{"id":"https://openalex.org/W1992855284","doi":"https://doi.org/10.1038/sj.bjp.0705616","title":"The human near\u2010term myometrial \u03b23\u2010adrenoceptor but not the \u03b22\u2010adrenoceptor is resistant to desensitisation after sustained agonist stimulation","display_name":"The human near\u2010term myometrial \u03b23\u2010adrenoceptor but not the \u03b22\u2010adrenoceptor is resistant to desensitisation after sustained agonist stimulation","publication_year":2004,"publication_date":"2004-03-01","ids":{"openalex":"https://openalex.org/W1992855284","doi":"https://doi.org/10.1038/sj.bjp.0705616","mag":"1992855284","pmid":"https://pubmed.ncbi.nlm.nih.gov/14769781","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1574252"},"language":"en","primary_location":{"id":"doi:10.1038/sj.bjp.0705616","doi":"https://doi.org/10.1038/sj.bjp.0705616","is_oa":false,"landing_page_url":"https://doi.org/10.1038/sj.bjp.0705616","pdf_url":null,"source":{"id":"https://openalex.org/S55107261","display_name":"British Journal of Pharmacology","issn_l":"0007-1188","issn":["0007-1188","1476-5381"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Pharmacology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1574252","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111869295","display_name":"C\u00e9line Rouget","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"C Rouget","raw_affiliation_strings":["UPRES EA220-Pharmacology, UFR Biom\u00e9dicale des Saints P\u00e8res, 45 rue des Saints P\u00e8res, Paris 75006, France. celine.rouget@biomedicale.univ-paris5.fr","INSERM U361, Pavillon Baudelocque, 123 Bd de Port-Royal, Paris 75014, France","UPRES EA220-Pharmacology, UFR Biom\u00e9dicale des Saints P\u00e8res, 45 rue des Saints P\u00e8res, Paris 75006, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UPRES EA220-Pharmacology, UFR Biom\u00e9dicale des Saints P\u00e8res, 45 rue des Saints P\u00e8res, Paris 75006, France. celine.rouget@biomedicale.univ-paris5.fr","institution_ids":[]},{"raw_affiliation_string":"INSERM U361, Pavillon Baudelocque, 123 Bd de Port-Royal, Paris 75014, France","institution_ids":["https://openalex.org/I154526488"]},{"raw_affiliation_string":"UPRES EA220-Pharmacology, UFR Biom\u00e9dicale des Saints P\u00e8res, 45 rue des Saints P\u00e8res, Paris 75006, France","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110181156","display_name":"Michelle Breuiller-Fouch\u00e9","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"M Breuiller\u2010Fouch\u00e9","raw_affiliation_strings":["INSERM U361, Pavillon Baudelocque, 123 Bd de Port-Royal, Paris 75014, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"INSERM U361, Pavillon Baudelocque, 123 Bd de Port-Royal, Paris 75014, France","institution_ids":["https://openalex.org/I154526488"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057074151","display_name":"Fr\u00e9d\u00e9ric Jean Mercier","orcid":"https://orcid.org/0000-0002-1289-2849","observed_orcids":["https://orcid.org/0000-0002-1289-2849"]},"institutions":[{"id":"https://openalex.org/I4210150149","display_name":"H\u00f4pital Antoine-B\u00e9cl\u00e8re","ror":"https://ror.org/04sb8a726","country_code":"FR","type":"company","lineage":["https://openalex.org/I4210097159","https://openalex.org/I4210150149","https://openalex.org/I4405259118"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"F J Mercier","raw_affiliation_strings":["Department of Anaesthesiology at CHU Antoine Be\u0301cle\u0300re, 157 rue de la Porte de Trivaux, Clamart 92141, France","UPRES EA220-Pharmacology, UFR Biome\u0301dicale des Saints Pe\u0300res, 45 rue des Saints Pe\u0300res, Paris 75006, France","Department of Anaesthesiology at CHU Antoine B\u00e9cl\u00e8re, 157 rue de la Porte de Trivaux, Clamart 92141, France","UPRES EA220-Pharmacology, UFR Biom\u00e9dicale des Saints P\u00e8res, 45 rue des Saints P\u00e8res, Paris 75006, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anaesthesiology at CHU Antoine Be\u0301cle\u0300re, 157 rue de la Porte de Trivaux, Clamart 