{"id":"https://openalex.org/W1992829778","doi":"https://doi.org/10.1159/000174371","title":"Is the Sympathetic Nervous System Altered in Children with Familial History of Arterial Hypertension?","display_name":"Is the Sympathetic Nervous System Altered in Children with Familial History of Arterial Hypertension?","publication_year":2008,"publication_date":"2008-11-11","ids":{"openalex":"https://openalex.org/W1992829778","doi":"https://doi.org/10.1159/000174371","mag":"1992829778","pmid":"https://pubmed.ncbi.nlm.nih.gov/3416329"},"language":"en","primary_location":{"id":"doi:10.1159/000174371","doi":"https://doi.org/10.1159/000174371","is_oa":false,"landing_page_url":"https://doi.org/10.1159/000174371","pdf_url":null,"source":{"id":"https://openalex.org/S4210184113","display_name":"Cardiology","issn_l":"0008-6312","issn":["0008-6312","1421-9751"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310317820","host_organization_name":"Karger Publishers","host_organization_lineage":["https://openalex.org/P4310317820"],"host_organization_lineage_names":["Karger Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cardiology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5086372268","display_name":"Liberato Aldo Ferrara","orcid":"https://orcid.org/0000-0001-7008-3700","observed_orcids":["https://orcid.org/0000-0001-7008-3700"]},"institutions":[{"id":"https://openalex.org/I71267560","display_name":"University of Naples Federico II","ror":"https://ror.org/05290cv24","country_code":"IT","type":"education","lineage":["https://openalex.org/I71267560"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Liberato Aldo Ferrara","raw_affiliation_strings":["Institute of Internal Medicine and Metabolic Diseases, University of Naples, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Internal Medicine and Metabolic Diseases, University of Naples, Italy","institution_ids":["https://openalex.org/I71267560"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081410944","display_name":"Tancredi Secondo Moscato","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I71267560","display_name":"University of Naples Federico II","ror":"https://ror.org/05290cv24","country_code":"IT","type":"education","lineage":["https://openalex.org/I71267560"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Tancredi Secondo Moscato","raw_affiliation_strings":["Institute of Internal Medicine and Metabolic Diseases, Clinica Medica, and","University of Naples-Federico II"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Internal Medicine and Metabolic Diseases, Clinica Medica, and","institution_ids":[]},{"raw_affiliation_string":"University of Naples-Federico II","institution_ids":["https://openalex.org/I71267560"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026589510","display_name":"Nicola Pisanti","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I197809005","display_name":"University of Campania \"Luigi Vanvitelli\"","ror":"https://ror.org/02kqnpp86","country_code":"IT","type":"education","lineage":["https://openalex.org/I197809005"]},{"id":"https://openalex.org/I71267560","display_name":"University of Naples Federico II","ror":"https://ror.org/05290cv24","country_code":"IT","type":"education","lineage":["https://openalex.org/I71267560"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Nicola Pisanti","raw_affiliation_strings":["Institute of Clinical and Experimental Pharmacology, 2nd Medical School, University of Naples, Italy","University of Naples-Federico II"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Clinical and Experimental Pharmacology, 2nd Medical School, University of Naples, Italy","institution_ids":["https://openalex.org/I197809005","https://openalex.org/I71267560"]},{"raw_affiliation_string":"University of Naples-Federico II","institution_ids":["https://openalex.org/I71267560"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049949929","display_name":"Teodoro Marotta","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I71267560","display_name":"University of Naples Federico II","ror":"https://ror.org/05290cv24","country_code":"IT","type":"education","lineage":["https://openalex.org/I71267560"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Teodoro Marotta","raw_affiliation_strings":["Institute of Internal Medicine and Metabolic Diseases, Clinica Medica, and","University of Naples-Federico II"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Internal Medicine and Metabolic Diseases, Clinica Medica, and","institution_ids":[]},{"raw_affiliation_string":"University of Naples-Federico II","institution_ids":["https://openalex.org/I71267560"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086839304","display_name":"Vittorio Krogh","orcid":"https://orcid.org/0000-0003-0122-8624","observed_orcids":["https://orcid.org/0000-0003-0122-8624"]},"institutions":[{"id":"https://openalex.org/I4210156707","display_name":"Fondazione IRCCS Istituto Nazionale dei Tumori","ror":"https://ror.org/05dwj7825","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210153126","https://openalex.org/I4210156707"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Vittorio Krogh","raw_affiliation_strings":["Institute of Internal Medicine and Metabolic Diseases, Clinica Medica, and","Fondazione IRCCS Istituto Nazionale dei Tumori"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Internal Medicine and Metabolic Diseases, Clinica Medica, and","institution_ids":[]},{"raw_affiliation_string":"Fondazione IRCCS Istituto Nazionale dei