,63],"circular":[25,44],"multimers.":[26],"The":[27,192],"electrophoretic":[28],"mobility":[29,60,113,187],"of":[30,42,61,69,72,75,144,195,203],"multimers":[33,64],"analyzed":[35],"polyacrylamide":[37],"gels":[38],"size":[41,79],"determined":[47],"by":[48,101,123],"electron":[49,189],"microscopy.":[50],"1-base":[52,98,116,120],"deletion":[53],"produced":[54,93,108,174],"a":[55,70,76,109,115,131,148],"marked":[56],"retardation":[57],"coincident":[65],"formation":[68],"population":[71],"multimeric":[73],"circles":[74],"smaller":[77],"average":[78],"than":[80,114],"deletionless":[82,138],"32-mer;":[83],"2-,":[84],"3-,":[85],"or":[86,164],"4-base":[87],"at":[89,147],"same":[91,106,128],"site":[92,150],"proportionately":[94],"greater":[95,110],"effects.":[96],"Two":[97],"separated":[100],"10":[102],"bp":[103,125],"on":[104,126,151],"strand":[107,129],"reduction":[111],"deletion,":[117],"whereas":[118],"two":[119],"spaced":[122],"5":[124],"yielded":[130],"molecule":[132],"that":[133,142,156],"behaved":[134],"more":[135],"like":[136],"DNA.":[139],"We":[140],"conclude":[141],"1-4":[145],"single":[149,168],"molecules":[155],"behave":[157],"as":[158],"if":[159],"they":[160],"contain":[161],"sharp":[162],"bends":[163],"kinks.":[165],"In":[166],"contrast,":[167],"mismatches":[169],"32-bp":[172],"no":[175],"abnormality":[176],"behavior":[178],"relative":[179],"normally":[181],"base-paired":[182],"gel":[186],"microscopic":[190],"assays.":[191],"possible":[193],"role":[194],"such":[196],"structures":[197],"organizing":[199],"three-dimensional":[201],"folding":[202],"single-stranded":[204],"nucleic":[205],"acids":[206],"is":[207],"considered.":[208]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
