{"id":"https://openalex.org/W1992653563","doi":"https://doi.org/10.1111/j.1476-5381.1983.tb09362.x","title":"Neostigmine augments responses of the rat anococcygeus muscle to field stimulation","display_name":"Neostigmine augments responses of the rat anococcygeus muscle to field stimulation","publication_year":1983,"publication_date":"1983-01-01","ids":{"openalex":"https://openalex.org/W1992653563","doi":"https://doi.org/10.1111/j.1476-5381.1983.tb09362.x","mag":"1992653563","pmid":"https://pubmed.ncbi.nlm.nih.gov/6297649","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2044789"},"language":"en","primary_location":{"id":"doi:10.1111/j.1476-5381.1983.tb09362.x","doi":"https://doi.org/10.1111/j.1476-5381.1983.tb09362.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1476-5381.1983.tb09362.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1476-5381.1983.tb09362.x","source":{"id":"https://openalex.org/S55107261","display_name":"British Journal of Pharmacology","issn_l":"0007-1188","issn":["0007-1188","1476-5381"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Pharmacology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1476-5381.1983.tb09362.x","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5079557592","display_name":"Jerry A. Smith","orcid":"https://orcid.org/0000-0002-5768-7750","observed_orcids":["https://orcid.org/0000-0002-5768-7750"]},"institutions":[{"id":"https://openalex.org/I79510175","display_name":"Cardiff University","ror":"https://ror.org/03kk7td41","country_code":"GB","type":"education","lineage":["https://openalex.org/I79510175"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"J. A. Smith","raw_affiliation_strings":["Department of Pharmacology & Therapeutics, Welsh National School of Medicine, Heath Park, Cardiff, CF4 4XN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology & Therapeutics, Welsh National School of Medicine, Heath Park, Cardiff, CF4 4XN","institution_ids":["https://openalex.org/I79510175"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110141124","display_name":"T. L. B. Spriggs","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79510175","display_name":"Cardiff University","ror":"https://ror.org/03kk7td41","country_code":"GB","type":"education","lineage":["https://openalex.org/I79510175"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"T.L.B. Spriggs","raw_affiliation_strings":["Department of Pharmacology & Therapeutics, Welsh National School of Medicine, Heath Park, Cardiff, CF4 4XN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology & Therapeutics, Welsh National School of Medicine, Heath Park, Cardiff, CF4 4XN","institution_ids":["https://openalex.org/I79510175"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I79510175"],"apc_list":{"value":4780,"currency":"USD","value_usd":4780},"apc_paid":null,"fwci":1.3628,"has_fulltext":true,"cited_by_count":10,"citation_normalized_percentile":{"value":0.78223496,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"78","issue":"1","first_page":"57","last_page":"65"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12023","display_name":"Cholinesterase and Neurodegenerative Diseases","score":0.5390999913215637,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12023","display_name":"Cholinesterase and Neurodegenerative Diseases","score":0.5390999913215637,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.18119999766349792,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11818","display_name":"Nicotinic Acetylcholine Receptors Study","score":0.09380000084638596,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/neostigmine","display_name":"neostigmine","score":1.0},{"id":"https://openalex.org/keywords/anococcygeus-muscle","display_name":"anococcygeus muscle","score":0.9259999990463257},{"id":"https://openalex.org/keywords/noradrenergic-transmission","display_name":"noradrenergic neurotransmission","score":0.9459999799728394},{"id":"https://openalex.org/keywords/electrical-field-stimulation","display_name":"electrical field stimulation","score":0.8669999837875366},{"id":"https://openalex.org/keywords/neuromuscular-junction","display_name":"neuromuscular junction","score":0.7269999980926514},{"id":"https://openalex.org/keywords/cholinesterase","display_name":"cholinesterase","score":0.7509999871253967},{"id":"https://openalex.org/keywords/atropine","display_name":"atropine","score":0.7260000109672546},{"id":"https://openalex.org/keywords/noradrenaline-release","display_name":"noradrenaline