{"id":"https://openalex.org/W1992467963","doi":"https://doi.org/10.1371/journal.pone.0059501","title":"Adaptation of Enterovirus 71 to Adult Interferon Deficient Mice","display_name":"Adaptation of Enterovirus 71 to Adult Interferon Deficient Mice","publication_year":2013,"publication_date":"2013-03-19","ids":{"openalex":"https://openalex.org/W1992467963","doi":"https://doi.org/10.1371/journal.pone.0059501","mag":"1992467963","pmid":"https://pubmed.ncbi.nlm.nih.gov/23527208","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3602422"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pone.0059501","doi":"https://doi.org/10.1371/journal.pone.0059501","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0059501","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0059501&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0059501&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5091797723","display_name":"Elizabeth A. Caine","orcid":"https://orcid.org/0000-0002-7548-7330","observed_orcids":["https://orcid.org/0000-0002-7548-7330","https://orcid.org/0000-0002-4055-5444"]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Elizabeth A. Caine","raw_affiliation_strings":["Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, Wisconsin, United States of America. ecaine@wisc.edu","Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, Wisconsin, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, Wisconsin, United States of America. ecaine@wisc.edu","institution_ids":["https://openalex.org/I135310074"]},{"raw_affiliation_string":"Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, Wisconsin, United States of America","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015711397","display_name":"Charalambos D. Partidos","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Charalambos D. Partidos","raw_affiliation_strings":["Inviragen Inc., Madison, Wisconsin, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Inviragen Inc., Madison, Wisconsin, United States of America","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023933952","display_name":"Joseph D. Santangelo","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Joseph D. Santangelo","raw_affiliation_strings":["Inviragen Inc., Singapore, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Inviragen Inc., Singapore, Singapore","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5048952101","display_name":"Jorge E. Osorio","orcid":"https://orcid.org/0000-0002-7474-6150","observed_orcids":["https://orcid.org/0000-0002-7474-6150"]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jorge E. Osorio","raw_affiliation_strings":["Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, Wisconsin, United States of America","Inviragen Inc., Madison, Wisconsin, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, Wisconsin, United States of America","institution_ids":["https://openalex.org/I135310074"]},{"raw_affiliation_string":"Inviragen Inc., Madison, Wisconsin, United States of America","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5091797723"],"corresponding_institution_ids":["https://openalex.org/I135310074"],"apc_list":{"value":2382,"currency":"USD","value_usd":2382},"apc_paid":{"value":2382,"currency":"USD","value_usd":2382},"fwci":3.1731,"has_fulltext":true,"cited_by_count":39,"citation_normalized_percentile":{"value":0.92359593,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"8","issue":"3","first_page":"e59501","last_page":"e59501"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11112","display_name":"Viral Infections and Immunology Research","score":0.5756999850273132,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11112","display_name":"Viral Infections and Immunology Research","score":0.5756999850273132,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11668","display_name":"interferon and immune responses","score":0.29269999265670776,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11581","display_name":"Viral Infections and Outbreaks Research","score":0.07639999687671661,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/enterovirus-71","display_name":"enterovirus 71","score":0.9940000176429749},{"id":"https://openalex.org/keywords/mouse-adaptation","display_name":"mouse adaptation","score":0.5379999876022339},{"id":"https://openalex.org/keywords/ag129-mice","display_name":"AG129 mice","score":0.9980000257492065},{"id":"https://openalex.org/keywords/hand-foot-and-mouth-disease","display_name":"hand, foot and mouth disease","score":0.8899999856948853},{"id":"https://openalex.org/keywords/inactivated-vaccine","display_name":"inactivated vaccine","score":0.7879999876022339},{"id":"https://openalex.org/keywords/humoral-immunity","display_name":"humoral immunity","score":0.8140000104904175},{"id":"https://openalex.org/keywords/passive-transfer-of-immunity","display_name":"passive transfer","score":0.7850000262260437},{"id":"https://openalex.org/keywords/aluminium-adjuvants","display_name":"alum