{"id":"https://openalex.org/W1992855760","doi":"https://doi.org/10.1016/s0005-2736(03)00049-x","title":"Cytosolic delivery of macromolecules: I. Synthesis and characterization of pH-sensitive acyloxyalkylimidazoles","display_name":"Cytosolic delivery of macromolecules: I. Synthesis and characterization of pH-sensitive acyloxyalkylimidazoles","publication_year":2003,"publication_date":"2003-04-01","ids":{"openalex":"https://openalex.org/W1992855760","doi":"https://doi.org/10.1016/s0005-2736(03)00049-x","mag":"1992855760","pmid":"https://pubmed.ncbi.nlm.nih.gov/12659955"},"language":"en","primary_location":{"id":"doi:10.1016/s0005-2736(03)00049-x","doi":"https://doi.org/10.1016/s0005-2736(03)00049-x","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0005-2736(03)00049-x","pdf_url":"https://www.sciencedirect.com/science/article/pii/S000527360300049X/pdf","source":{"id":"https://openalex.org/S4210187475","display_name":"Biochimica et Biophysica Acta (BBA) - Biomembranes","issn_l":"0005-2736","issn":["0005-2736","1879-2642"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochimica et Biophysica Acta (BBA) - Biomembranes","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","datacite","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.sciencedirect.com/science/article/pii/S000527360300049X/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5050547291","display_name":"Feng-Jing Chen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210134658","display_name":"Lipocine (United States)","ror":"https://ror.org/03hh80g63","country_code":"US","type":"company","lineage":["https://openalex.org/I4210134658"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Feng-Jing Chen","raw_affiliation_strings":["Lipocine Inc, Salt Lake City, UT 84103, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lipocine Inc, Salt Lake City, UT 84103, USA","institution_ids":["https://openalex.org/I4210134658"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019219512","display_name":"Aravind Asokan","orcid":"https://orcid.org/0000-0001-5563-4877","observed_orcids":["https://orcid.org/0000-0001-5563-4877"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Aravind Asokan","raw_affiliation_strings":["Division of Drug Delivery and Disposition, CB # 7360, School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7360, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Drug Delivery and Disposition, CB # 7360, School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7360, USA","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5060704313","display_name":"Moo J. Cho","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Moo J Cho","raw_affiliation_strings":["Division of Drug Delivery and Disposition, CB # 7360, School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7360, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Drug Delivery and Disposition, CB # 7360, School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7360, USA","institution_ids":["https://openalex.org/I114027177"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5060704313"],"corresponding_institution_ids":["https://openalex.org/I114027177"],"apc_list":{"value":3870,"currency":"USD","value_usd":3870},"apc_paid":null,"fwci":0.2829,"has_fulltext":true,"cited_by_count":13,"citation_normalized_percentile":{"value":0.45817889,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"1611","issue":"1-2","first_page":"140","last_page":"150"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.9765999913215637,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.9765999913215637,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.020600000396370888,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10407","display_name":"Lipid Membrane Structure and Behavior","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ph-sensitive-liposomes","display_name":"pH-sensitive liposomes","score":0.9430000185966492},{"id":"https://openalex.org/keywords/cytosolic-delivery","display_name":"cytosolic delivery","score":0.8019999861717224},{"id":"https://openalex.org/keywords/cytotoxicity","display_name":"cytotoxicity","score":0.7360000014305115},{"id":"https://openalex.org/keywords/endosomal-escape","display_name":"endosomal escape","score":0.5929999947547913},{"id":"https://openalex.org/keywords/nucleophilic-substitution","display_name":"nucleophilic substitution","score":0.6399999856948853}],"concepts":[{"id":"https://openalex.org/C185154212","wikidata":"https://www.wikidata.org/wiki/Q410454","display_name":"Liposome","level":2,"score":0.7519450187683105},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7100011110305786},{"id":"https://openalex.org/C2780874372","wikidata":"https://www.wikidata.org/wiki/Q328692","display_name":"Imidazole","level":2,"score":0.7078243494033813},{"id":"https://openalex.org/C175656101","wikidata":"https://www.wikidata.org/wiki/Q56646","display_name":"Chinese hamster ovary cell","level":3,"score":0.6697956323623657},{"id":"https://openalex.org/C98539663","wikidata":"https://www.wikidata.org/wiki/Q220599","display_name":"Cytosol","level":3,"score":0.5283435583114624},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.5123697519302368},{"id":"https://openalex.org/C2776568683","wikidata":"https://www.wikidata.org/wiki/Q23005640","display_name":"Moiety","level":2,"score":0.46861371397972107},{"id":"https://openalex.org/C2780783641","wikidata":"https://www.wikidata.org/wiki/Q738686","display_name":"MTT