92141, France","institution_ids":["https://openalex.org/I4210150149"]},{"raw_affiliation_string":"UPRES EA220-Pharmacology, UFR Biome\u0301dicale des Saints Pe\u0300res, 45 rue des Saints Pe\u0300res, Paris 75006, France","institution_ids":[]},{"raw_affiliation_string":"Department of Anaesthesiology at CHU Antoine B\u00e9cl\u00e8re, 157 rue de la Porte de Trivaux, Clamart 92141, France","institution_ids":["https://openalex.org/I4210150149"]},{"raw_affiliation_string":"UPRES EA220-Pharmacology, UFR Biom\u00e9dicale des Saints P\u00e8res, 45 rue des Saints P\u00e8res, Paris 75006, France","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109993259","display_name":"M Leroy","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"M J Leroy","raw_affiliation_strings":["INSERM U361, Pavillon Baudelocque, 123 Bd de Port-Royal, Paris 75014, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"INSERM U361, Pavillon Baudelocque, 123 Bd de Port-Royal, Paris 75014, France","institution_ids":["https://openalex.org/I154526488"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061565762","display_name":"Catherine Loustalot","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C Loustalot","raw_affiliation_strings":["Department of Gynaecology CHU du Bocage, 21 Bd de Lattre de Tassigny, BP 1542, Dijon 21000, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gynaecology CHU du Bocage, 21 Bd de Lattre de Tassigny, BP 1542, Dijon 21000, France","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100845962","display_name":"Emmanuel Naline","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"E Naline","raw_affiliation_strings":["UPRES EA220-Pharmacology, UFR Biome\u0301dicale des Saints Pe\u0300res, 45 rue des Saints Pe\u0300res, Paris 75006, France","UPRES EA220-Pharmacology, UFR Biom\u00e9dicale des Saints P\u00e8res, 45 rue des Saints P\u00e8res, Paris 75006, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UPRES EA220-Pharmacology, UFR Biome\u0301dicale des Saints Pe\u0300res, 45 rue des Saints Pe\u0300res, Paris 75006, France","institution_ids":[]},{"raw_affiliation_string":"UPRES EA220-Pharmacology, UFR Biom\u00e9dicale des Saints P\u00e8res, 45 rue des Saints P\u00e8res, Paris 75006, France","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002942381","display_name":"R Frydman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210150149","display_name":"H\u00f4pital Antoine-B\u00e9cl\u00e8re","ror":"https://ror.org/04sb8a726","country_code":"FR","type":"company","lineage":["https://openalex.org/I4210097159","https://openalex.org/I4210150149","https://openalex.org/I4405259118"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"R Frydman","raw_affiliation_strings":["Department of Gynaecology at CHU Antoine Be\u0301cle\u0300re, 157 rue de la Porte de Trivaux, Clamart 92141, France","Department of Gynaecology at CHU Antoine B\u00e9cl\u00e8re, 157 rue de la Porte de Trivaux, Clamart 92141, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gynaecology at CHU Antoine Be\u0301cle\u0300re, 157 rue de la Porte de Trivaux, Clamart 92141, France","institution_ids":["https://openalex.org/I4210150149"]},{"raw_affiliation_string":"Department of Gynaecology at CHU Antoine B\u00e9cl\u00e8re, 157 rue de la Porte de Trivaux, Clamart 92141, France","institution_ids":["https://openalex.org/I4210150149"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038289988","display_name":"Tiziano Croci","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210121481","display_name":"Sanofi (Italy)","ror":"https://ror.org/02mnmm768","country_code":"IT","type":"company","lineage":["https://openalex.org/I3018075036","https://openalex.org/I4210121481"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"T Croci","raw_affiliation_strings":["Research Centre Sanofi-Midy, Via Piranesi, 38, Milan 20137, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Centre Sanofi-Midy, Via Piranesi, 38, Milan 20137, Italy","institution_ids":["https://openalex.org/I4210121481"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024080563","display_name":"Esteban Jes\u00fas