{"id":"https://openalex.org/W1992949591","doi":"https://doi.org/10.1126/science.281.5373.96","title":"Visualization of Specific B and T Lymphocyte Interactions in the Lymph Node","display_name":"Visualization of Specific B and T Lymphocyte Interactions in the Lymph Node","publication_year":1998,"publication_date":"1998-07-03","ids":{"openalex":"https://openalex.org/W1992949591","doi":"https://doi.org/10.1126/science.281.5373.96","mag":"1992949591","pmid":"https://pubmed.ncbi.nlm.nih.gov/9651253"},"language":"en","primary_location":{"id":"doi:10.1126/science.281.5373.96","doi":"https://doi.org/10.1126/science.281.5373.96","is_oa":false,"landing_page_url":"https://doi.org/10.1126/science.281.5373.96","pdf_url":null,"source":{"id":"https://openalex.org/S3880285","display_name":"Science","issn_l":"0036-8075","issn":["0036-8075","0193-4511","1095-9203"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315823","host_organization_name":"American Association for the Advancement of Science","host_organization_lineage":["https://openalex.org/P4310315823"],"host_organization_lineage_names":["American Association for the Advancement of Science"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5051046892","display_name":"Paul Garside","orcid":"https://orcid.org/0000-0001-5944-0287","observed_orcids":["https://orcid.org/0000-0001-5944-0287"]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]},{"id":"https://openalex.org/I2801120601","display_name":"Western Infirmary","ror":"https://ror.org/02e22bh87","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2800201399","https://openalex.org/I2801120601"]},{"id":"https://openalex.org/I7882870","display_name":"University of Glasgow","ror":"https://ror.org/00vtgdb53","country_code":"GB","type":"education","lineage":["https://openalex.org/I7882870"]}],"countries":["GB","US"],"is_corresponding":true,"raw_author_name":"Paul Garside","raw_affiliation_strings":["P. Garside, University of Glasgow, Department of Immunology, Western Infirmary, Glasgow, G11 6NT, United Kingdom. E. Ingulli, Department of Pediatrics, University of Minnesota Medical School, Minneapolis, MN 55455, USA. R. R. Merica, J. G. Johnson, M. K. Jenkins, Department of Microbiology and the Center for Immunology at the University of Minneota Medical School, Minneapolis, MN 55455, USA. R. J. Noelle, Dartmouth Medical College, Department of Microbiology, Lebanon, NH, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"P. Garside, University of Glasgow, Department of Immunology, Western Infirmary, Glasgow, G11 6NT, United Kingdom. E. Ingulli, Department of Pediatrics, University of Minnesota Medical School, Minneapolis, MN 55455, USA. R. R. Merica, J. G. Johnson, M. K. Jenkins, Department of Microbiology and the Center for Immunology at the University of Minneota Medical School, Minneapolis, MN 55455, USA. R. J. Noelle, Dartmouth Medical College, Department of Microbiology, Lebanon, NH, USA","institution_ids":["https://openalex.org/I130238516","https://openalex.org/I2801120601","https://openalex.org/I7882870"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039281014","display_name":"Elizabeth G. Ingulli","orcid":"https://orcid.org/0000-0003-2591-8945","observed_orcids":["https://orcid.org/0000-0003-2591-8945"]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]},{"id":"https://openalex.org/I2801120601","display_name":"Western Infirmary","ror":"https://ror.org/02e22bh87","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2800201399","https://openalex.org/I2801120601"]},{"id":"https://openalex.org/I7882870","display_name":"University of Glasgow","ror":"https://ror.org/00vtgdb53","country_code":"GB","type":"education","lineage":["https://openalex.org/I7882870"]}],"countries":["GB","US"],"is_corresponding":true,"raw_author_name":"Elizabeth Ingulli","raw_affiliation_strings":["P. Garside, University of Glasgow, Department of Immunology, Western Infirmary, Glasgow, G11 6NT, United Kingdom. E. Ingulli, Department of Pediatrics, University of Minnesota Medical School, Minneapolis, MN 55455, USA. R. R. Merica, J. G. Johnson, M. K. Jenkins, Department of Microbiology and the Center for Immunology at the University of Minneota Medical School, Minneapolis, MN 55455, USA. R. J. Noelle, Dartmouth Medical College, Department of Microbiology, Lebanon, NH, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"P. Garside, University of Glasgow, Department of Immunology, Western Infirmary, Glasgow, G11 6NT, United Kingdom. E. Ingulli, Department of Pediatrics, University of Minnesota