{"id":"https://openalex.org/W1992907775","doi":"https://doi.org/10.2147/jbm.s7224","title":"Homeostatic and pathogenic extramedullary hematopoiesis","display_name":"Homeostatic and pathogenic extramedullary hematopoiesis","publication_year":2010,"publication_date":"2010-03-01","ids":{"openalex":"https://openalex.org/W1992907775","doi":"https://doi.org/10.2147/jbm.s7224","mag":"1992907775","pmid":"https://pubmed.ncbi.nlm.nih.gov/22282679","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3262334"},"language":"en","primary_location":{"id":"doi:10.2147/jbm.s7224","doi":"https://doi.org/10.2147/jbm.s7224","is_oa":true,"landing_page_url":"https://doi.org/10.2147/jbm.s7224","pdf_url":"https://www.dovepress.com/getfile.php?fileID=5940","source":{"id":"https://openalex.org/S2765050986","display_name":"Journal of Blood Medicine","issn_l":"1179-2736","issn":["1179-2736"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","norway-1","oarl","poland-100","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320348","host_organization_name":"Dove Medical Press","host_organization_lineage":["https://openalex.org/P4310320348","https://openalex.org/P4310320547"],"host_organization_lineage_names":["Dove Medical Press","Taylor & Francis"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Blood Medicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.dovepress.com/getfile.php?fileID=5940","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5084743693","display_name":"Chang H. Kim","orcid":"https://orcid.org/0000-0003-4618-9139","observed_orcids":["https://orcid.org/0000-0003-4618-9139"]},"institutions":[{"id":"https://openalex.org/I219193219","display_name":"Purdue University West Lafayette","ror":"https://ror.org/02dqehb95","country_code":"US","type":"education","lineage":["https://openalex.org/I219193219"]},{"id":"https://openalex.org/I4390039259","display_name":"Purdue University Institute for Cancer Research","ror":"https://ror.org/0371gg960","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039259"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Chang Kim","raw_affiliation_strings":["Laboratory of Immunology and Hematopoiesis, Department of Comparative Pathobiology; Purdue Cancer Center, Purdue University, West Lafayette, IN, USA","Laboratory of Immunology and Hematopoiesis, Department of Comparative Pathobiology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Immunology and Hematopoiesis, Department of Comparative Pathobiology; Purdue Cancer Center, Purdue University, West Lafayette, IN, USA","institution_ids":["https://openalex.org/I219193219","https://openalex.org/I4390039259"]},{"raw_affiliation_string":"Laboratory of Immunology and Hematopoiesis, Department of Comparative Pathobiology","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5084743693"],"corresponding_institution_ids":["https://openalex.org/I219193219","https://openalex.org/I4390039259"],"apc_list":{"value":2320,"currency":"USD","value_usd":2320},"apc_paid":{"value":2320,"currency":"USD","value_usd":2320},"fwci":2.746,"has_fulltext":true,"cited_by_count":255,"citation_normalized_percentile":{"value":0.90684254,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":100},"biblio":{"volume":"1","issue":null,"first_page":"13","last_page":"13"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.8568999767303467,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.8568999767303467,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.025200000032782555,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12919","display_name":"Blood disorders and treatments","score":0.018699999898672104,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/extramedullary-hematopoiesis","display_name":"extramedullary hematopoiesis","score":1.0},{"id":"https://openalex.org/keywords/fetal-hematopoiesis","display_name":"fetal