adjuvant","score":0.8619999885559082},{"id":"https://openalex.org/keywords/vaccine-efficacy","display_name":"vaccine efficacy","score":0.7179999947547913},{"id":"https://openalex.org/keywords/vaccine-immunogenicity","display_name":"vaccine immunogenicity","score":0.6779999732971191},{"id":"https://openalex.org/keywords/correlates-of-protection","display_name":"correlates of protection","score":0.7919999957084656}],"concepts":[{"id":"https://openalex.org/C2778889330","wikidata":"https://www.wikidata.org/wiki/Q1636618","display_name":"Enterovirus 71","level":4,"score":0.7192946672439575},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.6567749977111816},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.5993921756744385},{"id":"https://openalex.org/C2776178377","wikidata":"https://www.wikidata.org/wiki/Q188269","display_name":"Interferon","level":2,"score":0.5039672255516052},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4975188076496124},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.48378512263298035},{"id":"https://openalex.org/C2779341262","wikidata":"https://www.wikidata.org/wiki/Q182581","display_name":"Immunity","level":3,"score":0.482143372297287},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.4560437798500061},{"id":"https://openalex.org/C2777888124","wikidata":"https://www.wikidata.org/wiki/Q519796","display_name":"Enterovirus","level":3,"score":0.4409349262714386},{"id":"https://openalex.org/C2776872762","wikidata":"https://www.wikidata.org/wiki/Q3560939","display_name":"Inactivated vaccine","level":3,"score":0.4241480529308319},{"id":"https://openalex.org/C2780801004","wikidata":"https://www.wikidata.org/wiki/Q1415366","display_name":"Immunization","level":3,"score":0.4158411920070648},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.40413352847099304}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006232","descriptor_name":"Hand, Foot and Mouth Disease","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D006232","descriptor_name":"Hand, Foot and Mouth Disease","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D007106","descriptor_name":"Immune Sera","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D007106","descriptor_name":"Immune Sera","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D007106","descriptor_name":"Immune Sera","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D009500","descriptor_name":"Neutralization Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011817","descriptor_name":"Rabbits","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012692","descriptor_name":"Serial Passage","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D014765","descriptor_name":"Viral Vaccines","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020133","descriptor_name":"Reverse Transcriptase Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D029821","descriptor_name":"Enterovirus A, Human","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D029821","descriptor_name":"Enterovirus A, Human","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053633","descriptor_name":"Receptor, Interferon alpha-beta","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":true},{"descriptor_ui":"D053633","descriptor_name":"Receptor, Interferon alpha-beta","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D060888","descriptor_name":"Real-Time Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1371/journal.pone.0059501","doi":"https://doi.org/10.1371/journal.pone.0059501","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0059501","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0059501&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2601946","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3602422","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3602422","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3602422","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS One","raw_type":"Text"},{"id":"pmid:23527208","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23527208","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PloS one","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.856.7854","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.856.7854","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://www.plosone.org/article/fetchObject.action?representation%3DPDF%26uri%3Dinfo%3Adoi/10.1371/journal.pone.0059501","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:49b6499375cc44eab595eaef56ab7a89","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/49b6499375cc44eab595eaef56ab7a89","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE, Vol 8, Iss 3, p e59501 (2013)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1371/journal.pone.0059501","doi":"https://doi.org/10.1371/journal.pone.0059501","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0059501","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0059501&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9940000176429749}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320309434","display_name":"University