{"id":"https://openalex.org/W1992437585","doi":"https://doi.org/10.2147/rrbc.s57405","title":"The autophagosome: current understanding of formation and maturation","display_name":"The autophagosome: current understanding of formation and maturation","publication_year":2015,"publication_date":"2015-02-01","ids":{"openalex":"https://openalex.org/W1992437585","doi":"https://doi.org/10.2147/rrbc.s57405","mag":"1992437585"},"language":"en","primary_location":{"id":"doi:10.2147/rrbc.s57405","doi":"https://doi.org/10.2147/rrbc.s57405","is_oa":true,"landing_page_url":"https://doi.org/10.2147/rrbc.s57405","pdf_url":"https://www.dovepress.com/getfile.php?fileID=23773","source":{"id":"https://openalex.org/S4210202997","display_name":"Research and Reports in Biochemistry","issn_l":"2230-3154","issn":["2230-3154"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-20"],"host_organization":"https://openalex.org/P4310320348","host_organization_name":"Dove Medical Press","host_organization_lineage":["https://openalex.org/P4310320348","https://openalex.org/P4310320547"],"host_organization_lineage_names":["Dove Medical Press","Taylor & Francis"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Research and Reports in Biochemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://www.dovepress.com/getfile.php?fileID=23773","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5078928457","display_name":"Jon D. Lane","orcid":"https://orcid.org/0000-0002-6828-5888","observed_orcids":["https://orcid.org/0000-0002-6828-5888"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jon Lane","raw_affiliation_strings":["School of Biochemistry"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Biochemistry","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110642793","display_name":"Lilith Mannack","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I36234482","display_name":"University of Bristol","ror":"https://ror.org/0524sp257","country_code":"GB","type":"education","lineage":["https://openalex.org/I36234482"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Lilith Mannack","raw_affiliation_strings":["Cell Biology Laboratories , School of Biochemistry , University of Bristol , Bristol , UK","School of Biochemistry"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cell Biology Laboratories , School of Biochemistry , University of Bristol , Bristol , UK","institution_ids":["https://openalex.org/I36234482"]},{"raw_affiliation_string":"School of Biochemistry","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.2318,"has_fulltext":true,"cited_by_count":8,"citation_normalized_percentile":{"value":0.47473487,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":null,"issue":null,"first_page":"39","last_page":"39"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10587","display_name":"Autophagy in Disease and Therapy","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10587","display_name":"Autophagy in Disease and Therapy","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10617","display_name":"Cellular transport and secretion","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13415","display_name":"Calcium signaling and nucleotide metabolism","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1314","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/autophagy","display_name":"autophagy","score":0.8650000095367432},{"id":"https://openalex.org/keywords/autophagosome-biogenesis","display_name":"autophagosome formation","score":0.9539999961853027},{"id":"https://openalex.org/keywords/autophagy-related-proteins","display_name":"autophagy-related proteins","score":0.7900000214576721},{"id":"https://openalex.org/keywords/phagophore","display_name":"phagophore","score":0.9010000228881836},{"id":"https://openalex.org/keywords/isolation-membrane","display_name":"isolation membrane","score":0.703000009059906},{"id":"https://openalex.org/keywords/autophagosome-maturation","display_name":"autophagosome maturation","score":0.7760000228881836},{"id":"https://openalex.org/keywords/autophagosome-lysosome-fusion","display_name":"autophagosome-lysosome fusion","score":0.8970000147819519},{"id":"https://openalex.org/keywords/autolysosomes","display_name":"autolysosomes","score":0.9620000123977661},{"id":"https://openalex.org/keywords/mtor-signaling","display_name":"mTOR