hematopoiesis","score":0.7960000038146973},{"id":"https://openalex.org/keywords/myelofibrosis","display_name":"myelofibrosis","score":0.7730000019073486},{"id":"https://openalex.org/keywords/myelopoiesis","display_name":"myelopoiesis","score":0.8700000047683716},{"id":"https://openalex.org/keywords/cytokines","display_name":"cytokines","score":0.7730000019073486},{"id":"https://openalex.org/keywords/myeloid-derived-suppressor-cells","display_name":"myeloid-derived suppressor cells","score":0.9760000109672546},{"id":"https://openalex.org/keywords/t-cells","display_name":"T cells","score":0.7599999904632568},{"id":"https://openalex.org/keywords/infection","display_name":"infection","score":0.8970000147819519},{"id":"https://openalex.org/keywords/dendritic-cells","display_name":"dendritic cells","score":0.9950000047683716},{"id":"https://openalex.org/keywords/foxp3","display_name":"Foxp3","score":0.9860000014305115},{"id":"https://openalex.org/keywords/spleen","display_name":"spleen","score":0.7699999809265137},{"id":"https://openalex.org/keywords/liver","display_name":"liver","score":0.9470000267028809},{"id":"https://openalex.org/keywords/antigen-presenting-cells","display_name":"antigen-presenting cells","score":0.7639999985694885},{"id":"https://openalex.org/keywords/hematopoietic-stem-and-progenitor-cells","display_name":"hematopoietic stem and progenitor cells","score":0.7649999856948853}],"concepts":[{"id":"https://openalex.org/C2778080410","wikidata":"https://www.wikidata.org/wiki/Q5422215","display_name":"Extramedullary hematopoiesis","level":4,"score":0.7755225896835327},{"id":"https://openalex.org/C109159458","wikidata":"https://www.wikidata.org/wiki/Q919283","display_name":"Haematopoiesis","level":3,"score":0.7652575969696045},{"id":"https://openalex.org/C2780007613","wikidata":"https://www.wikidata.org/wiki/Q546523","display_name":"Bone marrow","level":2,"score":0.6974797248840332},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.592681348323822},{"id":"https://openalex.org/C2780931953","wikidata":"https://www.wikidata.org/wiki/Q9371","display_name":"Spleen","level":2,"score":0.5764658451080322},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.5325950980186462},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.5285680890083313},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.48827028274536133},{"id":"https://openalex.org/C2780076729","wikidata":"https://www.wikidata.org/wiki/Q1752571","display_name":"Myelofibrosis","level":3,"score":0.48037442564964294},{"id":"https://openalex.org/C518705261","wikidata":"https://www.wikidata.org/wiki/Q25615","display_name":"Connective tissue","level":2,"score":0.452623575925827},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.42729753255844116},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4164654314517975},{"id":"https://openalex.org/C2777043721","wikidata":"https://www.wikidata.org/wiki/Q369887","display_name":"Yolk sac","level":3,"score":0.4112669825553894},{"id":"https://openalex.org/C201750760","wikidata":"https://www.wikidata.org/wiki/Q1896218","display_name":"Progenitor cell","level":3,"score":0.41050633788108826},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3803071081638336},{"id":"https://openalex.org/C196843134","wikidata":"https://www.wikidata.org/wiki/Q33196","display_name":"Embryo","level":2,"score":0.0}],"mesh":[],"locations_count":6,"locations":[{"id":"doi:10.2147/jbm.s7224","doi":"https://doi.org/10.2147/jbm.s7224","is_oa":true,"landing_page_url":"https://doi.org/10.2147/jbm.s7224","pdf_url":"https://www.dovepress.com/getfile.php?fileID=5940","source":{"id":"https://openalex.org/S2765050986","display_name":"Journal of Blood Medicine","issn_l":"1179-2736","issn":["1179-2736"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","norway-1","oarl","poland-100","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320348","host_organization_name":"Dove Medical Press","host_organization_lineage":["https://openalex.org/P4310320348","https://openalex.org/P4310320547"],"host_organization_lineage_names":["Dove Medical Press","Taylor & Francis"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Blood