assay","level":3,"score":0.4102940261363983},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.3793447017669678},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.25339508056640625},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.17966699600219727},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.1566450297832489},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003600","descriptor_name":"Cytosol","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D003600","descriptor_name":"Cytosol","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004337","descriptor_name":"Drug Carriers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004355","descriptor_name":"Drug Stability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005227","descriptor_name":"Fatty Acids","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D006224","descriptor_name":"Cricetinae","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006863","descriptor_name":"Hydrogen-Ion Concentration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007093","descriptor_name":"Imidazoles","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":true},{"descriptor_ui":"D008081","descriptor_name":"Liposomes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008081","descriptor_name":"Liposomes","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D011992","descriptor_name":"Endosomes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013501","descriptor_name":"Surface-Active Agents","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015394","descriptor_name":"Molecular Structure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016466","descriptor_name":"CHO Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D046911","descriptor_name":"Macromolecular Substances","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1016/s0005-2736(03)00049-x","doi":"https://doi.org/10.1016/s0005-2736(03)00049-x","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0005-2736(03)00049-x","pdf_url":"https://www.sciencedirect.com/science/article/pii/S000527360300049X/pdf","source":{"id":"https://openalex.org/S4210187475","display_name":"Biochimica et Biophysica Acta (BBA) - Biomembranes","issn_l":"0005-2736","issn":["0005-2736","1879-2642"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochimica et Biophysica Acta (BBA) - Biomembranes","raw_type":"journal-article"},{"id":"pmid:12659955","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12659955","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochimica et biophysica acta","raw_type":"Journal Article"},{"id":"pmh:cdr.lib.unc.edu:dv140339m","doi":null,"is_oa":true,"landing_page_url":"https://doi.org/10.17615/pjcr-9q98","pdf_url":"https://cdr.lib.unc.edu/downloads/w3763g89g","source":{"id":"https://openalex.org/S4306401075","display_name":"Carolina Digital Repository (University of North Carolina at Chapel Hill)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I114027177","host_organization_name":"University of North Carolina at Chapel Hill","host_organization_lineage":["https://openalex.org/I114027177"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Biochimica et Biophysica Acta BBA - Gene Regulatory Mechanisms, 1611(43102)","raw_type":"Article"},{"id":"doi:10.17615/pjcr-9q98","doi":"https://doi.org/10.17615/pjcr-9q98","is_oa":true,"landing_page_url":"https://doi.org/10.17615/pjcr-9q98","pdf_url":null,"source":{"id":"https://openalex.org/S7407051488","display_name":"UNC Libraries","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article-journal"}],"best_oa_location":{"id":"doi:10.1016/s0005-2736(03)00049-x","doi":"https://doi.org/10.1016/s0005-2736(03)00049-x","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0005-2736(03)00049-x","pdf_url":"https://www.sciencedirect.com/science/article/pii/S000527360300049X/pdf","source":{"id":"https://openalex.org/S4210187475","display_name":"Biochimica et Biophysica Acta (BBA) - Biomembranes","issn_l":"0005-2736","issn":["0005-2736","1879-2642"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochimica et Biophysica Acta (BBA) - Biomembranes","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.504800021648407,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1992855760.pdf","grobid_xml":"https://content.openalex.org/works/W1992855760.grobid-xml"},"referenced_works_count":32,"referenced_works":["https://openalex.org/W422406868","https://openalex.org/W1493354087","https://openalex.org/W1512179335","https://openalex.org/W1967892393","https://openalex.org/W1980505972","https://openalex.org/W1982459820","https://openalex.org/W1984512523","https://openalex.org/W1985232912","https://openalex.org/W1985901407","https://openalex.org/W1991979573","https://openalex.org/W1994923263","https://openalex.org/W2008738738","https://openalex.org/W2011393926","https://openalex.org/W2013009465","https://openalex.org/W2014369102","https://openalex.org/W2027801321","https://openalex.org/W2036168344","https://openalex.org/W2048975657","https://openalex.org/W2054192565","https://openalex.org/W2066959435","https://openalex.org/W2067451034","https://openalex.org/W2069289981","https://openalex.org/W2075826322","https://openalex.org/W2079932601","https://openalex.org/W2085789977","https://openalex.org/W2087339674","https://openalex.org/W2099707944","https://openalex.org/W2126662679","https://openalex.org/W2140927361","https://openalex.org/W2159528299","https://openalex.org/W2164147916","https://openalex.org/W2169780885"],"related_works":["https://openalex.org/W2555438104","https://openalex.org/W4417211435","https://openalex.org/W2767891524","https://openalex.org/W13532651","https://openalex.org/W1030224185","https://openalex.org/W4298843368","https://openalex.org/W4214839593","https://openalex.org/W7212020044","https://openalex.org/W2416892704","https://openalex.org/W2003639620"],"abstract_inverted_index":null,"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}