signaling","score":0.7269999980926514},{"id":"https://openalex.org/keywords/pi-3-kinase","display_name":"PI3-kinase","score":0.7860000133514404},{"id":"https://openalex.org/keywords/phosphatidylinositol-3-phosphate","display_name":"phosphatidylinositol 3-phosphate","score":0.9100000262260437},{"id":"https://openalex.org/keywords/lir-motif","display_name":"LIR motif","score":0.9240000247955322},{"id":"https://openalex.org/keywords/ulk1","display_name":"ULK1","score":0.7549999952316284},{"id":"https://openalex.org/keywords/membrane-trafficking","display_name":"membrane trafficking","score":0.9089999794960022},{"id":"https://openalex.org/keywords/endosomes","display_name":"endosomes","score":0.6800000071525574},{"id":"https://openalex.org/keywords/lysosomes","display_name":"lysosomes","score":0.4009999930858612}],"concepts":[{"id":"https://openalex.org/C203522944","wikidata":"https://www.wikidata.org/wiki/Q288322","display_name":"Autophagy","level":3,"score":0.911693274974823},{"id":"https://openalex.org/C168296220","wikidata":"https://www.wikidata.org/wiki/Q14882441","display_name":"Autophagosome","level":4,"score":0.8801087141036987},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.8286084532737732},{"id":"https://openalex.org/C2780216420","wikidata":"https://www.wikidata.org/wiki/Q83330","display_name":"Lysosome","level":3,"score":0.7253221273422241},{"id":"https://openalex.org/C102747710","wikidata":"https://www.wikidata.org/wiki/Q824237","display_name":"Endosome","level":3,"score":0.6239272952079773},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5500704646110535},{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.5168783664703369},{"id":"https://openalex.org/C131934819","wikidata":"https://www.wikidata.org/wiki/Q135390","display_name":"Biogenesis","level":3,"score":0.5108849406242371},{"id":"https://openalex.org/C187092789","wikidata":"https://www.wikidata.org/wiki/Q4654662","display_name":"ATG16L1","level":4,"score":0.4277513027191162},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.33992862701416016},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.3067800998687744},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.20531940460205078},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.1436537504196167},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.06949099898338318},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.0},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.2147/rrbc.s57405","doi":"https://doi.org/10.2147/rrbc.s57405","is_oa":true,"landing_page_url":"https://doi.org/10.2147/rrbc.s57405","pdf_url":"https://www.dovepress.com/getfile.php?fileID=23773","source":{"id":"https://openalex.org/S4210202997","display_name":"Research and Reports in Biochemistry","issn_l":"2230-3154","issn":["2230-3154"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-20"],"host_organization":"https://openalex.org/P4310320348","host_organization_name":"Dove Medical Press","host_organization_lineage":["https://openalex.org/P4310320348","https://openalex.org/P4310320547"],"host_organization_lineage_names":["Dove Medical Press","Taylor & Francis"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Research and Reports in Biochemistry","raw_type":"journal-article"},{"id":"pmh:oai:research-information.bris.ac.uk:openaire/a7894cf8-dc54-4997-92f7-e195c5c70951","doi":null,"is_oa":true,"landing_page_url":"https://research-information.bris.ac.uk/en/publications/a7894cf8-dc54-4997-92f7-e195c5c70951","pdf_url":null,"source":{"id":"https://openalex.org/S4306400895","display_name":"Bristol Research (University of Bristol)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I36234482","host_organization_name":"University of Bristol","host_organization_lineage":["https://openalex.org/I36234482"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mannack, L V J & Lane, J D 2015, 'The autophagosome : current understanding of formation and maturation', Research and Reports in Biochemistry, vol. 2015, no. 5, pp. 39-58. https://doi.org/10.2147/RRBC.S57405","raw_type":"info:eu-repo/semantics/review"},{"id":"pmh:oai:dovepress.com/20490","doi":null,"is_oa":true,"landing_page_url":"https://www.dovepress.com/the-autophagosome-current-understanding-of-formation-and-maturation-peer-reviewed-article-RRBC","pdf_url":null,"source":{"id":"https://openalex.org/S4306401012","display_name":"Dove