Medicine","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2271399","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3262334","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3262334","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3262334","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Blood Med","raw_type":"Text"},{"id":"pmid:22282679","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22282679","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of blood medicine","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:8d23c02c95da4e739965a70660381567","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/8d23c02c95da4e739965a70660381567","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Blood Medicine, Vol 2010, Iss default, Pp 13-19 (2010)","raw_type":"article"},{"id":"pmh:oai:dovepress.com/4116","doi":null,"is_oa":true,"landing_page_url":"https://www.dovepress.com/homeostatic-and-pathogenic-extramedullary-hematopoiesis-peer-reviewed-article-JBM","pdf_url":null,"source":{"id":"https://openalex.org/S4306401012","display_name":"Dove Medical Press (Taylor and Francis Group)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Review"}],"best_oa_location":{"id":"doi:10.2147/jbm.s7224","doi":"https://doi.org/10.2147/jbm.s7224","is_oa":true,"landing_page_url":"https://doi.org/10.2147/jbm.s7224","pdf_url":"https://www.dovepress.com/getfile.php?fileID=5940","source":{"id":"https://openalex.org/S2765050986","display_name":"Journal of Blood Medicine","issn_l":"1179-2736","issn":["1179-2736"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","norway-1","oarl","poland-100","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320348","host_organization_name":"Dove Medical Press","host_organization_lineage":["https://openalex.org/P4310320348","https://openalex.org/P4310320547"],"host_organization_lineage_names":["Dove Medical Press","Taylor & Francis"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Blood Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"study_designs":[],"awards":[{"id":"https://openalex.org/G6944290068","display_name":"FoxP3+ T cells of mucosal tissues","funder_award_id":"R01AI074745","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G8094053593","display_name":"Migration and function of Th17 cells in the gut","funder_award_id":"R56AI080769","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G8360782975","display_name":"Therapeutic delivery of FoxP3+ T cells to the intestine","funder_award_id":"R01DK076616","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320306230","display_name":"American Heart Association","ror":"https://ror.org/013kjyp64"},{"id":"https://openalex.org/F4320306301","display_name":"Crohn's and Colitis Foundation of America","ror":"https://ror.org/05f2xbq60"},{"id":"https://openalex.org/F4320312926","display_name":"Crohn's and Colitis Foundation","ror":"https://ror.org/05f2xbq60"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1992907775.pdf","grobid_xml":"https://content.openalex.org/works/W1992907775.grobid-xml"},"referenced_works_count":56,"referenced_works":["https://openalex.org/W154007311","https://openalex.org/W247577800","https://openalex.org/W1486067478","https://openalex.org/W1516957658","https://openalex.org/W1862694926","https://openalex.org/W1942668068","https://openalex.org/W1962974321","https://openalex.org/W1974715609","https://openalex.org/W1975025595","https://openalex.org/W1977758974","https://openalex.org/W1981601043","https://openalex.org/W1982233679","https://openalex.org/W1987470267","https://openalex.org/W1989138809","https://openalex.org/W1992371996","https://openalex.org/W1993360280","https://openalex.org/W1995188840","https://openalex.org/W1997802371","https://openalex.org/W2001192978","https://openalex.org/W2002302430","https://openalex.org/W2004150448","https://openalex.org/W2010828705","https://openalex.org/W2014654537","https://openalex.org/W2021276131","https://openalex.org/W2028359609","https://openalex.org/W2057360098","https://