Medical School, Minneapolis, MN 55455, USA. R. R. Merica, J. G. Johnson, M. K. Jenkins, Department of Microbiology and the Center for Immunology at the University of Minneota Medical School, Minneapolis, MN 55455, USA. R. J. Noelle, Dartmouth Medical College, Department of Microbiology, Lebanon, NH, USA","institution_ids":["https://openalex.org/I130238516","https://openalex.org/I2801120601","https://openalex.org/I7882870"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064454086","display_name":"Rebecca R. Merica","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]},{"id":"https://openalex.org/I2801120601","display_name":"Western Infirmary","ror":"https://ror.org/02e22bh87","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2800201399","https://openalex.org/I2801120601"]},{"id":"https://openalex.org/I7882870","display_name":"University of Glasgow","ror":"https://ror.org/00vtgdb53","country_code":"GB","type":"education","lineage":["https://openalex.org/I7882870"]}],"countries":["GB","US"],"is_corresponding":false,"raw_author_name":"Rebecca R. Merica","raw_affiliation_strings":["P. Garside, University of Glasgow, Department of Immunology, Western Infirmary, Glasgow, G11 6NT, United Kingdom. E. Ingulli, Department of Pediatrics, University of Minnesota Medical School, Minneapolis, MN 55455, USA. R. R. Merica, J. G. Johnson, M. K. Jenkins, Department of Microbiology and the Center for Immunology at the University of Minneota Medical School, Minneapolis, MN 55455, USA. R. J. Noelle, Dartmouth Medical College, Department of Microbiology, Lebanon, NH, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"P. Garside, University of Glasgow, Department of Immunology, Western Infirmary, Glasgow, G11 6NT, United Kingdom. E. Ingulli, Department of Pediatrics, University of Minnesota Medical School, Minneapolis, MN 55455, USA. R. R. Merica, J. G. Johnson, M. K. Jenkins, Department of Microbiology and the Center for Immunology at the University of Minneota Medical School, Minneapolis, MN 55455, USA. R. J. Noelle, Dartmouth Medical College, Department of Microbiology, Lebanon, NH, USA","institution_ids":["https://openalex.org/I130238516","https://openalex.org/I2801120601","https://openalex.org/I7882870"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103483335","display_name":"Julia G. Johnson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]},{"id":"https://openalex.org/I2801120601","display_name":"Western Infirmary","ror":"https://ror.org/02e22bh87","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2800201399","https://openalex.org/I2801120601"]},{"id":"https://openalex.org/I7882870","display_name":"University of Glasgow","ror":"https://ror.org/00vtgdb53","country_code":"GB","type":"education","lineage":["https://openalex.org/I7882870"]}],"countries":["GB","US"],"is_corresponding":false,"raw_author_name":"Julia G. Johnson","raw_affiliation_strings":["P. Garside, University of Glasgow, Department of Immunology, Western Infirmary, Glasgow, G11 6NT, United Kingdom. E. Ingulli, Department of Pediatrics, University of Minnesota Medical School, Minneapolis, MN 55455, USA. R. R. Merica, J. G. Johnson, M. K. Jenkins, Department of Microbiology and the Center for Immunology at the University of Minneota Medical School, Minneapolis, MN 55455, USA. R. J. Noelle, Dartmouth Medical College, Department of Microbiology, Lebanon, NH, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"P. Garside, University of Glasgow, Department of Immunology, Western Infirmary, Glasgow, G11 6NT, United Kingdom. E. Ingulli, Department of Pediatrics, University of Minnesota Medical School, Minneapolis, MN 55455, USA. R. R. Merica, J. G. Johnson, M. K. Jenkins, Department of Microbiology and the Center for Immunology at the University of Minneota Medical School, Minneapolis, MN 55455, USA. R. J. Noelle, Dartmouth Medical College, Department of Microbiology, Lebanon, NH, USA","institution_ids":["https://openalex.org/I130238516","https://openalex.org/I2801120601","https://openalex.org/I7882870"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050616725","display_name":"Randolph J. Noelle","orcid":"https://orcid.org/0000-0002-2222-2136","observed_orcids":["https://orcid.org/0000-0002-2222-2136"]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]},{"id":"https://openalex.org/I2801120601","display_name":"Western Infirmary","ror":"https://ror.org/02e22bh87","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2800201399","https://openalex.org/I2801120601"]},{"id":"https://openalex.org/I7882870","display_name":"University