{"id":"https://openalex.org/W1992643899","doi":"https://doi.org/10.1073/pnas.0606956103","title":"Phosphoinositide 3-kinase \u03b3/\u03b4 inhibition limits infarct size after myocardial ischemia/reperfusion injury","display_name":"Phosphoinositide 3-kinase \u03b3/\u03b4 inhibition limits infarct size after myocardial ischemia/reperfusion injury","publication_year":2006,"publication_date":"2006-12-15","ids":{"openalex":"https://openalex.org/W1992643899","doi":"https://doi.org/10.1073/pnas.0606956103","mag":"1992643899","pmid":"https://pubmed.ncbi.nlm.nih.gov/17172449","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1702529"},"language":"en","primary_location":{"id":"doi:10.1073/pnas.0606956103","doi":"https://doi.org/10.1073/pnas.0606956103","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.0606956103","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1702529","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5076682507","display_name":"John Doukas","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"John Doukas","raw_affiliation_strings":["*TargeGen, Inc., 9380 Judicial Drive, San Diego, CA 92121;","TargeGen, Inc., 9380 Judicial Drive, San Diego, CA 92121, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"*TargeGen, Inc., 9380 Judicial Drive, San Diego, CA 92121;","institution_ids":[]},{"raw_affiliation_string":"TargeGen, Inc., 9380 Judicial Drive, San Diego, CA 92121, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109101617","display_name":"Wolfgang Wrasidlo","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Wolfgang Wrasidlo","raw_affiliation_strings":["*TargeGen, Inc., 9380 Judicial Drive, San Diego, CA 92121;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"*TargeGen, Inc., 9380 Judicial Drive, San Diego, CA 92121;","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002654513","display_name":"Glenn Noronha","orcid":"https://orcid.org/0000-0001-6241-9091","observed_orcids":["https://orcid.org/0000-0001-6241-9091"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Glenn Noronha","raw_affiliation_strings":["*TargeGen, Inc., 9380 Judicial Drive, San Diego, CA 92121;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"*TargeGen, Inc., 9380 Judicial Drive, San Diego, CA 92121;","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025985985","display_name":"Elena Dneprovskaia","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Elena Dneprovskaia","raw_affiliation_strings":["*TargeGen, Inc., 9380 Judicial Drive, San Diego, CA 92121;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"*TargeGen, Inc., 9380 Judicial Drive, San Diego, CA 92121;","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082782752","display_name":"Richard Fine","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210086725","display_name":"BioPredict (United States)","ror":"https://ror.org/004nrp689","country_code":"US","type":"company","lineage":["https://openalex.org/I4210086725"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Richard Fine","raw_affiliation_strings":["BioPredict, Inc., 660 Kinderkamack Road, Oradell, NJ 07649;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BioPredict, Inc., 660 Kinderkamack Road, Oradell, NJ 07649;","institution_ids":["https://openalex.org/I4210086725"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030557212","display_name":"Sara M. Weis","orcid":"https://orcid.org/0009-0008-3137-4239","observed_orcids":["https://orcid.org/0009-0008-3137-4239"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]},{"id":"https://openalex.org/I4390039236","display_name":"Moores Cancer Center","ror":"https://ror.org/01qkmtm61","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800935791","https://openalex.org/I36258959","https://openalex.org/I4390039236"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sara Weis","raw_affiliation_strings":["University of California at San Diego, Moores Cancer Center, 3855 Health Sciences Drive, La Jolla, CA 92093; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California at San Diego, Moores Cancer Center, 3855 Health Sciences Drive, La Jolla, CA 92093; and","institution_ids":["https://openalex.org/I36258959","https://openalex.org/I4390039236"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109426437","display_name":"John D. Hood","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"John Hood","raw_affiliation_strings":["*TargeGen, Inc., 9380 Judicial Drive, San Diego, CA 92121;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"*TargeGen, Inc., 9380 Judicial Drive, San Diego, CA 92121;","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045816524","display_name":"Anthony Nicholas DeMaria","orcid":"https://orcid.org/0000-0002-8944-397X","observed_orcids":["https://orcid.org/0000-0002-8944-397X"]},"institutions":[{"id":"https://openalex.org/I123431417","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I123431417"]},{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]},{"id":"https://openalex.org/I4210132395","display_name":"University of California San Diego Medical