{"id":"https://openalex.org/W1992436033","doi":"https://doi.org/10.1159/000146504","title":"Quantitative Aspects of Growth Hormone Cell Maturation in the Normal and Little Mutant Mouse","display_name":"Quantitative Aspects of Growth Hormone Cell Maturation in the Normal and Little Mutant Mouse","publication_year":1988,"publication_date":"1988-01-01","ids":{"openalex":"https://openalex.org/W1992436033","doi":"https://doi.org/10.1159/000146504","mag":"1992436033","pmid":"https://pubmed.ncbi.nlm.nih.gov/3369283"},"language":"en","primary_location":{"id":"doi:10.1159/000146504","doi":"https://doi.org/10.1159/000146504","is_oa":false,"landing_page_url":"https://doi.org/10.1159/000146504","pdf_url":null,"source":{"id":"https://openalex.org/S4394735558","display_name":"Cells Tissues Organs","issn_l":"1422-6405","issn":["1422-6405","1422-6421"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cells Tissues Organs","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113590757","display_name":"Doris Burda Wilson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I160856358","display_name":"University of San Diego","ror":"https://ror.org/03jbbze48","country_code":"US","type":"education","lineage":["https://openalex.org/I160856358"]},{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Doris B. Wilson","raw_affiliation_strings":["Division of Anatomy, School of Medicine, University of California, San Diego, La Jolla","Department of Biology, University of San Diego, San Diego, Calif. USA","Division of Anatomy, School of Medicine University of California San Diego La Jolla Calif"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Anatomy, School of Medicine, University of California, San Diego, La Jolla","institution_ids":["https://openalex.org/I36258959"]},{"raw_affiliation_string":"Department of Biology, University of San Diego, San Diego, Calif. USA","institution_ids":["https://openalex.org/I160856358"]},{"raw_affiliation_string":"Division of Anatomy, School of Medicine University of California San Diego La Jolla Calif","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109528855","display_name":"Darlene P. Wyatt","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I160856358","display_name":"University of San Diego","ror":"https://ror.org/03jbbze48","country_code":"US","type":"education","lineage":["https://openalex.org/I160856358"]},{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Darlene P. Wyatt","raw_affiliation_strings":["Department of Biology, University of San Diego, San Diego, Calif. USA","Division of Anatomy, School of Medicine University of California San Diego La Jolla Calif"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, University of San Diego, San Diego, Calif. USA","institution_ids":["https://openalex.org/I160856358"]},{"raw_affiliation_string":"Division of Anatomy, School of Medicine University of California San Diego La Jolla Calif","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041231319","display_name":"Richard M. Gadler","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I160856358","display_name":"University of San Diego","ror":"https://ror.org/03jbbze48","country_code":"US","type":"education","lineage":["https://openalex.org/I160856358"]},{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Richard M. Gadler","raw_affiliation_strings":["Department of Biology, University of San Diego, San Diego, Calif. USA","Division of Anatomy, School of Medicine University of California San Diego La Jolla Calif"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, University of San Diego, San Diego, Calif. USA","institution_ids":["https://openalex.org/I160856358"]},{"raw_affiliation_string":"Division of Anatomy, School of Medicine University of California San Diego La Jolla Calif","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111595254","display_name":"Carol A. Baker","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Carol A. Baker","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.283,"has_fulltext":false,"cited_by_count":25,"citation_normalized_percentile":{"value":0.51956985,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"131","issue":"2","first_page":"150","last_page":"155"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10748","display_name":"Growth Hormone and Insulin-like Growth Factors","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10748","display_name":"Growth Hormone and Insulin-like Growth Factors","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10832","display_name":"Pituitary Gland Disorders and Treatments","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10960","display_name":"Hypothalamic control of reproductive hormones","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/growth-hormone-cells","display_name":"growth hormone cells","score":0.7839999794960022},{"id":"https://openalex.org/keywords/pituitary-pars-distalis","display_name":"pituitary pars distalis","score":0.906000018119812},{"id":"https://openalex.org/keywords/growth-hormone-deficiency","display_name":"growth hormone deficiency","score":0.9369999766349792},{"id":"https://openalex.org/keywords/ultrastructural-morphometry","display_name":"ultrastructural