of Glasgow","ror":"https://ror.org/00vtgdb53","country_code":"GB","type":"education","lineage":["https://openalex.org/I7882870"]}],"countries":["GB","US"],"is_corresponding":false,"raw_author_name":"Randolph J. Noelle","raw_affiliation_strings":["P. Garside, University of Glasgow, Department of Immunology, Western Infirmary, Glasgow, G11 6NT, United Kingdom. E. Ingulli, Department of Pediatrics, University of Minnesota Medical School, Minneapolis, MN 55455, USA. R. R. Merica, J. G. Johnson, M. K. Jenkins, Department of Microbiology and the Center for Immunology at the University of Minneota Medical School, Minneapolis, MN 55455, USA. R. J. Noelle, Dartmouth Medical College, Department of Microbiology, Lebanon, NH, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"P. Garside, University of Glasgow, Department of Immunology, Western Infirmary, Glasgow, G11 6NT, United Kingdom. E. Ingulli, Department of Pediatrics, University of Minnesota Medical School, Minneapolis, MN 55455, USA. R. R. Merica, J. G. Johnson, M. K. Jenkins, Department of Microbiology and the Center for Immunology at the University of Minneota Medical School, Minneapolis, MN 55455, USA. R. J. Noelle, Dartmouth Medical College, Department of Microbiology, Lebanon, NH, USA","institution_ids":["https://openalex.org/I130238516","https://openalex.org/I2801120601","https://openalex.org/I7882870"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5007540366","display_name":"Marc K. Jenkins","orcid":"https://orcid.org/0000-0001-8009-7655","observed_orcids":["https://orcid.org/0000-0001-8009-7655"]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]},{"id":"https://openalex.org/I2801120601","display_name":"Western Infirmary","ror":"https://ror.org/02e22bh87","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2800201399","https://openalex.org/I2801120601"]},{"id":"https://openalex.org/I7882870","display_name":"University of Glasgow","ror":"https://ror.org/00vtgdb53","country_code":"GB","type":"education","lineage":["https://openalex.org/I7882870"]}],"countries":["GB","US"],"is_corresponding":true,"raw_author_name":"Marc K. Jenkins","raw_affiliation_strings":["P. Garside, University of Glasgow, Department of Immunology, Western Infirmary, Glasgow, G11 6NT, United Kingdom. E. Ingulli, Department of Pediatrics, University of Minnesota Medical School, Minneapolis, MN 55455, USA. R. R. Merica, J. G. Johnson, M. K. Jenkins, Department of Microbiology and the Center for Immunology at the University of Minneota Medical School, Minneapolis, MN 55455, USA. R. J. Noelle, Dartmouth Medical College, Department of Microbiology, Lebanon, NH, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"P. Garside, University of Glasgow, Department of Immunology, Western Infirmary, Glasgow, G11 6NT, United Kingdom. E. Ingulli, Department of Pediatrics, University of Minnesota Medical School, Minneapolis, MN 55455, USA. R. R. Merica, J. G. Johnson, M. K. Jenkins, Department of Microbiology and the Center for Immunology at the University of Minneota Medical School, Minneapolis, MN 55455, USA. R. J. Noelle, Dartmouth Medical College, Department of Microbiology, Lebanon, NH, USA","institution_ids":["https://openalex.org/I130238516","https://openalex.org/I2801120601","https://openalex.org/I7882870"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5007540366","https://openalex.org/A5039281014","https://openalex.org/A5051046892"],"corresponding_institution_ids":["https://openalex.org/I130238516","https://openalex.org/I2801120601","https://openalex.org/I7882870"],"apc_list":null,"apc_paid":null,"fwci":13.8789,"has_fulltext":false,"cited_by_count":774,"citation_normalized_percentile":{"value":0.99294703,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"281","issue":"5373","first_page":"96","last_page":"99"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/t-cell-b-cell-interaction","display_name":"T cell-B cell interaction","score":0.796999990940094},{"id":"https://openalex.org/keywords/lymph-nodes","display_name":"lymph nodes","score":0.6349999904632568},{"id":"https://openalex.org/keywords/germinal-center-formation","display_name":"germinal center formation","score":0.8880000114440918},{"id":"https://openalex.org/keywords/cd4-t-cells","display_name":"CD4+ T cells","score":0.8180000185966492},{"id":"https://openalex.org/keywords/b-cells","display_name":"B cells","score":0.828000009059906},{"id":"https://openalex.org/keywords/cd154","display_name":"CD154","score":0.7599999904632568},{"id":"https://openalex.org/keywords/b-cell-proliferation","display_name":"B