release","score":0.7239999771118164},{"id":"https://openalex.org/keywords/presynaptic-inhibition","display_name":"presynaptic inhibition","score":0.6880000233650208},{"id":"https://openalex.org/keywords/smooth-muscle","display_name":"smooth muscle","score":0.5049999952316284},{"id":"https://openalex.org/keywords/schwann-cells","display_name":"Schwann cells","score":0.6060000061988831},{"id":"https://openalex.org/keywords/cholinergic-transmission","display_name":"cholinergic neurotransmission","score":0.35100001096725464}],"concepts":[{"id":"https://openalex.org/C2777411258","wikidata":"https://www.wikidata.org/wiki/Q410546","display_name":"Neostigmine","level":2,"score":0.9044210910797119},{"id":"https://openalex.org/C2776232365","wikidata":"https://www.wikidata.org/wiki/Q420673","display_name":"Guanethidine","level":3,"score":0.8810452222824097},{"id":"https://openalex.org/C2775859210","wikidata":"https://www.wikidata.org/wiki/Q26272","display_name":"Atropine","level":2,"score":0.7895176410675049},{"id":"https://openalex.org/C2780253649","wikidata":"https://www.wikidata.org/wiki/Q420360","display_name":"Phentolamine","level":3,"score":0.7562911510467529},{"id":"https://openalex.org/C24998067","wikidata":"https://www.wikidata.org/wiki/Q4114622","display_name":"Stimulation","level":2,"score":0.6983152031898499},{"id":"https://openalex.org/C2775910092","wikidata":"https://www.wikidata.org/wiki/Q180623","display_name":"Acetylcholine","level":2,"score":0.5613712072372437},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5455947518348694},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5097505450248718},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4774923026561737},{"id":"https://openalex.org/C3020341438","wikidata":"https://www.wikidata.org/wiki/Q776995","display_name":"Neuromuscular transmission","level":2,"score":0.4679015576839447},{"id":"https://openalex.org/C2776050358","wikidata":"https://www.wikidata.org/wiki/Q127006","display_name":"Muscle contraction","level":2,"score":0.4264146685600281},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.21458739042282104},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.16935047507286072}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002795","descriptor_name":"Choline O-Acetyltransferase","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D002800","descriptor_name":"Cholinesterase Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004558","descriptor_name":"Electric Stimulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009130","descriptor_name":"Muscle, Smooth","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D009130","descriptor_name":"Muscle, Smooth","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D009388","descriptor_name":"Neostigmine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D009435","descriptor_name":"Synaptic Transmission","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009638","descriptor_name":"Norepinephrine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011919","descriptor_name":"Rats, Inbred Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013564","descriptor_name":"Sympathetic Nervous System","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066298","descriptor_name":"In Vitro Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1111/j.1476-5381.1983.tb09362.x","doi":"https://doi.org/10.1111/j.1476-5381.1983.tb09362.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1476-5381.1983.tb09362.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1476-5381.1983.tb09362.x","source":{"id":"https://openalex.org/S55107261","display_name":"British Journal of Pharmacology","issn_l":"0007-1188","issn":["0007-1188","1476-5381"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Pharmacology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2044789","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2044789","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Br J Pharmacol","raw_type":"Text"},{"id":"pmid:6297649","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6297649","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British journal of pharmacology","raw_type":"Journal Article"},{"id":"pmh:oai:https://orca.cardiff.ac.uk:10881","doi":null,"is_oa":false,"landing_page_url":"https://orca.cardiff.ac.uk/10881/","pdf_url":null,"source":{"id":"https://openalex.org/S4306401195","display_name":"ORCA Online Research @Cardiff (Cardiff University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I79510175","host_organization_name":"Cardiff University","host_organization_lineage":["https://openalex.org/I79510175"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"}],"best_oa_location":{"id":"doi:10.1111/j.1476-5381.1983.tb09362.x","doi":"https://doi.org/10.1111/j.1476-5381.1983.tb09362.