Morcillo","orcid":"https://orcid.org/0000-0003-4373-9457","observed_orcids":["https://orcid.org/0000-0003-4373-9457"]},"institutions":[{"id":"https://openalex.org/I16097986","display_name":"Universitat de Val\u00e8ncia","ror":"https://ror.org/043nxc105","country_code":"ES","type":"education","lineage":["https://openalex.org/I16097986"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"E J Morcillo","raw_affiliation_strings":["Department of Pharmacology, University of Valencia, Av. Blasco Iban\u0303ez 17, Valencia 46010, Spain","Department of Pharmacology, University of Valencia, Av. Blasco Iba\u00f1ez 17, Valencia 46010, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, University of Valencia, Av. Blasco Iban\u0303ez 17, Valencia 46010, Spain","institution_ids":["https://openalex.org/I16097986"]},{"raw_affiliation_string":"Department of Pharmacology, University of Valencia, Av. Blasco Iba\u00f1ez 17, Valencia 46010, Spain","institution_ids":["https://openalex.org/I16097986"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069946536","display_name":"Charles Advenier","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C Advenier","raw_affiliation_strings":["UPRES EA220-Pharmacology, UFR Biome\u0301dicale des Saints Pe\u0300res, 45 rue des Saints Pe\u0300res, Paris 75006, France","UPRES EA220-Pharmacology, UFR Biom\u00e9dicale des Saints P\u00e8res, 45 rue des Saints P\u00e8res, Paris 75006, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UPRES EA220-Pharmacology, UFR Biome\u0301dicale des Saints Pe\u0300res, 45 rue des Saints Pe\u0300res, Paris 75006, France","institution_ids":[]},{"raw_affiliation_string":"UPRES EA220-Pharmacology, UFR Biom\u00e9dicale des Saints P\u00e8res, 45 rue des Saints P\u00e8res, Paris 75006, France","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5075546352","display_name":"Marc Bardou","orcid":"https://orcid.org/0000-0003-0028-1837","observed_orcids":["https://orcid.org/0000-0003-0028-1837"]},"institutions":[{"id":"https://openalex.org/I177064439","display_name":"Universit\u00e9 de Bourgogne","ror":"https://ror.org/03k1bsr36","country_code":"FR","type":"education","lineage":["https://openalex.org/I177064439","https://openalex.org/I4405253280"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"M Bardou","raw_affiliation_strings":["Laboratory of Cardiovascular Physiopathology and Pharmacology, Faculty of Medicine, 7 Bd Jeanne d'Arc, BP 87900, Dijon 21079, France","UPRES EA220-Pharmacology, UFR Biome\u0301dicale des Saints Pe\u0300res, 45 rue des Saints Pe\u0300res, Paris 75006, France","UPRES EA220-Pharmacology, UFR Biom\u00e9dicale des Saints P\u00e8res, 45 rue des Saints P\u00e8res, Paris 75006, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Cardiovascular Physiopathology and Pharmacology, Faculty of Medicine, 7 Bd Jeanne d'Arc, BP 87900, Dijon 21079, France","institution_ids":["https://openalex.org/I177064439"]},{"raw_affiliation_string":"UPRES EA220-Pharmacology, UFR Biome\u0301dicale des Saints Pe\u0300res, 45 rue des Saints Pe\u0300res, Paris 75006, France","institution_ids":[]},{"raw_affiliation_string":"UPRES EA220-Pharmacology, UFR Biom\u00e9dicale des Saints P\u00e8res, 45 rue des Saints P\u00e8res, Paris 75006, France","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5075546352","https://openalex.org/A5111869295"],"corresponding_institution_ids":["https://openalex.org/I154526488","https://openalex.org/I177064439"],"apc_list":{"value":4780,"currency":"USD","value_usd":4780},"apc_paid":null,"fwci":0.976,"has_fulltext":false,"cited_by_count":34,"citation_normalized_percentile":{"value":0.68917786,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"141","issue":"5","first_page":"831","last_page":"841"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.9667999744415283,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.9667999744415283,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12434","display_name":"Phosphodiesterase function and regulation","score":0.029200000688433647,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10814","display_name":"Neuropeptides