cell proliferation","score":0.7120000123977661},{"id":"https://openalex.org/keywords/t-cell-activation","display_name":"T cell activation","score":0.7099999785423279},{"id":"https://openalex.org/keywords/humoral-immune-response","display_name":"humoral immune response","score":0.7990000247955322},{"id":"https://openalex.org/keywords/cell-tracking","display_name":"cell tracking","score":0.4749999940395355},{"id":"https://openalex.org/keywords/b-cell-follicles","display_name":"B cell follicles","score":0.7329999804496765}],"concepts":[{"id":"https://openalex.org/C96926380","wikidata":"https://www.wikidata.org/wiki/Q1737968","display_name":"Germinal center","level":4,"score":0.9256740808486938},{"id":"https://openalex.org/C2779234475","wikidata":"https://www.wikidata.org/wiki/Q14897851","display_name":"CD154","level":5,"score":0.8762719035148621},{"id":"https://openalex.org/C2778453870","wikidata":"https://www.wikidata.org/wiki/Q188930","display_name":"B cell","level":3,"score":0.6305829286575317},{"id":"https://openalex.org/C2780849966","wikidata":"https://www.wikidata.org/wiki/Q170758","display_name":"Lymph node","level":2,"score":0.6138513684272766},{"id":"https://openalex.org/C2779720271","wikidata":"https://www.wikidata.org/wiki/Q179422","display_name":"Lymph","level":2,"score":0.5838854312896729},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5296779870986938},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5161765217781067},{"id":"https://openalex.org/C39347974","wikidata":"https://www.wikidata.org/wiki/Q21135811","display_name":"CD40","level":4,"score":0.48811396956443787},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.4728394150733948},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4694010317325592},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.43899422883987427},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.43075573444366455},{"id":"https://openalex.org/C2777761686","wikidata":"https://www.wikidata.org/wiki/Q715347","display_name":"Lymphocyte","level":2,"score":0.4129975736141205},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.4113216996192932},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.3494030833244324},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.23202010989189148},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2215753197669983},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.19159695506095886},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.10116732120513916},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000917","descriptor_name":"Antibody Formation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001402","descriptor_name":"B-Lymphocytes","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D001402","descriptor_name":"B-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D002465","descriptor_name":"Cell Movement","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003713","descriptor_name":"Dendritic Cells","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D007075","descriptor_name":"Immunoglobulin M","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D007114","descriptor_name":"Immunization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008198","descriptor_name":"Lymph Nodes","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D008198","descriptor_name":"Lymph Nodes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D008213","descriptor_name":"Lymphocyte Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008562","descriptor_name":"Membrane Glycoproteins","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008807","descriptor_name":"Mice, Inbred BALB C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008822","descriptor_name":"Mice, Transgenic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010950","descriptor_name":"Plasma Cells","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015496","descriptor_name":"CD4-Positive T-Lymphocytes","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D015496","descriptor_name":"CD4-Positive T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D017951","descriptor_name":"Antigen Presentation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018858","descriptor_name":"Germinal Center","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D019264","descriptor_name":"Adoptive Transfer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023201","descriptor_name":"CD40 