{"id":"https://openalex.org/W1992670060","doi":"https://doi.org/10.1002/(sici)1097-4652(199603)166:3<643::aid-jcp20>3.0.co;2-6","title":"Subcloning the RBL-2H3 mucosal mast cell line reduces Ca2+ response heterogeneity at the single-cell level","display_name":"Subcloning the RBL-2H3 mucosal mast cell line reduces Ca2+ response heterogeneity at the single-cell level","publication_year":1996,"publication_date":"1996-03-01","ids":{"openalex":"https://openalex.org/W1992670060","doi":"https://doi.org/10.1002/(sici)1097-4652(199603)166:3<643::aid-jcp20>3.0.co;2-6","mag":"1992670060","pmid":"https://pubmed.ncbi.nlm.nih.gov/8600169"},"language":"en","primary_location":{"id":"doi:10.1002/(sici)1097-4652(199603)166:3<643::aid-jcp20>3.0.co;2-6","doi":"https://doi.org/10.1002/(sici)1097-4652(199603)166:3<643::aid-jcp20>3.0.co;2-6","is_oa":false,"landing_page_url":"https://doi.org/10.1002/(sici)1097-4652(199603)166:3<643::aid-jcp20>3.0.co;2-6","pdf_url":null,"source":{"id":"https://openalex.org/S43643205","display_name":"Journal of Cellular Physiology","issn_l":"0021-9541","issn":["0021-9541","1097-4652"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cellular Physiology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5004283621","display_name":"John Kuchtey","orcid":"https://orcid.org/0000-0001-5226-8648","observed_orcids":["https://orcid.org/0000-0001-5226-8648"]},"institutions":[{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"John Kuchtey","raw_affiliation_strings":["Department of Pharmacology, Cornell University, Ithaca, New York 14853, USA","Department of Pharmacology, Cornell University, Ithaca, New York 14853"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Cornell University, Ithaca, New York 14853, USA","institution_ids":["https://openalex.org/I205783295"]},{"raw_affiliation_string":"Department of Pharmacology, Cornell University, Ithaca, New York 14853","institution_ids":["https://openalex.org/I205783295"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5069750802","display_name":"Clare Fewtrell","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Clare Fewtrell","raw_affiliation_strings":["Department of Pharmacology, Cornell University, Ithaca, New York 14853"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Cornell University, Ithaca, New York 14853","institution_ids":["https://openalex.org/I205783295"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5004283621"],"corresponding_institution_ids":["https://openalex.org/I205783295"],"apc_list":{"value":5230,"currency":"USD","value_usd":5230},"apc_paid":null,"fwci":0.9593,"has_fulltext":false,"cited_by_count":14,"citation_normalized_percentile":{"value":0.75078571,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"166","issue":"3","first_page":"643","last_page":"652"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11346","display_name":"Mast cells and histamine","score":0.986299991607666,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11346","display_name":"Mast cells and histamine","score":0.986299991607666,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11204","display_name":"Ion Channels and Receptors","score":0.00559999980032444,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.0019000000320374966,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rbl-2h3-cells","display_name":"RBL-2H3 cells","score":0.9100000262260437},{"id":"https://openalex.org/keywords/mucosal-mast-cells","display_name":"mucosal mast cells","score":0.9879999756813049},{"id":"https://openalex.org/keywords/cell-to-cell-variability","display_name":"cell-to-cell variability","score":0.7940000295639038},{"id":"https://openalex.org/keywords/subcloning","display_name":"subcloning","score":0.8019999861717224},{"id":"https://openalex.org/keywords/genetic-heterogeneity","display_name":"genetic heterogeneity","score":0.8709999918937683},{"id":"https://openalex.org/keywords/antigenic-stimulation","display_name":"antigen stimulation","score":0.8820000290870667},{"id":"https://openalex.org/keywords/fura-2-calcium-imaging","display_name":"Fura-2 calcium imaging","score":0.8140000104904175},{"id":"https://openalex.org/keywords/mast-cell-degranulation","display_name":"mast cell degranulation","score":0.722000002861023}],"concepts":[{"id":"https://openalex.org/C2779726688","wikidata":"https://www.wikidata.org/wiki/Q191989","display_name":"Mast cell","level":2,"score":0.7117663621902466},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.612932026386261},{"id":"https://openalex.org/C64618202","wikidata":"https://www.wikidata.org/wiki/Q3733697","display_name":"Genetic heterogeneity","level":4,"score":0.6040678024291992},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.5814750790596008},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.5538347363471985},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.5178139805793762},{"id":"https://openalex.org/C163005120","wikidata":"https://www.wikidata.org/wiki/Q4115252","display_name":"Subcloning","level":4,"score":0.49136343598365784},{"id":"https://openalex.org/C24998067","wikidata":"https://www.wikidata.org/wiki/Q4114622","display_name":"Stimulation","level":2,"score":0.48956498503685},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.4420171082019806},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4251219928264618},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.42483747005462646},{"id":"https://openalex.org/C189014844","wikidata":"https://www.wikidata.org/wiki/Q189118","display_name":"Cell type","level":3,"score":0.4169624149799347},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2817596197128296},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.18744680285453796},{"id":"https://openalex.org/C40767141","wikidata":"https://www.wikidata.org/wiki/Q285697","display_name":"Recombinant