Center","ror":"https://ror.org/03aw5sn18","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800935791","https://openalex.org/I36258959","https://openalex.org/I4210132395"]},{"id":"https://openalex.org/I4390039236","display_name":"Moores Cancer Center","ror":"https://ror.org/01qkmtm61","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800935791","https://openalex.org/I36258959","https://openalex.org/I4390039236"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anthony DeMaria","raw_affiliation_strings":["University of California at San Diego Medical Center, Division of Cardiology, 200 West Arbor Drive, San Diego, CA 92103","The Scripps Research Institute, La Jolla, CA,","University of California at San Diego, Moores Cancer Center, Room 2344, 3855 Health Sciences Drive, #0803, La Jolla, CA 92093-0803"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California at San Diego Medical Center, Division of Cardiology, 200 West Arbor Drive, San Diego, CA 92103","institution_ids":["https://openalex.org/I36258959","https://openalex.org/I4210132395"]},{"raw_affiliation_string":"The Scripps Research Institute, La Jolla, CA,","institution_ids":["https://openalex.org/I123431417"]},{"raw_affiliation_string":"University of California at San Diego, Moores Cancer Center, Room 2344, 3855 Health Sciences Drive, #0803, La Jolla, CA 92093-0803","institution_ids":["https://openalex.org/I36258959","https://openalex.org/I4390039236"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011805749","display_name":"Richard S\u00f6ll","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Richard Soll","raw_affiliation_strings":["*TargeGen, Inc., 9380 Judicial Drive, San Diego, CA 92121;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"*TargeGen, Inc., 9380 Judicial Drive, San Diego, CA 92121;","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5089796560","display_name":"David A. Cheresh","orcid":"https://orcid.org/0000-0002-7193-8595","observed_orcids":["https://orcid.org/0000-0002-7193-8595"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]},{"id":"https://openalex.org/I4390039236","display_name":"Moores Cancer Center","ror":"https://ror.org/01qkmtm61","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800935791","https://openalex.org/I36258959","https://openalex.org/I4390039236"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David Cheresh","raw_affiliation_strings":["University of California at San Diego, Moores Cancer Center, 3855 Health Sciences Drive, La Jolla, CA 92093; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California at San Diego, Moores Cancer Center, 3855 Health Sciences Drive, La Jolla, CA 92093; and","institution_ids":["https://openalex.org/I36258959","https://openalex.org/I4390039236"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":8.6263,"has_fulltext":false,"cited_by_count":132,"citation_normalized_percentile":{"value":0.98062882,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"103","issue":"52","first_page":"19866","last_page":"19871"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11057","display_name":"Cardiac Ischemia and Reperfusion","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11057","display_name":"Cardiac Ischemia and Reperfusion","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11962","display_name":"Cardiac Fibrosis and Remodeling","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10952","display_name":"PI3K/AKT/mTOR signaling in cancer","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/phosphatidylinositol-3-kinase","display_name":"phosphatidylinositol 3-kinase","score":0.9330000281333923},{"id":"https://openalex.org/keywords/myocardial-ischemia-reperfusion-injury","display_name":"myocardial ischemia-reperfusion injury","score":0.9390000104904175},{"id":"https://openalex.org/keywords/myocardial-infarction","display_name":"myocardial infarction","score":0.8970000147819519},{"id":"https://openalex.org/keywords/cardioprotection","display_name":"cardioprotection","score":0.9509999752044678},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.6060000061988831},{"id":"https://openalex.org/keywords/edema","display_name":"edema","score":0.8040000200271606},{"id":"https://openalex.org/keywords/vascular-endothelial-growth-factor","display_name":"vascular endothelial growth factor","score":0.9520000219345093},{"id":"https://openalex.org/keywords/platelet-activating-factor","display_name":"platelet-activating factor","score":1.0},{"id":"https://openalex.org/keywords/isoform-selective-inhibitors","display_name":"isoform-selective inhibitors","score":0.593999981880188}],"concepts":[{"id":"https://openalex.org/C2779676291","wikidata":"https://www.wikidata.org/wiki/Q25325349","display_name":"Cardioprotection","level":3,"score":0.8552507162094116},{"id":"https://openalex.org/C2780114680","wikidata":"https://www.wikidata.org/wiki/Q1413991","display_name":"Reperfusion