openalex.org/W2060610551","https://openalex.org/W2070793750","https://openalex.org/W2077330278","https://openalex.org/W2080586246","https://openalex.org/W2081093457","https://openalex.org/W2082414007","https://openalex.org/W2086243699","https://openalex.org/W2087143957","https://openalex.org/W2090159434","https://openalex.org/W2090754147","https://openalex.org/W2093818708","https://openalex.org/W2094457899","https://openalex.org/W2097460448","https://openalex.org/W2116878961","https://openalex.org/W2120372000","https://openalex.org/W2125410884","https://openalex.org/W2133891229","https://openalex.org/W2139719464","https://openalex.org/W2140413558","https://openalex.org/W2143193295","https://openalex.org/W2146505525","https://openalex.org/W2155338282","https://openalex.org/W2156330412","https://openalex.org/W2157269800","https://openalex.org/W2161661627","https://openalex.org/W2282468090","https://openalex.org/W2396607455","https://openalex.org/W2409029922","https://openalex.org/W2505537325","https://openalex.org/W4377428108"],"related_works":["https://openalex.org/W4200413168","https://openalex.org/W3001823351","https://openalex.org/W4392472972","https://openalex.org/W2901905257","https://openalex.org/W7100366215","https://openalex.org/W7097633505","https://openalex.org/W3086930234","https://openalex.org/W4298328775","https://openalex.org/W2170969735","https://openalex.org/W3205214020"],"abstract_inverted_index":{"Homeostatic":[0],"and":[1,10,51,70,89,97,109,150],"pathogenic":[2],"extramedullary":[3],"hematopoiesis":[4,26,31],"Chang":[5],"H":[6],"KimLaboratory":[7],"of":[8,13,36,59,94,152,156],"Immunology":[9],"Hematopoiesis,":[11],"Department":[12],"Comparative":[14],"Pathobiology;":[15],"Purdue":[16,19],"Cancer":[17],"Center,":[18],"University,":[20],"West":[21],"Lafayette,":[22],"IN,":[23],"USAAbstract:":[24],"Extramedullary":[25],"(EH)":[27],"is":[28],"defined":[29],"as":[30],"occurring":[32],"in":[33,42,64,86,112,135,140],"organs":[34],"outside":[35],"the":[37,65,87,92,103,141,147,153],"bone":[38],"marrow;":[39],"it":[40],"occurs":[41,63,74,85,101,130],"diverse":[43,138],"conditions,":[44,115],"including":[45,116],"fetal":[46,55,68],"development,":[47,56],"normal":[48],"immune":[49,77],"responses,":[50],"pathological":[52,114],"circumstances.":[53],"During":[54],"before":[57],"formation":[58],"mature":[60],"marrow,":[61],"EH":[62,72,99,129],"yolk":[66],"sac,":[67],"liver,":[69],"spleen.":[71],"also":[73,100],"during":[75],"active":[76],"responses":[78],"to":[79,137],"pathogens.":[80],"Most":[81],"frequently,":[82],"this":[83],"response":[84,136],"spleen":[88],"liver":[90],"for":[91,107],"production":[93],"antigen-presenting":[95],"cells":[96,111,120],"phagocytes.":[98],"when":[102],"marrow":[104,119],"becomes":[105],"inhabitable":[106],"stem":[108],"progenitor":[110],"certain":[113],"myelofibrosis,":[117],"where":[118],"are":[121],"replaced":[122],"with":[123],"collagenous":[124],"connective":[125],"tissue":[126],"fibers.":[127],"Thus,":[128],"either":[131],"actively":[132],"or":[133],"passively":[134],"changes":[139],"hematopoietic":[142],"environment.":[143],"This":[144],"article":[145],"reviews":[146],"key":[148],"features":[149],"regulators":[151],"major":[154],"types":[155],"EH.Keywords:":[157],"myelopoiesis,":[158],"cytokines,":[159],"myeloid":[160],"derived":[161],"suppressor":[162],"cells,":[163,165,168],"T":[164],"infection,":[166],"dendritic":[167],"FoxP3,":[169],"myelofibrosis":[170]},"counts_by_year":[{"year":2026,"cited_by_count":15},{"year":2025,"cited_by_count":13},{"year":2024,"cited_by_count":19},{"year":2023,"cited_by_count":17},{"year":2022,"cited_by_count":26},{"year":2021,"cited_by_count":25},{"year":2020,"cited_by_count":26},{"year":2019,"cited_by_count":20},{"year":2018,"cited_by_count":27},{"year":2017,"cited_by_count":18},{"year":2016,"cited_by_count":10},{"year":2015,"cited_by_count":11},{"year":2014,"cited_by_count":14},{"year":2013,"cited_by_count":10},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
