{"id":"https://openalex.org/W1992575679","doi":"https://doi.org/10.1097/cji.0b013e3181998e03","title":"Differential Responsiveness to IL-2, IL-7, and IL-15 Common Receptor \u03b3 Chain Cytokines by Antigen-specific Peripheral Blood Naive or Memory Cytotoxic CD8+ T Cells From Healthy Donors and Melanoma Patients","display_name":"Differential Responsiveness to IL-2, IL-7, and IL-15 Common Receptor \u03b3 Chain Cytokines by Antigen-specific Peripheral Blood Naive or Memory Cytotoxic CD8+ T Cells From Healthy Donors and Melanoma Patients","publication_year":2009,"publication_date":"2009-04-01","ids":{"openalex":"https://openalex.org/W1992575679","doi":"https://doi.org/10.1097/cji.0b013e3181998e03","mag":"1992575679","pmid":"https://pubmed.ncbi.nlm.nih.gov/19242375"},"language":"en","primary_location":{"id":"doi:10.1097/cji.0b013e3181998e03","doi":"https://doi.org/10.1097/cji.0b013e3181998e03","is_oa":false,"landing_page_url":"https://doi.org/10.1097/cji.0b013e3181998e03","pdf_url":null,"source":{"id":"https://openalex.org/S177451610","display_name":"Journal of Immunotherapy","issn_l":"1524-9557","issn":["1524-9557","1537-4513"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Immunotherapy","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Rachel Rosenthal","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802542264","display_name":"University Hospital of Basel","ror":"https://ror.org/04k51q396","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2802542264"]}],"countries":["CH"],"is_corresponding":true,"raw_author_name":"Rachel Rosenthal","raw_affiliation_strings":["Institute of Surgical Research and Hospital Management, Department of Biomedicine, University Hospital of Basel, Switzerland","Institute of Surgical Research and Hospital Management, Department of Biomedicine, University Hospital of Basel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Surgical Research and Hospital Management, Department of Biomedicine, University Hospital of Basel, Switzerland","institution_ids":["https://openalex.org/I2802542264"]},{"raw_affiliation_string":"Institute of Surgical Research and Hospital Management, Department of Biomedicine, University Hospital of Basel","institution_ids":["https://openalex.org/I2802542264"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009045748","display_name":"C\u00e9lia Groeper","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802542264","display_name":"University Hospital of Basel","ror":"https://ror.org/04k51q396","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2802542264"]}],"countries":["CH"],"is_corresponding":true,"raw_author_name":"C\u00e9lia Groeper","raw_affiliation_strings":["Institute of Surgical Research and Hospital Management, Department of Biomedicine, University Hospital of Basel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Surgical Research and Hospital Management, Department of Biomedicine, University Hospital of Basel","institution_ids":["https://openalex.org/I2802542264"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025265080","display_name":"Laura Bracci","orcid":"https://orcid.org/0000-0002-2535-4353","observed_orcids":["https://orcid.org/0000-0002-2535-4353"]},"institutions":[{"id":"https://openalex.org/I27897274","display_name":"Istituto Superiore di Sanit\u00e0","ror":"https://ror.org/02hssy432","country_code":"IT","type":"government","lineage":["https://openalex.org/I27897274"]},{"id":"https://openalex.org/I2802542264","display_name":"University Hospital of Basel","ror":"https://ror.org/04k51q396","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2802542264"]}],"countries":["CH","IT"],"is_corresponding":true,"raw_author_name":"Laura Bracci","raw_affiliation_strings":["Institute of Surgical Research and Hospital Management, Department of Biomedicine, University Hospital of Basel","Present address of Laura Bracci is Department of Cell Biology and Neurosciences, Istituto Superiore di Sanit\u00e0, Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Surgical Research and Hospital Management, Department of Biomedicine, University Hospital of Basel","institution_ids":["https://openalex.org/I2802542264"]},{"raw_affiliation_string":"Present address of Laura Bracci is Department of Cell Biology and Neurosciences, Istituto Superiore di Sanit\u00e0, Rome, Italy","institution_ids":["https://openalex.org/I27897274"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026264950","display_name":"Michel Adamina","orcid":"https://orcid.org/0000-0002-5464-6953","observed_orcids":["https://orcid.org/0000-0002-5464-6953"]},"institutions":[{"id":"https://openalex.org/I2802542264","display_name":"University Hospital of Basel","ror":"https://ror.org/04k51q396","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2802542264"]}],"countries":["CH"],"is_corresponding":true,"raw_author_name":"Michel