{"id":"https://openalex.org/W1992829789","doi":"https://doi.org/10.1080/10406639908020585","title":"Biotransformation and DNA Adduct Formation ofTrans-8,9-Dihydroxy-8,9-Dihydrodibenzo[a, l]Pyrene by Induced Rat Liver and Human CYP1A1 Microsomes","display_name":"Biotransformation and DNA Adduct Formation ofTrans-8,9-Dihydroxy-8,9-Dihydrodibenzo[a, l]Pyrene by Induced Rat Liver and Human CYP1A1 Microsomes","publication_year":2000,"publication_date":"2000-06-01","ids":{"openalex":"https://openalex.org/W1992829789","doi":"https://doi.org/10.1080/10406639908020585","mag":"1992829789"},"language":"en","primary_location":{"id":"doi:10.1080/10406639908020585","doi":"https://doi.org/10.1080/10406639908020585","is_oa":false,"landing_page_url":"https://doi.org/10.1080/10406639908020585","pdf_url":null,"source":{"id":"https://openalex.org/S178924077","display_name":"Polycyclic aromatic compounds","issn_l":"1026-7743","issn":["1026-7743","1040-6638","1563-5333"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","norway-1","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Polycyclic Aromatic Compounds","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5014221194","display_name":"Stephen Nesnow","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1302368450","display_name":"Environmental Protection Agency","ror":"https://ror.org/03tns0030","country_code":"US","type":"government","lineage":["https://openalex.org/I1302368450"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S. Nesnow","raw_affiliation_strings":["Biochemistry and Pathobiology Branch, U.S. Environmental Protection Agency, Research Triangle Park, NC, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biochemistry and Pathobiology Branch, U.S. Environmental Protection Agency, Research Triangle Park, NC, USA","institution_ids":["https://openalex.org/I1302368450"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109271310","display_name":"Christine C. Davis","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1302368450","display_name":"Environmental Protection Agency","ror":"https://ror.org/03tns0030","country_code":"US","type":"government","lineage":["https://openalex.org/I1302368450"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"C. Davis","raw_affiliation_strings":["Biochemistry and Pathobiology Branch, U.S. Environmental Protection Agency, Research Triangle Park, NC, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biochemistry and Pathobiology Branch, U.S. Environmental Protection Agency, Research Triangle Park, NC, USA","institution_ids":["https://openalex.org/I1302368450"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017703510","display_name":"William T. Padgett","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1302368450","display_name":"Environmental Protection Agency","ror":"https://ror.org/03tns0030","country_code":"US","type":"government","lineage":["https://openalex.org/I1302368450"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"W. Padgett","raw_affiliation_strings":["Biochemistry and Pathobiology Branch, U.S. Environmental Protection Agency, Research Triangle Park, NC, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biochemistry and Pathobiology Branch, U.S. Environmental Protection Agency, Research Triangle Park, NC, USA","institution_ids":["https://openalex.org/I1302368450"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001345174","display_name":"Michael H. George","orcid":"https://orcid.org/0009-0009-9729-3391","observed_orcids":["https://orcid.org/0009-0009-9729-3391"]},"institutions":[{"id":"https://openalex.org/I1302368450","display_name":"Environmental Protection Agency","ror":"https://ror.org/03tns0030","country_code":"US","type":"government","lineage":["https://openalex.org/I1302368450"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M. George","raw_affiliation_strings":["Biochemistry and Pathobiology Branch, U.S. Environmental Protection Agency, Research Triangle Park, NC, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biochemistry and Pathobiology Branch, U.S. Environmental Protection Agency, Research Triangle Park, NC, USA","institution_ids":["https://openalex.org/I1302368450"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002116781","display_name":"Guy R. Lambert","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1302368450","display_name":"Environmental Protection Agency","ror":"https://ror.org/03tns0030","country_code":"US","type":"government","lineage":["https://openalex.org/I1302368450"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"G. Lambert","raw_affiliation_strings":["Biochemistry