{"id":"https://openalex.org/W1992397816","doi":"https://doi.org/10.1046/j.1365-2141.1996.d01-1748.x","title":"Exon/intron structure of the human ALL\u20101 (MLL) gene involved in translocations to chromosomal region 11q23 and acute leukaemias","display_name":"Exon/intron structure of the human ALL\u20101 (MLL) gene involved in translocations to chromosomal region 11q23 and acute leukaemias","publication_year":1996,"publication_date":"1996-06-01","ids":{"openalex":"https://openalex.org/W1992397816","doi":"https://doi.org/10.1046/j.1365-2141.1996.d01-1748.x","mag":"1992397816","pmid":"https://pubmed.ncbi.nlm.nih.gov/8703835"},"language":"en","primary_location":{"id":"doi:10.1046/j.1365-2141.1996.d01-1748.x","doi":"https://doi.org/10.1046/j.1365-2141.1996.d01-1748.x","is_oa":false,"landing_page_url":"https://doi.org/10.1046/j.1365-2141.1996.d01-1748.x","pdf_url":null,"source":{"id":"https://openalex.org/S153015021","display_name":"British Journal of Haematology","issn_l":"0007-1048","issn":["0007-1048","1365-2141"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Haematology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5047724414","display_name":"Iris Nilson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I181369854","display_name":"Friedrich-Alexander-Universit\u00e4t Erlangen-N\u00fcrnberg","ror":"https://ror.org/00f7hpc57","country_code":"DE","type":"education","lineage":["https://openalex.org/I181369854"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"I. NILSON","raw_affiliation_strings":["Department of Genetics, University of Erlangen-N\u00fcrnberg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genetics, University of Erlangen-N\u00fcrnberg, Germany","institution_ids":["https://openalex.org/I181369854"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029206471","display_name":"Klaus Lochner","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I181369854","display_name":"Friedrich-Alexander-Universit\u00e4t Erlangen-N\u00fcrnberg","ror":"https://ror.org/00f7hpc57","country_code":"DE","type":"education","lineage":["https://openalex.org/I181369854"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"K. L\u00f6CHNER","raw_affiliation_strings":["0 Departments of Genetics and 1Paediatrics, University of Erlangen\u2010Nu\u00a8rnberg, Erlangen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"0 Departments of Genetics and 1Paediatrics, University of Erlangen\u2010Nu\u00a8rnberg, Erlangen, Germany","institution_ids":["https://openalex.org/I181369854"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073286593","display_name":"Gabriele Margareta Siegler","orcid":"https://orcid.org/0000-0001-8918-4034","observed_orcids":["https://orcid.org/0000-0001-8918-4034"]},"institutions":[{"id":"https://openalex.org/I181369854","display_name":"Friedrich-Alexander-Universit\u00e4t Erlangen-N\u00fcrnberg","ror":"https://ror.org/00f7hpc57","country_code":"DE","type":"education","lineage":["https://openalex.org/I181369854"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"G. SIEGLER","raw_affiliation_strings":["0 Departments of Genetics and 1Paediatrics, University of Erlangen\u2010Nu\u00a8rnberg, Erlangen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"0 Departments of Genetics and 1Paediatrics, University of Erlangen\u2010Nu\u00a8rnberg, Erlangen, Germany","institution_ids":["https://openalex.org/I181369854"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071278301","display_name":"Johann Greil","orcid":"https://orcid.org/0000-0003-1821-1183","observed_orcids":["https://orcid.org/0000-0003-1821-1183"]},"institutions":[{"id":"https://openalex.org/I181369854","display_name":"Friedrich-Alexander-Universit\u00e4t Erlangen-N\u00fcrnberg","ror":"https://ror.org/00f7hpc57","country_code":"DE","type":"education","lineage":["https://openalex.org/I181369854"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"J. GREIL","raw_affiliation_strings":["0 Departments of Genetics and 1Paediatrics, University of Erlangen\u2010Nu\u00a8rnberg, Erlangen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"0 Departments of Genetics and 1Paediatrics, University of Erlangen\u2010Nu\u00a8rnberg, Erlangen, Germany","institution_ids":["https://openalex.org/I181369854"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111481432","display_name":"J\u00f6rn Dirk Beck","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I181369854","display_name":"Friedrich-Alexander-Universit\u00e4t Erlangen-N\u00fcrnberg","ror":"https://ror.org/00f7hpc57","country_code":"DE","type":"education","lineage":["https://openalex.org/I181369854"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"J. D. BECK","raw_affiliation_strings":["0 Departments of Genetics and 1Paediatrics, University of Erlangen\u2010Nu\u00a8rnberg, Erlangen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"0 