{"id":"https://openalex.org/W1992343398","doi":"https://doi.org/10.1097/hjh.0b013e32834a8a25","title":"Varying patterns of the antihypertensive and antialbuminuric response to higher doses of renin\u2013angiotensin\u2013aldosterone system blockade in albuminuric hypertensive type 2 diabetes mellitus patients","display_name":"Varying patterns of the antihypertensive and antialbuminuric response to higher doses of renin\u2013angiotensin\u2013aldosterone system blockade in albuminuric hypertensive type 2 diabetes mellitus patients","publication_year":2011,"publication_date":"2011-10-01","ids":{"openalex":"https://openalex.org/W1992343398","doi":"https://doi.org/10.1097/hjh.0b013e32834a8a25","mag":"1992343398","pmid":"https://pubmed.ncbi.nlm.nih.gov/21841500"},"language":"en","primary_location":{"id":"doi:10.1097/hjh.0b013e32834a8a25","doi":"https://doi.org/10.1097/hjh.0b013e32834a8a25","is_oa":false,"landing_page_url":"https://doi.org/10.1097/hjh.0b013e32834a8a25","pdf_url":null,"source":{"id":"https://openalex.org/S115964404","display_name":"Journal of Hypertension","issn_l":"0263-6352","issn":["0263-6352","1473-5598"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Hypertension","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Matthew R. Weir","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I126744593","display_name":"University of Maryland, Baltimore","ror":"https://ror.org/04rq5mt64","country_code":"US","type":"education","lineage":["https://openalex.org/I126744593"]},{"id":"https://openalex.org/I1315496137","display_name":"University of Maryland Medical Center","ror":"https://ror.org/00sde4n60","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1315496137","https://openalex.org/I14285509"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Matthew R. Weir","raw_affiliation_strings":["Department of Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA. mweir@medicine.umaryland.edu","Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland","e-mail: [email\u00a0protected]","fax: +1 410 328 5685","to Matthew R. Weir, MD, Division of Nephrology, University of Maryland School of Medicine Medical Center, 22 South Greene Street, Room N3W143, Baltimore, MD 21201, USATel: +1 410 328 5720"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA. mweir@medicine.umaryland.edu","institution_ids":["https://openalex.org/I126744593"]},{"raw_affiliation_string":"Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland","institution_ids":["https://openalex.org/I126744593"]},{"raw_affiliation_string":"e-mail: [email\u00a0protected]","institution_ids":[]},{"raw_affiliation_string":"fax: +1 410 328 5685","institution_ids":[]},{"raw_affiliation_string":"to Matthew R. Weir, MD, Division of Nephrology, University of Maryland School of Medicine Medical Center, 22 South Greene Street, Room N3W143, Baltimore, MD 21201, USATel: +1 410 328 5720","institution_ids":["https://openalex.org/I126744593","https://openalex.org/I1315496137"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113527981","display_name":"Norman K. Hollenberg","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Norman K. Hollenberg","raw_affiliation_strings":["Department of Medicine and Radiology, Brigham and Women's Hospital, Boston, Massachusetts, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine and Radiology, Brigham and Women's Hospital, Boston, Massachusetts, USA","institution_ids":["https://openalex.org/I1283280774"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023556434","display_name":"Giuseppe Remuzzi","orcid":"https://orcid.org/0000-0002-6194-3446","observed_orcids":["https://orcid.org/0000-0002-6194-3446"]},"institutions":[{"id":"https://openalex.org/I19630809","display_name":"Mario Negri Institute for Pharmacological Research","ror":"https://ror.org/05aspc753","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I19630809","https://openalex.org/I4210110338","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Giuseppe Remuzzi","raw_affiliation_strings":["Mario Negri Institute for Pharmacological Research, Bergamo, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mario Negri Institute for Pharmacological Research, Bergamo, Italy","institution_ids":["https://openalex.org/I19630809"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113120505","display_name":"Dion Zappe","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Dion H. Zappe","raw_affiliation_strings":["Novartis Pharmaceuticals, East Hanover, New Jersey, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Novartis Pharmaceuticals, East Hanover, New Jersey, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101721800","display_name":"Xiangyi Meng","orcid":"https://orcid.org/0000-0002-2034-4551","observed_orcids":["https://orcid.org/0000-0002-2034-4551"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xiangyi Meng","raw_affiliation_strings":["Novartis Pharmaceuticals, East Hanover, New Jersey, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Novartis