{"id":"https://openalex.org/W1992509138","doi":"https://doi.org/10.1038/sj.bjc.6602229","title":"Clinical anticancer drug development: targeting the cyclin-dependent kinases","display_name":"Clinical anticancer drug development: targeting the cyclin-dependent kinases","publication_year":2004,"publication_date":"2004-11-23","ids":{"openalex":"https://openalex.org/W1992509138","doi":"https://doi.org/10.1038/sj.bjc.6602229","mag":"1992509138","pmid":"https://pubmed.ncbi.nlm.nih.gov/15558073","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2361734"},"language":"en","primary_location":{"id":"doi:10.1038/sj.bjc.6602229","doi":"https://doi.org/10.1038/sj.bjc.6602229","is_oa":true,"landing_page_url":"https://doi.org/10.1038/sj.bjc.6602229","pdf_url":"https://www.nature.com/articles/6602229.pdf","source":{"id":"https://openalex.org/S62966998","display_name":"British Journal of Cancer","issn_l":"0007-0920","issn":["0007-0920","1532-1827"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Cancer","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://www.nature.com/articles/6602229.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5003031523","display_name":"Charlotte Benson","orcid":"https://orcid.org/0000-0002-3241-3630","observed_orcids":["https://orcid.org/0000-0002-3241-3630"]},"institutions":[{"id":"https://openalex.org/I2801316944","display_name":"Cancer Research UK","ror":"https://ror.org/054225q67","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I2801316944"]},{"id":"https://openalex.org/I4210121186","display_name":"Royal Marsden Hospital","ror":"https://ror.org/034vb5t35","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1325846038","https://openalex.org/I4210121186"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"C Benson","raw_affiliation_strings":["Section of Medicine and Cancer Research UK Centre for Cancer Therapeutics, Institute for Cancer Research and Royal Marsden Hospital, Downs Road, Sutton, Surrey SM2 5PT, UK","Section of Medicine and Cancer Research UK Centre for Cancer Therapeutics, Institute for Cancer Research and Royal Marsden Hospital, Downs Road, Sutton, Surrey, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section of Medicine and Cancer Research UK Centre for Cancer Therapeutics, Institute for Cancer Research and Royal Marsden Hospital, Downs Road, Sutton, Surrey SM2 5PT, UK","institution_ids":["https://openalex.org/I2801316944","https://openalex.org/I4210121186"]},{"raw_affiliation_string":"Section of Medicine and Cancer Research UK Centre for Cancer Therapeutics, Institute for Cancer Research and Royal Marsden Hospital, Downs Road, Sutton, Surrey, UK","institution_ids":["https://openalex.org/I2801316944","https://openalex.org/I4210121186"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109068159","display_name":"Stanley B. Kaye","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801316944","display_name":"Cancer Research UK","ror":"https://ror.org/054225q67","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I2801316944"]},{"id":"https://openalex.org/I4210121186","display_name":"Royal Marsden Hospital","ror":"https://ror.org/034vb5t35","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1325846038","https://openalex.org/I4210121186"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"S Kaye","raw_affiliation_strings":["Section of Medicine and Cancer Research UK Centre for Cancer Therapeutics, Institute for Cancer Research and Royal Marsden Hospital, Downs Road, Sutton, Surrey, SM2 5PT, UK","Section of Medicine and Cancer Research UK Centre for Cancer Therapeutics, Institute for Cancer Research and Royal Marsden Hospital, Downs Road, Sutton, Surrey, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section of Medicine and Cancer Research UK Centre for Cancer Therapeutics, Institute for Cancer Research and Royal Marsden Hospital, Downs Road, Sutton, Surrey, SM2 5PT, UK","institution_ids":["https://openalex.org/I2801316944","https://openalex.org/I4210121186"]},{"raw_affiliation_string":"Section of Medicine and Cancer Research UK Centre for Cancer Therapeutics, Institute for Cancer Research and Royal Marsden Hospital, Downs Road, Sutton, Surrey, UK","institution_ids":["https://openalex.org/I2801316944","https://openalex.org/I4210121186"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003965204","display_name":"Paul Workman","orcid":"https://orcid.org/0000-0003-1659-3034","observed_orcids":["https://orcid.org/0000-0003-1659-3034"]},"institutions":[{"id":"https://openalex.org/I2801316944","display_name":"Cancer Research UK","ror":"https://ror.org/054225q67","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I2801316944"]},{"id":"https://openalex.org/I4210121186","display_name":"Royal Marsden