Ligand","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1126/science.281.5373.96","doi":"https://doi.org/10.1126/science.281.5373.96","is_oa":false,"landing_page_url":"https://doi.org/10.1126/science.281.5373.96","pdf_url":null,"source":{"id":"https://openalex.org/S3880285","display_name":"Science","issn_l":"0036-8075","issn":["0036-8075","0193-4511","1095-9203"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315823","host_organization_name":"American Association for the Advancement of Science","host_organization_lineage":["https://openalex.org/P4310315823"],"host_organization_lineage_names":["American Association for the Advancement of Science"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science","raw_type":"journal-article"},{"id":"pmid:9651253","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9651253","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science (New York, N.Y.)","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1642810537","display_name":null,"funder_award_id":"AI27998","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G2685430039","display_name":null,"funder_award_id":"AI-35296","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G4015934978","display_name":"Tracking CD4+ Memory T Cells in Vivo","funder_award_id":"R01AI039614","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G598227692","display_name":null,"funder_award_id":"AI 39614","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G953428348","display_name":"Mechanisms of peripheral induction of T-cell tolerance","funder_award_id":"P01AI035296","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320311904","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":28,"referenced_works":["https://openalex.org/W1636162497","https://openalex.org/W1776883786","https://openalex.org/W1945926236","https://openalex.org/W1966949480","https://openalex.org/W1973842127","https://openalex.org/W1978790143","https://openalex.org/W1981525542","https://openalex.org/W2002073873","https://openalex.org/W2007289040","https://openalex.org/W2035470798","https://openalex.org/W2036160208","https://openalex.org/W2038574124","https://openalex.org/W2044163622","https://openalex.org/W2045008512","https://openalex.org/W2060640530","https://openalex.org/W2064438534","https://openalex.org/W2065973297","https://openalex.org/W2084072841","https://openalex.org/W2095903025","https://openalex.org/W2108914304","https://openalex.org/W2114955841","https://openalex.org/W2124010582","https://openalex.org/W2126503033","https://openalex.org/W2133951067","https://openalex.org/W2148753352","https://openalex.org/W2156961356","https://openalex.org/W2159149406","https://openalex.org/W6601760687"],"related_works":["https://openalex.org/W2114115717","https://openalex.org/W7095695634","https://openalex.org/W1990458269","https://openalex.org/W4255463871","https://openalex.org/W2612966494","https://openalex.org/W2017764407","https://openalex.org/W2063931211","https://openalex.org/W2069925530","https://openalex.org/W1621157891","https://openalex.org/W2790843038"],"abstract_inverted_index":{"Early":[0],"events":[1],"in":[2,9,30,43,62],"the":[3,31,36,44,53,56,85],"humoral":[4],"immune":[5],"response":[6],"were":[7,27,39],"visualized":[8],"lymph":[10],"nodes":[11],"by":[12],"simultaneous":[13],"tracking":[14],"of":[15,55,76],"antigen-specific":[16],"CD4":[17],"T":[18,25,32],"and":[19,58,67,81],"B":[20,37,45,64],"cells":[21,26,38],"after":[22],"immunization.":[23],"The":[24],"initially":[28],"activated":[29],"cell":[33,65,79],"areas":[34],"when":[35],"still":[40],"randomly":[41],"dispersed":[42],"cell-rich":[46],"follicles.":[47],"Both":[48],"populations":[49],"then":[50],"migrated":[51],"to":[52,84],"edges":[54],"follicles":[57],"interacted":[59],"there,":[60],"resulting":[61],"CD154-dependent":[63],"proliferation":[66],"germinal":[68],"center":[69],"formation.":[70],"These":[71],"results":[72],"provide":[73],"visual":[74],"documentation":[75],"cognate":[77],"T-B":[78],"interactions":[80],"localize":[82],"them":[83],"follicular":[86],"border.":[87]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":16},{"year":2024,"cited_by_count":16},{"year":2023,"cited_by_count":9},{"year":2022,"cited_by_count":12},{"year":2021,"cited_by_count":22},{"year":2020,"cited_by_count":18},{"year":2019,"cited_by_count":20},{"year":2018,"cited_by_count":28},{"year":2017,"cited_by_count":17},{"year":2016,"cited_by_count":18},{"year":2015,"cited_by_count":23},{"year":2014,"cited_by_count":24},{"year":2013,"cited_by_count":22},{"year":2012,"cited_by_count":37}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}