Adamina","raw_affiliation_strings":["Institute of Surgical Research and Hospital Management, Department of Biomedicine, University Hospital of Basel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Surgical Research and Hospital Management, Department of Biomedicine, University Hospital of Basel","institution_ids":["https://openalex.org/I2802542264"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057386401","display_name":"Chantal Feder\u2010Mengus","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802542264","display_name":"University Hospital of Basel","ror":"https://ror.org/04k51q396","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2802542264"]}],"countries":["CH"],"is_corresponding":true,"raw_author_name":"Chantal Feder-Mengus","raw_affiliation_strings":["Institute of Surgical Research and Hospital Management, Department of Biomedicine, University Hospital of Basel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Surgical Research and Hospital Management, Department of Biomedicine, University Hospital of Basel","institution_ids":["https://openalex.org/I2802542264"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057982041","display_name":"Paul Zajac","orcid":"https://orcid.org/0000-0003-3769-2218","observed_orcids":["https://orcid.org/0000-0003-3769-2218"]},"institutions":[{"id":"https://openalex.org/I2802542264","display_name":"University Hospital of Basel","ror":"https://ror.org/04k51q396","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2802542264"]}],"countries":["CH"],"is_corresponding":true,"raw_author_name":"Paul Zajac","raw_affiliation_strings":["Institute of Surgical Research and Hospital Management, Department of Biomedicine, University Hospital of Basel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Surgical Research and Hospital Management, Department of Biomedicine, University Hospital of Basel","institution_ids":["https://openalex.org/I2802542264"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023122501","display_name":"Giandomenica Iezzi","orcid":"https://orcid.org/0000-0001-5841-495X","observed_orcids":["https://orcid.org/0000-0001-5841-495X"]},"institutions":[{"id":"https://openalex.org/I2802542264","display_name":"University Hospital of Basel","ror":"https://ror.org/04k51q396","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2802542264"]}],"countries":["CH"],"is_corresponding":true,"raw_author_name":"Giandomenica Iezzi","raw_affiliation_strings":["Institute of Surgical Research and Hospital Management, Department of Biomedicine, University Hospital of Basel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Surgical Research and Hospital Management, Department of Biomedicine, University Hospital of Basel","institution_ids":["https://openalex.org/I2802542264"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077713749","display_name":"Martin Bolli","orcid":"https://orcid.org/0000-0002-2126-2996","observed_orcids":["https://orcid.org/0000-0002-2126-2996"]},"institutions":[{"id":"https://openalex.org/I2802542264","display_name":"University Hospital of Basel","ror":"https://ror.org/04k51q396","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2802542264"]}],"countries":["CH"],"is_corresponding":true,"raw_author_name":"Martin Bolli","raw_affiliation_strings":["Institute of Surgical Research and Hospital Management, Department of Biomedicine, University Hospital of Basel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Surgical Research and Hospital Management, Department of Biomedicine, University Hospital of Basel","institution_ids":["https://openalex.org/I2802542264"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081638136","display_name":"William P. Weber","orcid":"https://orcid.org/0000-0003-1667-7844","observed_orcids":["https://orcid.org/0000-0003-1667-7844"]},"institutions":[{"id":"https://openalex.org/I2802542264","display_name":"University Hospital of Basel","ror":"https://ror.org/04k51q396","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2802542264"]}],"countries":["CH"],"is_corresponding":true,"raw_author_name":"Walter P. Weber","raw_affiliation_strings":["Institute of Surgical Research and Hospital Management, Department of Biomedicine, University Hospital of Basel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Surgical Research and Hospital Management, Department of Biomedicine, University Hospital of Basel","institution_ids":["https://openalex.org/I2802542264"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029902719","display_name":"Daniel M. Frey","orcid":"https://orcid.org/0009-0004-5304-344X","observed_orcids":["https://orcid.org/0009-0004-5304-344X"]},"institutions":[{"id":"https://openalex.org/I2802542264","display_name":"University