and Pathobiology Branch, U.S. Environmental Protection Agency, Research Triangle Park, NC, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biochemistry and Pathobiology Branch, U.S. Environmental Protection Agency, Research Triangle Park, NC, USA","institution_ids":["https://openalex.org/I1302368450"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069076478","display_name":"Linda D. Adams","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1302368450","display_name":"Environmental Protection Agency","ror":"https://ror.org/03tns0030","country_code":"US","type":"government","lineage":["https://openalex.org/I1302368450"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"L. Adams","raw_affiliation_strings":["Biochemistry and Pathobiology Branch, U.S. Environmental Protection Agency, Research Triangle Park, NC, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biochemistry and Pathobiology Branch, U.S. Environmental Protection Agency, Research Triangle Park, NC, USA","institution_ids":["https://openalex.org/I1302368450"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5069734537","display_name":"Leon C. King","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1302368450","display_name":"Environmental Protection Agency","ror":"https://ror.org/03tns0030","country_code":"US","type":"government","lineage":["https://openalex.org/I1302368450"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"L. King","raw_affiliation_strings":["Biochemistry and Pathobiology Branch, U.S. Environmental Protection Agency, Research Triangle Park, NC, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biochemistry and Pathobiology Branch, U.S. Environmental Protection Agency, Research Triangle Park, NC, USA","institution_ids":["https://openalex.org/I1302368450"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I1302368450"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.09518349,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"16","issue":"1-4","first_page":"181","last_page":"190"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment","score":0.6035000085830688,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment","score":0.6035000085830688,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.2734000086784363,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10122","display_name":"Toxic Organic Pollutants Impact","score":0.06040000170469284,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dibenzo-a-l-pyrene","display_name":"dibenzo[a,l]pyrene","score":0.9480000138282776},{"id":"https://openalex.org/keywords/dna-adducts","display_name":"DNA adducts","score":0.7509999871253967},{"id":"https://openalex.org/keywords/cyp1a1","display_name":"CYP1A1","score":0.8659999966621399},{"id":"https://openalex.org/keywords/diol-epoxides","display_name":"diol epoxides","score":0.6460000276565552},{"id":"https://openalex.org/keywords/epoxide-hydrolase","display_name":"epoxide hydrolase","score":0.843999981880188},{"id":"https://openalex.org/keywords/biotransformation","display_name":"biotransformation","score":0.753000020980835},{"id":"https://openalex.org/keywords/polycyclic-aromatic-hydrocarbons","display_name":"polycyclic aromatic hydrocarbons","score":0.7490000128746033},{"id":"https://openalex.org/keywords/rat-liver-microsomes","display_name":"rat liver microsomes","score":0.7120000123977661},{"id":"https://openalex.org/keywords/human-liver-microsomes","display_name":"human liver microsomes","score":0.7770000100135803},{"id":"https://openalex.org/keywords/beta-naphthoflavone-induction","display_name":"beta-naphthoflavone induction","score":0.7990000247955322},{"id":"https://openalex.org/keywords/dna-binding","display_name":"DNA binding","score":0.3779999911785126}],"concepts":[{"id":"https://openalex.org/C108204754","wikidata":"https://www.wikidata.org/wiki/Q353392","display_name":"Adduct","level":2,"score":0.8985960483551025},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.8852952718734741},{"id":"https://openalex.org/C2778951431","wikidata":"https://www.wikidata.org/wiki/Q415723","display_name":"Pyrene","level":2,"score":0.6714776754379272},{"id":"https://openalex.org/C114246631","wikidata":"https://www.wikidata.org/wiki/Q187661","display_name":"Carcinogen","level":2,"score":0.6463568806648254},{"id":"https://openalex.org/C2779515768","wikidata":"https://www.wikidata.org/wiki/Q421916","display_name":"Diol","level":2,"score":0.6356130242347717},{"id":"https://openalex.org/C2776920199","