and Animal Physiology","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/beta3-adrenergic-receptor","display_name":"beta3-adrenergic receptor","score":0.8650000095367432},{"id":"https://openalex.org/keywords/beta2-adrenergic-receptor","display_name":"beta2-adrenergic receptor","score":0.9990000128746033},{"id":"https://openalex.org/keywords/receptor-desensitization","display_name":"receptor desensitization","score":0.8579999804496765},{"id":"https://openalex.org/keywords/salbutamol","display_name":"salbutamol","score":0.9539999961853027},{"id":"https://openalex.org/keywords/camp","display_name":"cyclic AMP","score":0.675000011920929},{"id":"https://openalex.org/keywords/phosphodiesterase-4","display_name":"phosphodiesterase 4","score":0.9449999928474426},{"id":"https://openalex.org/keywords/myometrial-relaxation","display_name":"myometrial relaxation","score":0.7120000123977661},{"id":"https://openalex.org/keywords/preterm-labour","display_name":"preterm labour","score":0.6600000262260437},{"id":"https://openalex.org/keywords/uterine-contractility","display_name":"uterine contractility","score":0.6259999871253967}],"concepts":[{"id":"https://openalex.org/C2777394947","wikidata":"https://www.wikidata.org/wiki/Q410358","display_name":"Salbutamol","level":3,"score":0.9287066459655762},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.7464812994003296},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7187681198120117},{"id":"https://openalex.org/C2778938600","wikidata":"https://www.wikidata.org/wiki/Q389934","display_name":"Agonist","level":3,"score":0.6447503566741943},{"id":"https://openalex.org/C2778164554","wikidata":"https://www.wikidata.org/wiki/Q2562472","display_name":"Myometrium","level":3,"score":0.5611326098442078},{"id":"https://openalex.org/C62826618","wikidata":"https://www.wikidata.org/wiki/Q424304","display_name":"Phosphodiesterase","level":3,"score":0.5186576247215271},{"id":"https://openalex.org/C24998067","wikidata":"https://www.wikidata.org/wiki/Q4114622","display_name":"Stimulation","level":2,"score":0.5157003998756409},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.49121779203414917},{"id":"https://openalex.org/C2776174256","wikidata":"https://www.wikidata.org/wiki/Q830842","display_name":"BETA (programming language)","level":2,"score":0.4727661907672882},{"id":"https://openalex.org/C2776668983","wikidata":"https://www.wikidata.org/wiki/Q210041","display_name":"Cyclic adenosine monophosphate","level":3,"score":0.467529296875},{"id":"https://openalex.org/C2908881489","wikidata":"https://www.wikidata.org/wiki/Q545234","display_name":"Tocolytic agent","level":5,"score":0.43776270747184753},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.3665609657764435},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2912081778049469},{"id":"https://openalex.org/C2779066055","wikidata":"https://www.wikidata.org/wiki/Q9612","display_name":"Uterus","level":2,"score":0.23828473687171936},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2269550859928131},{"id":"https://openalex.org/C172680121","wikidata":"https://www.wikidata.org/wiki/Q26513","display_name":"Fetus","level":3,"score":0.14219248294830322},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.09072768688201904},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.08891049027442932},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.08094736933708191},{"id":"https://openalex.org/C3019152611","wikidata":"https://www.wikidata.org/wiki/Q625506","display_name":"Preterm labor","level":4,"score":0.07528054714202881},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.0},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C2776042228","wikidata":"https://www.wikidata.org/wiki/Q35869","display_name":"Asthma","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000318","descriptor_name":"Adrenergic beta-Agonists","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000318","descriptor_name":"Adrenergic