Hospital","ror":"https://ror.org/034vb5t35","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1325846038","https://openalex.org/I4210121186"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"P Workman","raw_affiliation_strings":["Section of Medicine and Cancer Research UK Centre for Cancer Therapeutics, Institute for Cancer Research and Royal Marsden Hospital, Downs Road, Sutton, Surrey, SM2 5PT, UK","Section of Medicine and Cancer Research UK Centre for Cancer Therapeutics, Institute for Cancer Research and Royal Marsden Hospital, Downs Road, Sutton, Surrey, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section of Medicine and Cancer Research UK Centre for Cancer Therapeutics, Institute for Cancer Research and Royal Marsden Hospital, Downs Road, Sutton, Surrey, SM2 5PT, UK","institution_ids":["https://openalex.org/I2801316944","https://openalex.org/I4210121186"]},{"raw_affiliation_string":"Section of Medicine and Cancer Research UK Centre for Cancer Therapeutics, Institute for Cancer Research and Royal Marsden Hospital, Downs Road, Sutton, Surrey, UK","institution_ids":["https://openalex.org/I2801316944","https://openalex.org/I4210121186"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015193618","display_name":"Michelle Dawn Garrett","orcid":"https://orcid.org/0000-0002-3939-1673","observed_orcids":["https://orcid.org/0000-0002-3939-1673"]},"institutions":[{"id":"https://openalex.org/I2801316944","display_name":"Cancer Research UK","ror":"https://ror.org/054225q67","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I2801316944"]},{"id":"https://openalex.org/I4210121186","display_name":"Royal Marsden Hospital","ror":"https://ror.org/034vb5t35","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1325846038","https://openalex.org/I4210121186"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"M Garrett","raw_affiliation_strings":["Section of Medicine and Cancer Research UK Centre for Cancer Therapeutics, Institute for Cancer Research and Royal Marsden Hospital, Downs Road, Sutton, Surrey, SM2 5PT, UK","Section of Medicine and Cancer Research UK Centre for Cancer Therapeutics, Institute for Cancer Research and Royal Marsden Hospital, Downs Road, Sutton, Surrey, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section of Medicine and Cancer Research UK Centre for Cancer Therapeutics, Institute for Cancer Research and Royal Marsden Hospital, Downs Road, Sutton, Surrey, SM2 5PT, UK","institution_ids":["https://openalex.org/I2801316944","https://openalex.org/I4210121186"]},{"raw_affiliation_string":"Section of Medicine and Cancer Research UK Centre for Cancer Therapeutics, Institute for Cancer Research and Royal Marsden Hospital, Downs Road, Sutton, Surrey, UK","institution_ids":["https://openalex.org/I2801316944","https://openalex.org/I4210121186"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001781066","display_name":"Michael Walton","orcid":"https://orcid.org/0000-0001-9129-8313","observed_orcids":["https://orcid.org/0000-0001-9129-8313"]},"institutions":[{"id":"https://openalex.org/I2801316944","display_name":"Cancer Research UK","ror":"https://ror.org/054225q67","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I2801316944"]},{"id":"https://openalex.org/I4210121186","display_name":"Royal Marsden Hospital","ror":"https://ror.org/034vb5t35","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1325846038","https://openalex.org/I4210121186"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"M Walton","raw_affiliation_strings":["Section of Medicine and Cancer Research UK Centre for Cancer Therapeutics, Institute for Cancer Research and Royal Marsden Hospital, Downs Road, Sutton, Surrey, SM2 5PT, UK","Section of Medicine and Cancer Research UK Centre for Cancer Therapeutics, Institute for Cancer Research and Royal Marsden Hospital, Downs Road, Sutton, Surrey, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section of Medicine and Cancer Research UK Centre for Cancer Therapeutics, Institute for Cancer Research and Royal Marsden Hospital, Downs Road, Sutton, Surrey, SM2 5PT, UK","institution_ids":["https://openalex.org/I2801316944","https://openalex.org/I4210121186"]},{"raw_affiliation_string":"Section of Medicine and Cancer Research UK Centre for Cancer Therapeutics, Institute for Cancer Research and Royal Marsden Hospital, Downs Road, Sutton, Surrey, UK","institution_ids":["https://openalex.org/I2801316944","https://openalex.org/I4210121186"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5072378199","display_name":"Johann Sebastian De Bono","orcid":"https://orcid.org/0000-0002-2034-595X","observed_orcids":["https://orcid.org/0000-0002-2034-595X"]},"institutions":[{"id":"https://openalex.org/I2801316944","display_name":"Cancer Research UK","ror":"https://ror.org/054225q67","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I2801316944"]},{"id":"https://openalex.org/I4210121186","display_name":"Royal