Tumori","institution_ids":["https://openalex.org/I4210156707"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112094532","display_name":"Dom\u00eanico Capone","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I197809005","display_name":"University of Campania \"Luigi Vanvitelli\"","ror":"https://ror.org/02kqnpp86","country_code":"IT","type":"education","lineage":["https://openalex.org/I197809005"]},{"id":"https://openalex.org/I71267560","display_name":"University of Naples Federico II","ror":"https://ror.org/05290cv24","country_code":"IT","type":"education","lineage":["https://openalex.org/I71267560"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Domenico Capone","raw_affiliation_strings":["Institute of Clinical and Experimental Pharmacology, 2nd Medical School, University of Naples, Italy","University of Naples-Federico II"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Clinical and Experimental Pharmacology, 2nd Medical School, University of Naples, Italy","institution_ids":["https://openalex.org/I197809005","https://openalex.org/I71267560"]},{"raw_affiliation_string":"University of Naples-Federico II","institution_ids":["https://openalex.org/I71267560"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109001447","display_name":"Mario Mancini","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I71267560","display_name":"University of Naples Federico II","ror":"https://ror.org/05290cv24","country_code":"IT","type":"education","lineage":["https://openalex.org/I71267560"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Mario Mancini","raw_affiliation_strings":["Institute of Internal Medicine and Metabolic Diseases, Clinica Medica, and","University of Naples-Federico II"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Internal Medicine and Metabolic Diseases, Clinica Medica, and","institution_ids":[]},{"raw_affiliation_string":"University of Naples-Federico II","institution_ids":["https://openalex.org/I71267560"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":27,"citation_normalized_percentile":{"value":0.13518156,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"75","issue":"3","first_page":"200","last_page":"205"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10144","display_name":"Blood Pressure and Hypertension Studies","score":0.9765999913215637,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10144","display_name":"Blood Pressure and Hypertension Studies","score":0.9765999913215637,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10745","display_name":"Heart Rate Variability and Autonomic Control","score":0.018699999898672104,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10924","display_name":"Cardiovascular Health and Disease Prevention","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sympathetic-nervous-system","display_name":"sympathetic nervous system","score":0.9750000238418579},{"id":"https://openalex.org/keywords/hypertension","display_name":"hypertension","score":0.8149999976158142},{"id":"https://openalex.org/keywords/family-history-of-hypertension","display_name":"family history of hypertension","score":0.8709999918937683},{"id":"https://openalex.org/keywords/children","display_name":"children","score":0.9580000042915344},{"id":"https://openalex.org/keywords/mental-arithmetic-stress","display_name":"mental arithmetic stress","score":0.753000020980835},{"id":"https://openalex.org/keywords/isometric-handgrip-exercise","display_name":"isometric handgrip exercise","score":0.9399999976158142},{"id":"https://openalex.org/keywords/blood-pressure-response","display_name":"blood pressure response","score":0.7409999966621399},{"id":"https://openalex.org/keywords/heart-rate","display_name":"heart rate","score":0.824999988079071},{"id":"https://openalex.org/keywords/catecholamine-excretion","display_name":"catecholamine excretion","score":0.878000020980835},{"id":"https://openalex.org/keywords/urinary-catecholamines","display_name":"urinary catecholamines","score":0.7300000190734863}],"concepts":[{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.8372842073440552},{"id":"https://openalex.org/C103486182","wikidata":"https://www.wikidata.org/wiki/Q1216236","display_name":"Isometric exercise","level":2,"score":0.8050307035446167},{"id":"https://openalex.org/C2776533406","wikidata":"https://www.wikidata.org/wiki/Q187215","display_name":"Sympathetic nervous system","level":3,"score":0.734054684638977},{"id":"https://openalex.org/C2781179581","wikidata":"https://www.wikidata.org/wiki/Q2857712","display_name":"Family history","level":2,"score":0.6606463193893433},{"id":"https://openalex.org/C2777953023","wikidata":"https://www.wikidata.org/wiki/Q1073121","display_name":"Heart rate","level":3,"score":0.633203387260437},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6324098110198975},{"id":"https://openalex.org/C2775894120","wikidata":"https://www.wikidata.org/wiki/Q271663","display_name":"Catecholamine","level":2,"score":0.5804254412651062},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5737796425819397},{"id":"https://openalex.org/C112672928","wikidata":"https://www.wikidata.org/wiki/Q239526","display_name":"Offspring","level":3,"score":0.5470082759857178},{"id":"https://openalex.org/C10146269","wikidata":"https://www.wikidata.org/wiki/Q185557","display_name":"Excretion","level":2,"score":0.49831509590148926},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.4725883901119232},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3925148844718933},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.08000898361206055},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.05718150734901428},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D001794","descriptor_name":"Blood