{"id":"https://openalex.org/W1992871908","doi":"https://doi.org/10.1111/j.1365-2141.2008.07132.x","title":"Relapse prediction in acute myeloid leukaemia patients in complete remission using WT1 as a molecular marker: development of a mathematical model to predict time from molecular to clinical relapse and define optimal sampling intervals","display_name":"Relapse prediction in acute myeloid leukaemia patients in complete remission using WT1 as a molecular marker: development of a mathematical model to predict time from molecular to clinical relapse and define optimal sampling intervals","publication_year":2008,"publication_date":"2008-04-10","ids":{"openalex":"https://openalex.org/W1992871908","doi":"https://doi.org/10.1111/j.1365-2141.2008.07132.x","mag":"1992871908","pmid":"https://pubmed.ncbi.nlm.nih.gov/18410450"},"language":"en","primary_location":{"id":"doi:10.1111/j.1365-2141.2008.07132.x","doi":"https://doi.org/10.1111/j.1365-2141.2008.07132.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1365-2141.2008.07132.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1365-2141.2008.07132.x","source":{"id":"https://openalex.org/S153015021","display_name":"British Journal of Haematology","issn_l":"0007-1048","issn":["0007-1048","1365-2141"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Haematology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1365-2141.2008.07132.x","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5078544325","display_name":"Hans Beier Ommen","orcid":"https://orcid.org/0000-0001-7628-8694","observed_orcids":["https://orcid.org/0000-0001-7628-8694"]},"institutions":[{"id":"https://openalex.org/I2802335433","display_name":"Aarhus University Hospital","ror":"https://ror.org/040r8fr65","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2802335433"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Hans Beier Ommen","raw_affiliation_strings":["The Laboratory of Immunohematology, Department of Haematology, Arhus University Hospital, Arhus, Denmark","The Laboratory of Immunohematology, Department of Haematology, \u00c5rhus University Hospital, \u00c5rhus, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Laboratory of Immunohematology, Department of Haematology, Arhus University Hospital, Arhus, Denmark","institution_ids":["https://openalex.org/I2802335433"]},{"raw_affiliation_string":"The Laboratory of Immunohematology, Department of Haematology, \u00c5rhus University Hospital, \u00c5rhus, Denmark","institution_ids":["https://openalex.org/I2802335433"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021059631","display_name":"Charlotte Guldborg Nyvold","orcid":"https://orcid.org/0000-0002-0411-7594","observed_orcids":["https://orcid.org/0000-0002-0411-7594"]},"institutions":[{"id":"https://openalex.org/I2802335433","display_name":"Aarhus University Hospital","ror":"https://ror.org/040r8fr65","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2802335433"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Charlotte Guldborg Nyvold","raw_affiliation_strings":["The Laboratory of Immunohematology, Department of Haematology, A\u030arhus University Hospital, A\u030arhus, Denmark","The Laboratory of Immunohematology, Department of Haematology, \u00c5rhus University Hospital, \u00c5rhus, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Laboratory of Immunohematology, Department of Haematology, A\u030arhus University Hospital, A\u030arhus, Denmark","institution_ids":["https://openalex.org/I2802335433"]},{"raw_affiliation_string":"The Laboratory of Immunohematology, Department of Haematology, \u00c5rhus University Hospital, \u00c5rhus, Denmark","institution_ids":["https://openalex.org/I2802335433"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083863081","display_name":"Karin Br\u00e6ndstrup","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802335433","display_name":"Aarhus University Hospital","ror":"https://ror.org/040r8fr65","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2802335433"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Karin Br\u00e6ndstrup","raw_affiliation_strings":["The Laboratory of Immunohematology, Department of Haematology, A\u030arhus University Hospital, A\u030arhus, Denmark","The Laboratory of Immunohematology, Department of Haematology, \u00c5rhus University Hospital, \u00c5rhus, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Laboratory of Immunohematology, Department of Haematology, A\u030arhus University Hospital, A\u030arhus, Denmark","institution_ids":["https://openalex.org/I2802335433"]},{"raw_affiliation_string":"The Laboratory of Immunohematology, Department of Haematology, \u00c5rhus University