injury","level":3,"score":0.675582766532898},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6732969880104065},{"id":"https://openalex.org/C541997718","wikidata":"https://www.wikidata.org/wiki/Q188151","display_name":"Ischemia","level":2,"score":0.5909292697906494},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5182166695594788},{"id":"https://openalex.org/C500558357","wikidata":"https://www.wikidata.org/wiki/Q12152","display_name":"Myocardial infarction","level":2,"score":0.5012495517730713},{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.4779493808746338},{"id":"https://openalex.org/C2781322055","wikidata":"https://www.wikidata.org/wiki/Q423725","display_name":"Phosphoinositide 3-kinase","level":4,"score":0.4743298888206482},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.46288132667541504},{"id":"https://openalex.org/C2777025900","wikidata":"https://www.wikidata.org/wiki/Q29725","display_name":"Vascular endothelial growth factor","level":3,"score":0.4363569915294647},{"id":"https://openalex.org/C164027704","wikidata":"https://www.wikidata.org/wiki/Q3491837","display_name":"Proinflammatory cytokine","level":3,"score":0.4363382160663605},{"id":"https://openalex.org/C75217442","wikidata":"https://www.wikidata.org/wiki/Q423650","display_name":"Protein kinase B","level":3,"score":0.41337355971336365},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.36841702461242676},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2927299737930298},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.26722604036331177},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.2263706922531128},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2012917399406433},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.152155339717865},{"id":"https://openalex.org/C167734588","wikidata":"https://www.wikidata.org/wiki/Q4356503","display_name":"VEGF receptors","level":2,"score":0.06895223259925842}],"mesh":[{"descriptor_ui":"D000081082","descriptor_name":"Phosphoinositide-3 Kinase Inhibitors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013552","descriptor_name":"Swine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015427","descriptor_name":"Reperfusion Injury","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D015427","descriptor_name":"Reperfusion Injury","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D015427","descriptor_name":"Reperfusion Injury","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015427","descriptor_name":"Reperfusion Injury","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D017202","descriptor_name":"Myocardial Ischemia","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D017202","descriptor_name":"Myocardial Ischemia","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D017202","descriptor_name":"Myocardial Ischemia","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017202","descriptor_name":"Myocardial Ischemia","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D017434","descriptor_name":"Protein Structure, Tertiary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019869","descriptor_name":"Phosphatidylinositol 3-Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D019869","descriptor_name":"Phosphatidylinositol 3-Kinases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D021122","descriptor_name":"Protein Subunits","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D021122","descriptor_name":"Protein Subunits","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D021122","descriptor_name":"Protein Subunits","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D036341","descriptor_name":"Intercellular Signaling Peptides and Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D047428","descriptor_name":"Protein Kinase Inhibitors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D047428","descriptor_name":"Protein Kinase Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D047428","descriptor_name":"Protein Kinase Inhibitors","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1073/pnas.0606956103","doi":"https://doi.org/10.1073/pnas.0606956103","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.0606956103","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:1702529","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1702529","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"},{"id":"pmid:17172449","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17172449","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences of the United States of America","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:1702529","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1702529","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9763000011444092}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1091699278","display_name":null,"funder_award_id":"HL 57900","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G5954555810","display_name":"Endothelial Barrier Function Regulation by VEGF","funder_award_id":"R01HL078912","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G7063744252","display_name":null,"funder_award_id":"HL78912","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G8931877706","display_name":"Integrin Signaling