Hospital of Basel","ror":"https://ror.org/04k51q396","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2802542264"]}],"countries":["CH"],"is_corresponding":true,"raw_author_name":"Daniel M. Frey","raw_affiliation_strings":["Institute of Surgical Research and Hospital Management, Department of Biomedicine, University Hospital of Basel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Surgical Research and Hospital Management, Department of Biomedicine, University Hospital of Basel","institution_ids":["https://openalex.org/I2802542264"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022845568","display_name":"Urs W. von Holzen","orcid":"https://orcid.org/0000-0003-3746-6237","observed_orcids":["https://orcid.org/0000-0003-3746-6237"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Urs von Holzen","raw_affiliation_strings":["Department of Surgery, Kantonsspital Olten, Olten, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Kantonsspital Olten, Olten, Switzerland","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008894098","display_name":"Daniel Oertli","orcid":"https://orcid.org/0000-0002-1936-300X","observed_orcids":["https://orcid.org/0000-0002-1936-300X"]},"institutions":[{"id":"https://openalex.org/I2802542264","display_name":"University Hospital of Basel","ror":"https://ror.org/04k51q396","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2802542264"]}],"countries":["CH"],"is_corresponding":true,"raw_author_name":"Daniel Oertli","raw_affiliation_strings":["Institute of Surgical Research and Hospital Management, Department of Biomedicine, University Hospital of Basel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Surgical Research and Hospital Management, Department of Biomedicine, University Hospital of Basel","institution_ids":["https://openalex.org/I2802542264"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113671661","display_name":"Michael Heberer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802542264","display_name":"University Hospital of Basel","ror":"https://ror.org/04k51q396","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2802542264"]}],"countries":["CH"],"is_corresponding":true,"raw_author_name":"Michael Heberer","raw_affiliation_strings":["Institute of Surgical Research and Hospital Management, Department of Biomedicine, University Hospital of Basel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Surgical Research and Hospital Management, Department of Biomedicine, University Hospital of Basel","institution_ids":["https://openalex.org/I2802542264"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5038497681","display_name":"Giulio C. Spagnoli","orcid":"https://orcid.org/0000-0002-1904-2011","observed_orcids":["https://orcid.org/0000-0002-1904-2011"]},"institutions":[{"id":"https://openalex.org/I2802542264","display_name":"University Hospital of Basel","ror":"https://ror.org/04k51q396","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2802542264"]}],"countries":["CH"],"is_corresponding":true,"raw_author_name":"Giulio C. Spagnoli","raw_affiliation_strings":["Institute of Surgical Research and Hospital Management, Department of Biomedicine, University Hospital of Basel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Surgical Research and Hospital Management, Department of Biomedicine, University Hospital of Basel","institution_ids":["https://openalex.org/I2802542264"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5008894098","https://openalex.org/A5009045748","https://openalex.org/A5023122501","https://openalex.org/A5025265080","https://openalex.org/A5026264950","https://openalex.org/A5029902719","https://openalex.org/A5038497681","https://openalex.org/A5057386401","https://openalex.org/A5057982041","https://openalex.org/A5077713749","https://openalex.org/A5081638136","https://openalex.org/A5113671661"],"corresponding_institution_ids":["https://openalex.org/I27897274","https://openalex.org/I2802542264"],"apc_list":null,"apc_paid":null,"fwci":0.9646,"has_fulltext":false,"cited_by_count":14,"citation_normalized_percentile":{"value":0.74130557,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"32","issue":"3","first_page":"252","last_page":"261"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.006599999964237213,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11503","display_name":"Cytokine Signaling Pathways and Interactions","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/common-gamma-chain-cytokines","display_name":"common gamma chain cytokines","score":0.9639999866485596},{"id":"https://openalex.org/keywords/interleukin-2","display_name":"interleukin-2","score":0.8360000252723694},{"id":"https://openalex.org/keywords/interleukin-7","display_name":"IL-7","score":1.0},{"id":"https://openalex.org/keywords/il-15","display_name":"IL-15","score":1.0},{"id":"https://openalex.org/keywords/cd8-t-cells","display_name":"CD8+ T cells","score":0.9470000267028809},{"id":"https://openalex.org/keywords/naive-t-cells","display_name":"naive T cells","score":0.8230000138282776},{"id":"https://openalex.org/keywords/memory-t-cells","display_name":"memory T cells","score":0.9829999804496765},{"id":"https://openalex.org/keywords/cytotoxic-t-lymphocytes","display_name":"cytotoxic T lymphocytes","score":0.890999972820282},{"id":"https://openalex.org/keywords/melanoma","display_name":"melanoma","score":0.7730000019073486},{"id":"https://openalex.org/keywords/melan-a-mart-1","display_name":"Melan-A/MART-1","score":0.847000002861023},{"id":"https://openalex.org/keywords/cytomegalovirus-specific-t-cells","display_name":"cytomegalovirus-specific T cells","score":0.8500000238418579},{"id":"https://openalex.org/keywords/t-cell-proliferation","display_name":"T cell proliferation","score":0.6600000262260437},{"id":"https://openalex.org/keywords/cytotoxicity","display_name":"cytotoxicity","score":0.6200000047683716},{"id":"https://openalex.org/keywords/melanoma-immunotherapy","display_name":"melanoma immunotherapy","score":0.5709999799728394},{"id":"https://openalex.org/keywords/hla-a-0201","display_name":"HLA-A*0201","score":0.8019999861717224}],"concepts":[{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.7768431901931763},{"id":"https://openalex.org/C3017910909","wikidata":"https://www.wikidata.org/wiki/Q618363","display_name":"Peripheral blood","level":2,"score":0.6692761778831482},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6448296904563904},{"id":"https://openalex.org/C167672396","wikidata":"https://www.wikidata.org/wiki/Q417800","display_name":"CD8","level":3,"score":0.6021748781204224},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5348085165023804},{"id":"https://openalex.org/C46762472","wikidata":"https://www.wikidata.org/wiki/Q178648","display_name":"Peripheral","level":2,"score":0.5181707143783569},{"id":"https://openalex.org/C98119934","wikidata":"https://www.wikidata.org/wiki/Q14907167","display_name":"Interleukin 15","level":4,"score":0.4781937599182129},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.3955390751361847},{"id":"https://openalex.org/C74172505","wikidata":"https://www.wikidata.org/wiki/Q194908","display_name":"Interleukin","level":3,"score":0.34818118810653687},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.2982602119445801},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.19189390540122986},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.1455671787261963},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000956","descriptor_name":"Antigens, Viral","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D000956","descriptor_name":"Antigens, Viral","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007156","descriptor_name":"Immunologic Memory","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007167","descriptor_name":"Immunotherapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007376","descriptor_name":"Interleukin-2","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D008545","descriptor_name":"Melanoma","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013602","descriptor_name":"T-Lymphocytes, Cytotoxic","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D013602","descriptor_name":"T-Lymphocytes, Cytotoxic","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015851","descriptor_name":"Interleukin-7","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D019409","descriptor_name":"Interleukin-15","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D053631","descriptor_name":"Interleukin Receptor Common gamma Subunit","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1097/cji.0b013e3181998e03","doi":"https://doi.org/10.1097/cji.0b013e3181998e03","is_oa":false,"landing_page_url":"https://doi.org/10.1097/cji.0b013e3181998e03","pdf_url":null,"source":{"id":"https://openalex.org/S177451610","display_name":"Journal of Immunotherapy","issn_l":"1524-9557","issn":["1524-9557","1537-4513"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Immunotherapy","raw_type":"journal-article"},{"id":"pmid:19242375","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19242375","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of immunotherapy (Hagerstown, Md. : 