Marsden Hospital","ror":"https://ror.org/034vb5t35","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1325846038","https://openalex.org/I4210121186"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"J de Bono","raw_affiliation_strings":["Section of Medicine and Cancer Research UK Centre for Cancer Therapeutics, Institute for Cancer Research and Royal Marsden Hospital, Downs Road, Sutton, Surrey, SM2 5PT, UK","Section of Medicine and Cancer Research UK Centre for Cancer Therapeutics, Institute for Cancer Research and Royal Marsden Hospital, Downs Road, Sutton, Surrey, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section of Medicine and Cancer Research UK Centre for Cancer Therapeutics, Institute for Cancer Research and Royal Marsden Hospital, Downs Road, Sutton, Surrey, SM2 5PT, UK","institution_ids":["https://openalex.org/I2801316944","https://openalex.org/I4210121186"]},{"raw_affiliation_string":"Section of Medicine and Cancer Research UK Centre for Cancer Therapeutics, Institute for Cancer Research and Royal Marsden Hospital, Downs Road, Sutton, Surrey, UK","institution_ids":["https://openalex.org/I2801316944","https://openalex.org/I4210121186"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5072378199"],"corresponding_institution_ids":["https://openalex.org/I2801316944","https://openalex.org/I4210121186"],"apc_list":{"value":5190,"currency":"USD","value_usd":5190},"apc_paid":{"value":5190,"currency":"USD","value_usd":5190},"fwci":1.0408,"has_fulltext":true,"cited_by_count":100,"citation_normalized_percentile":{"value":0.74812433,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"92","issue":"1","first_page":"7","last_page":"12"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.989300012588501,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.989300012588501,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10274","display_name":"Synthesis and biological activity","score":0.0020000000949949026,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T13779","display_name":"Cancer Mechanisms and Therapy","score":0.0017999999690800905,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cyclin-dependent-kinases","display_name":"cyclin-dependent kinases","score":0.9980000257492065},{"id":"https://openalex.org/keywords/anticancer-drug-development","display_name":"anticancer drug development","score":0.9480000138282776},{"id":"https://openalex.org/keywords/cell-cycle","display_name":"cell cycle","score":0.7300000190734863},{"id":"https://openalex.org/keywords/cyclins","display_name":"cyclins","score":0.9570000171661377},{"id":"https://openalex.org/keywords/cyclin-dependent-kinase-inhibitors","display_name":"cyclin-dependent kinase inhibitors","score":0.9440000057220459},{"id":"https://openalex.org/keywords/cell-cycle-checkpoint-proteins","display_name":"cell cycle checkpoint proteins","score":0.6769999861717224},{"id":"https://openalex.org/keywords/cancer-cell-division","display_name":"cancer cell division","score":0.49399998784065247},{"id":"https://openalex.org/keywords/selective-cytotoxicity","display_name":"selective cytotoxicity","score":0.8579999804496765}],"concepts":[{"id":"https://openalex.org/C124320809","wikidata":"https://www.wikidata.org/wiki/Q46292","display_name":"Cyclin-dependent kinase","level":4,"score":0.8756968975067139},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.6784836053848267},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.6718279123306274},{"id":"https://openalex.org/C120089663","wikidata":"https://www.wikidata.org/wiki/Q59250999","display_name":"Cyclin","level":4,"score":0.6546170711517334},{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.5895130634307861},{"id":"https://openalex.org/C2911011838","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell Cycle Protein","level":4,"score":0.5517350435256958},{"id":"https://openalex.org/C85813293","wikidata":"https://www.wikidata.org/wiki/Q188909","display_name":"Cell division","level":3,"score":0.5329158306121826},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5323781371116638},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5069049000740051},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.4586695432662964},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.42137718200683594},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.37287330627441406},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.24385884404182434},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D002453","descriptor_name":"Cell Cycle","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D013678","descriptor_name":"Technology, Pharmaceutical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015195","descriptor_name":"Drug Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016503","descriptor_name":"Drug