Hospital, \u00c5rhus, Denmark","institution_ids":["https://openalex.org/I2802335433"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071186126","display_name":"Bodil Lind Andersen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802335433","display_name":"Aarhus University Hospital","ror":"https://ror.org/040r8fr65","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2802335433"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Bodil Lind Andersen","raw_affiliation_strings":["The Laboratory of Immunohematology, Department of Haematology, A\u030arhus University Hospital, A\u030arhus, Denmark","The Laboratory of Immunohematology, Department of Haematology, \u00c5rhus University Hospital, \u00c5rhus, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Laboratory of Immunohematology, Department of Haematology, A\u030arhus University Hospital, A\u030arhus, Denmark","institution_ids":["https://openalex.org/I2802335433"]},{"raw_affiliation_string":"The Laboratory of Immunohematology, Department of Haematology, \u00c5rhus University Hospital, \u00c5rhus, Denmark","institution_ids":["https://openalex.org/I2802335433"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071982662","display_name":"Ingrid Beier Ommen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802335433","display_name":"Aarhus University Hospital","ror":"https://ror.org/040r8fr65","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2802335433"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Ingrid Beier Ommen","raw_affiliation_strings":["The Laboratory of Immunohematology, Department of Haematology, A\u030arhus University Hospital, A\u030arhus, Denmark","The Laboratory of Immunohematology, Department of Haematology, \u00c5rhus University Hospital, \u00c5rhus, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Laboratory of Immunohematology, Department of Haematology, A\u030arhus University Hospital, A\u030arhus, Denmark","institution_ids":["https://openalex.org/I2802335433"]},{"raw_affiliation_string":"The Laboratory of Immunohematology, Department of Haematology, \u00c5rhus University Hospital, \u00c5rhus, Denmark","institution_ids":["https://openalex.org/I2802335433"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073788325","display_name":"Henrik Hasle","orcid":"https://orcid.org/0000-0003-3976-9231","observed_orcids":["https://orcid.org/0000-0003-3976-9231"]},"institutions":[{"id":"https://openalex.org/I2802335433","display_name":"Aarhus University Hospital","ror":"https://ror.org/040r8fr65","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2802335433"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Henrik Hasle","raw_affiliation_strings":["The Department of Paediatrics, A\u030arhus University Hospital Skejby, A\u030arhus, Denmark","The Department of Paediatrics, \u00c5rhus University Hospital Skejby, \u00c5rhus, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Department of Paediatrics, A\u030arhus University Hospital Skejby, A\u030arhus, Denmark","institution_ids":["https://openalex.org/I2802335433"]},{"raw_affiliation_string":"The Department of Paediatrics, \u00c5rhus University Hospital Skejby, \u00c5rhus, Denmark","institution_ids":["https://openalex.org/I2802335433"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017390964","display_name":"Peter Hokland","orcid":"https://orcid.org/0000-0002-1177-9756","observed_orcids":["https://orcid.org/0000-0002-1177-9756"]},"institutions":[{"id":"https://openalex.org/I2802335433","display_name":"Aarhus University Hospital","ror":"https://ror.org/040r8fr65","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2802335433"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Peter Hokland","raw_affiliation_strings":["The Laboratory of Immunohematology, Department of Haematology, A\u030arhus University Hospital, A\u030arhus, Denmark","These authors contributed equally to this study","The Laboratory of Immunohematology, Department of Haematology, \u00c5rhus University Hospital, \u00c5rhus, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Laboratory of Immunohematology, Department of Haematology, A\u030arhus University Hospital, A\u030arhus, Denmark","institution_ids":["https://openalex.org/I2802335433"]},{"raw_affiliation_string":"These authors contributed equally to this study","institution_ids":[]},{"raw_affiliation_string":"The Laboratory of Immunohematology, Department of Haematology, \u00c5rhus University Hospital, \u00c5rhus, Denmark","institution_ids":["https://openalex.org/I2802335433"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5044540545","display_name":"Mette \u00d8stergaard","orcid":"https://orcid.org/0000-0002-0620-6910","observed_orcids":["https://orcid.org/0000-0002-0620-6910"]},"institutions":[{"id":"https://openalex.org/I2802335433","display_name":"Aarhus