Departments of Genetics and 1Paediatrics, University of Erlangen\u2010Nu\u00a8rnberg, Erlangen, Germany","institution_ids":["https://openalex.org/I181369854"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110345911","display_name":"Georg H. Fey","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I181369854","display_name":"Friedrich-Alexander-Universit\u00e4t Erlangen-N\u00fcrnberg","ror":"https://ror.org/00f7hpc57","country_code":"DE","type":"education","lineage":["https://openalex.org/I181369854"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"G. H. FEY","raw_affiliation_strings":["0 Departments of Genetics and 1Paediatrics, University of Erlangen\u2010Nu\u00a8rnberg, Erlangen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"0 Departments of Genetics and 1Paediatrics, University of Erlangen\u2010Nu\u00a8rnberg, Erlangen, Germany","institution_ids":["https://openalex.org/I181369854"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5053681765","display_name":"Rolf Marschalek","orcid":"https://orcid.org/0000-0003-4870-3445","observed_orcids":["https://orcid.org/0000-0003-4870-3445"]},"institutions":[{"id":"https://openalex.org/I181369854","display_name":"Friedrich-Alexander-Universit\u00e4t Erlangen-N\u00fcrnberg","ror":"https://ror.org/00f7hpc57","country_code":"DE","type":"education","lineage":["https://openalex.org/I181369854"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"R. MARSCHALEK","raw_affiliation_strings":["0 Departments of Genetics and 1Paediatrics, University of Erlangen\u2010Nu\u00a8rnberg, Erlangen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"0 Departments of Genetics and 1Paediatrics, University of Erlangen\u2010Nu\u00a8rnberg, Erlangen, Germany","institution_ids":["https://openalex.org/I181369854"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5053681765"],"corresponding_institution_ids":["https://openalex.org/I181369854"],"apc_list":{"value":5190,"currency":"USD","value_usd":5190},"apc_paid":null,"fwci":3.5111,"has_fulltext":false,"cited_by_count":127,"citation_normalized_percentile":{"value":0.92995335,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"93","issue":"4","first_page":"966","last_page":"972"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10950","display_name":"Acute Lymphoblastic Leukemia research","score":0.9779999852180481,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10950","display_name":"Acute Lymphoblastic Leukemia research","score":0.9779999852180481,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11213","display_name":"Genomic variations and chromosomal abnormalities","score":0.004699999932199717,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.004000000189989805,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mll-gene","display_name":"MLL gene","score":0.8769999742507935},{"id":"https://openalex.org/keywords/exon-intron-structure","display_name":"exon-intron structure","score":0.796999990940094},{"id":"https://openalex.org/keywords/11q23-translocation","display_name":"11q23 translocation","score":0.8140000104904175},{"id":"https://openalex.org/keywords/acute-lymphoblastic-leukemia","display_name":"acute lymphoblastic leukemia","score":0.9539999961853027},{"id":"https://openalex.org/keywords/acute-myeloid-leukemia","display_name":"acute myeloid leukemia","score":0.8460000157356262},{"id":"https://openalex.org/keywords/chromosomal-rearrangements","display_name":"chromosomal rearrangements","score":0.621999979019165},{"id":"https://openalex.org/keywords/intron-phase","display_name":"intron phase","score":0.5669999718666077},{"id":"https://openalex.org/keywords/restriction-mapping","display_name":"restriction mapping","score":0.6370000243186951},{"id":"https://openalex.org/keywords/gene-structure","display_name":"gene structure","score":0.4790000021457672}],"concepts":[{"id":"https://openalex.org/C36823959","wikidata":"https://www.wikidata.org/wiki/Q373027","display_name":"Exon","level":3,"score":0.904961347579956},{"id":"https://openalex.org/C94671646","wikidata":"https://www.wikidata.org/wiki/Q207551","display_name":"Intron","level":3,"score":0.8008946180343628},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7711465954780579},{"id":"https://openalex.org/C138626823","wikidata":"https://www.wikidata.org/wiki/Q916504","display_name":"Chromosomal translocation","level":3,"score":0.7216401696205139},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.7087410092353821},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.6712902784347534},{"id":"https://openalex.org/C156446351","wikidata":"https://www.wikidata.org/wiki/Q7682435","display_name":"Tandem exon duplication","level":4,"score":0.5168440937995911},{"id":"https://openalex.org/C91779695","wikidata":"https://www.wikidata.org/wiki/Q3780824","display_name":"Coding