Pharmaceuticals, East Hanover, New Jersey, USA","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109208822","display_name":"Hans\u2010Henrik Parving","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802709434","display_name":"Rigshospitalet","ror":"https://ror.org/03mchdq19","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2802567020","https://openalex.org/I2802709434","https://openalex.org/I4210145385"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Hans-Henrik Parving","raw_affiliation_strings":["Department of Medical Endocrinology, Rigshospitalet, Copenhagen, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Endocrinology, Rigshospitalet, Copenhagen, Denmark","institution_ids":["https://openalex.org/I2802709434"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I126744593","https://openalex.org/I1315496137"],"apc_list":null,"apc_paid":null,"fwci":0.6584,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.75223765,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"29","issue":"10","first_page":"2031","last_page":"2037"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11001","display_name":"Renin-Angiotensin System Studies","score":0.4000999927520752,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11001","display_name":"Renin-Angiotensin System Studies","score":0.4000999927520752,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10144","display_name":"Blood Pressure and Hypertension Studies","score":0.3127000033855438,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10408","display_name":"Chronic Kidney Disease and Diabetes","score":0.25369998812675476,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/valsartan","display_name":"valsartan","score":0.8289999961853027},{"id":"https://openalex.org/keywords/renin-angiotensin-aldosterone-system-blockade","display_name":"renin-angiotensin-aldosterone system blockade","score":0.9940000176429749},{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.972000002861023},{"id":"https://openalex.org/keywords/hypertension","display_name":"hypertension","score":0.722000002861023},{"id":"https://openalex.org/keywords/albuminuria","display_name":"albuminuria","score":0.9359999895095825},{"id":"https://openalex.org/keywords/urinary-albumin-excretion-rate","display_name":"urinary albumin excretion rate","score":0.9760000109672546},{"id":"https://openalex.org/keywords/blood-pressure-reduction","display_name":"blood pressure reduction","score":0.8029999732971191},{"id":"https://openalex.org/keywords/dose-response-relationship","display_name":"dose-response relationship","score":0.6710000038146973},{"id":"https://openalex.org/keywords/antihypertensive-drug-response","display_name":"antihypertensive drug response","score":0.6940000057220459}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9473600387573242},{"id":"https://openalex.org/C2777387769","wikidata":"https://www.wikidata.org/wiki/Q155472","display_name":"Valsartan","level":3,"score":0.9188462495803833},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.5898275375366211},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.577690601348877},{"id":"https://openalex.org/C198710026","wikidata":"https://www.wikidata.org/wiki/Q898218","display_name":"Renin\u2013angiotensin system","level":3,"score":0.5036086440086365},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.474293977022171},{"id":"https://openalex.org/C2778525890","wikidata":"https://www.wikidata.org/wiki/Q184564","display_name":"Aldosterone","level":2,"score":0.4658409357070923},{"id":"https://openalex.org/C126894567","wikidata":"https://www.wikidata.org/wiki/Q105650","display_name":"Urology","level":1,"score":0.4629455804824829},{"id":"https://openalex.org/C2776174234","wikidata":"https://www.wikidata.org/wiki/Q974792","display_name":"Albuminuria","level":3,"score":0.43940481543540955},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.4266423285007477},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4139673113822937}],"mesh":[{"descriptor_ui":"D000068756","descriptor_name":"Valsartan","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000419","descriptor_name":"Albuminuria","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D000419","descriptor_name":"Albuminuria","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D000419","descriptor_name":"Albuminuria","qualifier_ui":"Q000652","qualifier_name":"urine","is_major_topic":false},{"descriptor_ui":"D000959","descriptor_name":"Antihypertensive Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D001794","descriptor_name":"Blood Pressure","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004311","descriptor_name":"Double-Blind Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006973","descriptor_name":"Hypertension","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D006973","descriptor_name":"Hypertension","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D006973","descriptor_name":"Hypertension","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012084","descriptor_name":"Renin-Angiotensin