of Wisconsin-Madison","ror":"https://ror.org/01y2jtd41"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1992467963.pdf","grobid_xml":"https://content.openalex.org/works/W1992467963.grobid-xml"},"referenced_works_count":32,"referenced_works":["https://openalex.org/W1546665933","https://openalex.org/W1623942788","https://openalex.org/W1972176873","https://openalex.org/W1976420412","https://openalex.org/W1987053779","https://openalex.org/W2003914801","https://openalex.org/W2004775359","https://openalex.org/W2012113393","https://openalex.org/W2014967723","https://openalex.org/W2015427936","https://openalex.org/W2020664904","https://openalex.org/W2026318193","https://openalex.org/W2041769542","https://openalex.org/W2061245026","https://openalex.org/W2064449313","https://openalex.org/W2078824295","https://openalex.org/W2094112206","https://openalex.org/W2094715078","https://openalex.org/W2099315132","https://openalex.org/W2114173013","https://openalex.org/W2118821366","https://openalex.org/W2129981327","https://openalex.org/W2134403134","https://openalex.org/W2140526135","https://openalex.org/W2141292446","https://openalex.org/W2153545807","https://openalex.org/W2161175100","https://openalex.org/W2162245456","https://openalex.org/W2167102696","https://openalex.org/W2256756668","https://openalex.org/W2414366630","https://openalex.org/W2797295276"],"related_works":["https://openalex.org/W2492114245","https://openalex.org/W2003914801","https://openalex.org/W2885104075","https://openalex.org/W3007290227","https://openalex.org/W2388705582","https://openalex.org/W2902906917","https://openalex.org/W1536154693","https://openalex.org/W2110767077","https://openalex.org/W2354092100","https://openalex.org/W2360437823"],"abstract_inverted_index":{"Non-polio":[0],"enteroviruses,":[1],"including":[2,117],"enterovirus":[3],"71":[4],"(EV71),":[5],"have":[6],"caused":[7,129],"severe":[8],"and":[9,15,66,88,96,125,164,182,283,288],"fatal":[10],"cases":[11],"of":[12,25,39,78,123,143,176,186,193,239,254,267,281,285,295],"hand,":[13],"foot":[14],"mouth":[16],"disease":[17,240],"(HFMD)":[18],"in":[19,103,133,140,161,189,204,209,217,245],"the":[20,37,141,169,174,184,199,223,231,279,290],"Asia-Pacific":[21],"region.":[22],"The":[23,265],"development":[24,266],"a":[26,40,48,144,205,250],"vaccine":[27,181,201,226,286],"or":[28,241],"antiviral":[29,277],"against":[30,198,230],"these":[31],"pathogens":[32],"has":[33,289],"been":[34],"hampered":[35],"by":[36,55,155],"lack":[38],"reliable":[41],"small":[42],"animal":[43,269],"model.":[44],"In":[45],"this":[46,108,268],"study,":[47],"mouse":[49,232],"adapted":[50,109,156,170,233],"EV71":[51,79,157,171,179,200,275],"strain":[52,110],"was":[53,80,91],"produced":[54,111],"conducting":[56],"serial":[57],"passages":[58],"through":[59,94],"A129":[60,99,136,166,212],"(\u03b1/\u03b2":[61],"interferon":[62],"(IFN)":[63],"receptor":[64,71],"deficient)":[65,72],"AG129":[67,86,106,149,163,220],"(\u03b1/\u03b2,":[68],"\u03b3":[69],"IFN":[70,146],"mice.":[73,100,213],"A":[74],"B2":[75],"sub":[76],"genotype":[77],"inoculated":[81],"intraperitoneally":[82],"(i.p.)":[83],"into":[84],"neonatal":[85],"mice":[87,150,167,221],"brain-harvested":[89],"virus":[90,128,172],"subsequently":[92],"passaged":[93],"12":[95],"15":[97,210],"day-old":[98,211],"When":[101],"tested":[102],"10":[104],"week-old":[105,219],"mice,":[107,137],"100%":[112],"lethality":[113],"with":[114,168,222],"clinical":[115,237,262],"signs":[116,238,263],"limb":[118],"paralysis,":[119],"eye":[120],"irritation,":[121],"loss":[122],"balance,":[124],"death.":[126],"This":[127],"only":[130],"17%":[131],"mortality":[132,242],"same":[134],"age":[135],"confirming":[138],"that":[139],"absence":[142],"functional":[145],"response,":[147],"adult":[148,162],"are":[151],"susceptible":[152],"to":[153,292],"infection":[154],"isolates.":[158],"Subsequent":[159],"studies":[160,273],"young":[165],"examined":[173],"efficacy":[175,284],"an":[177],"inactivated":[178],"candidate":[180],"determined":[183],"role":[185],"humoral":[187],"immunity":[188],"protection.":[190],"Passive":[191],"transfer":[192],"rabbit":[194],"immune":[195],"sera":[196],"raised":[197],"provided":[202,228],"protection":[203,229,296],"dose":[206],"dependent":[207],"manner":[208],"Intramuscular":[214],"injections":[215],"(i.m.)":[216],"five":[218],"alum":[224],"adjuvanted":[225],"also":[227],"homologous":[234],"strain.":[235],"No":[236],"were":[243,257],"observed":[244],"vaccinated":[246],"animals,":[247],"which":[248],"received":[249],"prime-and-boost,":[251],"whereas":[252],"71%":[253],"control":[255],"animals":[256],"euthanized":[258],"after":[259],"exhibiting":[260],"systemic":[261],"(P<0.05).":[264],"model":[270],"will":[271],"facilitate":[272],"on":[274],"pathogenesis,":[276],"testing,":[278],"evaluation":[280],"immunogenicity":[282],"candidates,":[287],"potential":[291],"establish":[293],"correlates":[294],"studies.":[297]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}