beta-Agonists","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000420","descriptor_name":"Albuterol","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000420","descriptor_name":"Albuterol","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000704","descriptor_name":"Analysis of Variance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009215","descriptor_name":"Myometrium","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009215","descriptor_name":"Myometrium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011247","descriptor_name":"Pregnancy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D018343","descriptor_name":"Receptors, Adrenergic, beta-2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D022702","descriptor_name":"Receptors, Adrenergic, beta-3","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D058666","descriptor_name":"Adrenergic beta-2 Receptor Agonists","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058667","descriptor_name":"Adrenergic beta-3 Receptor Agonists","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066298","descriptor_name":"In Vitro Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1038/sj.bjp.0705616","doi":"https://doi.org/10.1038/sj.bjp.0705616","is_oa":false,"landing_page_url":"https://doi.org/10.1038/sj.bjp.0705616","pdf_url":null,"source":{"id":"https://openalex.org/S55107261","display_name":"British Journal of Pharmacology","issn_l":"0007-1188","issn":["0007-1188","1476-5381"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Pharmacology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:1574252","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1574252","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Br J Pharmacol","raw_type":"Text"},{"id":"pmid:14769781","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/14769781","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British journal of pharmacology","raw_type":"Comparative Study"},{"id":"pmh:oai:HAL:inserm-00322035v1","doi":null,"is_oa":false,"landing_page_url":"https://inserm.hal.science/inserm-00322035","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"British Journal of Pharmacology, 2004, 141 (5), pp.831-41. &#x27E8;10.1038/sj.bjp.0705616&#x27E9;","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:1574252","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1574252","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Br J Pharmacol","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":64,"referenced_works":["https://openalex.org/W235739265","https://openalex.org/W957301491","https://openalex.org/W1523677047","https://openalex.org/W1563076194","https://openalex.org/W1823679757","https://openalex.org/W1965011234","https://openalex.org/W1968429293","https://openalex.org/W1970874069","https://openalex.org/W1971514676","https://openalex.org/W1973925167","https://openalex.org/W1975972186","https://openalex.org/W1977144374","https://openalex.org/W1978054987","https://openalex.org/W1982108210","https://openalex.org/W1982730444","https://openalex.org/W1983856846","https://openalex.org/W1984739325","https://openalex.org/W1987558063","https://openalex.org/W1987971457","https://openalex.org/W1996632588","https://openalex.org/W1996972993","https://openalex.org/W1997978754","https://openalex.org/W2002896923","https://openalex.org/W2004169102","https://openalex.org/W2006155400","https://openalex.org/W2009829962","https://openalex.org/W2012679882","https://openalex.org/W2014366401","https://openalex.org/W2015557754","https://openalex.org/W2015912619","https://openalex.org/W2020181071","https://openalex.org/W2038732563","https://openalex.org/W2042329556","https://openalex.org/W2051346056","https://openalex.org/W2054019567","https://openalex.org/W2056916852","https://openalex.org/W2059889135","https://openalex.org/W2060295670","https://openalex.org/W2072514099","https://openalex.org/W2074631079","https://openalex.org/W2083850374","https://openalex.org/W2091107134","https://openalex.org/W2099210988","https://openalex.org/W2112387528","https://openalex.org/W2113028638","https://openalex.org/W2123066014","