DNA","level":3,"score":0.1214204728603363},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.09409233927726746},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.08671814203262329},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.08359292149543762},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000941","descriptor_name":"Antigens","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002999","descriptor_name":"Clone Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005456","descriptor_name":"Fluorescent Dyes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005719","descriptor_name":"gamma-Globulins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007091","descriptor_name":"Image Processing, Computer-Assisted","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008407","descriptor_name":"Mast Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D008407","descriptor_name":"Mast Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009092","descriptor_name":"Mucous Membrane","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015471","descriptor_name":"Leukemia, Basophilic, Acute","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016257","descriptor_name":"Fura-2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018740","descriptor_name":"Genetic Heterogeneity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/(sici)1097-4652(199603)166:3<643::aid-jcp20>3.0.co;2-6","doi":"https://doi.org/10.1002/(sici)1097-4652(199603)166:3<643::aid-jcp20>3.0.co;2-6","is_oa":false,"landing_page_url":"https://doi.org/10.1002/(sici)1097-4652(199603)166:3<643::aid-jcp20>3.0.co;2-6","pdf_url":null,"source":{"id":"https://openalex.org/S43643205","display_name":"Journal of Cellular Physiology","issn_l":"0021-9541","issn":["0021-9541","1097-4652"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cellular Physiology","raw_type":"journal-article"},{"id":"pmid:8600169","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8600169","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of cellular physiology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G168591354","display_name":null,"funder_award_id":"GM 08210","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G2383587547","display_name":"Biophysical and Biochemical Pharmacology","funder_award_id":"T32GM008210","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":41,"referenced_works":["https://openalex.org/W297918892","https://openalex.org/W439019705","https://openalex.org/W1481352843","https://openalex.org/W1487303560","https://openalex.org/W1492343139","https://openalex.org/W1510877630","https://openalex.org/W1542954456","https://openalex.org/W1563458114","https://openalex.org/W1572564124","https://openalex.org/W1575381933","https://openalex.org/W1575874096","https://openalex.org/W1575979011","https://openalex.org/W1704017123","https://openalex.org/W1964801849","https://openalex.org/W1966724400","https://openalex.org/W1968585354","https://openalex.org/W1973727303","https://openalex.org/W1974602742","https://openalex.org/W1978800240","https://openalex.org/W1989774654","https://openalex.org/W1994102377","https://openalex.org/W1994942368","https://openalex.org/W2009437937","https://openalex.org/W2014543453","https://openalex.org/W2019758826","https://openalex.org/W2029458131","https://openalex.org/W2035997372","https://openalex.org/W2036674677","https://openalex.org/W2045546690","https://openalex.org/W2048345403","https://openalex.org/W2067523166","https://openalex.org/W2067997407","https://openalex.org/W2071789586","https://openalex.org/W2106217238","https://openalex.org/W2110041210","https://openalex.org/W2134606648","https://openalex.org/W2136623476","https://openalex.org/W2140488772","https://openalex.org/W2141260882","https://openalex.org/W2146861726","https://openalex.org/W4251499038"],"related_works":["https://openalex.org/W1974602742","https://openalex.org/W4388324875","https://openalex.org/W7098867437","https://openalex.org/W2064680225","https://openalex.org/W2949348351","https://openalex.org/W2133899865","https://openalex.org/W2051358693","https://openalex.org/W1994102377","https://openalex.org/W4385686728","https://openalex.org/W1994565985"],"abstract_inverted_index":{"Ca2+":[0,25,94,144,158,196],"imaging":[1],"experiments":[2],"have":[3,53,71],"revealed":[4],"that":[5,83,99,150,165],"for":[6,143],"a":[7,46,62,191],"wide":[8,63],"variety":[9,64],"of":[10,23,27,40,50,65,92,107,129,156,162,186,193],"cell":[11,77,179,181],"types,":[12],"including":[13],"RBL-2H3":[14,74],"mucosal":[15,75],"mast":[16,76],"cells,":[17],"there":[18,166],"are":[19,160,167],"considerable":[20],"cell-to-cell":[21,100],"differences":[22,125,177],"the":[24,36,41,73,81,87,90,93,116,127,151,157,163,171,194],"responses":[26,66,159],"individual":[28,133],"cells.":[29,134],"This":[30],"heterogeneity":[31,85,113,139],"is":[32,89,148],"evident":[33],"in":[34,105,126,182],"both":[35],"shape":[37],"and":[38,58,154],"latency":[39],"responses.":[42],"Mast":[43],"cells":[44],"within":[45,86,115],"single":[47],"microscopic":[48],"field":[49],"view,":[51],"which":[52],"experienced":[54],"identical":[55],"culture":[56],"conditions":[57],"experimental":[59,121],"preparation,":[60],"display":[61],"upon":[67],"antigen":[68,174],"stimulation.":[69,175],"We":[70,97],"subcloned":[72],"line":[78],"to":[79,173,180],"test":[80],"hypothesis":[82],"genetic":[84,138],"population":[88],"cause":[91,192],"response":[95,112,145,197],"heterogeneity.":[96,146,198],"found":[98],"variability":[101,155],"was":[102,118],"significantly":[103],"reduced":[104],"four":[106],"five":[108],"clonal":[109],"lines.":[110],"The":[111],"remaining":[114,195],"clones":[117],"not":[119],"an":[120],"artifact":[122],"caused":[123],"by":[124,132],"amount":[128],"fura-2":[130],"loaded":[131],"Factors":[135],"other":[136],"than":[137],"must":[140],"partly":[141],"account":[142],"It":[147],"possible":[149],"complex":[152],"shapes":[153],"reflections":[161],"fact":[164],"multiple":[168],"factors":[169,188],"underlying":[170],"Ca2-response":[172],"Small":[176],"from":[178],"one":[183],"or":[184],"more":[185],"these":[187],"could":[189],"be":[190]},"counts_by_year":[{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