Medical Press (Taylor and Francis Group)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Review"}],"best_oa_location":{"id":"doi:10.2147/rrbc.s57405","doi":"https://doi.org/10.2147/rrbc.s57405","is_oa":true,"landing_page_url":"https://doi.org/10.2147/rrbc.s57405","pdf_url":"https://www.dovepress.com/getfile.php?fileID=23773","source":{"id":"https://openalex.org/S4210202997","display_name":"Research and Reports in Biochemistry","issn_l":"2230-3154","issn":["2230-3154"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-20"],"host_organization":"https://openalex.org/P4310320348","host_organization_name":"Dove Medical Press","host_organization_lineage":["https://openalex.org/P4310320348","https://openalex.org/P4310320547"],"host_organization_lineage_names":["Dove Medical Press","Taylor & Francis"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Research and Reports in Biochemistry","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1992437585.pdf","grobid_xml":"https://content.openalex.org/works/W1992437585.grobid-xml"},"referenced_works_count":233,"referenced_works":["https://openalex.org/W1484276963","https://openalex.org/W1487317148","https://openalex.org/W1496026049","https://openalex.org/W1541181512","https://openalex.org/W1554325855","https://openalex.org/W1555054913","https://openalex.org/W1570925259","https://openalex.org/W1654297979","https://openalex.org/W1754519657","https://openalex.org/W1855321011","https://openalex.org/W1861728615","https://openalex.org/W1938711770","https://openalex.org/W1964322868","https://openalex.org/W1964552652","https://openalex.org/W1965661521","https://openalex.org/W1966227354","https://openalex.org/W1970637701","https://openalex.org/W1973638222","https://openalex.org/W1974067508","https://openalex.org/W1974279922","https://openalex.org/W1976080126","https://openalex.org/W1976196055","https://openalex.org/W1978397479","https://openalex.org/W1981817858","https://openalex.org/W1985068721","https://openalex.org/W1986290546","https://openalex.org/W1987467930","https://openalex.org/W1990345723","https://openalex.org/W1990619980","https://openalex.org/W1990960113","https://openalex.org/W1991418047","https://openalex.org/W1992580502","https://openalex.org/W1993316859","https://openalex.org/W1993646391","https://openalex.org/W1993902882","https://openalex.org/W1993950505","https://openalex.org/W1994423882","https://openalex.org/W1995042437","https://openalex.org/W1997056914","https://openalex.org/W1999211990","https://openalex.org/W1999811798","https://openalex.org/W1999836892","https://openalex.org/W2001160077","https://openalex.org/W2001675597","https://openalex.org/W2004582874","https://openalex.org/W2005249937","https://openalex.org/W2006544096","https://openalex.org/W2007123036","https://openalex.org/W2008379702","https://openalex.org/W2008417639","https://openalex.org/W2009741382","https://openalex.org/W2011580247","https://openalex.org/W2013114609","https://openalex.org/W2013958792","https://openalex.org/W2014918593","https://openalex.org/W2015140940","https://openalex.org/W2016556242","https://openalex.org/W2017322442","https://openalex.org/W2018302034","https://openalex.org/W2019341627","https://openalex.org/W2024099469","https://openalex.org/W2025176940","https://openalex.org/W2025261814","https://openalex.org/W2030636070","https://openalex.org/W2031565698","https://openalex.org/W2032186831","https://openalex.org/W2032377673","https://openalex.org/W2032601500","https://openalex.org/W2034198209","https://openalex.org/W2034766627","https://openalex.org/W2035900036","https://openalex.org/W2036568535","https://openalex.org/W2036712227","https://openalex.org/W2040089067","https://openalex.org/W2040157483","https://openalex.org/W2041255615","https://openalex.org/W2041491503","https://openalex.org/W2041687573","https://openalex.org/W2042073478","https://openalex.org/W2043291430","https://openalex.org/W2043983867","https://openalex.org/W2044829505","https://openalex.org/W2044889666","https://openalex.org/W2045373134","https://openalex.org/W2045516425","https://openalex.org/W2046705115","https://openalex.org/W2047802226","https://openalex.org/W2048984899","https://openalex.org/W2049528479","https://openalex.org/W2049797765","https://openalex.org/W2051744916","https://openalex.org/W2052403003","https://openalex.org/W2053112016","https://openalex.org/W2053215139","https://openalex.org/W2054970278","https://openalex.org/W2055654995","https://openalex.org/W2055731427","https://openalex.org/W2056663185","https://openalex.org/W2056735204","https://openalex.org/W2056862039","https://openalex.org/W2057274775","https://openalex.org/W2057813271","https://openalex.org/W2060215125","https://openalex.org/W2060309271","https://openalex.org/W2060579362","https://openalex.org/W2061704745","https://openalex.org/W2064080426","https://openalex.org/W2064381459","https://openalex.org/W2065575458","https://openalex.org/W2066697766","https://openalex.org/W2067683713","https://openalex.org/W2068153705","https://openalex.org/W2069938223","https://openalex.org/W2071993554","https://openalex.org/W2072544389","https://openalex.org/W2073901870","https://openalex.org/W2073963703","https://openalex.org/W2076570319","https://openalex.org/W2077165816","https://openalex.org/W2077409117","https://openalex.org/W2078144537","https://openalex.org/W2078527512","https://openalex.org/W2078893058","https://openalex.org/W2081962941","https://openalex.org/W2083230124","https://openalex.org/W2086096948","https://openalex.org/W2086585380","https://openalex.org/W2087098731","https://openalex.org/W2087536904","https://openalex.org/W2087920955","https://openalex.org/W2091884933","https://openalex.org/W2092321143","https://openalex.org/W2093521208","https://openalex.org/W2093527800","https://openalex.org/W2093530916","https://openalex.org/W2094205174","https://openalex.org/W2094241924","https://openalex.org/W2094396222","https://openalex.org/W2096065711","https://openalex.org/W2096308078","https://openalex.org/W2100605768","https://openalex.org/W2103046269","https://openalex.org/W2103275390","https://openalex.org/W2103470698","https://openalex.org/W2103545941","https://openalex.org/W2104987598","https://openalex.org/W2105114667","https://openalex.org/W2109167860","https://openalex.org/W2109826292","https://openalex.org/W2110676385","https://openalex.org/W2111362374","https://openalex.org/W2112323649","https://openalex.org/W2112989471","https://openalex.org/W2113432343","https://openalex.org/W2113892331","https://openalex.org/W2114806766","https://openalex.org/W2114847797","https://openalex.org/W2115888489","https://openalex.org/W2116504706","https://openalex.org/W2118732775","https://openalex.org/W2119821121","https://openalex.org/W2119914706","https://openalex.org/W2121077787","https://openalex.org/W2121633863","https://openalex.org/W2123758431","https://openalex.org/W2124644922","https://openalex.org/W2126003136","https://openalex.org/W2126801593","https://openalex.org/W2127440157","https://openalex.org/W2127767424","https://openalex.org/W2127939726","https://openalex.org/W2129714618","https://openalex.org/W2129792417","https://openalex.org/W2130458413","https://openalex.org/W2131089732","https://openalex.org/W2132005005","https://openalex.org/W2132763961","https://openalex.org/W2133284292","https://openalex.org/W2133922530","https://openalex.org/W2135901758","https://openalex.org/W2137498550","https://openalex.org/W2137690550","https://openalex.org/W2138537428","https://openalex.org/W2138617109","https://openalex.org/W2139987952","https://openalex.org/W2141488468","https://openalex.org/W2142044474","https://openalex.org/W2143013308","https://openalex.org/W2143035803","https://openalex.org/W2144718635","https://openalex.org/W2145206598","https://openalex.org/W2145265436","https://openalex.org/W2146122852","https://openalex.org/W2146304525","https://openalex.org/W2147057682","https://openalex.org/W2147799082","https://openalex.org/W2148281700","https://openalex.org/W2149572123","https://openalex.org/W2149771125","https://openalex.org/W2151413638","https://openalex.org/W2151456890","https://openalex.org/W2152148024","https://openalex.org/W2154993563","https://openalex.org/W2155175976","https://openalex.org/W2155452700","https://openalex.org/W2156144699","https://openalex.org/W2159018448","https://openalex.org/W2159042370","https://openalex.org