1997)","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9476000070571899,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":53,"referenced_works":["https://openalex.org/W1601504908","https://openalex.org/W1788680537","https://openalex.org/W1915022257","https://openalex.org/W1964628806","https://openalex.org/W1970563382","https://openalex.org/W1978351757","https://openalex.org/W1981480494","https://openalex.org/W1983806918","https://openalex.org/W1988181926","https://openalex.org/W1994340919","https://openalex.org/W1997196319","https://openalex.org/W1997660985","https://openalex.org/W2000208875","https://openalex.org/W2004345869","https://openalex.org/W2006027051","https://openalex.org/W2010462935","https://openalex.org/W2016671320","https://openalex.org/W2017672874","https://openalex.org/W2027853738","https://openalex.org/W2047102094","https://openalex.org/W2047954806","https://openalex.org/W2064006160","https://openalex.org/W2067650601","https://openalex.org/W2070552972","https://openalex.org/W2070770310","https://openalex.org/W2077027589","https://openalex.org/W2082797461","https://openalex.org/W2097568643","https://openalex.org/W2107208338","https://openalex.org/W2111762521","https://openalex.org/W2117216774","https://openalex.org/W2121733174","https://openalex.org/W2127996358","https://openalex.org/W2129860342","https://openalex.org/W2133680443","https://openalex.org/W2137564018","https://openalex.org/W2140457183","https://openalex.org/W2147246759","https://openalex.org/W2148523692","https://openalex.org/W2149162836","https://openalex.org/W2150895619","https://openalex.org/W2151246207","https://openalex.org/W2156449737","https://openalex.org/W2164061160","https://openalex.org/W2166598514","https://openalex.org/W2167008563","https://openalex.org/W2168879228","https://openalex.org/W2170904230","https://openalex.org/W2270208951","https://openalex.org/W2329639934","https://openalex.org/W2416742310","https://openalex.org/W4285719527","https://openalex.org/W6662325930"],"related_works":["https://openalex.org/W1646277151","https://openalex.org/W145943608","https://openalex.org/W1976945722","https://openalex.org/W7171546493","https://openalex.org/W1964628806","https://openalex.org/W2783906640","https://openalex.org/W2094018334","https://openalex.org/W2150895619","https://openalex.org/W2003959861","https://openalex.org/W2022626810"],"abstract_inverted_index":{"Common":[0],"receptor":[1],"gamma":[2],"chain":[3],"(c-gamma)":[4],"cytokines":[5],"(CKs)":[6],"support":[7],"proliferation":[8],"of":[9,17,30,72,139,186,238],"CD8+":[10,48,53,103,196,241],"T":[11,49,79,104,151,158,197,242],"cells":[12,105,159,198,213],"in":[13,59,89],"presence":[14],"or":[15,33,40,235],"absence":[16],"antigen":[18,112],"triggering":[19],"and":[20,45,64,176],"help":[21],"maintaining":[22],"the":[23,28,122,149],"immunologic":[24],"memory.":[25],"We":[26],"addressed":[27],"effects":[29,138],"low":[31],"(<":[32],"=":[34],"5":[35],"ng/mL)-dose":[36],"interleukin":[37],"(IL)-2,":[38],"IL-7,":[39,63,98],"IL-15":[41,68,92,220],"on":[42],"human":[43],"naive":[44,156,193,234],"memory":[46,75,236],"antigen-specific":[47,179],"cells.":[50,243],"Peripheral":[51],"blood":[52,240],"lymphocytes":[54,80],"proliferated":[55,88],"with":[56,109,124],"decreasing":[57],"efficiency":[58],"response":[60,90,218],"to":[61,91,94,97,101,188,201,219,222,227],"IL-15,":[62,125],"IL-2.":[65,102],"Of":[66],"note,":[67],"preferentially":[69],"promoted":[70],"expansion":[71],"CD45RA/CD8+":[73],"T-cell":[74],"subset.":[76],"Accordingly,":[77],"cytotoxic":[78,119,135,150],"specific":[81,118,164],"for":[82,165],"cytomegalovirus-derived":[83],"antigens":[84,132],"from":[85,154,160,170],"seropositive":[86],"donors":[87],"and,":[93],"lesser":[95],"extent":[96],"but":[99,126],"poorly":[100],"were":[106,141,173,203],"then":[107],"pretreated":[108],"CK":[110,229],"before":[111,175],"stimulation":[113],"using,":[114],"as":[115],"read":[116],"out,":[117],"activity.":[120],"After":[121,211],"pretreatment":[123],"not":[127],"IL-2,":[128],"previously":[129],"experienced":[130],"viral":[131],"induced":[133],"vigorous":[134],"responses.":[136],"Minor":[137],"IL-7":[140],"also":[142],"detectable.":[143,210],"In":[144],"contrast,":[145],"IL-2":[146,202,223],"best":[147,199],"supported":[148],"lymphocyte":[152],"generation":[153],"prevailingly":[155],"CD8":[157],"HLA-A*0201":[161],"healthy":[162],"donors,":[163],"L27Melan-A/MART-126-35":[166],"melanoma-associated":[167],"antigen.":[168],"Cells":[169],"melanoma":[171],"patients":[172,182,194],"tested":[174],"after":[177],"Melan-A/MART-1-targeted":[178],"immunotherapy.":[180],"Untreated":[181],"showed":[183],"heterogeneous":[184],"patterns":[185],"responsiveness":[187,207,226],"c-gamma":[189,228],"CK.":[190],"However,":[191],"when":[192],"whose":[195],"responded":[200],"vaccinated,":[204],"a":[205,215],"modified":[206],"pattern":[208],"was":[209],"immunization,":[212],"displayed":[214],"significantly":[216],"higher":[217],"than":[221],"pretreatment.":[224],"Thus,":[225],"is":[230],"critically":[231],"influenced":[232],"by":[233],"status":[237],"peripheral":[239]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