University Hospital","ror":"https://ror.org/040r8fr65","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2802335433"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Mette \u00d8stergaard","raw_affiliation_strings":["The Laboratory of Immunohematology, Department of Haematology, A\u030arhus University Hospital, A\u030arhus, Denmark","These authors contributed equally to this study","The Laboratory of Immunohematology, Department of Haematology, \u00c5rhus University Hospital, \u00c5rhus, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Laboratory of Immunohematology, Department of Haematology, A\u030arhus University Hospital, A\u030arhus, Denmark","institution_ids":["https://openalex.org/I2802335433"]},{"raw_affiliation_string":"These authors contributed equally to this study","institution_ids":[]},{"raw_affiliation_string":"The Laboratory of Immunohematology, Department of Haematology, \u00c5rhus University Hospital, \u00c5rhus, Denmark","institution_ids":["https://openalex.org/I2802335433"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I2802335433"],"apc_list":{"value":5190,"currency":"USD","value_usd":5190},"apc_paid":null,"fwci":4.389,"has_fulltext":true,"cited_by_count":72,"citation_normalized_percentile":{"value":0.94449137,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"141","issue":"6","first_page":"782","last_page":"791"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11559","display_name":"Retinoids in leukemia and cellular processes","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11215","display_name":"Chronic Myeloid Leukemia Treatments","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/acute-myeloid-leukemia","display_name":"acute myeloid leukemia","score":0.996999979019165},{"id":"https://openalex.org/keywords/wt1-expression","display_name":"WT1 expression","score":0.7039999961853027},{"id":"https://openalex.org/keywords/recurrence-prediction","display_name":"recurrence prediction","score":0.796999990940094},{"id":"https://openalex.org/keywords/complete-remission","display_name":"complete remission","score":0.9509999752044678},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.7260000109672546},{"id":"https://openalex.org/keywords/bone-marrow-sampling","display_name":"bone marrow sampling","score":0.7200000286102295},{"id":"https://openalex.org/keywords/peripheral-blood-sampling","display_name":"peripheral blood sampling","score":0.9890000224113464},{"id":"https://openalex.org/keywords/sampling-interval-optimization","display_name":"sampling interval optimization","score":0.7749999761581421},{"id":"https://openalex.org/keywords/mathematical-model","display_name":"mathematical model","score":0.7210000157356262},{"id":"https://openalex.org/keywords/disease-free-survival","display_name":"disease-free survival","score":0.8989999890327454},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.9750000238418579}],"concepts":[{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6523830890655518},{"id":"https://openalex.org/C207103383","wikidata":"https://www.wikidata.org/wiki/Q3930246","display_name":"Hazard ratio","level":3,"score":0.6305480599403381},{"id":"https://openalex.org/C2993296363","wikidata":"https://www.wikidata.org/wiki/Q11688946","display_name":"Myeloid leukaemia","level":2,"score":0.6016970872879028},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5725582242012024},{"id":"https://openalex.org/C2780007613","wikidata":"https://www.wikidata.org/wiki/Q546523","display_name":"Bone marrow","level":2,"score":0.5212050676345825},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.49920010566711426},{"id":"https://openalex.org/C50382708","wikidata":"https://www.wikidata.org/wiki/Q223218","display_name":"Proportional hazards model","level":2,"score":0.4693611264228821},{"id":"https://openalex.org/C2779282312","wikidata":"https://www.wikidata.org/wiki/Q1956561","display_name":"Myeloid","level":2,"score":0.4326735734939575},{"id":"https://openalex.org/C3018657049","wikidata":"https://www.wikidata.org/wiki/Q1595418","display_name":"Complete remission","level":3,"score":0.4273056983947754},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.39582207798957825},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.26269644498825073},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.20592379570007324}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001856","descriptor_name":"Bone Marrow Examination","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D001856","descriptor_name":"Bone Marrow Examination","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D001856","descriptor_name":"Bone Marrow