region","level":3,"score":0.4584585726261139},{"id":"https://openalex.org/C39917842","wikidata":"https://www.wikidata.org/wiki/Q1384125","display_name":"Exon trapping","level":5,"score":0.4132333993911743},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3753528892993927},{"id":"https://openalex.org/C194583182","wikidata":"https://www.wikidata.org/wiki/Q21114084","display_name":"Alternative splicing","level":4,"score":0.1261889934539795}],"mesh":[{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002880","descriptor_name":"Chromosomes, Human, Pair 11","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005091","descriptor_name":"Exons","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007438","descriptor_name":"Introns","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012091","descriptor_name":"Repetitive Sequences, Nucleic Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014178","descriptor_name":"Translocation, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D054198","descriptor_name":"Precursor Cell Lymphoblastic Leukemia-Lymphoma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1046/j.1365-2141.1996.d01-1748.x","doi":"https://doi.org/10.1046/j.1365-2141.1996.d01-1748.x","is_oa":false,"landing_page_url":"https://doi.org/10.1046/j.1365-2141.1996.d01-1748.x","pdf_url":null,"source":{"id":"https://openalex.org/S153015021","display_name":"British Journal of Haematology","issn_l":"0007-1048","issn":["0007-1048","1365-2141"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Haematology","raw_type":"journal-article"},{"id":"pmid:8703835","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8703835","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British journal of haematology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8199999928474426,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":11,"referenced_works":["https://openalex.org/W198522398","https://openalex.org/W1982640053","https://openalex.org/W2034081121","https://openalex.org/W2037775998","https://openalex.org/W2052985326","https://openalex.org/W2079604568","https://openalex.org/W2091020352","https://openalex.org/W2154215238","https://openalex.org/W2241166952","https://openalex.org/W2438479965","https://openalex.org/W3143099716"],"related_works":["https://openalex.org/W1732851998","https://openalex.org/W2121179361","https://openalex.org/W2316413722","https://openalex.org/W1550707773","https://openalex.org/W2132947105","https://openalex.org/W1982640053","https://openalex.org/W1997670036","https://openalex.org/W2007402803","https://openalex.org/W2405158460","https://openalex.org/W2071916629"],"abstract_inverted_index":{"The":[0,106,120,134],"acute":[1,24],"lymphoblastic":[2],"leukaemia":[3],"(ALL)-1":[4],"gene":[5,39,56,152],"on":[6],"human":[7],"chromosome":[8],"11q23":[9],"is":[10],"the":[11,37,42,55,91,100,104,123,137,144,151,155,166],"site":[12],"of":[13,23,45,58,73,82,90,103,122,143,150,165],"many":[14],"locally":[15],"clustered":[16],"chromosomal":[17],"alterations":[18,149],"associated":[19],"with":[20],"several":[21],"types":[22],"leukaemias,":[25],"including":[26],"deletions,":[27],"partial":[28],"duplications":[29],"and":[30,97,99,113,128,146,159],"translocations.":[31],"Structurally":[32],"variant":[33],"proteins":[34],"derived":[35],"from":[36],"altered":[38],"presumably":[40,162],"cause":[41],"malignant":[43],"transformation":[44],"early":[46],"haemopoietic":[47],"progenitor":[48],"cells.":[49],"According":[50],"to":[51],"previously":[52],"published":[53],"reports,":[54],"consisted":[57],"at":[59],"least":[60],"21":[61],"exons":[62,84,95,110],"spread":[63],"over":[64],"approximately":[65],"100":[66],"kb.":[67],"In":[68],"this":[69],"report":[70],"a":[71,80,114,140],"set":[72],"genomic":[74],"fragments":[75],"was":[76,118,132],"isolated":[77],"that":[78,153],"represent":[79],"total":[81],"35":[83],"(exons":[85],"3-37)":[86],"encompassing":[87],">":[88],"95%":[89],"protein-coding":[92],"region":[93,102],"(except":[94],"1":[96],"2)":[98],"3'-non-translated":[101],"gene.":[105],"distances":[107],"between":[108],"these":[109],"were":[111,126],"determined":[112],"detailed":[115],"restriction":[116],"map":[117],"produced.":[119],"majority":[121],"exon/intron":[124],"boundaries":[125],"sequenced":[127],"an":[129],"intron-phase":[130],"analysis":[131],"performed.":[133],"results":[135],"form":[136],"basis":[138],"for":[139],"greater":[141],"understanding":[142],"translocations":[145],"other":[147],"structural":[148],"conserve":[154],"open":[156],"reading":[157],"frame":[158],"thus":[160],"produce":[161],"oncogenic":[163],"variants":[164],"ALL-1":[167],"protein.":[168]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":3},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
