{"id":"https://openalex.org/W1992590800","doi":"https://doi.org/10.1126/science.158.3807.1484","title":"\"Intrinsic\" Immunological Tolerance in Allophenic Mice","display_name":"\"Intrinsic\" Immunological Tolerance in Allophenic Mice","publication_year":1967,"publication_date":"1967-12-15","ids":{"openalex":"https://openalex.org/W1992590800","doi":"https://doi.org/10.1126/science.158.3807.1484","mag":"1992590800","pmid":"https://pubmed.ncbi.nlm.nih.gov/6058691"},"language":"en","primary_location":{"id":"doi:10.1126/science.158.3807.1484","doi":"https://doi.org/10.1126/science.158.3807.1484","is_oa":false,"landing_page_url":"https://doi.org/10.1126/science.158.3807.1484","pdf_url":null,"source":{"id":"https://openalex.org/S3880285","display_name":"Science","issn_l":"0036-8075","issn":["0036-8075","0193-4511","1095-9203"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315823","host_organization_name":"American Association for the Advancement of Science","host_organization_lineage":["https://openalex.org/P4310315823"],"host_organization_lineage_names":["American Association for the Advancement of Science"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5013030326","display_name":"Beatrice Mintz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1289437631","display_name":"Fox Chase Cancer Center","ror":"https://ror.org/0567t7073","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1289437631","https://openalex.org/I4210122924"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Beatrice Mintz","raw_affiliation_strings":["Institute for Cancer Research, Fox Chase, Philadelphia, Pennsylvania 19111"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Cancer Research, Fox Chase, Philadelphia, Pennsylvania 19111","institution_ids":["https://openalex.org/I1289437631"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111430893","display_name":"Willys Kent Silvers","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Willys K. Silvers","raw_affiliation_strings":["Department of Medical Genetics, University of Pennsylvania, Philadelphia 19104"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Genetics, University of Pennsylvania, Philadelphia 19104","institution_ids":["https://openalex.org/I79576946"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.0128,"has_fulltext":false,"cited_by_count":109,"citation_normalized_percentile":{"value":0.90510183,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":87,"max":98},"biblio":{"volume":"158","issue":"3807","first_page":"1484","last_page":"1487"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11510","display_name":"Reproductive System and Pregnancy","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/immune-tolerance","display_name":"immune tolerance","score":0.8320000171661377},{"id":"https://openalex.org/keywords/histocompatibility","display_name":"histocompatibility","score":0.8140000104904175},{"id":"https://openalex.org/keywords/runt-disease","display_name":"runt disease","score":0.7979999780654907},{"id":"https://openalex.org/keywords/autoimmunity","display_name":"autoimmunity","score":0.8920000195503235},{"id":"https://openalex.org/keywords/cell-transplantation","display_name":"cell transplantation","score":0.3409999907016754}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6369121074676514},{"id":"https://openalex.org/C2780130043","wikidata":"https://www.wikidata.org/wiki/Q192360","display_name":"Autoimmunity","level":3,"score":0.6307588815689087},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.625388503074646},{"id":"https://openalex.org/C202965653","wikidata":"https://www.wikidata.org/wiki/Q2664028","display_name":"Histocompatibility","level":4,"score":0.6168301105499268},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5816530585289001},{"id":"https://openalex.org/C207936829","wikidata":"https://www.wikidata.org/wiki/Q423163","display_name":"Major histocompatibility complex","level":3,"score":0.5344741940498352},{"id":"https://openalex.org/C2777702733","wikidata":"https://www.wikidata.org/wiki/Q1356761","display_name":"Immune tolerance","level":3,"score":0.49903345108032227},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4615609049797058},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.43131914734840393},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3721272349357605},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2907485365867615},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.20304560661315918},{"id":"https://openalex.org/C188280979","wikidata":"https://www.wikidata.org/wiki/Q911125","display_name":"Human leukocyte antigen","level":3,"score":0.12743410468101501}],"mesh":[{"descriptor_ui":"D000483","descriptor_name":"Alleles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001947","descriptor_name":"Breeding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007108","descriptor_name":"Immune Tolerance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009030","descriptor_name":"Mosaicism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014181","descriptor_name":"Transplantation Immunology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1126/science.158.3807.1484","doi":"https://doi.org/10.1126/science.158.3807.1484","is_oa":false,"landing_page_url":"https://doi.org/10.1126/science.158.3807.1484","pdf_url":null,"source":{"id":"https://openalex.org/S3880285","display_name":"Science","issn_l":"0036-8075","issn":["0036-8075","0193-4511","1095-9203"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315823","host_organization_name":"American Association for the Advancement of Science","host_organization_lineage":["https://openalex.org/P4310315823"],"host_organization_lineage_names":["American Association for the Advancement of Science"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science","raw_type":"journal-article"},{"id":"pmid:6058691","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6058691","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science (New York, N.Y.)","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.5683000087738037}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":19,"referenced_works":["https://openalex.org/W20961334","https://openalex.org/W1967702267","https://openalex.org/W1978900926","https://openalex.org/W1983284134","https://openalex.org/W1988795049","https://openalex.org/W2000683951","https://openalex.org/W2011736451","https://openalex.org/W2011775923","https://openalex.org/W2039801541","https://openalex.org/W2042954723","https://openalex.org/W2054126901","https://openalex.org/W2057406466","https://openalex.org/W2060761608","https://openalex.org/W2071641757","https://openalex.org/W2072736434","https://openalex.org/W2111294531","https://openalex.org/W2187745128","https://openalex.org/W2274051453","https://openalex.org/W2424350596"],"related_works":["https://openalex.org/W4408962076","https://openalex.org/W390804987","https://openalex.org/W2151937963","https://openalex.org/W2316284487","https://openalex.org/W2107870455","https://openalex.org/W2063724621","https://openalex.org/W7099080823","https://openalex.org/W1532699504","https://openalex.org/W2080847536","https://openalex.org/W1578844064"],"abstract_inverted_index":{"Mice":[0],"experimentally":[1],"derived":[2],"from":[3],"pairs":[4],"of":[5,10,17,32,34,40,53,58,62,71],"conjoined,":[6],"undifferentiated,":[7],"cleavage-stage":[8],"embryos":[9],"different":[11],"histocompatibility":[12],"genotypes":[13],"can":[14],"retain":[15],"cells":[16,33],"each":[18],"strain,":[19],"which":[20],"still":[21],"produce":[22],"their":[23],"characteristic":[24],"antigenic":[25],"products.":[26],"The":[27],"animals":[28,64],"are":[29],"permanently":[30],"tolerant":[31],"both":[35],"original":[36],"types,":[37],"remain":[38],"free":[39],"runt":[41],"disease,":[42],"and":[43,47],"display":[44],"a":[45,54],"normal":[46],"specific":[48],"immune":[49],"response":[50],"to":[51],"introduction":[52],"foreign":[55],"antigen.":[56],"Absence":[57],"autoimmunity":[59],"in":[60],"development":[61],"ordinary":[63],"is":[65],"explainable":[66],"by":[67],"the":[68],"\"intrinsic\"":[69],"kind":[70],"tolerance":[72],"found":[73],"here.":[74]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":4},{"year":2017,"cited_by_count":1},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}