in Hemostasis and Blood Diseases","funder_award_id":"P01HL057900","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":43,"referenced_works":["https://openalex.org/W1510017290","https://openalex.org/W1560426633","https://openalex.org/W1762256219","https://openalex.org/W1964841658","https://openalex.org/W1965339862","https://openalex.org/W1973775002","https://openalex.org/W1977070803","https://openalex.org/W1983064145","https://openalex.org/W1987218173","https://openalex.org/W1991928393","https://openalex.org/W1993849505","https://openalex.org/W1994139672","https://openalex.org/W2013874802","https://openalex.org/W2017788211","https://openalex.org/W2025128877","https://openalex.org/W2034691869","https://openalex.org/W2035570213","https://openalex.org/W2042204791","https://openalex.org/W2050744280","https://openalex.org/W2053753698","https://openalex.org/W2061440101","https://openalex.org/W2080477342","https://openalex.org/W2081356898","https://openalex.org/W2086928528","https://openalex.org/W2099078722","https://openalex.org/W2117344826","https://openalex.org/W2120007291","https://openalex.org/W2130271956","https://openalex.org/W2137309020","https://openalex.org/W2137904098","https://openalex.org/W2138694854","https://openalex.org/W2142980653","https://openalex.org/W2146815743","https://openalex.org/W2146892797","https://openalex.org/W2147791296","https://openalex.org/W2150863197","https://openalex.org/W2151410975","https://openalex.org/W2153570396","https://openalex.org/W2155668811","https://openalex.org/W2163401883","https://openalex.org/W2167953429","https://openalex.org/W2283891782","https://openalex.org/W2312691634"],"related_works":["https://openalex.org/W1964963261","https://openalex.org/W21659394","https://openalex.org/W2087312096","https://openalex.org/W2047323543","https://openalex.org/W2168251353","https://openalex.org/W2766027236","https://openalex.org/W4214757503","https://openalex.org/W4380730049","https://openalex.org/W2159443173","https://openalex.org/W7097938280"],"abstract_inverted_index":{"Although":[0],"phosphoinositide":[1],"3-kinases":[2],"(PI3Ks)":[3],"play":[4],"beneficial":[5],"pro-cell":[6],"survival":[7,129],"roles":[8],"during":[9,40],"tissue":[10,48,128],"ischemia,":[11],"some":[12],"isoforms":[13,39],"(gamma":[14],"and":[15,59,97,115,148],"delta)":[16],"paradoxically":[17],"contribute":[18],"to":[19,101,105,127,163],"the":[20,32,41,167,206],"inflammation":[21,98],"that":[22,34],"damages":[23],"these":[24],"same":[25,168],"tissues":[26],"upon":[27],"reperfusion.":[28],"We":[29],"therefore":[30],"considered":[31],"possibility":[33],"selectively":[35],"inhibiting":[36],"proinflammatory":[37],"PI3K":[38,61,91],"reperfusion":[42,161],"phase":[43],"could":[44],"ultimately":[45],"limit":[46],"overall":[47],"damage":[49],"seen":[50],"in":[51,99,107,188,205],"ischemia/reperfusion":[52],"injuries":[53],"such":[54],"as":[55,88],"myocardial":[56,108,150,160,189],"infarction.":[57],"Panreactive":[58],"isoform-restricted":[60],"inhibitors":[62],"were":[63],"identified":[64,87,193],"by":[65,118,181],"screening":[66],"a":[67,89,123,194],"novel":[68],"chemical":[69],"family;":[70],"molecular":[71],"modeling":[72],"studies":[73],"attributed":[74],"isoform":[75],"specificity":[76],"based":[77],"on":[78],"rotational":[79],"freedom":[80],"of":[81,197],"substituent":[82],"groups.":[83],"One":[84],"compound":[85],"(TG100-115)":[86],"selective":[90],"gamma/delta":[92],"inhibitor":[93],"potently":[94],"inhibited":[95],"edema":[96],"response":[100],"multiple":[102],"mediators":[103],"known":[104],"participate":[106],"infarction,":[109],"including":[110],"vascular":[111],"endothelial":[112,120],"growth":[113],"factor":[114],"platelet-activating":[116],"factor;":[117],"contrast,":[119],"cell":[121],"mitogenesis,":[122],"repair":[124],"process":[125],"important":[126],"after":[130,159],"ischemic":[131],"damage,":[132,190],"was":[133,154],"not":[134],"disrupted.":[135],"In":[136,179],"rigorous":[137],"animal":[138],"MI":[139],"models,":[140],"TG100-115":[141],"provided":[142],"potent":[143],"cardioprotection,":[144],"reducing":[145],"infarct":[146],"development":[147],"preserving":[149],"function.":[151],"Importantly,":[152],"this":[153],"achieved":[155],"when":[156,171],"dosing":[157],"well":[158],"(up":[162],"3":[164],"h":[165],"after),":[166],"time":[169,208],"period":[170],"patients":[172],"are":[173],"most":[174],"accessible":[175],"for":[176],"therapeutic":[177],"intervention.":[178],"conclusion,":[180],"targeting":[182],"pathologic":[183],"events":[184],"occurring":[185],"relatively":[186],"late":[187],"we":[191],"have":[192],"potential":[195],"means":[196],"addressing":[198],"an":[199],"elusive":[200],"clinical":[201],"goal:":[202],"meaningful":[203],"cardioprotection":[204],"postreperfusion":[207],"period.":[209]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":9},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":7},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":9},{"year":2012,"cited_by_count":10}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}