/W2161050915","https://openalex.org/W2161234475","https://openalex.org/W2164778558","https://openalex.org/W2164926713","https://openalex.org/W2164945122","https://openalex.org/W2165218453","https://openalex.org/W2169368410","https://openalex.org/W2170333695","https://openalex.org/W2170447535","https://openalex.org/W2171374570","https://openalex.org/W2325860767","https://openalex.org/W4230179232","https://openalex.org/W4235635998","https://openalex.org/W4236059336","https://openalex.org/W4248425543","https://openalex.org/W4249201383","https://openalex.org/W4285719527","https://openalex.org/W6603845117","https://openalex.org/W6649508379","https://openalex.org/W6651521006","https://openalex.org/W6656581361","https://openalex.org/W6662910616","https://openalex.org/W6665097313","https://openalex.org/W6671272404","https://openalex.org/W6683398980"],"related_works":["https://openalex.org/W2758121922","https://openalex.org/W2570108117","https://openalex.org/W2100434800","https://openalex.org/W3022527720","https://openalex.org/W2056478340","https://openalex.org/W2035959494","https://openalex.org/W7162873759","https://openalex.org/W1521025961","https://openalex.org/W4207065382","https://openalex.org/W3030241412"],"abstract_inverted_index":{"Abstract:":[0],"Autophagy":[1],"is":[2],"an":[3,119,132],"important":[4],"and":[5,15,34,42,58,74,128,138,163,166,172],"highly":[6],"conserved":[7],"catabolic":[8],"process":[9],"with":[10,77,141],"roles":[11],"in":[12,92,149,185,230],"development,":[13],"homeostasis,":[14],"cellular":[16],"stress":[17],"responses.":[18],"It":[19],"describes":[20,52],"various":[21,186],"distinct":[22],"pathways":[23,154,189,208],"for":[24,40,227],"the":[25,38,53,67,78,116,143,156,192,198,206,214,225],"delivery":[26],"of":[27,49,60,100,118,159,181],"cytoplasmic":[28,72],"materials":[29,73],"(including":[30],"misfolded":[31],"protein":[32,165],"aggregates":[33],"some":[35],"organelles)":[36],"to":[37,81,94,109,115,130,136,151,201,223],"lysosome":[39],"degradation":[41],"component":[43],"recycling.":[44],"The":[45],"best":[46],"understood":[47],"form":[48,82,131],"autophagy":[50,228],"(macroautophagy)":[51],"de":[54],"novo":[55],"assembly,":[56],"maturation,":[57],"trafficking":[59,188],"a":[61,83,90,98,179],"unique":[62,173],"double":[63],"membrane-bound":[64],"organelle":[65],"\u2013":[66,69,137,142],"autophagosomes":[68],"that":[70,106,134,209],"sequesters":[71],"ultimately":[75,139],"merges":[76],"lysosomal":[79],"compartment":[80,194],"degradative":[84],"autolysosome.":[85],"To":[86],"rapidly":[87],"assemble":[88],"such":[89],"structure":[91],"response":[93,150],"stimuli,":[95],"cells":[96],"express":[97],"family":[99],"dedicated":[101],"autophagy-related":[102],"(ATG)":[103],"gene":[104],"products":[105],"act":[107],"sequentially":[108],"control":[110],"membrane":[111,121,170,187,242],"events":[112],"leading":[113],"first":[114],"nucleation":[117],"isolation":[120],"or":[122],"phagophore,":[123,239],"followed":[124],"by":[125],"phagophore":[126],"expansion,":[127],"sealing":[129],"autophagosome":[133,203,211],"traffics":[135],"fuses":[140],"lysosome.":[144],"These":[145],"molecules":[146],"are":[147,195,222],"activated":[148],"upstream":[152],"signaling":[153],"(notably,":[155],"mechanistic":[157],"target":[158],"rapamycin":[160],"[mTOR]":[161],"pathway),":[162],"comprise":[164],"lipid":[167],"kinases,":[168],"putative":[169],"coats,":[171],"ubiquitin-like":[174],"conjugation":[175],"systems.":[176],"In":[177],"concert,":[178],"barrage":[180],"accessory":[182],"proteins":[183],"involved":[184],"focused":[190],"on":[191],"endosomal":[193],"co-opted":[196],"at":[197,213],"assembly":[199,212],"site":[200],"facilitate":[202],"biogenesis.":[204],"Understanding":[205],"integrated":[207],"coordinate":[210],"molecular":[215],"level":[216],"will":[217],"be":[218],"crucial":[219],"if":[220],"we":[221],"realize":[224],"potential":[226],"manipulation":[229],"future":[231],"disease":[232],"therapies.":[233],"Keywords:":[234],"autophagy,":[235],"ATG":[236],"proteins,":[237],"lysosome,":[238],"omegasome,":[240],"autolysosome,":[241],"trafficking,":[243],"ULK1,":[244],"mTOR,":[245],"PI(3)":[246],"kinase,":[247],"PI3P,":[248],"LIR":[249],"motif":[250]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