System","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D013777","descriptor_name":"Tetrazoles","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D014633","descriptor_name":"Valine","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D014633","descriptor_name":"Valine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1097/hjh.0b013e32834a8a25","doi":"https://doi.org/10.1097/hjh.0b013e32834a8a25","is_oa":false,"landing_page_url":"https://doi.org/10.1097/hjh.0b013e32834a8a25","pdf_url":null,"source":{"id":"https://openalex.org/S115964404","display_name":"Journal of Hypertension","issn_l":"0263-6352","issn":["0263-6352","1473-5598"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Hypertension","raw_type":"journal-article"},{"id":"pmid:21841500","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21841500","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of hypertension","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":19,"referenced_works":["https://openalex.org/W1968445120","https://openalex.org/W1997932141","https://openalex.org/W2003670762","https://openalex.org/W2031534703","https://openalex.org/W2051473531","https://openalex.org/W2059911502","https://openalex.org/W2064025400","https://openalex.org/W2108595845","https://openalex.org/W2111374000","https://openalex.org/W2125431201","https://openalex.org/W2138910414","https://openalex.org/W2139851703","https://openalex.org/W2140926653","https://openalex.org/W2148719618","https://openalex.org/W2149054302","https://openalex.org/W2157527675","https://openalex.org/W2157934116","https://openalex.org/W2162061026","https://openalex.org/W3021250193"],"related_works":["https://openalex.org/W2051473531","https://openalex.org/W166874866","https://openalex.org/W2171406274","https://openalex.org/W2118286022","https://openalex.org/W2409907624","https://openalex.org/W2064025400","https://openalex.org/W3139615875","https://openalex.org/W2136948246","https://openalex.org/W2140172772","https://openalex.org/W1492141966"],"abstract_inverted_index":{"OBJECTIVE:":[0],"In":[1],"patients":[2,32,55,78,87,124,239,244],"with":[3,38,56,170,240,252],"type":[4],"2":[5],"diabetes":[6],"mellitus":[7],"(T2DM),":[8],"blocking":[9],"of":[10,49,53,61,65,92,131,146,192,217,223,275],"the":[11,59,66,72,156,234,263],"renin-angiotensin-aldosterone":[12],"system":[13],"(RAAS)":[14],"has":[15],"demonstrated":[16,150],"efficacy":[17],"in":[18,41,77,114,153,238,247,255,260,266],"lowering":[19],"blood":[20],"pressure":[21],"(BP)":[22],"and":[23,43,74,159,178,257,271],"urinary":[24],"albumin":[25],"excretion":[26],"rate":[27],"(UAER).":[28],"Nonetheless,":[29],"not":[30,226],"all":[31,202,243],"successfully":[33,245],"respond":[34,246],"to":[35,70,101,129,161,190,228,249],"RAAS":[36,67,250],"blockade":[37,251],"a":[39,50,89,97],"reduction":[40,113],"BP":[42,73,256,261],"UAER.":[44,258],"METHODS:":[45],"This":[46],"secondary":[47],"analysis":[48],"double-blind":[51],"study":[52,193],"391":[54],"T2DM":[57],"assessed":[58],"importance":[60],"using":[62],"higher":[63,207],"doses":[64,145,209,222],"blocker":[68],"valsartan":[69,93,133,147,171,203,208,224,268],"improve":[71],"UAER":[75],"response":[76],"initially":[79],"identified":[80],"as":[81,104],"prompt":[82,106,157,235,269],"or":[83,112,119,137],"delayed":[84,120,184,230,272],"responders.":[85],"All":[86,123],"received":[88],"starting":[90],"dose":[91],"160":[94,172],"mg":[95,180],"for":[96,140],"4-week":[98],"run-in":[99],"period":[100],"classify":[102],"them":[103],"either":[105],"responders":[107,121,158,270,273],"(SBP":[108],"<":[109,176],"130":[110],"mmHg":[111],"SBP":[115,154,163,186],"\u226510":[116],"mmHg,":[117,174,197],"53%)":[118],"(47%).":[122],"were":[125,194],"then":[126],"subsequently":[127],"randomized":[128],"one":[130],"three":[132],"doses:":[134],"160,":[135],"320,":[136],"640":[138],"mg/day":[139],"26":[141],"weeks.":[142],"RESULTS:":[143],"Higher":[144,221],"(640":[148],"mg)":[149],"additional":[151],"reductions":[152,164,187,212,254],"among":[155],"led":[160],"greater":[162],"from":[165,188],"baseline":[166,189],"(19.8":[167],"mmHg)":[168],"compared":[169],"(14.4":[173],"P":[175,198],"0.05)":[177,200],"320":[179],"(16.5":[181],"mmHg).":[182],"Among":[183],"responders,":[185,231],"end":[191],"similar":[195],"(11-14":[196],">":[199],"across":[201],"doses.":[204],"For":[205],"UAER,":[206],"produced":[210],"further":[211],"by":[213],"week":[214],"30,":[215],"regardless":[216],"initial":[218],"response.":[219],"CONCLUSION:":[220],"did":[225],"appear":[227],"recruit":[229],"but":[232],"enhanced":[233],"responder":[236],"effects":[237],"T2DM.":[241],"Not":[242],"concordance":[248],"both":[253,267],"Reduction":[259],"dominates":[262],"antialbuminuric":[264],"effect":[265],"independent":[274],"dose.":[276]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}