Delivery Systems","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018844","descriptor_name":"Cyclin-Dependent Kinases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1038/sj.bjc.6602229","doi":"https://doi.org/10.1038/sj.bjc.6602229","is_oa":true,"landing_page_url":"https://doi.org/10.1038/sj.bjc.6602229","pdf_url":"https://www.nature.com/articles/6602229.pdf","source":{"id":"https://openalex.org/S62966998","display_name":"British Journal of Cancer","issn_l":"0007-0920","issn":["0007-0920","1532-1827"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Cancer","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2361734","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2361734","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Br J Cancer","raw_type":"Text"},{"id":"pmid:15558073","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15558073","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British journal of cancer","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1038/sj.bjc.6602229","doi":"https://doi.org/10.1038/sj.bjc.6602229","is_oa":true,"landing_page_url":"https://doi.org/10.1038/sj.bjc.6602229","pdf_url":"https://www.nature.com/articles/6602229.pdf","source":{"id":"https://openalex.org/S62966998","display_name":"British Journal of Cancer","issn_l":"0007-0920","issn":["0007-0920","1532-1827"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Cancer","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1992509138.pdf","grobid_xml":"https://content.openalex.org/works/W1992509138.grobid-xml"},"referenced_works_count":47,"referenced_works":["https://openalex.org/W15036479","https://openalex.org/W178062456","https://openalex.org/W1481663693","https://openalex.org/W1483995411","https://openalex.org/W1536145619","https://openalex.org/W1552030014","https://openalex.org/W1611726375","https://openalex.org/W1777669545","https://openalex.org/W1831621090","https://openalex.org/W1896635905","https://openalex.org/W1908291951","https://openalex.org/W1959988533","https://openalex.org/W1990750564","https://openalex.org/W2012722789","https://openalex.org/W2016987929","https://openalex.org/W2021695924","https://openalex.org/W2024680115","https://openalex.org/W2031196294","https://openalex.org/W2036804890","https://openalex.org/W2039771541","https://openalex.org/W2058314877","https://openalex.org/W2061349037","https://openalex.org/W2062120857","https://openalex.org/W2071622027","https://openalex.org/W2089020917","https://openalex.org/W2097173890","https://openalex.org/W2109003160","https://openalex.org/W2113604152","https://openalex.org/W2115276278","https://openalex.org/W2130030195","https://openalex.org/W2134654194","https://openalex.org/W2135129680","https://openalex.org/W2136682666","https://openalex.org/W2139461773","https://openalex.org/W2139582914","https://openalex.org/W2141972206","https://openalex.org/W2144240156","https://openalex.org/W2153574313","https://openalex.org/W2162517036","https://openalex.org/W2170302386","https://openalex.org/W2171054569","https://openalex.org/W2177166422","https://openalex.org/W2199338820","https://openalex.org/W2271112841","https://openalex.org/W2289687094","https://openalex.org/W2301131921","https://openalex.org/W2595798132"],"related_works":["https://openalex.org/W2061189534","https://openalex.org/W2318787901","https://openalex.org/W4327654310","https://openalex.org/W1994224457","https://openalex.org/W2014613601","https://openalex.org/W2057272791","https://openalex.org/W1977213265","https://openalex.org/W2772174090","https://openalex.org/W1867781945","https://openalex.org/W2050228107"],"abstract_inverted_index":{"Cell":[0],"division":[1,23],"involves":[2],"a":[3,25],"cyclical":[4],"biochemical":[5],"process":[6],"composed":[7],"of":[8,21,27,41,59],"several":[9],"step-wise":[10],"reactions":[11],"that":[12,67],"have":[13],"to":[14],"occur":[15],"once":[16],"per":[17],"cell":[18,22,63],"cycle.":[19],"Dysregulation":[20],"is":[24],"hallmark":[26],"all":[28],"cancers.":[29],"Genetic":[30],"and":[31,52,75],"epigenetic":[32],"mechanisms":[33],"frequently":[34],"result":[35,71],"in":[36,62,72],"deranged":[37],"expression":[38],"and/or":[39],"activity":[40],"cell-cycle":[42],"proteins":[43,61],"including":[44],"the":[45],"cyclins,":[46],"cyclin-dependent":[47],"kinases":[48],"(Cdks),":[49],"Cdk":[50],"inhibitors":[51],"checkpoint":[53],"control":[54],"proteins.":[55],"The":[56],"critical":[57],"nature":[58],"these":[60],"cycling":[64],"raises":[65],"hope":[66],"targeting":[68],"them":[69],"may":[70],"selective":[73],"cytotoxicity":[74],"valuable":[76],"anticancer":[77],"activity.":[78]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":7},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}