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1476-5381.1983.tb09362.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1476-5381.1983.tb09362.x","source":{"id":"https://openalex.org/S55107261","display_name":"British Journal of Pharmacology","issn_l":"0007-1188","issn":["0007-1188","1476-5381"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Pharmacology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.4043000042438507,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1992653563.pdf","grobid_xml":"https://content.openalex.org/works/W1992653563.grobid-xml"},"referenced_works_count":21,"referenced_works":["https://openalex.org/W1978115312","https://openalex.org/W1995375290","https://openalex.org/W2000114235","https://openalex.org/W2007248577","https://openalex.org/W2021852569","https://openalex.org/W2032981850","https://openalex.org/W2037820656","https://openalex.org/W2044210562","https://openalex.org/W2059752909","https://openalex.org/W2065053314","https://openalex.org/W2085792542","https://openalex.org/W2087417290","https://openalex.org/W2094773007","https://openalex.org/W2095873344","https://openalex.org/W2111668341","https://openalex.org/W2123629158","https://openalex.org/W2129632465","https://openalex.org/W2252996918","https://openalex.org/W2291270621","https://openalex.org/W2298259941","https://openalex.org/W4406989624"],"related_works":["https://openalex.org/W2045910523","https://openalex.org/W1999582638","https://openalex.org/W2232358661","https://openalex.org/W173522095","https://openalex.org/W2123610280","https://openalex.org/W1974613973","https://openalex.org/W2165098778","https://openalex.org/W4234571279","https://openalex.org/W2889060063","https://openalex.org/W2415054582"],"abstract_inverted_index":{"1":[0],"The":[1,61,94],"effects":[2,187],"of":[3,18,57,63,133,148,174,188],"neostigmine":[4,76,189],"on":[5,142,197],"noradrenergic":[6,198],"transmission":[7],"have":[8],"been":[9],"studied":[10],"in":[11,71,130],"the":[12,19,26,58,64,91,131,143,170,175,185],"field":[13,30,67],"stimulated,":[14],"isolated":[15],"anococcygeus":[16],"muscle":[17,160,176],"rat.":[20],"2":[21],"In":[22],"those":[23],"muscles":[24],"where":[25],"excitatory":[27],"response":[28,65],"to":[29,41,66,80,158,193],"stimulation":[31,68,99],"was":[32,69,107],"not":[33,191],"completely":[34],"inhibited":[35],"by":[36,75,109,117],"guanethidine":[37],"(5":[38,49,77,111,135],"X":[39,50,78,82,112,124,136],"10(-6)":[40,83,125],"10(-5)":[42],"M)":[43,52,114],"or":[44,129,145],"phentolamine":[45],"(10(-6)":[46,119],"M),":[47,84,126,138],"atropine":[48,110,134],"10(-8)":[51,113,137],"gave":[53],"no":[54,140],"further":[55],"inhibition":[56],"response.":[59],"3":[60,103],"shape":[62],"altered":[70],"a":[72,87,194],"dose-dependent":[73],"manner":[74],"10(-7)":[79],"5":[81,150],"such":[85],"that":[86,184],"'shoulder'":[88],"appeared":[89],"during":[90],"relaxation":[92],"phase.":[93],"'shoulder',":[95],"present":[96],"at":[97,169],"all":[98],"frequencies":[100],"tested":[101],"between":[102],"and":[104,115],"40":[105],"Hz,":[106],"abolished":[108],"unaffected":[116],"tubocurarine":[118],"M).":[120],"4":[121],"Neostigmine":[122],"(2.5":[123],"whether":[127],"alone":[128],"presence":[132],"had":[139],"effect":[141,196],"uptake":[144],"stimulation-induced":[146],"release":[147],"[3H]-noradrenaline.":[149],"Using":[151],"electron":[152],"microscopy,":[153],"small":[154],"Schwann/axon":[155],"bundles":[156,168],"close":[157],"smooth":[159],"cells":[161],"rarely":[162],"showed":[163],"cholinesterase":[164],"staining,":[165],"whereas":[166],"larger":[167],"outer":[171],"serosal":[172],"aspects":[173],"exhibited":[177],"dense":[178],"staining.":[179],"6":[180],"It":[181],"is":[182],"concluded":[183],"observed":[186],"are":[190],"due":[192],"presynaptic":[195],"transmission.":[199]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