Examination","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002675","descriptor_name":"Child, Preschool","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002675","descriptor_name":"Child, Preschool","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002675","descriptor_name":"Child, Preschool","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005500","descriptor_name":"Follow-Up Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005500","descriptor_name":"Follow-Up Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005500","descriptor_name":"Follow-Up Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007223","descriptor_name":"Infant","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007223","descriptor_name":"Infant","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007223","descriptor_name":"Infant","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007231","descriptor_name":"Infant, Newborn","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007231","descriptor_name":"Infant, Newborn","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007231","descriptor_name":"Infant, Newborn","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012008","descriptor_name":"Recurrence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012008","descriptor_name":"Recurrence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012008","descriptor_name":"Recurrence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012074","descriptor_name":"Remission Induction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012074","descriptor_name":"Remission Induction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012074","descriptor_name":"Remission Induction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015470","descriptor_name":"Leukemia, Myeloid, Acute","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D015470","descriptor_name":"Leukemia, Myeloid, Acute","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D015470","descriptor_name":"Leukemia, Myeloid, Acute","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D015470","descriptor_name":"Leukemia, Myeloid, Acute","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015470","descriptor_name":"Leukemia, Myeloid, Acute","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015470","descriptor_name":"Leukemia, Myeloid, Acute","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016019","descriptor_name":"Survival Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016019","descriptor_name":"Survival Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016019","descriptor_name":"Survival Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D025721","descriptor_name":"WT1 Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D025721","descriptor_name":"WT1 Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D025721","descriptor_name":"WT1 Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1111/j.1365-2141.2008.07132.x","doi":"https://doi.org/10.1111/j.1365-2141.2008.07132.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1365-2141.2008.07132.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1365-2141.2008.07132.x","source":{"id":"https://openalex.org/S153015021","display_name":"British Journal of Haematology","issn_l":"0007-1048","issn":["0007-1048","1365-2141"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Haematology","raw_type":"journal-article"},{"id":"pmid:18410450","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18410450","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British journal of haematology","raw_type":"Journal Article"},{"id":"pmh:oai:pure.atira.dk:publications/fe1c1320-aefb-11dd-889c-000ea68e967b","doi":null,"is_oa":false,"landing_page_url":"https://pure.au.dk/portal/en/publications/fe1c1320-aefb-11dd-889c-000ea68e967b","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Ommen, H B, Nyvold, C G, Braendstrup, K, Andersen, B L, Ommen, I B, Hasle, H, Hokland, P & Ostergaard, M 2008, 'Relapse prediction in acute myeloid leukaemia patients in complete remission using WT1 as a molecular marker: development of a mathematical model to predict time from molecular to clinical relapse and define optimal sampling intervals.', British Journal of Haematology, vol. 141, no. 6, pp. 782-91. https://doi.org/10.1111/j.1365-2141.2008.07132.x","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1111/j.1365-2141.2008.07132.x","doi":"https://doi.org/10.1111/j.1365-2141.2008.07132.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1365-2141.2008.07132.