wikidata":"https://www.wikidata.org/wiki/Q408028","display_name":"Epoxide","level":3,"score":0.6306473612785339},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.6184024214744568},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.6070882081985474},{"id":"https://openalex.org/C87644729","wikidata":"https://www.wikidata.org/wiki/Q547502","display_name":"Microsome","level":3,"score":0.5962797999382019},{"id":"https://openalex.org/C138716334","wikidata":"https://www.wikidata.org/wiki/Q268477","display_name":"Diastereomer","level":2,"score":0.5931209921836853},{"id":"https://openalex.org/C2781247443","wikidata":"https://www.wikidata.org/wiki/Q4153410","display_name":"DNA adduct","level":3,"score":0.5814667344093323},{"id":"https://openalex.org/C2777538855","wikidata":"https://www.wikidata.org/wiki/Q306051","display_name":"Benzo(a)pyrene","level":3,"score":0.5502085089683533},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3344835042953491},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.29395046830177307},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.12950000166893005},{"id":"https://openalex.org/C161790260","wikidata":"https://www.wikidata.org/wiki/Q82264","display_name":"Catalysis","level":2,"score":0.07218298316001892}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1080/10406639908020585","doi":"https://doi.org/10.1080/10406639908020585","is_oa":false,"landing_page_url":"https://doi.org/10.1080/10406639908020585","pdf_url":null,"source":{"id":"https://openalex.org/S178924077","display_name":"Polycyclic aromatic compounds","issn_l":"1026-7743","issn":["1026-7743","1040-6638","1563-5333"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","norway-1","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Polycyclic Aromatic Compounds","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":13,"referenced_works":["https://openalex.org/W1996033279","https://openalex.org/W2011777524","https://openalex.org/W2017418899","https://openalex.org/W2027433468","https://openalex.org/W2029518000","https://openalex.org/W2044282573","https://openalex.org/W2054114446","https://openalex.org/W2148821777","https://openalex.org/W2148913517","https://openalex.org/W2153973178","https://openalex.org/W2155073279","https://openalex.org/W2322556426","https://openalex.org/W2396843460"],"related_works":["https://openalex.org/W2028523547","https://openalex.org/W2042759677","https://openalex.org/W2120844492","https://openalex.org/W7095453609","https://openalex.org/W2171755667","https://openalex.org/W1970819714","https://openalex.org/W2068132457","https://openalex.org/W2022447460","https://openalex.org/W2112893029","https://openalex.org/W2087937320"],"abstract_inverted_index":{"In":[0],"order":[1],"to":[2,18],"explain":[3],"the":[4,9,23,110,117],"adduct":[5,28,114,129,135],"patterns":[6],"observed":[7],"from":[8,116],"human":[10,38],"CYP1A1-mediated":[11],"binding":[12],"of":[13,30,59,81,85,120,127],"dibenzo[a,":[14],"l]pyrene":[15],"(DB[a,":[16],"l]P)":[17],"DNA,":[19],"we":[20],"have":[21],"investigated":[22],"further":[24],"metabolism":[25],"and":[26,37,45,62,73,90],"DNA":[27,76,82,113],"activity":[29],"trans-DB[a,":[31,41,121],"l]P-8,9-diol":[32,42],"by":[33,69],"induced":[34],"rat":[35,50],"liver":[36,51],"CYP1A1":[39],"microsomes.":[40],"was":[43],"synthesized":[44],"metabolic":[46],"studies":[47],"with":[48,88,109],"\u03b2-naphthoflavone-induced":[49],"microsomes":[52],"indicated":[53],"three":[54],"major":[55,112],"metabolites:":[56],"2":[57],"diastereomers":[58],"trans,trans-8,9,11,12-tetrahydro-8,9,11,12-tetrahydroxy-DB[a,":[60],"l]P":[61,66,92],"8,9,13,14-tetrahydro-8,9,13,14-tetrahydroxy-DB[a,":[63],"l]P.":[64],"DB[a,":[65],"when":[67],"activated":[68],"CYP1A1/epoxide":[70],"hydrase":[71],"(EH)":[72],"calf":[74],"thymus":[75],"gave":[77],"a":[78,132,137],"complex":[79],"pattern":[80],"adducts":[83,102],"most":[84],"which":[86,107],"cochromatograph":[87],"syn-":[89],"anti-DB[a,":[91],"fjord":[93],"region":[94],"diol":[95,140],"epoxide-DNA":[96],"standards.":[97],"Two":[98],"highly":[99],"polar":[100,139],"eluting":[101],"were":[103],"also":[104],"observed,":[105],"one":[106],"cochromatographs":[108],"single":[111],"obtained":[115],"CYP1A1/EH":[118],"activation":[119],"l]P-8,9-diol.":[122],"The":[123],"relative":[124],"retention":[125],"time":[126],"this":[128],"suggests":[130],"either":[131],"bis-diol":[133],"epoxide":[134,141],"or":[136],"more":[138],"adduct.":[142]},"counts_by_year":[],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2016-06-24T00:00:00"}