https://openalex.org/W2128635872","https://openalex.org/W2130394237","https://openalex.org/W2136408144","https://openalex.org/W2137547145","https://openalex.org/W2146144995","https://openalex.org/W2160766402","https://openalex.org/W2161939380","https://openalex.org/W2163405413","https://openalex.org/W2166748873","https://openalex.org/W2172208110","https://openalex.org/W2172234096","https://openalex.org/W2276390905","https://openalex.org/W2313220264","https://openalex.org/W2409723788","https://openalex.org/W2409835869","https://openalex.org/W4240991168","https://openalex.org/W4247377047","https://openalex.org/W4248096658"],"related_works":["https://openalex.org/W1997978754","https://openalex.org/W2409835869","https://openalex.org/W2037077491","https://openalex.org/W2160766402","https://openalex.org/W2917831885","https://openalex.org/W1987558063","https://openalex.org/W2146678381","https://openalex.org/W2019435560","https://openalex.org/W2009829962","https://openalex.org/W2072148951"],"abstract_inverted_index":{"1.":[0],"In":[1,275],"order":[2],"to":[3,165,271],"compare":[4],"the":[5,18,49,52,67,72,78,84,92,99,169,180,210,214,223,245,272,296],"beta(2)-":[6,29,87,93,211,226,246],"and":[7,45,51,88,94,98,134,227,247],"beta(3)-adrenoceptor":[8],"(beta-AR)":[9],"desensitisation":[10,74,279],"process":[11],"in":[12,71,125,187,222],"human":[13],"near-term":[14],"myometrium,":[15],"we":[16,76],"examined":[17],"influence":[19,79],"of":[20,23,66,80,86,162,205,225,286,295],"a":[21,28,31,116,122,150,193,234,283],"pretreatment":[22],"myometrial":[24,163,206],"strips":[25,164,207],"with":[26,121,154],"either":[27],"or":[30,35,256],"beta(3)-AR":[32,89,95,215,228,248],"agonist":[33],"(salbutamol":[34],"SR":[36,108,144,155,181,196,237,257],"59119A,":[37,109],"respectively,":[38,139],"both":[39],"at":[40],"10":[41],"microm,":[42],"for":[43,132],"5":[44],"15":[46,117,135,151,159,194,201,235],"h)":[47],"on":[48,83],"relaxation":[50],"cyclic":[53],"adenosine":[54],"monophosphate":[55],"(cAMP)":[56],"production":[57,189],"induced":[58],"by":[59,115,254,282,292],"these":[60],"agonists.":[61],"2.":[62],"To":[63],"assess":[64],"some":[65],"mechanisms":[68],"potentially":[69],"implicated":[70],"beta-AR":[73],"process,":[75],"studied":[77],"such":[81],"treatment":[82],"number":[85,224,285],"binding":[90,216,229],"sites,":[91],"transcripts":[96],"expression":[97,250],"phosphodiesterase":[100],"4":[101],"(PDE4)":[102],"activity.":[103],"3.":[104],"Salbutamol,":[105],"but":[106,178,212,266],"not":[107,179,213,267,290],"concentration-response":[110],"curve":[111],"(CRC)":[112],"was":[113,190,231,289],"shifted":[114],"h":[118,136,152,160,195,202,236],"salbutamol":[119,137,142,166,203,255],"preincubation,":[120],"significant":[123],"difference":[124],"-log":[126],"EC(20)":[127],"values":[128],"(6.31+/-0.13":[129],"vs":[130,172],"5.58+/-0.24,":[131],"control":[133],"pretreatment,":[138],"P<0.05).":[140],"Neither":[141,241],"nor":[143,244],"59119A":[145,197,238,258],"CRCs":[146],"were":[147,252],"modified":[148],"after":[149,192,233],"preincubation":[153],"59119A.":[156],"4.":[157],"A":[158,200],"exposure":[161,204],"significantly":[167,208],"reduced":[168,209],"salbutamol-induced":[170],"(0.60+/-0.26":[171],"1.54+/-0.24":[173],"pmol":[174],"mg(-1)":[175],"protein,":[176],"P<0.05),":[177],"59119A-induced,":[182],"cAMP":[183,188],"production.":[184],"No":[185],"decrease":[186,221],"observed":[191,232],"exposure.":[198],"5.":[199],"site":[217],"density,":[218],"whereas":[219],"no":[220],"sites":[230],"treatment.":[239],"6.":[240],"PDE4":[242],"activity":[243],"mRNA":[249],"levels":[251],"affected":[253],"treatments.":[259],"7.":[260],"Our":[261],"results":[262],"indicate":[263],"that":[264,288],"beta(3)-AR,":[265],"beta(2)-AR,":[268],"are":[269],"resistant":[270],"agonist-induced":[273],"desensitisation.":[274],"our":[276],"model,":[277],"beta(2)-AR":[278,287],"is":[280],"mediated":[281],"decreased":[284],"explained":[291],"transcriptional":[293],"regulation":[294],"receptor.":[297]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