morphometry","score":0.8629999756813049},{"id":"https://openalex.org/keywords/secretory-granules","display_name":"secretory granules","score":0.8650000095367432},{"id":"https://openalex.org/keywords/immunocytochemistry","display_name":"immunocytochemistry","score":0.6549999713897705},{"id":"https://openalex.org/keywords/colloidal-gold-labeling","display_name":"colloidal gold labeling","score":0.6729999780654907},{"id":"https://openalex.org/keywords/pituitary-development","display_name":"pituitary development","score":0.640999972820282}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.681799590587616},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6670011281967163},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6593037843704224},{"id":"https://openalex.org/C87555872","wikidata":"https://www.wikidata.org/wiki/Q3141316","display_name":"Ultrastructure","level":2,"score":0.5669288635253906},{"id":"https://openalex.org/C49760210","wikidata":"https://www.wikidata.org/wiki/Q5596727","display_name":"Granule (geology)","level":2,"score":0.5564422011375427},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.4941754639148712},{"id":"https://openalex.org/C2777658017","wikidata":"https://www.wikidata.org/wiki/Q156871","display_name":"Pituitary gland","level":3,"score":0.49090129137039185},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.47834083437919617},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.19120287895202637},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.08398783206939697},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.06915402412414551},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008817","descriptor_name":"Mice, Mutant Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010902","descriptor_name":"Pituitary Gland","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D010902","descriptor_name":"Pituitary Gland","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":false},{"descriptor_ui":"D010902","descriptor_name":"Pituitary Gland","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D013006","descriptor_name":"Growth Hormone","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1159/000146504","doi":"https://doi.org/10.1159/000146504","is_oa":false,"landing_page_url":"https://doi.org/10.1159/000146504","pdf_url":null,"source":{"id":"https://openalex.org/S4394735558","display_name":"Cells Tissues Organs","issn_l":"1422-6405","issn":["1422-6405","1422-6421"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cells Tissues Organs","raw_type":"journal-article"},{"id":"pmid:3369283","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3369283","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta anatomica","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.428600013256073}],"study_designs":[],"awards":[{"id":"https://openalex.org/G5499578174","display_name":"GROWTH AND DIFFERENTIATION OF THE PITUITARY GLAND","funder_award_id":"R01HD012308","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"}],"funders":[{"id":"https://openalex.org/F4320337611","display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2415567517","https://openalex.org/W2419871641","https://openalex.org/W1996969226","https://openalex.org/W1974827484","https://openalex.org/W2170158706","https://openalex.org/W2028964723","https://openalex.org/W2018442907","https://openalex.org/W2025216824","https://openalex.org/W1604486805","https://openalex.org/W2068356865"],"abstract_inverted_index":{"Growth":[0],"hormone":[1],"(GH)":[2],"cells":[3,68],"were":[4,33],"analyzed":[5],"by":[6],"means":[7],"of":[8,15,49,57,63,71,79,84,120,130],"ultrastructural":[9],"morphometry":[10],"in":[11,82,89,98,108,114],"the":[12,42,46,53,64,99,105,116,126,131,134,137],"pars":[13,47],"distalis":[14,48],"pituitary":[16],"glands":[17],"from":[18],"male":[19],"adult":[20,50],"and":[21,25,38,73],"immature":[22,90],"normal":[23,65],"(C57BL)":[24],"homozygous":[26],"little":[27],"(lit/lit)":[28],"mutant":[29,110],"mice.":[30],"Thin":[31],"sections":[32],"exposed":[34],"to":[35,93],"anti-GH":[36],"serum":[37],"processed":[39],"immunocytochemically":[40],"with":[41,133],"colloidal-gold":[43],"technique.":[44],"In":[45],"lit/lit":[51],"mice,":[52],"mean":[54],"volume":[55],"density":[56],"GH":[58,106,121,127],"cells/total":[59],"tissue":[60,75],"was":[61,69,76],"24%":[62],"value,":[66],"granules/GH":[67],"58%":[70],"normal,":[72],"granules/total":[74],"only":[77],"12%":[78],"normal.":[80],"Deficits":[81],"all":[83],"these":[85],"parameters":[86],"likewise":[87],"occurred":[88],"glands,":[91],"though":[92],"a":[94],"lesser":[95],"extent":[96],"than":[97],"adults.":[100],"The":[101],"results":[102],"indicate":[103],"that":[104],"deficiency":[107],"this":[109],"reflects":[111],"quantitative":[112],"deficits":[113],"both":[115],"secretory":[117],"granule":[118],"content":[119,129],"cells,":[122],"as":[123,125],"well":[124],"cell":[128],"gland,":[132],"latter":[135],"being":[136],"more":[138],"severely":[139],"affected.":[140]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2016,"cited_by_count":1}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}