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1365-2141.2008.07132.x","source":{"id":"https://openalex.org/S153015021","display_name":"British Journal of Haematology","issn_l":"0007-1048","issn":["0007-1048","1365-2141"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Haematology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.5299999713897705}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320310455","display_name":"Kr\u00e6ftens Bek\u00e6mpelse","ror":"https://ror.org/03ytt7k16"},{"id":"https://openalex.org/F4320310483","display_name":"Sundhed og Sygdom, Det Frie Forskningsr\u00e5d","ror":"https://ror.org/03ge1nb22"},{"id":"https://openalex.org/F4320322314","display_name":"Karen Elise Jensens Fond","ror":"https://ror.org/00kaqnj29"},{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1992871908.pdf","grobid_xml":"https://content.openalex.org/works/W1992871908.grobid-xml"},"referenced_works_count":31,"referenced_works":["https://openalex.org/W45100087","https://openalex.org/W109011834","https://openalex.org/W147310725","https://openalex.org/W1493021534","https://openalex.org/W1534965621","https://openalex.org/W1964661337","https://openalex.org/W1970740283","https://openalex.org/W1979365992","https://openalex.org/W1991265993","https://openalex.org/W1993267519","https://openalex.org/W2017666957","https://openalex.org/W2021380995","https://openalex.org/W2022404774","https://openalex.org/W2028774099","https://openalex.org/W2036436627","https://openalex.org/W2036862498","https://openalex.org/W2060842588","https://openalex.org/W2067072111","https://openalex.org/W2082229999","https://openalex.org/W2085076699","https://openalex.org/W2113027268","https://openalex.org/W2124120836","https://openalex.org/W2128233608","https://openalex.org/W2130027047","https://openalex.org/W2136826571","https://openalex.org/W2141324982","https://openalex.org/W2153620104","https://openalex.org/W2159763992","https://openalex.org/W2161930777","https://openalex.org/W2170846829","https://openalex.org/W2324104222"],"related_works":["https://openalex.org/W2994686985","https://openalex.org/W4281722959","https://openalex.org/W2015115473","https://openalex.org/W2106930088","https://openalex.org/W2407467520","https://openalex.org/W2972140937","https://openalex.org/W1970779268","https://openalex.org/W2055765936","https://openalex.org/W2000468149","https://openalex.org/W2003088317"],"abstract_inverted_index":{"We":[0],"hypothesized":[1],"that":[2,119],"Wilms":[3],"tumour":[4],"1":[5],"gene":[6],"(WT1)":[7],"expression":[8,175],"levels":[9],"in":[10,36,102,181],"acute":[11],"myeloid":[12],"leukaemia":[13],"(AML)":[14],"patients":[15,38],"might":[16],"have":[17],"predictive":[18],"value":[19],"and":[20,33,82,94,113,150,157,160],"reveal":[21],"molecular":[22],"relapse":[23,125,191],"kinetics.":[24],"WT1":[25,56,136,174],"level":[26,57],"was":[27,65,111,143],"determined":[28],"at":[29],"diagnosis,":[30],"during":[31],"therapy":[32],"post-therapy":[34],"follow-up":[35],"89":[37],"who":[39],"reached":[40],"first":[41],"complete":[42,99],"remission":[43,100],"(CR1)":[44],"(952":[45],"samples,":[46],"median":[47,132],"8":[48],"samples/patient,":[49],"range":[50],"2-38).":[51],"CR1":[52,173],"bone":[53],"marrow":[54],"(BM)":[55],"above":[58,148,152],"normal":[59],"(based":[60],"on":[61],"39":[62],"healthy":[63],"donors)":[64],"an":[66,177],"independent":[67,178],"adverse":[68],"prognostic":[69,179],"factor":[70,180],"regarding":[71],"both":[72],"disease-free":[73],"survival":[74,84],"[hazard":[75],"ratio":[76],"(HR)":[77],"4.46,":[78],"P":[79,87],"=":[80,88],"0.001]":[81],"overall":[83],"(HR":[85],"2.62,":[86],"0.019).":[89],"By":[90],"grouping":[91],"34":[92],"BM":[93,141,187],"99":[95],"peripheral":[96],"blood":[97],"(PB)":[98],"samples":[101,195],"monthly":[103],"intervals":[104,201],"prior":[105],"to":[106,138,145,184],"clinical":[107,139],"relapse,":[108],"disease":[109],"development":[110],"delineated":[112],"a":[114],"simple":[115],"mathematical":[116],"model":[117],"constructed,":[118],"allowed":[120],"for":[121,190],"the":[122],"prediction":[123],"of":[124],"detection":[126],"rates":[127],"(RDRs)":[128],"as":[129,131],"well":[130],"times":[133],"[t(m)s]":[134],"from":[135],"positivity":[137],"relapse.":[140],"sampling":[142,200],"required":[144],"obtain":[146],"RDRs":[147,156],"93%":[149],"t(m)s":[151,158],"67":[153],"d.":[154],"Acceptable":[155],"(81%":[159],"44":[161],"d,":[162],"respectively)":[163],"could":[164],"be":[165],"acquired":[166],"by":[167],"bimonthly":[168],"PB":[169,194],"sampling.":[170],"In":[171],"conclusion,":[172],"is":[176,188],"AML.":[182],"According":[183],"our":[185],"model,":[186],"superior":[189],"prediction,":[192],"but":[193],"are":[196,202],"useful":[197],"when":[198],"shorter":[199],"possible.":[203]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":4},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":6},{"year":2012,"cited_by_count":7}],"updated_date":"2026-10-08T09:06:37.294493","created_date":"2016-06-24T00:00:00"}