Pressure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001794","descriptor_name":"Blood Pressure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001794","descriptor_name":"Blood Pressure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002395","descriptor_name":"Catecholamines","qualifier_ui":"Q000652","qualifier_name":"urine","is_major_topic":false},{"descriptor_ui":"D002395","descriptor_name":"Catecholamines","qualifier_ui":"Q000652","qualifier_name":"urine","is_major_topic":false},{"descriptor_ui":"D002395","descriptor_name":"Catecholamines","qualifier_ui":"Q000652","qualifier_name":"urine","is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006339","descriptor_name":"Heart Rate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006339","descriptor_name":"Heart Rate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006339","descriptor_name":"Heart Rate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006973","descriptor_name":"Hypertension","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006973","descriptor_name":"Hypertension","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006973","descriptor_name":"Hypertension","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006973","descriptor_name":"Hypertension","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D006973","descriptor_name":"Hypertension","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D006973","descriptor_name":"Hypertension","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D007537","descriptor_name":"Isometric Contraction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007537","descriptor_name":"Isometric Contraction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007537","descriptor_name":"Isometric Contraction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013315","descriptor_name":"Stress, Psychological","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D013315","descriptor_name":"Stress, Psychological","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D013315","descriptor_name":"Stress, Psychological","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D013564","descriptor_name":"Sympathetic Nervous System","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D013564","descriptor_name":"Sympathetic Nervous System","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D013564","descriptor_name":"Sympathetic Nervous System","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1159/000174371","doi":"https://doi.org/10.1159/000174371","is_oa":false,"landing_page_url":"https://doi.org/10.1159/000174371","pdf_url":null,"source":{"id":"https://openalex.org/S4210184113","display_name":"Cardiology","issn_l":"0008-6312","issn":["0008-6312","1421-9751"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310317820","host_organization_name":"Karger Publishers","host_organization_lineage":["https://openalex.org/P4310317820"],"host_organization_lineage_names":["Karger Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cardiology","raw_type":"journal-article"},{"id":"pmid:3416329","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3416329","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cardiology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9940000176429749,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.8399999737739563,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2110681150","https://openalex.org/W2064652474","https://openalex.org/W3160140598","https://openalex.org/W2009428258","https://openalex.org/W1591616590","https://openalex.org/W2104914661","https://openalex.org/W2031086529","https://openalex.org/W2138733863","https://openalex.org/W2046261096","https://openalex.org/W1992829778"],"abstract_inverted_index":{"The":[0,60],"sympathetic":[1,142],"nervous":[2],"system":[3],"has":[4],"been":[5],"investigated":[6],"in":[7,38,62,74,84,95,110,147],"42":[8],"children":[9,18,75],"with":[10,42,76,113],"family":[11,77,114],"history":[12,78,115],"of":[13,19,79,116,140,150],"arterial":[14],"hypertension":[15,117],"and":[16,31,50,87],"68":[17],"the":[20,66,111,141],"same":[21],"age":[22],"without":[23,98],"hypertensive":[24,151],"relatives.":[25],"Pressure":[26],"responses":[27],"to":[28,32,134],"mental":[29,67],"arithmetic":[30,68],"isometric":[33,93],"handgrip":[34,94],"stress":[35],"were":[36],"measured":[37],"both":[39,96],"groups,":[40],"along":[41],"24":[43],"h":[44],"catecholamine":[45,104],"excretion.":[46],"Resting":[47],"blood":[48,85],"pressure":[49,64,86],"heart":[51,88],"rate":[52,89],"did":[53],"not":[54],"show":[55],"any":[56,99],"difference":[57],"between":[58],"groups.":[59],"increase":[61,83],"diastolic":[63],"during":[65,92],"exercise":[69],"was,":[70],"however,":[71],"significantly":[72,108],"greater":[73],"hypertension.":[80],"A":[81],"sharp":[82],"was":[90,107],"observed":[91],"groups":[97],"significant":[100],"difference.":[101],"Twenty-four":[102],"hour":[103],"urinary":[105],"excretion":[106],"higher":[109],"group":[112],"(31":[118],"+/-":[119,123],"15":[120],"vs.":[121],"23":[122],"13":[124],"micrograms/24":[125],"h;":[126],"p":[127],"less":[128],"than":[129],"0.05).":[130],"These":[131],"results":[132],"seem":[133],"indicate":[135],"that":[136],"an":[137],"initial":[138],"impairment":[139],"activity":[143],"is":[144],"already":[145],"detectable":[146],"young":[148],"offspring":[149],"patients.":[152]},"counts_by_year":[{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-01T08:54:57.152042","created_date":"2025-10-10T00:00:00"}